{"id":"https://openalex.org/W2019367173","doi":"https://doi.org/10.1016/s0022-3476(05)82674-5","title":"Pharmacokinetics, outcome of treatment, and toxic effects of amphotericin B and 5-fluorocytosine in neonates","display_name":"Pharmacokinetics, outcome of treatment, and toxic effects of amphotericin B and 5-fluorocytosine in neonates","publication_year":1990,"publication_date":"1990-05-01","ids":{"openalex":"https://openalex.org/W2019367173","doi":"https://doi.org/10.1016/s0022-3476(05)82674-5","mag":"2019367173","pmid":"https://pubmed.ncbi.nlm.nih.gov/2329429"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-3476(05)82674-5","doi":"https://doi.org/10.1016/s0022-3476(05)82674-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-3476(05)82674-5","pdf_url":null,"source":{"id":"https://openalex.org/S3774022","display_name":"The Journal of Pediatrics","issn_l":"0022-3476","issn":["0022-3476","1085-8695","1097-6833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109036075","display_name":"Jill E. Baley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jill E. Baley","raw_affiliation_strings":["Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, OH 44106","Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, OH 44106","institution_ids":["https://openalex.org/I4210151235"]},{"raw_affiliation_string":"Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025071135","display_name":"Carolyn Meyers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn Meyers","raw_affiliation_strings":["Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089893859","display_name":"Robert M. Kliegman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Kliegman","raw_affiliation_strings":["Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069770283","display_name":"Michael R. Jacobs","orcid":"https://orcid.org/0000-0002-4235-7855","observed_orcids":["https://orcid.org/0000-0002-4235-7855","https://orcid.org/0000-0002-2979-5551"]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Jacobs","raw_affiliation_strings":["Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107447050","display_name":"Jeffrey L. Blumer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey L. Blumer","raw_affiliation_strings":["Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pediatrics Rainbow Babies and Childrens Hospital and Case Western Reserve University, Cleveland, Ohio USA","institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109036075"],"corresponding_institution_ids":["https://openalex.org/I4210151235","https://openalex.org/I58956616"],"apc_list":{"value":4570,"currency":"USD","value_usd":4570},"apc_paid":null,"fwci":2.0873,"has_fulltext":false,"cited_by_count":182,"citation_normalized_percentile":{"value":0.86990204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"116","issue":"5","first_page":"791","last_page":"797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.05609999969601631,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":1.0},{"id":"https://openalex.org/keywords/5-fluorocytosine","display_name":"5-fluorocytosine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9610000252723694},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-drug-concentration","display_name":"cerebrospinal fluid drug concentration","score":0.8529999852180481},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7400000095367432},{"id":"https://openalex.org/keywords/drug-elimination","display_name":"drug elimination","score":0.4779999852180481},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.4429999887943268},{"id":"https://openalex.org/keywords/low-birth-weight-infants","display_name":"low birth weight infants","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dosing-interval","display_name":"dosing interval","score":0.6079999804496765},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9117365479469299},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.7795105576515198},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7203580737113953},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.4676384925842285},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43938812613487244},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4263206720352173},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.3237359821796417},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.08504727482795715},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005437","descriptor_name":"Flucytosine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005437","descriptor_name":"Flucytosine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005437","descriptor_name":"Flucytosine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005437","descriptor_name":"Flucytosine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005437","descriptor_name":"Flucytosine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007230","descriptor_name":"Infant, Low Birth Weight","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-3476(05)82674-5","doi":"https://doi.org/10.1016/s0022-3476(05)82674-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-3476(05)82674-5","pdf_url":null,"source":{"id":"https://openalex.org/S3774022","display_name":"The Journal of Pediatrics","issn_l":"0022-3476","issn":["0022-3476","1085-8695","1097-6833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:2329429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2329429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W130647520","https://openalex.org/W1551302926","https://openalex.org/W1978311942","https://openalex.org/W1995683435","https://openalex.org/W1997032499","https://openalex.org/W2008696558","https://openalex.org/W2008968938","https://openalex.org/W2009323841","https://openalex.org/W2010939732","https://openalex.org/W2035216688","https://openalex.org/W2035302724","https://openalex.org/W2036526096","https://openalex.org/W2040248710","https://openalex.org/W2051996271","https://openalex.org/W2054367260","https://openalex.org/W2075615506","https://openalex.org/W2102868689","https://openalex.org/W2106817934","https://openalex.org/W2120541149","https://openalex.org/W2270919037","https://openalex.org/W2326171482","https://openalex.org/W2430484217","https://openalex.org/W4206627883","https://openalex.org/W6769768378"],"related_works":["https://openalex.org/W2075615506","https://openalex.org/W2054367260","https://openalex.org/W2116359244","https://openalex.org/W2017780628","https://openalex.org/W1965908253","https://openalex.org/W2320097153","https://openalex.org/W2101656115","https://openalex.org/W2087562494","https://openalex.org/W1992638339","https://openalex.org/W2094375983"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
