{"id":"https://openalex.org/W2019376113","doi":"https://doi.org/10.2174/187152007781668742","title":"Oncologists Current Opinion on the Treatment of Colon Carcinoma","display_name":"Oncologists Current Opinion on the Treatment of Colon Carcinoma","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W2019376113","doi":"https://doi.org/10.2174/187152007781668742","mag":"2019376113","pmid":"https://pubmed.ncbi.nlm.nih.gov/17896910"},"language":"en","primary_location":{"id":"doi:10.2174/187152007781668742","doi":"https://doi.org/10.2174/187152007781668742","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187152007781668742","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Agents in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039513955","display_name":"Martin Majer","orcid":"https://orcid.org/0000-0001-7570-0771","observed_orcids":["https://orcid.org/0000-0001-7570-0771"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Majer","raw_affiliation_strings":["Huntsman Cancer Institute, Department of Medicine, University of Utah, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, Department of Medicine, University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016686763","display_name":"Wallace Akerley","orcid":"https://orcid.org/0000-0002-3090-4778","observed_orcids":["https://orcid.org/0000-0002-3090-4778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wallace Akerley","raw_affiliation_strings":["Nevada Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nevada Cancer Institute","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012555125","display_name":"Scott K. Kuwada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott K. Kuwada","raw_affiliation_strings":["Division of Gastroenterology,Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology,Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0178,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.86104611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"5","first_page":"492","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9039999842643738},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7110000252723694},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9369999766349792},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.996999979019165},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":1.0},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":1.0},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chemotherapy-schedule","display_name":"chemotherapy schedule","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8751834034919739},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.7857009768486023},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.7854489088058472},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.7627259492874146},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7488001585006714},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6444008350372314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5585696697235107},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4590626358985901},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4481104612350464},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43868398666381836},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4234321713447571},{"id":"https://openalex.org/C2778332735","wikidata":"https://www.wikidata.org/wiki/Q417775","display_name":"Panitumumab","level":5,"score":0.42004865407943726},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41631433367729187},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/187152007781668742","doi":"https://doi.org/10.2174/187152007781668742","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187152007781668742","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Agents in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:17896910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17896910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-cancer agents in medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2155063664","https://openalex.org/W2126255570","https://openalex.org/W2113993732","https://openalex.org/W2068267954","https://openalex.org/W1975647291","https://openalex.org/W2143125130","https://openalex.org/W2401210616","https://openalex.org/W2073256875","https://openalex.org/W197158564","https://openalex.org/W2013361444"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1],"is":[2,25,52,205],"a":[3,11],"major":[4],"global":[5],"health":[6],"problem":[7],"with":[8,30,39,72,131,144],"more":[9,154],"than":[10,54],"million":[12],"new":[13,32,64,82,86,161],"cases":[14,33],"diagnosed":[15],"worldwide":[16],"in":[17,42,48,62,129,157,226,237],"2005.":[18,43],"In":[19],"the":[20,26,35,49,109,148,158,167,212,228],"United":[21],"States,":[22],"this":[23],"malignancy":[24],"third":[27],"most":[28,37],"common":[29],"145,000":[31],"and":[34,84,89,108,194,220],"second":[36],"lethal":[38],"56,000":[40],"deaths":[41],"Unfortunately,":[44],"preclinical":[45],"diagnostic":[46],"screening":[47],"U.S.":[50],"population":[51],"less":[53],"30-40":[55],"percent.":[56],"The":[57,75,181],"last":[58],"decade":[59],"has":[60,151],"ushered":[61],"exciting":[63],"advances":[65],"for":[66,70,119,170,187,202,218],"medical":[67],"oncologists":[68],"caring":[69],"patients":[71,130,143],"colorectal":[73,121,134,146,238],"cancer.":[74,239],"older":[76],"cytotoxic":[77,172],"chemotherapy":[78,125,173,217],"drug":[79],"5-fluorouracil":[80],"underwent":[81],"formulation,":[83],"two":[85],"drugs,":[87],"oxaliplatine":[88],"irinotecan,":[90],"were":[91,174],"investigated":[92],"as":[93,234],"adjunctive":[94],"therapies.":[95],"Finally,":[96],"targeted":[97],"therapies,":[98],"including":[99],"monoclonal":[100],"antibodies":[101],"against":[102],"vascular":[103],"endothelial":[104],"growth":[105,111],"factor":[106,112],"(bevacizumab)":[107],"epidermal":[110],"receptor":[113],"(cetuximab),":[114],"are":[115],"now":[116],"standard":[117],"treatment":[118],"metastatic":[120,145,221],"carcinoma.":[122],"Systemic":[123],"adjuvant":[124,219],"can":[126],"be":[127],"lifesaving":[128],"locally":[132],"advanced":[133],"carcinomas,":[135],"which":[136],"represent":[137],"60-70":[138],"percent":[139],"of":[140,183,191,231],"cases.":[141],"For":[142],"cancer,":[147],"survival":[149],"rate":[150],"doubled.":[152],"With":[153],"effective":[155],"drugs":[156],"therapeutic":[159,235],"armamentarium,":[160],"controversies":[162],"have":[163,196],"arisen.":[164],"Questions":[165],"regarding":[166],"best":[168],"schedules":[169],"classical":[171],"largely":[175],"answered":[176],"by":[177],"contemporary":[178],"clinical":[179,203],"trials.":[180],"potential":[182],"molecular":[184],"genetic":[185],"markers":[186],"prognosis":[188],"or":[189],"prediction":[190],"drug-specific":[192],"toxicity":[193],"efficacy":[195],"been":[197],"explored,":[198],"but":[199],"their":[200],"utility":[201],"practice":[204],"still":[206],"being":[207],"investigated.":[208],"We":[209,223],"will":[210,224],"review":[211],"rapidly":[213],"changing,":[214],"state-of-the-art":[215],"combination":[216],"disease.":[222],"discuss":[225],"detail":[227],"c-ERBB":[229],"family":[230],"tyrosine":[232],"kinases":[233],"targets":[236]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}