{"id":"https://openalex.org/W2019199342","doi":"https://doi.org/10.1186/1471-2326-10-8","title":"Patan hospital experience in treating philadelphia chromosome/BCR-ABL1 positive chronic myeloid leukemia patients with gleevec (imatinib mesylate); the first generation specific tyrosine kinase inhibitor","display_name":"Patan hospital experience in treating philadelphia chromosome/BCR-ABL1 positive chronic myeloid leukemia patients with gleevec (imatinib mesylate); the first generation specific tyrosine kinase inhibitor","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2019199342","doi":"https://doi.org/10.1186/1471-2326-10-8","mag":"2019199342","pmid":"https://pubmed.ncbi.nlm.nih.gov/21138592","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3017013"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2326-10-8","doi":"https://doi.org/10.1186/1471-2326-10-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2326-10-8","pdf_url":"https://bmchematol.biomedcentral.com/counter/pdf/10.1186/1471-2326-10-8","source":{"id":"https://openalex.org/S2738849190","display_name":"BMC Hematology","issn_l":"2052-1839","issn":["2052-1839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bmchematol.biomedcentral.com/counter/pdf/10.1186/1471-2326-10-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020633688","display_name":"Gyan Krishna Kayastha","orcid":"https://orcid.org/0000-0001-8043-9694","observed_orcids":["https://orcid.org/0000-0001-8043-9694"]},"institutions":[{"id":"https://openalex.org/I2801573932","display_name":"Patan Hospital","ror":"https://ror.org/02vhxx141","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I2801573932"]}],"countries":["NP"],"is_corresponding":true,"raw_author_name":"Gyan K Kayastha","raw_affiliation_strings":["Department of Internal Medicine, Patan Hospital, Lalitpur Nepal. kayasthagk@hotmail.com","Department of Internal Medicine, Patan Hospital, Lalitpur Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Patan Hospital, Lalitpur Nepal. kayasthagk@hotmail.com","institution_ids":["https://openalex.org/I2801573932"]},{"raw_affiliation_string":"Department of Internal Medicine, Patan Hospital, Lalitpur Nepal","institution_ids":["https://openalex.org/I2801573932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027193491","display_name":"Padma Gurung","orcid":"https://orcid.org/0000-0002-6382-2445","observed_orcids":["https://orcid.org/0000-0002-6382-2445"]},"institutions":[{"id":"https://openalex.org/I2801573932","display_name":"Patan Hospital","ror":"https://ror.org/02vhxx141","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I2801573932"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Padma Gurung","raw_affiliation_strings":["Department of Internal Medicine, Patan Hospital, Lalitpur, Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Patan Hospital, Lalitpur, Nepal","institution_ids":["https://openalex.org/I2801573932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041973904","display_name":"Paras Kumar Acharya","orcid":"https://orcid.org/0000-0002-2645-2553","observed_orcids":["https://orcid.org/0000-0002-2645-2553"]},"institutions":[{"id":"https://openalex.org/I2801573932","display_name":"Patan Hospital","ror":"https://ror.org/02vhxx141","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I2801573932"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Paras K Acharya","raw_affiliation_strings":["Department of Internal Medicine, Patan Hospital, Lalitpur, Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Patan Hospital, Lalitpur, Nepal","institution_ids":["https://openalex.org/I2801573932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055732385","display_name":"Buddhi Prasad Paudyal","orcid":"https://orcid.org/0000-0002-5119-4082","observed_orcids":["https://orcid.org/0000-0002-5119-4082"]},"institutions":[{"id":"https://openalex.org/I2801573932","display_name":"Patan Hospital","ror":"https://ror.org/02vhxx141","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I2801573932"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Buddhi P Paudyal","raw_affiliation_strings":["Department of Internal Medicine, Patan Hospital, Lalitpur, Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Patan Hospital, Lalitpur, Nepal","institution_ids":["https://openalex.org/I2801573932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090724721","display_name":"Bruce W Hayes","orcid":"https://orcid.org/0000-0002-0457-1690","observed_orcids":["https://orcid.org/0000-0002-0457-1690"]},"institutions":[{"id":"https://openalex.org/I2801573932","display_name":"Patan Hospital","ror":"https://ror.org/02vhxx141","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I2801573932"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Bruce Hayes","raw_affiliation_strings":["Department of Emergency Medicine, Patan Hospital, Lalitpur, Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Patan Hospital, Lalitpur, Nepal","institution_ids":["https://openalex.org/I2801573932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103866874","display_name":"Mark Zimmerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090860","display_name":"Nick Simons Institute","ror":"https://ror.org/009s7cn04","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I4210090860"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Mark Zimmerman","raw_affiliation_strings":["Nick Simon Institute, Lalitpur, Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nick Simon Institute, Lalitpur, Nepal","institution_ids":["https://openalex.org/I4210090860"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102911620","display_name":"Arjun Karki","orcid":"https://orcid.org/0000-0003-3922-7782","observed_orcids":["https://orcid.org/0000-0003-3922-7782"]},"institutions":[{"id":"https://openalex.org/I2801573932","display_name":"Patan Hospital","ror":"https://ror.org/02vhxx141","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I2801573932"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Arjun Karki","raw_affiliation_strings":["Department of Internal Medicine, Patan Hospital, Lalitpur, Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Patan Hospital, Lalitpur, Nepal","institution_ids":["https://openalex.org/I2801573932"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron S Mansfield","raw_affiliation_strings":["Division of Hematology of the Department of Internal Medicine, and Department of Oncology, Mayo Clinic, Rochester, MN, USA","Division of Hematology of the Department of Internal Medicine, and Department of Oncology, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology of the Department of Internal Medicine, and Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology of the Department of Internal Medicine, and Department of Oncology, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020633688"],"corresponding_institution_ids":["https://openalex.org/I2801573932"],"apc_list":{"value":2170,"currency":"USD","value_usd":2170},"apc_paid":{"value":2170,"currency":"USD","value_usd":2170},"fwci":0.0,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.12072372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":"1","first_page":"8","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/imatinib-mesylate","display_name":"imatinib mesylate","score":0.9169999957084656},{"id":"https://openalex.org/keywords/bcr-abl1","display_name":"BCR-ABL1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/philadelphia-chromosome","display_name":"Philadelphia chromosome","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cytogenetic-response","display_name":"cytogenetic response","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hematological-response","display_name":"hematologic response","score":0.9850000143051147},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8989999890327454},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/developing-countries","display_name":"developing countries","score":0.36899998784065247},{"id":"https://openalex.org/keywords/nepal","display_name":"Nepal","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.8823211789131165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8678649663925171},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.8358182907104492},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7164708971977234},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.7017114758491516},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.6081125736236572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5895421504974365},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.517760694026947},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.5096490383148193},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4833030700683594},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.4778063893318176},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.45278191566467285},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.37082260847091675},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36249637603759766},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3263307511806488},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.270693302154541},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.06986603140830994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06804141402244568},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.065325528383255},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2326-10-8","doi":"https://doi.org/10.1186/1471-2326-10-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2326-10-8","pdf_url":"https://bmchematol.biomedcentral.com/counter/pdf/10.1186/1471-2326-10-8","source":{"id":"https://openalex.org/S2738849190","display_name":"BMC Hematology","issn_l":"2052-1839","issn":["2052-1839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Hematology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3017013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3017013","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Blood Disord","raw_type":"Text"},{"id":"pmid:21138592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21138592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC blood disorders","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.292.7254","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.7254","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/09/55/BMC_Blood_Disord_2010_Dec_7_10_8.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:fb9e198987764cd7a700cce56f5c3d20","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fb9e198987764cd7a700cce56f5c3d20","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Blood Disorders, Vol 10, Iss 1, p 8 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2326-10-8","doi":"https://doi.org/10.1186/1471-2326-10-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2326-10-8","pdf_url":"https://bmchematol.biomedcentral.com/counter/pdf/10.1186/1471-2326-10-8","source":{"id":"https://openalex.org/S2738849190","display_name":"BMC Hematology","issn_l":"2052-1839","issn":["2052-1839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019199342.pdf","grobid_xml":"https://content.openalex.org/works/W2019199342.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1888451435","https://openalex.org/W1976244025","https://openalex.org/W1986058924","https://openalex.org/W1994309500","https://openalex.org/W1998593414","https://openalex.org/W2006917576","https://openalex.org/W2011474502","https://openalex.org/W2014653983","https://openalex.org/W2015616444","https://openalex.org/W2021095507","https://openalex.org/W2026389791","https://openalex.org/W2028728760","https://openalex.org/W2028959752","https://openalex.org/W2030154801","https://openalex.org/W2037878975","https://openalex.org/W2054251966","https://openalex.org/W2057718276","https://openalex.org/W2075706560","https://openalex.org/W2076736727","https://openalex.org/W2079446921","https://openalex.org/W2089483984","https://openalex.org/W2101390452","https://openalex.org/W2107268345","https://openalex.org/W2126129237","https://openalex.org/W2126742110","https://openalex.org/W2131171876","https://openalex.org/W2137583478","https://openalex.org/W2141954485","https://openalex.org/W2142969636","https://openalex.org/W2158460758","https://openalex.org/W2159863363","https://openalex.org/W2164872817","https://openalex.org/W2165537263","https://openalex.org/W2171722798","https://openalex.org/W2312804644","https://openalex.org/W2314938037","https://openalex.org/W2329648702"],"related_works":["https://openalex.org/W7100636877","https://openalex.org/W2602643470","https://openalex.org/W2121209161","https://openalex.org/W1963577235","https://openalex.org/W2331692467","https://openalex.org/W2610326758","https://openalex.org/W2981474976","https://openalex.org/W2093017212","https://openalex.org/W2103974518","https://openalex.org/W2381201292"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chronic":[1],"Myeloid":[2],"Leukemia":[3],"(CML)":[4],"is":[5,27,38,52,188,201,221],"caused":[6],"by":[7,224],"the":[8,21,55,124,141,154,233],"abnormal":[9],"fusion":[10],"protein":[11],"BCR-ABL1,":[12],"a":[13,28,130,193,210],"constitutively":[14],"active":[15],"tyrosine":[16],"kinase":[17],"and":[18,45,84,87,116,149,180,204,247],"product":[19],"of":[20,31,54,70,89,101,123,134,140,153,161,166,213,229,235],"Philadelphia":[22,72],"chromosome.":[23],"Gleevec":[24,56],"(Imatinib":[25],"mesylate)":[26],"selective":[29],"inhibitor":[30],"this":[32,36],"kinase.":[33],"Treatment":[34],"with":[35,65,126,215],"agent":[37],"known":[39],"to":[40,190,241,245],"result":[41],"in":[42,78,114,120,146,192,209,232],"hematologic,":[43],"cytogenetic,":[44],"molecular":[46],"responses.":[47],"Patan":[48],"hospital":[49],"(Patan,":[50],"Nepal)":[51],"one":[53],"International":[57],"Patient":[58],"Assistance":[59],"Program":[60],"(GIPAP)":[61],"centers":[62],"for":[63,93],"patients":[64,75,105,125,142,155,162,171,214,237],"CML.":[66,128,219],"METHODS:":[67],"A":[68,169],"total":[69],"106":[71],"positive":[73,218],"CML":[74],"were":[76,91],"enrolled":[77],"our":[79,225,236,239],"center":[80],"between":[81],"Feb":[82],"2003":[83],"Jun":[85],"2008,":[86],"103":[88,102],"them":[90],"eligible":[92],"cytogenetic":[94,107,112,230],"and/or":[95],"hematologic":[96,118,147],"response":[97],"analyses.":[98],"RESULTS:":[99],"Out":[100],"patients,":[103],"27%":[104],"underwent":[106],"analysis.":[108],"Imatinib":[109,220],"induced":[110,205],"major":[111],"responses":[113,119,208,244],"89%":[115],"complete":[117],"almost":[121],"100%":[122],"confirmed":[127],"After":[129],"mean":[131],"follow":[132],"up":[133],"27":[135],"months,":[136],"an":[137],"estimated":[138],"90%":[139,152],"on":[143],"imatinib":[144,187,200,246],"remained":[145],"remission":[148],"more":[150],"than":[151],"are":[156],"still":[157],"alive.":[158],"About":[159],"30%":[160],"developed":[163,172],"some":[164],"form":[165],"manageable":[167],"myelosuppression.":[168],"few":[170],"non-hematologic":[173],"toxic":[174],"side":[175],"effects":[176],"such":[177],"as":[178],"edema":[179],"hepatotoxicity.":[181],"CONCLUSIONS:":[182],"Our":[183],"study":[184],"demonstrates":[185],"that":[186,199],"safe":[189],"use":[191],"developing":[194],"country.":[195],"Furthermore,":[196],"we":[197],"demonstrate":[198],"very":[202],"effective":[203],"long":[206],"lasting":[207],"high":[211],"proportion":[212],"Ph":[216],"chromosome/BCR-ABL1":[217],"well":[222],"tolerated":[223],"patients.":[226],"The":[227],"lack":[228],"analysis":[231],"majority":[234],"hindered":[238],"ability":[240],"detect":[242],"inadequate":[243],"adjust":[248],"therapy":[249],"appropriately.":[250]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}