{"id":"https://openalex.org/W2019480901","doi":"https://doi.org/10.1016/j.ajem.2008.05.004","title":"Combination pharmacotherapy in the treatment of experimental cardiac arrest","display_name":"Combination pharmacotherapy in the treatment of experimental cardiac arrest","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W2019480901","doi":"https://doi.org/10.1016/j.ajem.2008.05.004","mag":"2019480901","pmid":"https://pubmed.ncbi.nlm.nih.gov/19751621"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajem.2008.05.004","doi":"https://doi.org/10.1016/j.ajem.2008.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ajem.2008.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S172125442","display_name":"The American Journal of Emergency Medicine","issn_l":"0735-6757","issn":["0735-6757","1532-8171"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Emergency Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035104463","display_name":"Theodoros T Xanthos","orcid":"https://orcid.org/0000-0003-3670-9305","observed_orcids":["https://orcid.org/0000-0003-3670-9305"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Theodoros Xanthos","raw_affiliation_strings":["Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece. theodorosxanthos@yahoo.com","Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece. theodorosxanthos@yahoo.com","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037979609","display_name":"Eleni Bassiakou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Bassiakou","raw_affiliation_strings":["Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111472622","display_name":"Eleni Koudouna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Koudouna","raw_affiliation_strings":["Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009579049","display_name":"Georgios Rokas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Rokas","raw_affiliation_strings":["Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050613742","display_name":"Sotirios Goulas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Sotirios Goulas","raw_affiliation_strings":["Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046051185","display_name":"Ismene A. Dontas","orcid":"https://orcid.org/0000-0002-2440-0119","observed_orcids":["https://orcid.org/0000-0002-2440-0119"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ismene Dontas","raw_affiliation_strings":["Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040915682","display_name":"Evaggelia Kouskouni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evaggelia Kouskouni","raw_affiliation_strings":["Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064466570","display_name":"Despina N Perrea","orcid":"https://orcid.org/0000-0002-1396-6184","observed_orcids":["https://orcid.org/0000-0002-1396-6184"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Despina Perrea","raw_affiliation_strings":["Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110118647","display_name":"Lila Papadimitriou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Lila Papadimitriou","raw_affiliation_strings":["Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery and Surgical Research, University of Athens, Medical School, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200777214"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":5.0578,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.94612714,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"6","first_page":"651","last_page":"659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiopulmonary-resuscitation","display_name":"cardiopulmonary resuscitation","score":0.902999997138977},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"ventricular fibrillation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.8939999938011169},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":0.9950000047683716},{"id":"https://openalex.org/keywords/levosimendan","display_name":"levosimendan","score":0.9890000224113464},{"id":"https://openalex.org/keywords/combination-pharmacotherapy","display_name":"combination pharmacotherapy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6679999828338623},{"id":"https://openalex.org/keywords/troponin-i","display_name":"troponin I","score":0.765999972820282},{"id":"https://openalex.org/keywords/s100-protein","display_name":"S-100 protein","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neuron-specific-enolase","display_name":"neuron-specific enolase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurological-outcome","display_name":"neurological outcome","score":0.7229999899864197},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9214932322502136},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.839331328868866},{"id":"https://openalex.org/C2776525901","wikidata":"https://www.wikidata.org/wiki/Q411325","display_name":"Atenolol","level":3,"score":0.8199650049209595},{"id":"https://openalex.org/C2777055891","wikidata":"https://www.wikidata.org/wiki/Q185325","display_name":"Cardiopulmonary resuscitation","level":3,"score":0.815644383430481},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.736657977104187},{"id":"https://openalex.org/C2777335384","wikidata":"https://www.wikidata.org/wiki/Q162541","display_name":"Levosimendan","level":3,"score":0.6320976614952087},{"id":"https://openalex.org/C2777795826","wikidata":"https://www.wikidata.org/wiki/Q954202","display_name":"Defibrillation","level":2,"score":0.627371072769165},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.6112539172172546},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.5519586801528931},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.44581273198127747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37451523542404175},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32472872734069824},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09948855638504028},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.07089319825172424}],"mesh":[{"descriptor_ui":"D000077464","descriptor_name":"Simendan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009418","descriptor_name":"S100 Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ajem.2008.05.004","doi":"https://doi.org/10.1016/j.ajem.2008.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ajem.2008.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S172125442","display_name":"The American Journal of Emergency Medicine","issn_l":"0735-6757","issn":["0735-6757","1532-8171"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Emergency Medicine","raw_type":"journal-article"},{"id":"pmid:19751621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19751621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of emergency medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W205152666","https://openalex.org/W1963838778","https://openalex.org/W1971467312","https://openalex.org/W1983477070","https://openalex.org/W1986175383","https://openalex.org/W1987430653","https://openalex.org/W2007532628","https://openalex.org/W2016543754","https://openalex.org/W2028055119","https://openalex.org/W2033243117","https://openalex.org/W2041683772","https://openalex.org/W2043546261","https://openalex.org/W2066272863","https://openalex.org/W2071841560","https://openalex.org/W2079613960","https://openalex.org/W2087126519","https://openalex.org/W2098746076","https://openalex.org/W2108435498","https://openalex.org/W2111376231","https://openalex.org/W2114815546","https://openalex.org/W2133488495","https://openalex.org/W2140809979","https://openalex.org/W2140827003","https://openalex.org/W2160779026","https://openalex.org/W2164492024","https://openalex.org/W2164854110","https://openalex.org/W2164884888","https://openalex.org/W2421710437","https://openalex.org/W2917971741"],"related_works":["https://openalex.org/W2108435498","https://openalex.org/W2098746076","https://openalex.org/W2008169345","https://openalex.org/W2377136956","https://openalex.org/W2075462952","https://openalex.org/W2367425326","https://openalex.org/W2302187050","https://openalex.org/W1971450149","https://openalex.org/W2053498636","https://openalex.org/W2099687485"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}