{"id":"https://openalex.org/W2019164152","doi":"https://doi.org/10.3109/02841868909111253","title":"Combination Chemotherapy with Vinblastine, Ifosfamide and Cisplatin in Bulky Seminoma","display_name":"Combination Chemotherapy with Vinblastine, Ifosfamide and Cisplatin in Bulky Seminoma","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2019164152","doi":"https://doi.org/10.3109/02841868909111253","mag":"2019164152","pmid":"https://pubmed.ncbi.nlm.nih.gov/2736112"},"language":"en","primary_location":{"id":"doi:10.3109/02841868909111253","doi":"https://doi.org/10.3109/02841868909111253","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02841868909111253","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841868909111253?needAccess=true&role=button","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841868909111253?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072829117","display_name":"Christoph Clemm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Clemm","raw_affiliation_strings":["Department of Internal Medicine III, University of Munich, West Germany","Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, University of Munich, West Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109341596","display_name":"Reiner C. Hartenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Hartenstein","raw_affiliation_strings":["Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052340981","display_name":"Norman Willich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Willich","raw_affiliation_strings":["Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043953193","display_name":"Georg Ledderose","orcid":"https://orcid.org/0000-0002-8451-6498","observed_orcids":["https://orcid.org/0000-0002-8451-6498"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Ledderose","raw_affiliation_strings":["Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108534913","display_name":"W. Wilmanns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Wilmanns","raw_affiliation_strings":["Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Klinikum Grosshadern of the University of Munich, D-8000 Munich 70, West Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":1.1569,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.78601133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"2","first_page":"231","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/seminoma","display_name":"seminoma","score":0.824999988079071},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/ifosfamide","display_name":"ifosfamide","score":1.0},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":1.0},{"id":"https://openalex.org/keywords/vip-regimen","display_name":"VIP regimen","score":0.9679999947547913},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.8489999771118164},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9380000233650208},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.7950000166893005},{"id":"https://openalex.org/keywords/testicular-cancer","display_name":"testicular cancer","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9489830732345581},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.9194739460945129},{"id":"https://openalex.org/C2777506904","wikidata":"https://www.wikidata.org/wiki/Q418560","display_name":"Ifosfamide","level":4,"score":0.8289704322814941},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6847169399261475},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6486037373542786},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.62298583984375},{"id":"https://openalex.org/C2778074268","wikidata":"https://www.wikidata.org/wiki/Q1786953","display_name":"Seminoma","level":3,"score":0.5703806281089783},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5487894415855408},{"id":"https://openalex.org/C2776581026","wikidata":"https://www.wikidata.org/wiki/Q864868","display_name":"Bone marrow suppression","level":3,"score":0.5183137655258179},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5132265090942383},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.49238502979278564},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41216573119163513},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.39449936151504517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37241852283477783}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004407","descriptor_name":"Dysgerminoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004407","descriptor_name":"Dysgerminoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007069","descriptor_name":"Ifosfamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/02841868909111253","doi":"https://doi.org/10.3109/02841868909111253","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02841868909111253","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841868909111253?needAccess=true&role=button","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},{"id":"pmid:2736112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2736112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oncologica (Stockholm, Sweden)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/02841868909111253","doi":"https://doi.org/10.3109/02841868909111253","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02841868909111253","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841868909111253?needAccess=true&role=button","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019164152.pdf","grobid_xml":"https://content.openalex.org/works/W2019164152.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W572905106","https://openalex.org/W1908316323","https://openalex.org/W1957139198","https://openalex.org/W1994137958","https://openalex.org/W2006101749","https://openalex.org/W2035455598","https://openalex.org/W2035597153","https://openalex.org/W2052638102","https://openalex.org/W2059310993","https://openalex.org/W2078125348","https://openalex.org/W2083105900","https://openalex.org/W2253416740","https://openalex.org/W2263143764","https://openalex.org/W2266575209","https://openalex.org/W2297194799","https://openalex.org/W2323139555","https://openalex.org/W2396165298","https://openalex.org/W2403331838","https://openalex.org/W2411938410","https://openalex.org/W2419181555","https://openalex.org/W2469477293","https://openalex.org/W2471861039"],"related_works":["https://openalex.org/W2052638102","https://openalex.org/W359929618","https://openalex.org/W1994137958","https://openalex.org/W2327727334","https://openalex.org/W2028328871","https://openalex.org/W4385516106","https://openalex.org/W2081116268","https://openalex.org/W2040479154","https://openalex.org/W1964323811","https://openalex.org/W2119118310"],"abstract_inverted_index":{"Since":[0],"1982,":[1],"24":[2],"patients":[3,49,75],"with":[4,9],"bulky":[5,121],"seminoma":[6],"were":[7,110],"treated":[8],"the":[10,43,47,103,115,125],"VIP-regimen":[11],"consisting":[12],"of":[13,86,102,124,131],"vinblastine":[14,126],"6":[15],"mg/m2":[16,26],"days":[17,22,27],"1+2,":[18],"ifosfamide":[19],"1.5":[20],"g/m2":[21],"1-5,":[23],"cisplatin":[24],"20":[25],"1-5.":[28],"One":[29,63],"patient":[30,35,40,64],"showed":[31],"primary":[32],"progression,":[33],"another":[34],"partial":[36],"remission,":[37],"and":[38],"one":[39],"died":[41],"during":[42],"first":[44],"cycle.":[45],"All":[46],"other":[48,106],"had":[50],"complete":[51,68],"remission":[52,69],"(21/24":[53],"=":[54],"87%),":[55],"which":[56],"was":[57,92],"documented":[58],"histologically":[59],"in":[60,98,120],"9":[61],"patients.":[62,104],"relapsed":[65],"but":[66],"obtained":[67],"after":[70,81],"repeated":[71],"treatment.":[72],"Thus":[73],"21":[74],"are":[76],"currently":[77],"living":[78],"without":[79],"disease":[80],"a":[82],"median":[83],"observation":[84],"time":[85],"30+":[87],"months.":[88],"Bone":[89],"marrow":[90,133],"toxicity":[91],"severe,":[93],"leading":[94],"to":[95],"dose":[96,127],"reduction":[97],"more":[99],"than":[100],"50%":[101],"No":[105],"severe":[107],"side":[108],"effects":[109],"observed.":[111],"We":[112],"conclude":[113],"that":[114],"regimen":[116],"is":[117,128],"highly":[118],"effective":[119],"seminoma.":[122],"Reduction":[123],"recommended":[129],"because":[130],"bone":[132],"toxicity.":[134]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}