{"id":"https://openalex.org/W2019479727","doi":"https://doi.org/10.1097/00001573-199309000-00006","title":"Epidemiologic, physiologic, and clinical implications of hypertension and insulin resistance","display_name":"Epidemiologic, physiologic, and clinical implications of hypertension and insulin resistance","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W2019479727","doi":"https://doi.org/10.1097/00001573-199309000-00006","mag":"2019479727"},"language":"en","primary_location":{"id":"doi:10.1097/00001573-199309000-00006","doi":"https://doi.org/10.1097/00001573-199309000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001573-199309000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S57372075","display_name":"Current Opinion in Cardiology","issn_l":"0268-4705","issn":["0268-4705","1080-787X","1531-7080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013038053","display_name":"Irene M. O\u2019Shaughnessy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene M. O\u02bcShaughnessy","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005404977","display_name":"Theodore A. Kotchen","orcid":"https://orcid.org/0000-0002-8060-8096","observed_orcids":["https://orcid.org/0000-0002-8060-8096"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore A. Kotchen","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin, USA","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":0.9323,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.75849057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"5","first_page":"757","last_page":"764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.32519999146461487,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9950000047683716},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.640999972820282},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.8629999756813049},{"id":"https://openalex.org/keywords/ion-transport","display_name":"ion transport","score":0.7350000143051147},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.746999979019165},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":0.9490000009536743},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.699999988079071},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9509135484695435},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.8726129531860352},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8579432964324951},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6388176679611206},{"id":"https://openalex.org/C2780437262","wikidata":"https://www.wikidata.org/wiki/Q665843","display_name":"Thiazide","level":3,"score":0.5718312859535217},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5579765439033508},{"id":"https://openalex.org/C57190642","wikidata":"https://www.wikidata.org/wiki/Q7144839","display_name":"Pathophysiology of hypertension","level":3,"score":0.553596019744873},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5395609140396118},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5238960981369019},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4926193356513977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4647127389907837}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00001573-199309000-00006","doi":"https://doi.org/10.1097/00001573-199309000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001573-199309000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S57372075","display_name":"Current Opinion in Cardiology","issn_l":"0268-4705","issn":["0268-4705","1080-787X","1531-7080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cardiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2039412011","https://openalex.org/W2393378262","https://openalex.org/W2987751125","https://openalex.org/W2372035975","https://openalex.org/W1572905580","https://openalex.org/W1964550047","https://openalex.org/W2366041794","https://openalex.org/W1988062963","https://openalex.org/W3214989315","https://openalex.org/W2174743250"],"abstract_inverted_index":{"Hypertension":[0],"and":[1,8,30,54,73,84,109,114],"dyslipidemia":[2],"tend":[3],"to":[4,63,69,78],"cluster":[5],"within":[6],"individuals,":[7],"insulin":[9,28,34,79,107],"resistance":[10,29,35],"may":[11,61,76],"be":[12],"the":[13,82,99,117],"link":[14],"between":[15,27],"these":[16],"two":[17],"cardiovascular":[18,92],"disease":[19,75,93],"risk":[20],"factors.":[21],"However,":[22],"despite":[23],"a":[24],"recognized":[25],"association":[26],"hypertension,":[31],"evidence":[32,68],"that":[33,71],"elevates":[36],"blood":[37],"pressure":[38],"is":[39,67],"inconclusive.":[40],"Insulin":[41],"has":[42],"an":[43],"antinatriuretic":[44],"effect,":[45],"stimulates":[46,55],"sympathetic":[47],"nervous":[48],"system":[49],"activity,":[50],"alters":[51],"ion":[52],"transport,":[53],"cell":[56],"growth,":[57],"all":[58],"of":[59,86,101],"which":[60],"contribute":[62,77],"hypertension.":[64],"Conversely,":[65],"there":[66],"suggest":[70],"hypertension":[72,102],"vascular":[74],"resistance.":[80],"Clinically,":[81],"evaluation":[83],"therapy":[85],"hypertensive":[87],"patients":[88],"should":[89],"address":[90],"overall":[91],"risk.":[94],"Medications":[95],"currently":[96],"available":[97],"for":[98],"treatment":[100],"have":[103],"various":[104],"effects":[105],"on":[106],"sensitivity":[108],"dyslipidemia,":[110],"with":[111],"thiazide":[112],"diuretics":[113],"\u03b2-blockers":[115],"having":[116],"most":[118],"detrimental":[119],"effects.":[120]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
