{"id":"https://openalex.org/W2019276195","doi":"https://doi.org/10.1006/abbi.2001.2671","title":"The Role of Heme and Iron-Sulfur Clusters in Mitochondrial Biogenesis, Maintenance, and Decay with Age","display_name":"The Role of Heme and Iron-Sulfur Clusters in Mitochondrial Biogenesis, Maintenance, and Decay with Age","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2019276195","doi":"https://doi.org/10.1006/abbi.2001.2671","mag":"2019276195","pmid":"https://pubmed.ncbi.nlm.nih.gov/11795893"},"language":"en","primary_location":{"id":"doi:10.1006/abbi.2001.2671","doi":"https://doi.org/10.1006/abbi.2001.2671","is_oa":false,"landing_page_url":"https://doi.org/10.1006/abbi.2001.2671","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004879671","display_name":"Hani Atamna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hani Atamna","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley/CHORI, 5700 Martin Luther King Jr. Way, Oakland, California 94609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley/CHORI, 5700 Martin Luther King Jr. Way, Oakland, California 94609, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076983469","display_name":"Patrick B. Walter","orcid":"https://orcid.org/0000-0002-1254-4086","observed_orcids":["https://orcid.org/0000-0002-1254-4086"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick B Walter","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley/CHORI, 5700 Martin Luther King Jr. Way, Oakland, California, 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley/CHORI, 5700 Martin Luther King Jr. Way, Oakland, California, 94609","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110195895","display_name":"Bruce N. Ames","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce N Ames","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley/CHORI, 5700 Martin Luther King Jr. Way, Oakland, California, 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley/CHORI, 5700 Martin Luther King Jr. Way, Oakland, California, 94609","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110195895"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":0.6594,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.55045872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"397","issue":"2","first_page":"345","last_page":"353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme","display_name":"heme","score":0.9860000014305115},{"id":"https://openalex.org/keywords/iron-sulfur-clusters","display_name":"iron-sulfur clusters","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitochondrial-aging","display_name":"mitochondrial aging","score":0.7720000147819519},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/electron-transfer-complex","display_name":"electron transfer complex","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.8435384035110474},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.75242018699646},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.7405409812927246},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.580480694770813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5667904615402222},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5302236676216125},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.5082754492759705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5076817274093628},{"id":"https://openalex.org/C2780265247","wikidata":"https://www.wikidata.org/wiki/Q620072","display_name":"Heme A","level":4,"score":0.48069459199905396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45462846755981445},{"id":"https://openalex.org/C24840226","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Electron transport chain","level":2,"score":0.4455653429031372},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.42726367712020874},{"id":"https://openalex.org/C65192284","wikidata":"https://www.wikidata.org/wiki/Q7636225","display_name":"Sulfur metabolism","level":3,"score":0.42098382115364075},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37515389919281006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33518508076667786},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2886528968811035},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15516158938407898},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007506","descriptor_name":"Iron-Sulfur Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1006/abbi.2001.2671","doi":"https://doi.org/10.1006/abbi.2001.2671","is_oa":false,"landing_page_url":"https://doi.org/10.1006/abbi.2001.2671","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:11795893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11795893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2793094153","display_name":"ENVIRONMENTAL HEALTH SCIENCES CENTER","funder_award_id":"P30ES001896","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7770385910","display_name":"DELAYING MITOCHONDRIAL DECAY WITH CARNITINE AND LIPOATE","funder_award_id":"R01AG017140","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W10383398","https://openalex.org/W47302231","https://openalex.org/W62747462","https://openalex.org/W140144922","https://openalex.org/W151933253","https://openalex.org/W153121858","https://openalex.org/W170823829","https://openalex.org/W307329154","https://openalex.org/W1480159764","https://openalex.org/W1484379620","https://openalex.org/W1506920432","https://openalex.org/W1509127316","https://openalex.org/W1518778430","https://openalex.org/W1523213544","https://openalex.org/W1530657831","https://openalex.org/W1533321987","https://openalex.org/W1553161361","https://openalex.org/W1565459224","https://openalex.org/W1576683498","https://openalex.org/W1584053469","https://openalex.org/W1601203296","https://openalex.org/W1603564922","https://openalex.org/W1607985964","https://openalex.org/W1655162787","https://openalex.org/W1838477969","https://openalex.org/W1902487112","https://openalex.org/W1953682488","https://openalex.org/W1964803638","https://openalex.org/W1964923649","https://openalex.org/W1966571906","https://openalex.org/W1967432418","https://openalex.org/W1970673189","https://openalex.org/W1971045564","https://openalex.org/W1972429414","https://openalex.org/W1977290021","https://openalex.org/W1978004953","https://openalex.org/W1984761908","https://openalex.org/W1985154969","https://openalex.org/W1985844569","https://openalex.org/W1987325894","https://openalex.org/W1987873761","https://openalex.org/W1992222348","https://openalex.org/W1993406712","https://openalex.org/W1995360843","https://openalex.org/W1998295783","https://openalex.org/W2000352757","https://openalex.org/W2000359426","https://openalex.org/W2001016611","https://openalex.org/W2001174541","https://openalex.org/W2002593242","https://openalex.org/W2002769318","https://openalex.org/W2003418336","https://openalex.org/W2004384294","https://openalex.org/W2005211684","https://openalex.org/W2005678783","https://openalex.org/W2006383772","https://openalex.org/W2009525995","https://openalex.org/W2014111038","https://openalex.org/W2018209460","https://openalex.org/W2020220420","https://openalex.org/W2021089668","https://openalex.org/W2023015137","https://openalex.org/W2024460455","https://openalex.org/W2025595360","https://openalex.org/W2027402883","https://openalex.org/W2028597809","https://openalex.org/W2029152058","https://openalex.org/W2030925207","https://openalex.org/W2033367616","https://openalex.org/W2034035211","https://openalex.org/W2037074028","https://openalex.org/W2039603759","https://openalex.org/W2040892857","https://openalex.org/W2044494908","https://openalex.org/W2045197265","https://openalex.org/W2050994990","https://openalex.org/W2050999079","https://openalex.org/W2053893341","https://openalex.org/W2056293291","https://openalex.org/W2058299415","https://openalex.org/W2060399663","https://openalex.org/W2063617352","https://openalex.org/W2065246627","https://openalex.org/W2070594969","https://openalex.org/W2071219983","https://openalex.org/W2071316456","https://openalex.org/W2071805611","https://openalex.org/W2075975601","https://openalex.org/W2077701124","https://openalex.org/W2077880605","https://openalex.org/W2079167667","https://openalex.org/W2081848534","https://openalex.org/W2082895331","https://openalex.org/W2087669983","https://openalex.org/W2088404957","https://openalex.org/W2090079874","https://openalex.org/W2090669609","https://openalex.org/W2092645565","https://openalex.org/W2101119157","https://openalex.org/W2103432221","https://openalex.org/W2107919301","https://openalex.org/W2113007696","https://openalex.org/W2116347119","https://openalex.org/W2132228000","https://openalex.org/W2135248938","https://openalex.org/W2148626789","https://openalex.org/W2171401176","https://openalex.org/W2172170767","https://openalex.org/W2174879024","https://openalex.org/W2316825990","https://openalex.org/W2406978356","https://openalex.org/W2413006449","https://openalex.org/W2416296127","https://openalex.org/W2434326234","https://openalex.org/W2442719123","https://openalex.org/W2461075158","https://openalex.org/W2575789697","https://openalex.org/W3034319525","https://openalex.org/W3149792679","https://openalex.org/W4244473822"],"related_works":["https://openalex.org/W2065586977","https://openalex.org/W3194726437","https://openalex.org/W2105427103","https://openalex.org/W7101169666","https://openalex.org/W2532882725","https://openalex.org/W1516477892","https://openalex.org/W2022758805","https://openalex.org/W2049009393","https://openalex.org/W2043541600","https://openalex.org/W2559410759"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
