{"id":"https://openalex.org/W2019332302","doi":"https://doi.org/10.1126/science.3484558","title":"T-Cell Recognition of Ia Molecules Selectively Altered by a Single Amino Acid Substitution","display_name":"T-Cell Recognition of Ia Molecules Selectively Altered by a Single Amino Acid Substitution","publication_year":1986,"publication_date":"1986-01-17","ids":{"openalex":"https://openalex.org/W2019332302","doi":"https://doi.org/10.1126/science.3484558","mag":"2019332302","pmid":"https://pubmed.ncbi.nlm.nih.gov/3484558"},"language":"en","primary_location":{"id":"doi:10.1126/science.3484558","doi":"https://doi.org/10.1126/science.3484558","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3484558","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Melissa A. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A. Brown","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074049778","display_name":"Laurie H. Glimcher","orcid":"https://orcid.org/0000-0002-4971-0404","observed_orcids":["https://orcid.org/0000-0002-4971-0404"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie A. Glimcher","raw_affiliation_strings":["Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079418794","display_name":"Ellen A. Nielsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen A. Nielsen","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110180932","display_name":"William E. Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Paul","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088777789","display_name":"Ronald N. Germain","orcid":"https://orcid.org/0000-0003-1495-9143","observed_orcids":["https://orcid.org/0000-0003-1495-9143"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald N. Germain","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0653,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.94744745,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"231","issue":"4735","first_page":"255","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-recognition","display_name":"T cell recognition","score":0.871999979019165},{"id":"https://openalex.org/keywords/ia-molecules","display_name":"Ia molecules","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.718999981880188},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.8379999995231628},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.5070000290870667},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.5239999890327454},{"id":"https://openalex.org/keywords/b-cell-hybridomas","display_name":"B cell hybridomas","score":0.6740000247955322},{"id":"https://openalex.org/keywords/dna-mediated-gene-transfer","display_name":"DNA-mediated gene transfer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6058623194694519},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5997903347015381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5801411271095276},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5271487236022949},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.516760528087616},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.51352459192276},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4983184337615967},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.4801139831542969},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4777921140193939},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3842659294605255}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.3484558","doi":"https://doi.org/10.1126/science.3484558","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3484558","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:3484558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3484558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W211161208","https://openalex.org/W1521286109","https://openalex.org/W1612712833","https://openalex.org/W1966115309","https://openalex.org/W1968095512","https://openalex.org/W1973884559","https://openalex.org/W1977488695","https://openalex.org/W2000924875","https://openalex.org/W2003769309","https://openalex.org/W2008150995","https://openalex.org/W2010867882","https://openalex.org/W2011275780","https://openalex.org/W2012723339","https://openalex.org/W2018150276","https://openalex.org/W2030416301","https://openalex.org/W2043663228","https://openalex.org/W2051470342","https://openalex.org/W2051655066","https://openalex.org/W2063450941","https://openalex.org/W2070455130","https://openalex.org/W2092023329","https://openalex.org/W2093542001","https://openalex.org/W2113684474","https://openalex.org/W2138270253","https://openalex.org/W2158055057","https://openalex.org/W2170704309","https://openalex.org/W2171482213","https://openalex.org/W2176716563","https://openalex.org/W2911320348"],"related_works":["https://openalex.org/W2084114446","https://openalex.org/W1577806995","https://openalex.org/W1978411379","https://openalex.org/W2130308749","https://openalex.org/W1986379028","https://openalex.org/W2025886180","https://openalex.org/W2010147070","https://openalex.org/W7095537868","https://openalex.org/W2010059560","https://openalex.org/W2287471106"],"abstract_inverted_index":{"T":[0],"lymphocytes":[1],"recognize":[2],"foreign":[3],"antigen":[4,131],"together":[5],"with":[6],"allele-specific":[7],"determinants":[8],"on":[9],"membrane-bound":[10],"class":[11,14,29,126],"I":[12],"and":[13,54,63,69,132],"II":[15,30],"(Ia)":[16],"gene":[17,71],"products":[18],"of":[19,28,43,103,112,122,130,136],"the":[20,37,40,44,92,99,104,110,118,134],"major":[21],"histocompatibility":[22],"complex.":[23],"To":[24],"identify":[25],"amino":[26,119],"acids":[27],"molecules":[31],"critical":[32],"to":[33,86,115,143],"this":[34,141,145],"recognition":[35,129,146],"process,":[36],"genes":[38],"encoding":[39,80],"beta":[41,94,124],"chains":[42],"I-Ak":[45,93],"molecule":[46,95],"were":[47],"cloned":[48],"from":[49,55,83],"a":[50,75,81,137],"wild-type":[51],"B-cell":[52],"hybridoma":[53],"an":[56],"immunoselected":[57],"variant":[58,105],"subline":[59],"showing":[60],"distinct":[61],"serological":[62],"T-cell":[64,128],"stimulatory":[65],"properties.":[66],"Nucleotide":[67],"sequencing":[68],"DNA-mediated":[70],"transfer":[72],"established":[73],"that":[74],"single":[76,138],"base":[77],"transition":[78],"(G----A)":[79],"change":[82],"glutamic":[84],"acid":[85],"lysine":[87],"at":[88],"position":[89],"67":[90],"in":[91,117,140],"accounted":[96],"for":[97,125],"all":[98],"observed":[100],"phenotypic":[101],"changes":[102],"cells.":[106],"These":[107],"results":[108],"confirm":[109],"importance":[111],"residues":[113],"62":[114],"78":[116],"terminal":[120],"domain":[121],"I-A":[123],"II-restricted":[127],"demonstrate":[133],"ability":[135],"substitution":[139],"region":[142],"alter":[144],"event.":[147]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
