{"id":"https://openalex.org/W2019306808","doi":"https://doi.org/10.1016/0162-3109(96)00064-1","title":"Activation of the contact and fibrinolytic systems after intravenous administration of endotoxin to normal human volunteers: correlation with the cytokine profile","display_name":"Activation of the contact and fibrinolytic systems after intravenous administration of endotoxin to normal human volunteers: correlation with the cytokine profile","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W2019306808","doi":"https://doi.org/10.1016/0162-3109(96)00064-1","mag":"2019306808","pmid":"https://pubmed.ncbi.nlm.nih.gov/8856155"},"language":"en","primary_location":{"id":"doi:10.1016/0162-3109(96)00064-1","doi":"https://doi.org/10.1016/0162-3109(96)00064-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0162-3109(96)00064-1","pdf_url":null,"source":{"id":"https://openalex.org/S131233414","display_name":"Immunopharmacology","issn_l":"0162-3109","issn":["0162-3109","1879-047X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111826851","display_name":"Raul A. DeLa Cadena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raul A. Dela Cadena","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046145617","display_name":"Abraham Majluf\u2010Cruz","orcid":"https://orcid.org/0000-0002-7697-5790","observed_orcids":["https://orcid.org/0000-0002-7697-5790"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Majluf-Cruz","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059276453","display_name":"Antoni Stadnicki","orcid":"https://orcid.org/0000-0003-2675-3732","observed_orcids":["https://orcid.org/0000-0003-2675-3732"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antoni Stadnicki","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077262508","display_name":"Jan M. Agosti","orcid":"https://orcid.org/0000-0002-4952-3297","observed_orcids":["https://orcid.org/0000-0002-4952-3297"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan M. Agosti","raw_affiliation_strings":["Immunex Corporation, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunex Corporation, Seattle, WA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025157938","display_name":"Anthony F. Suffredini","orcid":"https://orcid.org/0000-0003-4179-0902","observed_orcids":["https://orcid.org/0000-0003-4179-0902"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony F. Suffredini","raw_affiliation_strings":["Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health. Bethesda, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health. Bethesda, MA, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111826851"],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":null,"apc_paid":null,"fwci":0.2867,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.30243902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"33","issue":"1-3","first_page":"231","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.42820000648498535,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.42820000648498535,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.2858999967575073,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.22669999301433563,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-syndrome","display_name":"systemic inflammatory response syndrome","score":0.9789999723434448},{"id":"https://openalex.org/keywords/contact-system","display_name":"contact system","score":0.5120000243186951},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cytokine-cascade","display_name":"cytokine cascade","score":0.7609999775886536},{"id":"https://openalex.org/keywords/plasma-proteins","display_name":"plasma proteins","score":0.5139999985694885},{"id":"https://openalex.org/keywords/human-volunteers","display_name":"human volunteers","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.7695454955101013},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7512996196746826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.706457257270813},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6858159303665161},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6271962523460388},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6011093258857727},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5131638646125793},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5006909370422363},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4576936364173889},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3958311975002289},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20818176865577698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19504684209823608},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016234","descriptor_name":"Kallikrein-Kinin System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016234","descriptor_name":"Kallikrein-Kinin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0162-3109(96)00064-1","doi":"https://doi.org/10.1016/0162-3109(96)00064-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0162-3109(96)00064-1","pdf_url":null,"source":{"id":"https://openalex.org/S131233414","display_name":"Immunopharmacology","issn_l":"0162-3109","issn":["0162-3109","1879-047X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:8856155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8856155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2003942496","display_name":null,"funder_award_id":"HL 45486","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G453486279","display_name":"SCOR IN THROMBOSIS","funder_award_id":"5p50hl045486-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6386476527","display_name":null,"funder_award_id":"2681-05","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320322967","display_name":"Instituto Mexicano del Seguro Social","ror":"https://ror.org/03xddgg98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W41549515","https://openalex.org/W281257934","https://openalex.org/W1564665720","https://openalex.org/W1567817045","https://openalex.org/W1705999641","https://openalex.org/W1981083900","https://openalex.org/W1992644897","https://openalex.org/W1994990169","https://openalex.org/W2007178546","https://openalex.org/W2011291552","https://openalex.org/W2040854989","https://openalex.org/W2042775328","https://openalex.org/W2055566895","https://openalex.org/W2065022523","https://openalex.org/W2067338751","https://openalex.org/W2068145342","https://openalex.org/W2131547680","https://openalex.org/W2144583342","https://openalex.org/W2148583002","https://openalex.org/W2160388336","https://openalex.org/W2162777829","https://openalex.org/W2215672966","https://openalex.org/W2319070317","https://openalex.org/W2326770573","https://openalex.org/W2328804315","https://openalex.org/W4248387811","https://openalex.org/W4250323632","https://openalex.org/W4299790488"],"related_works":["https://openalex.org/W2990695388","https://openalex.org/W1567817045","https://openalex.org/W2004774935","https://openalex.org/W2125317149","https://openalex.org/W2040854989","https://openalex.org/W1932895848","https://openalex.org/W88936571","https://openalex.org/W3093780906","https://openalex.org/W7100752688","https://openalex.org/W1996267694"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
