{"id":"https://openalex.org/W2019234385","doi":"https://doi.org/10.1097/pas.0b013e3181b7c7ae","title":"BRAF Mutational Analysis in Papillary Carcinomas With Mixed Follicular and Papillary Growth Patterns","display_name":"BRAF Mutational Analysis in Papillary Carcinomas With Mixed Follicular and Papillary Growth Patterns","publication_year":2009,"publication_date":"2009-10-22","ids":{"openalex":"https://openalex.org/W2019234385","doi":"https://doi.org/10.1097/pas.0b013e3181b7c7ae","mag":"2019234385","pmid":"https://pubmed.ncbi.nlm.nih.gov/19738460"},"language":"en","primary_location":{"id":"doi:10.1097/pas.0b013e3181b7c7ae","doi":"https://doi.org/10.1097/pas.0b013e3181b7c7ae","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pas.0b013e3181b7c7ae","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Surgical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007700866","display_name":"Maureen A. Jakubowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maureen Jakubowski","raw_affiliation_strings":["Department of Clinical Pathology, Cleveland Clinic, Cleveland, Ohio, USA","Clinical Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Cleveland Clinic, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Clinical Pathology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059315630","display_name":"Jennifer Leigh Hunt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Hunt","raw_affiliation_strings":["Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio","Jennifer Hunt, MD, Department of Anatomic Pathology, L25, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH (e-mail: [email\u00a0protected])"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Jennifer Hunt, MD, Department of Anatomic Pathology, L25, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH (e-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007700866"],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":null,"apc_paid":null,"fwci":1.1435,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.80041929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"33","issue":"11","first_page":"1590","last_page":"1593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12631","display_name":"Head and Neck Anomalies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/follicular-variant-of-papillary-carcinoma","display_name":"follicular variant of papillary carcinoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/braf-exon-15","display_name":"BRAF exon 15","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-classification","display_name":"tumor classification","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.5479228496551514},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5457737445831299},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5342565774917603},{"id":"https://openalex.org/C2993477687","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary carcinoma","level":4,"score":0.4849967658519745},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.48489242792129517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47504568099975586},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.44197240471839905},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.42382827401161194},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4183710813522339},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40405863523483276},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.37274664640426636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2877623438835144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23109745979309082},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12990084290504456}],"mesh":[{"descriptor_ui":"D000231","descriptor_name":"Adenocarcinoma, Papillary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000231","descriptor_name":"Adenocarcinoma, Papillary","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D000231","descriptor_name":"Adenocarcinoma, Papillary","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009378","descriptor_name":"Neoplasms, Multiple Primary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D018263","descriptor_name":"Adenocarcinoma, Follicular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018263","descriptor_name":"Adenocarcinoma, Follicular","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D018263","descriptor_name":"Adenocarcinoma, Follicular","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D042282","descriptor_name":"Microdissection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/pas.0b013e3181b7c7ae","doi":"https://doi.org/10.1097/pas.0b013e3181b7c7ae","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pas.0b013e3181b7c7ae","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Surgical Pathology","raw_type":"journal-article"},{"id":"pmid:19738460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19738460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of surgical pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W102402079","https://openalex.org/W1539993673","https://openalex.org/W1978189407","https://openalex.org/W1985982375","https://openalex.org/W1992803849","https://openalex.org/W1993130687","https://openalex.org/W1998629131","https://openalex.org/W2011699883","https://openalex.org/W2019930929","https://openalex.org/W2029010919","https://openalex.org/W2030488165","https://openalex.org/W2043078598","https://openalex.org/W2044332009","https://openalex.org/W2045020328","https://openalex.org/W2045865878","https://openalex.org/W2046468922","https://openalex.org/W2070718056","https://openalex.org/W2091986955","https://openalex.org/W2101888941","https://openalex.org/W2109544257","https://openalex.org/W2121319472","https://openalex.org/W2151431733","https://openalex.org/W2320571359","https://openalex.org/W2413382648","https://openalex.org/W2999879745","https://openalex.org/W4297676537"],"related_works":["https://openalex.org/W1507713782","https://openalex.org/W2313988166","https://openalex.org/W2061903640","https://openalex.org/W2104875539","https://openalex.org/W3149623884","https://openalex.org/W2350275990","https://openalex.org/W4409285431","https://openalex.org/W7099086349","https://openalex.org/W2065430948","https://openalex.org/W2068668619"],"abstract_inverted_index":{"BACKGROUND:":[0],"Current":[1],"literature":[2],"suggests":[3],"that":[4,115,256],"up":[5],"to":[6],"60%":[7],"of":[8,20,28,34,39,52,59,165,199,213,221,228,262,275,278],"papillary":[9,21,42,60,67,180,201,217,245,264,272],"carcinomas":[10,212],"have":[11,44,224],"mutations":[12],"in":[13,111,160,189,237,242],"the":[14,50,53,99,117,125,166,171,176,179,184,207,214,238,243,252,276],"BRAF":[15,54,112,172,185,208,229,232],"gene.":[16],"However,":[17],"follicular":[18,40,74,177,222,239,279],"variant":[19],"carcinoma":[22,61],"has":[23],"a":[24,225,257,270],"much":[25],"lower":[26],"frequency":[27,227],"mutation.":[29,56,173,209],"Tumors":[30],"with":[31,64,73,83,216,259],"mixed":[32],"patterns":[33],"growth,":[35,43],"including":[36],"distinctive":[37],"area":[38],"and":[41,94,129,142,153,178,219,241],"not":[45],"been":[46],"well":[47],"studied":[48],"for":[49,108,147,170,206],"presence":[51,277],"gene":[55],"DESIGN:":[57],"Cases":[58],"were":[62,91,145,168,204],"identified":[63],"well-defined":[65],"conventional":[66,244,263,271],"growth":[68,75,88,181,218,223,246,265,280],"pattern,":[69],"alongside":[70],"other":[71],"areas":[72,90,220,240],"pattern.":[76],"The":[77,86,140,231],"tumor":[78,258],"stage":[79],"was":[80,96,106,122,131,158,187],"obtained,":[81],"along":[82],"demographic":[84],"information.":[85],"different":[87],"pattern":[89,281],"separately":[92],"microdissected":[93],"DNA":[95,151],"extracted":[97],"from":[98],"resulting":[100],"tissue":[101],"fragments.":[102],"Polymerase":[103],"chain":[104,155],"reaction":[105,156],"performed":[107,123,132],"an":[109,134,195],"amplicon":[110],"exon":[113],"15":[114],"includes":[116],"mutation":[118,186],"site.":[119],"Cycle":[120],"sequencing":[121],"using":[124],"BigDye":[126],"Terminator":[127],"kit":[128],"analysis":[130],"on":[133],"ABI":[135],"automated":[136],"sequencer":[137],"(Applied":[138],"Biosystems).":[139],"forward":[141],"reverse":[143],"sequences":[144],"analyzed":[146],"point":[148],"mutations.":[149,230],"RESULTS:":[150],"extraction":[152],"polymerase":[154],"amplification":[157],"successful":[159],"all":[161,190],"cases.":[162,191],"Seventy":[163],"percent":[164],"tumors":[167],"positive":[169],"In":[174],"comparing":[175],"patterned":[182],"areas,":[183],"concordant":[188],"Four":[192],"cases":[193],"had":[194],"additional":[196],"separate":[197],"focus":[198],"microscopic":[200],"carcinomas.":[202],"These":[203,248],"negative":[205],"CONCLUSIONS:":[210],"Papillary":[211],"thyroid":[215],"high":[226],"mutational":[233],"profile":[234],"is":[235],"identical":[236],"areas.":[247,282],"molecular":[249],"data":[250],"support":[251],"common":[253],"diagnostic":[254],"decision":[255],"any":[260],"amount":[261],"should":[266],"be":[267],"designated":[268],"as":[269],"carcinoma,":[273],"regardless":[274]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}