{"id":"https://openalex.org/W2019359543","doi":"https://doi.org/10.1038/198186a0","title":"Isolation and Characterization of Spleen Acid Deoxyribonuclease","display_name":"Isolation and Characterization of Spleen Acid Deoxyribonuclease","publication_year":1963,"publication_date":"1963-04-01","ids":{"openalex":"https://openalex.org/W2019359543","doi":"https://doi.org/10.1038/198186a0","mag":"2019359543","pmid":"https://pubmed.ncbi.nlm.nih.gov/13971035"},"language":"en","primary_location":{"id":"doi:10.1038/198186a0","doi":"https://doi.org/10.1038/198186a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/198186a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083068771","display_name":"Giorgio Bernardi","orcid":"https://orcid.org/0000-0001-8630-6657","observed_orcids":["https://orcid.org/0000-0001-8630-6657"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GIORGIO BERNARDI","raw_affiliation_strings":["Centre de Recherches sur les Macromol\u00e9cules, Strasbourg, France","Department of Biophysics and Biology, Johns Hopkins University, Baltimore, Md","Department of Biophysics and Biology, Johns Hopkins University, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches sur les Macromol\u00e9cules, Strasbourg, France","institution_ids":[]},{"raw_affiliation_string":"Department of Biophysics and Biology, Johns Hopkins University, Baltimore, Md","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biophysics and Biology, Johns Hopkins University, Baltimore","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058945925","display_name":"Maurice Griffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MAURICE GRIFF\u00c9","raw_affiliation_strings":["Centre de Recherches sur les Macromol\u00e9cules, Strasbourg, France","Department of Biophysics and Biology, Johns Hopkins University, Baltimore, Md","Department of Biophysics and Biology, Johns Hopkins University, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches sur les Macromol\u00e9cules, Strasbourg, France","institution_ids":[]},{"raw_affiliation_string":"Department of Biophysics and Biology, Johns Hopkins University, Baltimore, Md","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biophysics and Biology, Johns Hopkins University, Baltimore","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036354240","display_name":"Ettore Appella","orcid":"https://orcid.org/0000-0003-0569-9722","observed_orcids":["https://orcid.org/0000-0003-0569-9722"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ETTORE APPELLA","raw_affiliation_strings":["Centre de Recherches sur les Macromol\u00e9cules, Strasbourg, France","Department of Biophysics and Biology, Johns Hopkins University, Baltimore, Md","Department of Biophysics and Biology, Johns Hopkins University, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches sur les Macromol\u00e9cules, Strasbourg, France","institution_ids":[]},{"raw_affiliation_string":"Department of Biophysics and Biology, Johns Hopkins University, Baltimore, Md","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biophysics and Biology, Johns Hopkins University, Baltimore","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":2.5506,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89173881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"198","issue":"4876","first_page":"186","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.09910000115633011,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dnase-i","display_name":"DNase I","score":0.7120000123977661},{"id":"https://openalex.org/keywords/dnase-ii","display_name":"DNase II","score":0.7179999947547913},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.828000009059906},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.5600000023841858},{"id":"https://openalex.org/keywords/dna-degradation","display_name":"DNA degradation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2778659741","wikidata":"https://www.wikidata.org/wiki/Q420690","display_name":"Deoxyribonuclease","level":3,"score":0.8756948709487915},{"id":"https://openalex.org/C2910588993","wikidata":"https://www.wikidata.org/wiki/Q420690","display_name":"Deoxyribonucleases","level":3,"score":0.7057453989982605},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.6783223748207092},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6724144816398621},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6489331722259521},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5838592052459717},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5515685081481934},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5079055428504944},{"id":"https://openalex.org/C2779377703","wikidata":"https://www.wikidata.org/wiki/Q14901483","display_name":"Deoxyribonuclease I","level":4,"score":0.507552981376648},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.44338130950927734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3341295123100281},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.10603582859039307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08079525828361511},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.06781280040740967},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003851","descriptor_name":"Deoxyribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/198186a0","doi":"https://doi.org/10.1038/198186a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/198186a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:13971035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13971035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W79336906","https://openalex.org/W205272131","https://openalex.org/W945493595","https://openalex.org/W1974418429","https://openalex.org/W1988070571","https://openalex.org/W2021658235","https://openalex.org/W2031638451","https://openalex.org/W2056441510"],"related_works":["https://openalex.org/W2048920161","https://openalex.org/W2056441510","https://openalex.org/W1988070571","https://openalex.org/W2983857319","https://openalex.org/W2065544765","https://openalex.org/W259450741","https://openalex.org/W7073691486","https://openalex.org/W1592729748","https://openalex.org/W2333420954","https://openalex.org/W1965268536"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
