{"id":"https://openalex.org/W2019372820","doi":"https://doi.org/10.3892/or.5.6.1329","title":"Chromosome 10 alterations in prostate adenocarcinoma (review).","display_name":"Chromosome 10 alterations in prostate adenocarcinoma (review).","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W2019372820","doi":"https://doi.org/10.3892/or.5.6.1329","mag":"2019372820","pmid":"https://pubmed.ncbi.nlm.nih.gov/9769364"},"language":"en","primary_location":{"id":"doi:10.3892/or.5.6.1329","doi":"https://doi.org/10.3892/or.5.6.1329","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.5.6.1329","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066263660","display_name":"Michael Ittmann","orcid":"https://orcid.org/0000-0003-4802-0978","observed_orcids":["https://orcid.org/0000-0003-4802-0978"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M M Ittmann","raw_affiliation_strings":["Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066263660"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":2.4568,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.89981651,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"5","issue":"6","first_page":"1329","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/chromosome-10","display_name":"chromosome 10","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9070000052452087},{"id":"https://openalex.org/keywords/10q23","display_name":"10q23","score":0.859000027179718},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.7179999947547913},{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.8450000286102295},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.7993080615997314},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.7188756465911865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7131577730178833},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.712181568145752},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.700566828250885},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.5689030885696411},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4839044511318207},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.436969518661499},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.42821168899536133},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4161493182182312},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3798621892929077},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37383365631103516},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2698397636413574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2410147488117218},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.22500690817832947},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002879","descriptor_name":"Chromosomes, Human, Pair 10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.5.6.1329","doi":"https://doi.org/10.3892/or.5.6.1329","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.5.6.1329","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:9769364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9769364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1951189073","https://openalex.org/W2808785641","https://openalex.org/W82812767","https://openalex.org/W1986093999","https://openalex.org/W2117905749","https://openalex.org/W2186926469","https://openalex.org/W1552645317","https://openalex.org/W2103851244","https://openalex.org/W2562553620","https://openalex.org/W2058733098"],"abstract_inverted_index":{"Inactivations":[0],"of":[1,21,23,34,36,48,105,113,165,178,180,199,208,235],"tumor":[2,29,74,84,187,222,236],"suppressor":[3,30,75,85,188,223,237],"genes":[4,224,238,252],"are":[5,16,60,122,228,242,253],"the":[6,24,28,102,123,196,213],"most":[7],"common":[8],"genetic":[9],"alterations":[10],"in":[11,44,69,161,248],"prostate":[12,49,166,170,191,226,249],"adenocarcinoma.":[13],"Such":[14,119],"inactivations":[15,234],"frequently":[17],"accompanied":[18],"by":[19],"loss":[20,179],"portions":[22,35],"chromosome":[25,240],"on":[26,195,230,239],"which":[27,97,126],"gene":[31,76,86,90,158,189],"resides.":[32],"Loss":[33],"both":[37,138,202,256],"10p":[38],"and":[39,57,66,100,135,141,154,205,219,260],"10q":[40],"have":[41],"been":[42,79],"identified":[43,80],"a":[45,92,110,162],"significant":[46,163],"percentage":[47],"carcinomas,":[50,167],"as":[51,53,81,150,257,261],"well":[52],"other":[54],"malignant":[55],"neoplasms,":[56],"such":[58,149],"losses":[59],"associated":[61,243],"with":[62,99,131,137,244],"advanced":[63,245],"clinical":[64,246],"stage":[65,247],"aggressive":[67],"behavior":[68],"these":[70,251],"neoplasms.":[71],"The":[72,156],"PTEN":[73,157],"has":[77],"recently":[78],"an":[82],"important":[83],"at":[87,125,183,216],"10q23.":[88],"This":[89],"encodes":[91],"dual":[93],"specificity":[94],"protein":[95],"phosphatase":[96],"interacts":[98],"controls":[101],"tyrosine":[103],"phosphorylation":[104],"focal":[106,117,120],"adhesion":[107],"kinase":[108],"(FAK),":[109],"key":[111,147],"regulator":[112],"signal":[114,142],"transduction":[115,143],"via":[116],"adhesions.":[118],"adhesions":[121],"site":[124],"integrins":[127],"cluster":[128],"following":[129],"interactions":[130],"extracellular":[132],"matrix":[133],"ligands":[134],"interact":[136],"cytoskeletal":[139],"proteins":[140],"molecules":[144],"to":[145],"effect":[146],"processes":[148],"cell":[151],"migration,":[152],"spreading":[153],"proliferation.":[155],"is":[159,173,193],"inactivated":[160],"proportion":[164],"particularly":[168],"metastatic":[169],"cancers.":[171],"There":[172],"also":[174],"evidence":[175],"from":[176],"studies":[177,204],"heterozygosity":[181],"that":[182,215,233],"least":[184,217],"one":[185],"additional":[186],"for":[190,225,264],"cancer":[192,227,250],"present":[194,229],"distal":[197],"portion":[198],"10q.":[200],"Similarly,":[201],"functional":[203],"direct":[206],"analysis":[207],"human":[209],"tumors":[210],"strongly":[211],"support":[212],"idea":[214],"one,":[218],"possibly":[220],"two,":[221],"10p.":[231],"Given":[232],"10":[241],"attractive":[254],"candidates":[255],"prognostic":[258],"markers":[259],"potential":[262],"targets":[263],"therapeutic":[265],"intervention.":[266]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
