{"id":"https://openalex.org/W2019458766","doi":"https://doi.org/10.1172/jci110243","title":"Extracellular calcium and cholinergic stimulation of isolated canine parietal cells.","display_name":"Extracellular calcium and cholinergic stimulation of isolated canine parietal cells.","publication_year":1981,"publication_date":"1981-07-01","ids":{"openalex":"https://openalex.org/W2019458766","doi":"https://doi.org/10.1172/jci110243","mag":"2019458766","pmid":"https://pubmed.ncbi.nlm.nih.gov/7251863","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/370794"},"language":"en","primary_location":{"id":"doi:10.1172/jci110243","doi":"https://doi.org/10.1172/jci110243","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110243","pdf_url":"http://www.jci.org/articles/view/110243/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/110243/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083325211","display_name":"Andrew H. Soll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A H Soll","raw_affiliation_strings":["Medical and Research Services and Centerfor Ulcer Research and Education at Veterans Administration Wadsworth Hospital Center , and University of California at Los Angeles , California 90073","Education at Veterans Administration Wadsworth Hospital Center, and University of California at Los Angeles, California 90073","Medical and Research Services and Centerfor Ulcer Research and","Wadsworth Hospital Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Research Services and Centerfor Ulcer Research and Education at Veterans Administration Wadsworth Hospital Center , and University of California at Los Angeles , California 90073","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I161318765"]},{"raw_affiliation_string":"Education at Veterans Administration Wadsworth Hospital Center, and University of California at Los Angeles, California 90073","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Medical and Research Services and Centerfor Ulcer Research and","institution_ids":[]},{"raw_affiliation_string":"Wadsworth Hospital Center","institution_ids":["https://openalex.org/I1339417872"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083325211"],"corresponding_institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I1339417872","https://openalex.org/I161318765"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":2.2935,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.88268606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"68","issue":"1","first_page":"270","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parietal-cells","display_name":"parietal cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/extracellular-calcium","display_name":"extracellular calcium","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cholinergic-stimulation","display_name":"cholinergic stimulation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/carbachol","display_name":"carbachol","score":0.8930000066757202},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.625},{"id":"https://openalex.org/keywords/lanthanum","display_name":"lanthanum","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gastrin","display_name":"gastrin","score":0.7239999771118164},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aminopyrine-accumulation","display_name":"aminopyrine accumulation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/45ca2-uptake","display_name":"45Ca uptake","score":0.8019999861717224},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.7910000085830688},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.7749999761581421},{"id":"https://openalex.org/keywords/gastric-acid-secretion","display_name":"gastric acid secretion","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C2778988552","wikidata":"https://www.wikidata.org/wiki/Q419401","display_name":"Carbachol","level":3,"score":0.8790854215621948},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7411466836929321},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6933867931365967},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6864568591117859},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6862162351608276},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.666659951210022},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6241756081581116},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5933265089988708},{"id":"https://openalex.org/C2779743957","wikidata":"https://www.wikidata.org/wiki/Q1640093","display_name":"Parietal cell","level":4,"score":0.5696464776992798},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.47376683354377747},{"id":"https://openalex.org/C2776986829","wikidata":"https://www.wikidata.org/wiki/Q407181","display_name":"Gastrin","level":3,"score":0.4487553536891937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22792482376098633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1465126872062683},{"id":"https://openalex.org/C2777504413","wikidata":"https://www.wikidata.org/wiki/Q846270","display_name":"Gastric acid","level":3,"score":0.12828466296195984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10396742820739746},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.08378481864929199}],"mesh":[{"descriptor_ui":"D000632","descriptor_name":"Aminopyrine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000632","descriptor_name":"Aminopyrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007811","descriptor_name":"Lanthanum","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci110243","doi":"https://doi.org/10.1172/jci110243","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110243","pdf_url":"http://www.jci.org/articles/view/110243/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1295293","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/370794","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:370794","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/370794","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:7251863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7251863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci110243","doi":"https://doi.org/10.1172/jci110243","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110243","pdf_url":"http://www.jci.org/articles/view/110243/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019458766.pdf","grobid_xml":"https://content.openalex.org/works/W2019458766.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W123764744","https://openalex.org/W1548893495","https://openalex.org/W1990968812","https://openalex.org/W2029347331","https://openalex.org/W2034827961","https://openalex.org/W2041372918","https://openalex.org/W2059657466","https://openalex.org/W2063944756","https://openalex.org/W2067679143","https://openalex.org/W2083334512","https://openalex.org/W2091317847","https://openalex.org/W2102296663","https://openalex.org/W2105563311","https://openalex.org/W2109191216","https://openalex.org/W2122828308","https://openalex.org/W2130105549","https://openalex.org/W2150612129","https://openalex.org/W2231298982","https://openalex.org/W2338986710","https://openalex.org/W2340471737","https://openalex.org/W2396016867","https://openalex.org/W2408107086","https://openalex.org/W2417999608","https://openalex.org/W2462920353","https://openalex.org/W2465503172","https://openalex.org/W2510033977"],"related_works":["https://openalex.org/W7098978787","https://openalex.org/W2472543039","https://openalex.org/W2043498040","https://openalex.org/W2073023290","https://openalex.org/W2179872398","https://openalex.org/W2406736895","https://openalex.org/W2429339949","https://openalex.org/W7096758238","https://openalex.org/W2475128335","https://openalex.org/W2271315921"],"abstract_inverted_index":{"The":[0,119,196],"role":[1],"of":[2,8,11,41,47,64,68,121,136,149,154,170,198,208,237,274,291,299,311,317],"calcium":[3,107,128,141,200,242,266,293,318],"gating":[4],"in":[5,34,71,105,267],"cholinergic":[6,122,321],"stimulation":[7,51,95,123,153,163,174,181,310],"the":[9,39,62,77,83,109,134,204,209],"function":[10,314],"parietal":[12,48,69,205,300,312],"cells":[13,17,70],"was":[14,58,96,130,216,276],"studied":[15],"using":[16],"isolated":[18],"from":[19,222],"canine":[20],"fundic":[21],"mucosa":[22],"by":[23,31,52,56,89,98,115,164,175,182,279,320],"treatment":[24,280],"with":[25,133,157,203,245,262,281],"collagenase":[26],"and":[27,29,179,215,234,239,254,315],"EDTA":[28],"enriched":[30],"velocity":[32],"separation":[33],"an":[35,45],"elutriator":[36],"rotor.":[37],"Monitoring":[38],"accumulation":[40,256],"[14C[":[42],"aminopyrine":[43,155],"as":[44,294],"index":[46],"cell":[49,206,301,313],"response,":[50],"carbachol,":[53,285],"but":[54,188],"not":[55,189,277],"histamine,":[57,282],"highly":[59],"dependent":[60],"upon":[61],"concentration":[63,169],"extracellular":[65,106,127],"calcium.":[66,137],"Incubation":[67],"0-.1":[72],"mM":[73,80],"calcium,":[74],"rather":[75],"than":[76],"usual":[78],"1.8":[79],"concentration,":[81],"reduced":[82],"response":[84,110],"to":[85,111,225,288],"100":[86,158],"microM":[87,159,224],"carbachol":[88,162,220,238],"92":[90],"+/-":[91,100,117,166,177,185],"2%,":[92],"whereas":[93],"histamine":[94,180,190],"impaired":[97],"28":[99],"5%.":[101],"A":[102],"similar":[103,147],"reduction":[104],"suppressed":[108,172],"gastrin":[112,173],"(100":[113,229],"nM)":[114,230],"67":[116],"7%.":[118],"impairment":[120],"found":[124],"at":[125],"low":[126],"concentrations":[129,221],"rapidly":[131],"reversed":[132],"readdition":[135],"Lanthanum,":[138],"which":[139],"blocks":[140],"movement":[142],"across":[143],"membranes,":[144],"caused":[145,231],"a":[146,268,306],"pattern":[148],"effects":[150,236,247],"on":[151,241,248],"secretagogue":[152],"accumulation,":[156],"lanthanum":[160,171],"suppressing":[161],"83":[165],"2%.":[167],"This":[168],"40":[176],"7%":[178],"only":[183],"12":[184],"9%.":[186],"Carbachol,":[187],"nor":[191],"gastrin,":[192,283],"stimulated":[193],"45Ca++":[194,263],"uptake.":[195],"magnitude":[197],"carbachol-stimulated":[199],"uptake":[201,243],"correlated":[202,244],"content":[207],"fractions":[210],"examined":[211],"(r":[212,251,257],"=":[213,252,258],"0.88),":[214],"dose":[217],"responsive":[218],"over":[219],"1":[223,226],"mM.":[227],"Atropine":[228],"surmountable":[232],"inhibition,":[233],"these":[235],"atropine":[240],"their":[246],"oxygen":[249],"consumption":[250],"0.93)":[253],"[14C]-aminopyrine":[255],"0.90).":[259],"Cells":[260],"preloaded":[261],"lost":[264],"cellular":[265],"time-dependent":[269],"fashion;":[270],"however,":[271],"this":[272],"rate":[273],"egress":[275],"accelerated":[278],"or":[284],"thus":[286],"failing":[287],"implicate":[289],"mobilization":[290],"intracellular":[292],"primary":[295],"mechanism":[296],"for":[297],"activation":[298],"function.":[302],"These":[303],"data":[304],"indicate":[305],"close":[307],"link":[308],"between":[309],"enhancement":[316],"influx":[319],"agents.":[322]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}