{"id":"https://openalex.org/W2019213239","doi":"https://doi.org/10.1097/00002030-200012220-00002","title":"Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice","display_name":"Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2019213239","doi":"https://doi.org/10.1097/00002030-200012220-00002","mag":"2019213239","pmid":"https://pubmed.ncbi.nlm.nih.gov/11153662"},"language":"en","primary_location":{"id":"doi:10.1097/00002030-200012220-00002","doi":"https://doi.org/10.1097/00002030-200012220-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002030-200012220-00002","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020953238","display_name":"Kamel Sanhadji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamel Sanhadji","raw_affiliation_strings":["Laboratoires des D\u00e9ficits Immunitaires et de R\u00e9trovirologie, Facult\u00e9 de M\u00e9decine RTH La\u00ebnnec, Lyon, France","co-first author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires des D\u00e9ficits Immunitaires et de R\u00e9trovirologie, Facult\u00e9 de M\u00e9decine RTH La\u00ebnnec, Lyon, France","institution_ids":[]},{"raw_affiliation_string":"co-first author","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067077009","display_name":"Linda Grave","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linda Grave","raw_affiliation_strings":["Transg\u00e8ne SA, 11 rue de Molsheim, 67000 Strasbourg, France;","co-first author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transg\u00e8ne SA, 11 rue de Molsheim, 67000 Strasbourg, France;","institution_ids":[]},{"raw_affiliation_string":"co-first author","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110198951","display_name":"J.L. Touraine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]},{"id":"https://openalex.org/I4210140403","display_name":"Virologie et Pathologies Humaines","ror":"https://ror.org/031xg0236","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210089901","https://openalex.org/I4210100596","https://openalex.org/I4210139971","https://openalex.org/I4210140403","https://openalex.org/I4210155509","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Louis Touraine","raw_affiliation_strings":["Laboratoires des D\u00e9ficits Immunitaires et de R\u00e9trovirologie, Facult\u00e9 de M\u00e9decine RTH La\u00ebnnec, rue Guillaume Paradin, 69008 Lyon, and Pavillon P, H\u00f4pital E. Herriot, 69437 Lyon, France;","France","author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires des D\u00e9ficits Immunitaires et de R\u00e9trovirologie, Facult\u00e9 de M\u00e9decine RTH La\u00ebnnec, rue Guillaume Paradin, 69008 Lyon, and Pavillon P, H\u00f4pital E. Herriot, 69437 Lyon, France;","institution_ids":["https://openalex.org/I4210123600","https://openalex.org/I4210140403"]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"author","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016746462","display_name":"Philippe Leissner","orcid":"https://orcid.org/0000-0001-7503-2873","observed_orcids":["https://orcid.org/0000-0001-7503-2873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philippe Leissner","raw_affiliation_strings":["Transg\u00e8ne SA, 11 rue de Molsheim, 67000 Strasbourg, France;","France","author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transg\u00e8ne SA, 11 rue de Molsheim, 67000 Strasbourg, France;","institution_ids":[]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"author","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107838912","display_name":"Christine Rouzioux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Rouzioux","raw_affiliation_strings":["Departement de Virologie, Groupe Hospitalier Necker-Enfants Malades, 149 rue de S\u00e8vres, 75743 Paris, France; and","France","author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement de Virologie, Groupe Hospitalier Necker-Enfants Malades, 149 rue de S\u00e8vres, 75743 Paris, France; and","institution_ids":["https://openalex.org/I1288880153"]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"author","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082049092","display_name":"R\u00e9za Firouzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]},{"id":"https://openalex.org/I4210140403","display_name":"Virologie et Pathologies Humaines","ror":"https://ror.org/031xg0236","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210089901","https://openalex.org/I4210100596","https://openalex.org/I4210139971","https://openalex.org/I4210140403","https://openalex.org/I4210155509","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R\u00e9za Firouzi","raw_affiliation_strings":["Laboratoires des D\u00e9ficits Immunitaires et de R\u00e9trovirologie, Facult\u00e9 de M\u00e9decine RTH La\u00ebnnec, rue Guillaume Paradin, 69008 Lyon, and Pavillon P, H\u00f4pital E. Herriot, 69437 Lyon, France;","France","author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires des D\u00e9ficits Immunitaires et de R\u00e9trovirologie, Facult\u00e9 de M\u00e9decine RTH La\u00ebnnec, rue Guillaume Paradin, 69008 Lyon, and Pavillon P, H\u00f4pital E. Herriot, 69437 Lyon, France;","institution_ids":["https://openalex.org/I4210123600","https://openalex.org/I4210140403"]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"author","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073082983","display_name":"Laurence Kehrli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]},{"id":"https://openalex.org/I4210140403","display_name":"Virologie et Pathologies Humaines","ror":"https://ror.org/031xg0236","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210089901","https://openalex.org/I4210100596","https://openalex.org/I4210139971","https://openalex.org/I4210140403","https://openalex.org/I4210155509","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Kehrli","raw_affiliation_strings":["Laboratoires des D\u00e9ficits Immunitaires et de R\u00e9trovirologie, Facult\u00e9 de M\u00e9decine RTH La\u00ebnnec, rue Guillaume Paradin, 69008 Lyon, and Pavillon P, H\u00f4pital E. Herriot, 69437 Lyon, France;","France","author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires des D\u00e9ficits Immunitaires et de R\u00e9trovirologie, Facult\u00e9 de M\u00e9decine RTH La\u00ebnnec, rue Guillaume Paradin, 69008 Lyon, and Pavillon P, H\u00f4pital E. Herriot, 69437 Lyon, France;","institution_ids":["https://openalex.org/I4210123600","https://openalex.org/I4210140403"]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"author","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jean-Claude Tardy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Claude Tardy","raw_affiliation_strings":["Laboratoire de Virologie, Facult\u00e9 de M\u00e9decine Rockefeller, 69008 Lyon, France","France","author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Virologie, Facult\u00e9 de M\u00e9decine Rockefeller, 69008 Lyon, France","institution_ids":[]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"author","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015708974","display_name":"Majid Mehtali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Majid Mehtali","raw_affiliation_strings":["Transg\u00e8ne SA, 11 rue de Molsheim, 67000 Strasbourg, France;","France","author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transg\u00e8ne SA, 11 rue de Molsheim, 67000 Strasbourg, France;","institution_ids":[]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"author","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110198951"],"corresponding_institution_ids":["https://openalex.org/I4210123600","https://openalex.org/I4210140403"],"apc_list":null,"apc_paid":null,"fwci":0.7813,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.64505906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"14","issue":"18","first_page":"2813","last_page":"2822"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/2f5-antibody","display_name":"2F5 antibody","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/ex-vivo-gene-transfer","display_name":"ex vivo gene transfer","score":0.6010000109672546},{"id":"https://openalex.org/keywords/hiv-1-viral-load","display_name":"HIV-1 viral load","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.6340000033378601},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.703500509262085},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6467748880386353},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5868089199066162},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.5603080987930298},{"id":"https://openalex.org/C2776258796","wikidata":"https://www.wikidata.org/wiki/Q5590520","display_name":"Gp41","level":4,"score":0.5597881078720093},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5444106459617615},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5175575613975525},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5087323784828186},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4839930534362793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4216892719268799},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41437479853630066},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35476547479629517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3206935226917267},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14431104063987732},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.08937034010887146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07019263505935669},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015700","descriptor_name":"HIV Envelope Protein gp41","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016860","descriptor_name":"CD4 Immunoadhesins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016860","descriptor_name":"CD4 Immunoadhesins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00002030-200012220-00002","doi":"https://doi.org/10.1097/00002030-200012220-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002030-200012220-00002","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},{"id":"pmid:11153662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11153662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310985","display_name":"Sidaction","ror":"https://ror.org/04z6q9z55"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1534972788","https://openalex.org/W1607434342","https://openalex.org/W1635348995","https://openalex.org/W1678829828","https://openalex.org/W1761980395","https://openalex.org/W1786960389","https://openalex.org/W1964660200","https://openalex.org/W1969379511","https://openalex.org/W1977389533","https://openalex.org/W1978827291","https://openalex.org/W1984836566","https://openalex.org/W1993158981","https://openalex.org/W1999730476","https://openalex.org/W2010519150","https://openalex.org/W2011630381","https://openalex.org/W2015349792","https://openalex.org/W2018643676","https://openalex.org/W2027791522","https://openalex.org/W2033611972","https://openalex.org/W2034937976","https://openalex.org/W2037865355","https://openalex.org/W2056802413","https://openalex.org/W2063049455","https://openalex.org/W2063950143","https://openalex.org/W2074969682","https://openalex.org/W2075135942","https://openalex.org/W2083966567","https://openalex.org/W2087565826","https://openalex.org/W2102559570","https://openalex.org/W2103302581","https://openalex.org/W2109425369","https://openalex.org/W2110287237","https://openalex.org/W2117845861","https://openalex.org/W2118820599","https://openalex.org/W2120446560","https://openalex.org/W2123204050","https://openalex.org/W2149956490","https://openalex.org/W2151835606","https://openalex.org/W2170412417","https://openalex.org/W2318770038","https://openalex.org/W2320498484","https://openalex.org/W2327921621","https://openalex.org/W2416177690","https://openalex.org/W2474438553"],"related_works":["https://openalex.org/W2408183011","https://openalex.org/W7131653452","https://openalex.org/W2131490666","https://openalex.org/W4319766290","https://openalex.org/W1964660200","https://openalex.org/W2773352887","https://openalex.org/W2082354489","https://openalex.org/W2782631496","https://openalex.org/W2020625880","https://openalex.org/W2174534542"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,7,68,72,76,156,196,211],"anti-HIV-1":[4,39],"effects":[5,82,201],"of":[6,9,35,43,75,85,214],"delivery":[8],"anti-gp41":[10],"monoclonal":[11],"antibody":[12,122],"(mAb)":[13],"and":[14,42,107,144,162,216],"soluble":[15],"CD4":[16,103,192],"(sCD4)":[17],"immunoadhesin":[18,46],"by":[19],"genetically":[20],"modified":[21],"cells":[22,51,59,106,193],"in":[23,83,94,136,155,174,191,220,226],"HIV-1-infected,":[24],"humanized":[25],"severe":[26],"combined":[27],"immunodeficient":[28],"(SCID)":[29],"mice.":[30,139,198,228],"DESIGN:":[31],"The":[32,58,80,184],"complementary":[33],"DNA":[34],"mAb":[36],"2F5,":[37],"an":[38],"gp41":[40],"antibody,":[41],"sCD4-IgG":[44,88,217],"chimeric":[45],"were":[47,60,92,99,133,150,172,202],"transferred":[48],"into":[49,63],"3T3":[50],"using":[52],"Moloney":[53],"murine":[54],"leukaemia":[55],"virus":[56],"vectors.":[57],"then":[61],"incorporated":[62],"a":[64],"collagen":[65],"structure":[66],"called":[67],"neo-organ,":[69],"which":[70],"allowed":[71],"continuous":[73],"production":[74],"therapeutic":[77],"molecules.":[78],"METHODS:":[79],"antiviral":[81,200],"vivo":[84,221],"2F5":[86,120,215],"or":[87,89,112,182],"both":[90],"compounds":[91],"evaluated":[93],"neo-organ-implanted":[95,137],"SCID":[96,116,227],"mice":[97,117,177],"that":[98],"grafted":[100],"with":[101,109,119,160,179,204],"human":[102],"CEM":[104],"T":[105],"challenged":[108],"HIV-1":[110,131],"Lai":[111,161,181],"MN.":[113,183],"RESULTS:":[114],"In":[115],"implanted":[118,176,197],"neo-organs,":[121],"plasma":[123],"levels":[124],"reached":[125],"500-2000":[126],"ng/ml.":[127],"Viral":[128],"loads":[129],"after":[130,222],"challenge":[132],"significantly":[134],"reduced":[135,190],"HIV-infected":[138],"Although":[140],"29":[141],"x":[142,146,168],"10(7)":[143],"13":[145],"10(8)":[147],"HIV-1-RNA":[148,170],"copies/ml":[149,171],"detected":[151],"at":[152],"12":[153],"days":[154],"controls":[157],"(mice":[158],"injected":[159,178],"MN,":[163],"respectively)":[164],"less":[165],"than":[166],"16.5":[167],"10(3)":[169],"observed":[173],"all":[175],"either":[180],"intracellular":[185],"viral":[186],"load":[187],"was":[188],"also":[189],"recovered":[194],"from":[195],"Comparable":[199],"obtained":[203],"CD4-IgG":[205],"neo-organs.":[206],"CONCLUSION:":[207],"Our":[208],"results":[209],"confirm":[210],"anti-HIV":[212],"properties":[213],"continuously":[218],"produced":[219],"ex-vivo":[223],"gene":[224],"therapy":[225]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
