{"id":"https://openalex.org/W2019279189","doi":"https://doi.org/10.1074/jbc.272.43.26899","title":"Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T Lymphocytes","display_name":"Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T Lymphocytes","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2019279189","doi":"https://doi.org/10.1074/jbc.272.43.26899","mag":"2019279189","pmid":"https://pubmed.ncbi.nlm.nih.gov/9341123"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.43.26899","doi":"https://doi.org/10.1074/jbc.272.43.26899","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.43.26899","pdf_url":"http://www.jbc.org/article/S0021925818679906/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818679906/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057318208","display_name":"Toshihiko Hanada","orcid":"https://orcid.org/0000-0002-6587-4118","observed_orcids":["https://orcid.org/0000-0002-6587-4118"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I3018163063","display_name":"St. Elizabeth's Medical Center","ror":"https://ror.org/00cr15z55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3018163063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshihiko Hanada","raw_affiliation_strings":["Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I3018163063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060860655","display_name":"Lunhui Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I3018163063","display_name":"St. Elizabeth's Medical Center","ror":"https://ror.org/00cr15z55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3018163063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lunhui Lin","raw_affiliation_strings":["Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135","Tufts University, Medford, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I3018163063"]},{"raw_affiliation_string":"Tufts University, Medford, United States","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043567383","display_name":"K. George Chandy","orcid":"https://orcid.org/0000-0002-5237-8756","observed_orcids":["https://orcid.org/0000-0002-5237-8756"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. George Chandy","raw_affiliation_strings":["Departments of Microbiology and Molecular Genetics, University of California, Irvine, California 92697","Tufts University, Medford, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology and Molecular Genetics, University of California, Irvine, California 92697","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Tufts University, Medford, United States","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040256114","display_name":"Steven S. Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I3018163063","display_name":"St. Elizabeth's Medical Center","ror":"https://ror.org/00cr15z55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3018163063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Steven Oh","raw_affiliation_strings":["Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135","Tufts University, Medford, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I3018163063"]},{"raw_affiliation_string":"Tufts University, Medford, United States","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046912410","display_name":"Athar H. Chishti","orcid":"https://orcid.org/0000-0003-0335-1861","observed_orcids":["https://orcid.org/0000-0003-0335-1861"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I3018163063","display_name":"St. Elizabeth's Medical Center","ror":"https://ror.org/00cr15z55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3018163063"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Athar H. Chishti","raw_affiliation_strings":["Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135","Tufts University, Medford, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I3018163063"]},{"raw_affiliation_string":"Tufts University, Medford, United States","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046912410"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I3018163063"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5748,"has_fulltext":true,"cited_by_count":122,"citation_normalized_percentile":{"value":0.82814378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"272","issue":"43","first_page":"26899","last_page":"26904"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maguk-proteins","display_name":"MAGUK proteins","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.8939999938011169},{"id":"https://openalex.org/keywords/lck","display_name":"Lck","score":0.9039999842643738},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.8799999952316284},{"id":"https://openalex.org/keywords/kv1-3","display_name":"Kv1.3 potassium channel","score":0.9350000023841858},{"id":"https://openalex.org/keywords/shaker-channel","display_name":"Shaker channel","score":0.7670000195503235},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9390000104904175},{"id":"https://openalex.org/keywords/proline-rich-region","display_name":"proline-rich region","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tyrosine-kinase-signaling","display_name":"tyrosine kinase signaling","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6392279267311096},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5772882699966431},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.5339677929878235},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.499802827835083},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.4637024998664856},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.4432944357395172},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.44096148014068604},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.4267326295375824},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4235977232456207},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4181545674800873},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31071460247039795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20734179019927979},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074288","descriptor_name":"Discs Large Homolog 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019860","descriptor_name":"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D019860","descriptor_name":"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051664","descriptor_name":"Kv1.3 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.43.26899","doi":"https://doi.org/10.1074/jbc.272.43.26899","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.43.26899","pdf_url":"http://www.jbc.org/article/S0021925818679906/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9341123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9341123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.43.26899","doi":"https://doi.org/10.1074/jbc.272.43.26899","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.43.26899","pdf_url":"http://www.jbc.org/article/S0021925818679906/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2222332973","display_name":null,"funder_award_id":"CA66 263","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2771530453","display_name":null,"funder_award_id":"AI24783","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3207599266","display_name":"MEMBRANE-ASSOCIATED GUANYLATE KINASE HOMOLOGS","funder_award_id":"P01CA066263","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5399400159","display_name":null,"funder_award_id":"GM-OD54872-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8850125082","display_name":"ION CHANNELS IN LYMPHOCYTES--GENETIC PROBES","funder_award_id":"5r01ai024783-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019279189.pdf","grobid_xml":"https://content.openalex.org/works/W2019279189.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1523783037","https://openalex.org/W1532807823","https://openalex.org/W1910853730","https://openalex.org/W1964285407","https://openalex.org/W1967448808","https://openalex.org/W1982991759","https://openalex.org/W1986493103","https://openalex.org/W2002503549","https://openalex.org/W2005536723","https://openalex.org/W2006498306","https://openalex.org/W2012462160","https://openalex.org/W2019863974","https://openalex.org/W2021580435","https://openalex.org/W2025081899","https://openalex.org/W2028669354","https://openalex.org/W2034064985","https://openalex.org/W2034204508","https://openalex.org/W2035562653","https://openalex.org/W2040227924","https://openalex.org/W2047945116","https://openalex.org/W2052124270","https://openalex.org/W2059124316","https://openalex.org/W2060061784","https://openalex.org/W2068240232","https://openalex.org/W2073360590","https://openalex.org/W2085140159","https://openalex.org/W2085252478","https://openalex.org/W2088028188","https://openalex.org/W2088303433","https://openalex.org/W2092442184","https://openalex.org/W2092667406","https://openalex.org/W2114122754","https://openalex.org/W2125173504","https://openalex.org/W2125469822","https://openalex.org/W2133656397","https://openalex.org/W2141578443","https://openalex.org/W2144935474","https://openalex.org/W2152331062","https://openalex.org/W2171573307","https://openalex.org/W2253333228","https://openalex.org/W2303297867"],"related_works":["https://openalex.org/W2076971050","https://openalex.org/W2091828932","https://openalex.org/W2021153052","https://openalex.org/W2152331062","https://openalex.org/W1504224222","https://openalex.org/W2001541051","https://openalex.org/W2016733897","https://openalex.org/W288019351","https://openalex.org/W2766078941","https://openalex.org/W2144971085"],"abstract_inverted_index":{"Human":[0],"homologue":[1],"of":[2,17,36,40,43,76,94,108,133,141,147,151,156,164,188,209,221,250,265],"the":[3,33,44,59,74,131,139,148,157,162,172,195,206,247],"Drosophila":[4],"discs":[5],"large":[6],"tumor":[7],"suppressor":[8],"protein":[9,124,235],"(hDlg)":[10],"belongs":[11],"to":[12,23,91],"a":[13,53,88,145,237,251,262],"newly":[14],"discovered":[15],"family":[16,150],"proteins":[18,187],"termed":[19],"MAGUKs":[20],"that":[21,66,123,138],"appear":[22],"have":[24],"structural":[25],"as":[26,28,87,232],"well":[27],"signaling":[29,80],"functions.":[30],"Consistent":[31],"with":[32,96,130,223],"multi-domain":[34],"organization":[35],"MAGUKs,":[37],"hDlg":[38,60,77,95,109,142,173,178,189,210,222,255,266],"consists":[39],"three":[41],"copies":[42],"PDZ":[45],"(PSD-95/Discs":[46],"large/zO-1)":[47],"domain,":[48],"an":[49,62,233],"SH3":[50],"motif,":[51],"and":[52,115,168,179,190,256,260,271],"guanylate":[54],"kinase-like":[55],"domain.":[56,213],"In":[57,100,214],"addition,":[58,215],"contains":[61],"amino-terminal":[63,207],"proline-rich":[64,212],"domain":[65],"is":[67,128,159,181],"absent":[68],"in":[69,78,171,194,218,229,267,275],"other":[70],"MAGUKs.":[71],"To":[72],"explore":[73],"role":[75],"cell":[79,104],"pathways,":[81],"we":[82,216],"used":[83],"human":[84,101],"T":[85,102,230,276],"lymphocytes":[86,231],"model":[89],"system":[90],"investigate":[92],"interaction":[93,158,176,253],"known":[97],"tyrosine":[98,125,152,166,258,269],"kinases.":[99,153],"lymphocyte":[103],"lines,":[105],"binding":[106,201],"properties":[107],"were":[110],"studied":[111],"by":[112,161],"immunoprecipitation,":[113],"immunoblotting,":[114],"immune":[116],"complex":[117],"kinase":[118,126,167,259,270],"assays.":[119],"Our":[120],"results":[121,245],"show":[122,217],"activity":[127],"associated":[129],"immunoprecipitates":[132,140],"hDlg.":[134],"Immunoblotting":[135],"experiments":[136],"revealed":[137],"contain":[143],"p56lck,":[144],"member":[146],"Src":[149],"The":[154,199],"specificity":[155],"demonstrated":[160,182],"lack":[163],"p59fyn":[165],"phosphotidylinositol":[169],"3-kinase":[170],"immunoprecipitates.":[174],"Direct":[175],"between":[177,254],"p56lck":[180,192,200,257],"using":[183,236],"glutathione":[184],"S-transferase":[185],"fusion":[186],"recombinant":[191],"expressed":[193,228],"baculovirus-infected":[196],"Sf9":[197],"cells.":[198],"site":[202],"was":[203,227],"localized":[204],"within":[205],"segment":[208],"containing":[211],"vivo":[219],"association":[220],"Kv1.3":[224],"channel,":[225],"which":[226],"epitope-tagged":[234],"vaccinia":[238],"virus":[239],"expression":[240],"system.":[241],"Taken":[242],"together,":[243],"these":[244],"provide":[246],"first":[248],"evidence":[249],"direct":[252],"suggest":[261],"novel":[263],"function":[264],"coupling":[268],"voltage-gated":[272],"potassium":[273],"channel":[274],"lymphocytes.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}