{"id":"https://openalex.org/W2019490673","doi":"https://doi.org/10.1074/jbc.273.33.20828","title":"Endosomal Recycling of the Na+/H+Exchanger NHE3 Isoform Is Regulated by the Phosphatidylinositol 3-Kinase Pathway","display_name":"Endosomal Recycling of the Na+/H+Exchanger NHE3 Isoform Is Regulated by the Phosphatidylinositol 3-Kinase Pathway","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W2019490673","doi":"https://doi.org/10.1074/jbc.273.33.20828","mag":"2019490673","pmid":"https://pubmed.ncbi.nlm.nih.gov/9694828"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.33.20828","doi":"https://doi.org/10.1074/jbc.273.33.20828","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.33.20828","pdf_url":"http://www.jbc.org/article/S0021925818489211/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818489211/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002342142","display_name":"Kazuyoshi Kurashima","orcid":"https://orcid.org/0000-0002-1076-2549","observed_orcids":["https://orcid.org/0000-0002-1076-2549"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Kurashima","raw_affiliation_strings":["Cell Biology Programme, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Programme, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043893408","display_name":"El\u00f6d Z. Szab\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"El\u00f6d Z. Szab\u00f3","raw_affiliation_strings":["Department of Physiology, McGill University, Montre\u0301al, Que\u0301bec H3G 1Y6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, McGill University, Montre\u0301al, Que\u0301bec H3G 1Y6, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052136826","display_name":"Gergely L. Luk\u00e1cs","orcid":"https://orcid.org/0000-0003-0900-0675","observed_orcids":["https://orcid.org/0000-0003-0900-0675"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gergely Lukacs","raw_affiliation_strings":["Cell Biology Programme, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Programme, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081564951","display_name":"John Orlowski","orcid":"https://orcid.org/0000-0001-7371-175X","observed_orcids":["https://orcid.org/0000-0001-7371-175X"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Orlowski","raw_affiliation_strings":["Department of Physiology, McGill University, Montre\u0301al, Que\u0301bec H3G 1Y6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, McGill University, Montre\u0301al, Que\u0301bec H3G 1Y6, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063705444","display_name":"Sergio Grinstein","orcid":"https://orcid.org/0000-0002-0795-4160","observed_orcids":["https://orcid.org/0000-0002-0795-4160"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sergio Grinstein","raw_affiliation_strings":["Cell Biology Programme, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Programme, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada","institution_ids":["https://openalex.org/I2801317318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063705444"],"corresponding_institution_ids":["https://openalex.org/I2801317318"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.8802,"has_fulltext":true,"cited_by_count":158,"citation_normalized_percentile":{"value":0.94142463,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"273","issue":"33","first_page":"20828","last_page":"20836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nhe3","display_name":"NHE3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.9750000238418579},{"id":"https://openalex.org/keywords/endosomal-recycling","display_name":"endosomal recycling","score":0.9120000004768372},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9980000257492065},{"id":"https://openalex.org/keywords/proton-extrusion","display_name":"proton extrusion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.809860110282898},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.698714017868042},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.684246301651001},{"id":"https://openalex.org/C114574056","wikidata":"https://www.wikidata.org/wiki/Q7553395","display_name":"Sodium\u2013hydrogen antiporter","level":3,"score":0.6782784461975098},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5864194631576538},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5565723180770874},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5212967395782471},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2382436990737915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20949608087539673},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.09628063440322876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09135282039642334},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077191","descriptor_name":"Wortmannin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.273.33.20828","doi":"https://doi.org/10.1074/jbc.273.33.20828","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.33.20828","pdf_url":"http://www.jbc.org/article/S0021925818489211/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9694828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9694828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.mcgill.ca:rn3016764","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.mcgill.ca/concern/articles/rn3016764","pdf_url":null,"source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:mcgill.scholaris.ca:20.500.14905/80848","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14905/80848","pdf_url":null,"source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"https://vocabularies.coar-repositories.org/resource_types/c_6501/"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.33.20828","doi":"https://doi.org/10.1074/jbc.273.33.20828","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.33.20828","pdf_url":"http://www.jbc.org/article/S0021925818489211/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320319947","display_name":"Kidney Foundation of Canada","ror":"https://ror.org/019a0gk53"},{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019490673.pdf","grobid_xml":"https://content.openalex.org/works/W2019490673.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W9261019","https://openalex.org/W1481519187","https://openalex.org/W1525701947","https://openalex.org/W1529396499","https://openalex.org/W1551443142","https://openalex.org/W1554578780","https://openalex.org/W1557874430","https://openalex.org/W1572775048","https://openalex.org/W1583256888","https://openalex.org/W1712871378","https://openalex.org/W1732973792","https://openalex.org/W1818313483","https://openalex.org/W1831695206","https://openalex.org/W1954929088","https://openalex.org/W1981260497","https://openalex.org/W1982437598","https://openalex.org/W1982620154","https://openalex.org/W1982683257","https://openalex.org/W1983768617","https://openalex.org/W1997316859","https://openalex.org/W2000298437","https://openalex.org/W2013131355","https://openalex.org/W2017734122","https://openalex.org/W2025998518","https://openalex.org/W2031928941","https://openalex.org/W2033936610","https://openalex.org/W2043206871","https://openalex.org/W2046836400","https://openalex.org/W2051562673","https://openalex.org/W2057734442","https://openalex.org/W2078450213","https://openalex.org/W2078564480","https://openalex.org/W2086811440","https://openalex.org/W2094180395","https://openalex.org/W2100943227","https://openalex.org/W2103642422","https://openalex.org/W2110609540","https://openalex.org/W2145782063","https://openalex.org/W2155653958","https://openalex.org/W2157189324","https://openalex.org/W2164098579","https://openalex.org/W2167897285","https://openalex.org/W2180589711","https://openalex.org/W2397137157","https://openalex.org/W2404142064","https://openalex.org/W2411726527","https://openalex.org/W2426284719","https://openalex.org/W2442275722"],"related_works":["https://openalex.org/W2026489455","https://openalex.org/W7099451962","https://openalex.org/W1972598425","https://openalex.org/W575483703","https://openalex.org/W2167897285","https://openalex.org/W2132812934","https://openalex.org/W2055941645","https://openalex.org/W2004104084","https://openalex.org/W1973480659","https://openalex.org/W1998626317"],"abstract_inverted_index":{"The":[0,97,179],"NHE3":[1,32,108,126,174,185,209],"isoform":[2],"of":[3,31,46,56,80,100,117,125,170,172,184,201],"the":[4,10,29,43,52,70,88,101,115,128,161,168,176,197,202],"Na+/H+":[5],"exchanger":[6],"localizes":[7],"to":[8,175],"both":[9,77],"plasmalemmal":[11],"and":[12,18,54,75,94,131,143,182,216],"endosomal":[13,71],"compartments":[14,35],"in":[15,50,65,69,91,134,167],"polarized":[16],"epithelial":[17],"transfected":[19,151],"Chinese":[20],"hamster":[21],"ovary":[22],"(AP-1)":[23],"cells.":[24,111],"It":[25],"is":[26,36,211],"unclear":[27],"how":[28],"distribution":[30,55,99],"between":[33],"these":[34],"regulated.":[37],"In":[38,112],"this":[39,59],"study,":[40],"we":[41],"examined":[42],"potential":[44],"involvement":[45],"phosphatidylinositol":[47],"3'-kinase":[48],"(PI3-K)":[49],"regulating":[51],"activity":[53,210],"NHE3,":[57],"as":[58,138],"lipid":[60],"kinase":[61],"has":[62],"been":[63],"implicated":[64],"modulating":[66],"vesicular":[67],"traffic":[68],"recycling":[72,171,217],"pathway.":[73],"Wortmannin":[74],"LY294002,":[76],"potent":[78],"inhibitors":[79],"PI3-K,":[81],"markedly":[82],"inhibited":[83],"NHE3-mediated":[84],"H+":[85],"extrusion":[86],"across":[87],"plasma":[89],"membrane":[90],"a":[92,122,165],"concentration-":[93],"time-dependent":[95],"manner.":[96],"subcellular":[98],"antiporters":[102,153],"was":[103],"monitored":[104],"by":[105,140,213,222],"transfecting":[106],"epitope-tagged":[107],"into":[109],"AP-1":[110],"parallel":[113],"with":[114,152,196],"inhibition":[116,181],"transport,":[118],"PI3-K":[119],"antagonists":[120],"induced":[121],"pronounced":[123],"loss":[124],"from":[127],"cell":[129,177],"surface":[130],"its":[132],"accumulation":[133],"an":[135,155],"intracellular":[136,173],"compartment,":[137],"assessed":[139],"immunofluorescence":[141],"microscopy":[142],"enzyme-linked":[144],"immunosorbent":[145],"assays.":[146],"Further":[147],"analysis":[148],"using":[149],"cells":[150,189],"bearing":[154],"external":[156],"epitope":[157],"tag":[158],"revealed":[159],"that":[160,208,219],"redistribution":[162,183],"reflected":[163],"primarily":[164],"decrease":[166],"rate":[169],"surface.":[178],"wortmannin-induced":[180],"were":[186,190],"prevented":[187],"when":[188],"incubated":[191],"at":[192],"4":[193],"degreesC,":[194],"consistent":[195],"known":[198],"temperature":[199],"dependence":[200],"endocytic":[203,215],"process.":[204],"These":[205],"observations":[206],"demonstrate":[207],"controlled":[212],"dynamic":[214],"events":[218],"are":[220],"modulated":[221],"PI3-K.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}