{"id":"https://openalex.org/W2019129277","doi":"https://doi.org/10.1101/cshperspect.a000596","title":"Chromatin Higher-order Structure and Dynamics","display_name":"Chromatin Higher-order Structure and Dynamics","publication_year":2010,"publication_date":"2010-04-07","ids":{"openalex":"https://openalex.org/W2019129277","doi":"https://doi.org/10.1101/cshperspect.a000596","mag":"2019129277","pmid":"https://pubmed.ncbi.nlm.nih.gov/20452954","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857170"},"language":"en","primary_location":{"id":"doi:10.1101/cshperspect.a000596","doi":"https://doi.org/10.1101/cshperspect.a000596","is_oa":false,"landing_page_url":"https://doi.org/10.1101/cshperspect.a000596","pdf_url":null,"source":{"id":"https://openalex.org/S160223955","display_name":"Cold Spring Harbor Perspectives in Biology","issn_l":"1943-0264","issn":["1943-0264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Biology","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857170","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111866704","display_name":"Christopher L. F. Woodcock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. L. Woodcock","raw_affiliation_strings":["Biology Department, University of Massachusetts, Amherst, Massachusetts 01003, USA. chris@bio.umass.edu","Biology Department, University of Massachusetts, Amherst, Massachusetts 01003","Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts, Amherst, Massachusetts 01003, USA. chris@bio.umass.edu","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Biology Department, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055261141","display_name":"Rajarshi P. Ghosh","orcid":"https://orcid.org/0000-0002-0020-6194","observed_orcids":["https://orcid.org/0000-0002-0020-6194","https://orcid.org/0000-0003-2348-6333"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. P. Ghosh","raw_affiliation_strings":["Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":438,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"5","first_page":"a000596","last_page":"a000596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/higher-order-chromatin-structure","display_name":"higher-order chromatin structure","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/chromatin-dynamics","display_name":"chromatin dynamics","score":0.7979999780654907},{"id":"https://openalex.org/keywords/structural-plasticity","display_name":"structural plasticity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/genome-organization","display_name":"genome organization","score":0.9169999957084656},{"id":"https://openalex.org/keywords/nucleosome","display_name":"nucleosome","score":0.781000018119812},{"id":"https://openalex.org/keywords/interphase-nucleus","display_name":"interphase nuclei","score":0.6510000228881836},{"id":"https://openalex.org/keywords/mitotic-chromosomes","display_name":"metaphase chromosomes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dna-condensation","display_name":"DNA condensation","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8864415884017944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8455002307891846},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.7018489837646484},{"id":"https://openalex.org/C29452124","wikidata":"https://www.wikidata.org/wiki/Q835950","display_name":"Interphase","level":2,"score":0.5968685150146484},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5610386729240417},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45418867468833923},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.39193516969680786},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.38127198815345764},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3224397301673889},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30406874418258667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08768269419670105}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1101/cshperspect.a000596","doi":"https://doi.org/10.1101/cshperspect.a000596","is_oa":false,"landing_page_url":"https://doi.org/10.1101/cshperspect.a000596","pdf_url":null,"source":{"id":"https://openalex.org/S160223955","display_name":"Cold Spring Harbor Perspectives in Biology","issn_l":"1943-0264","issn":["1943-0264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2857170","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857170","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harb Perspect Biol","raw_type":"Text"},{"id":"pmid:20452954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20452954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor perspectives in biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2857170","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857170","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harb Perspect Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":136,"referenced_works":["https://openalex.org/W1492511763","https://openalex.org/W1493549734","https://openalex.org/W1505408219","https://openalex.org/W1635552303","https://openalex.org/W1652729057","https://openalex.org/W1822988701","https://openalex.org/W1964259506","https://openalex.org/W1968127700","https://openalex.org/W1968554285","https://openalex.org/W1968894421","https://openalex.org/W1968954227","https://openalex.org/W1970398821","https://openalex.org/W1971733888","https://openalex.org/W1972321276","https://openalex.org/W1973860395","https://openalex.org/W1977339483","https://openalex.org/W1977387171","https://openalex.org/W1977748078","https://openalex.org/W1978583145","https://openalex.org/W1978967539","https://openalex.org/W1982295124","https://openalex.org/W1987362169","https://openalex.org/W1989855790","https://openalex.org/W1992425415","https://openalex.org/W1993377453","https://openalex.org/W1994926961","https://openalex.org/W1996183597","https://openalex.org/W2001885831","https://openalex.org/W2001929989","https://openalex.org/W2002137232","https://openalex.org/W2004694336","https://openalex.org/W2005358168","https://openalex.org/W2008181290","https://openalex.org/W2008699882","https://openalex.org/W2010295908","https://openalex.org/W2011064892","https://openalex.org/W2015324225","https://openalex.org/W2015697863","https://openalex.org/W2016314394","https://openalex.org/W2017314177","https://openalex.org/W2017429695","https://openalex.org/W2018825948","https://openalex.org/W2018832483","https://openalex.org/W2021779654","https://openalex.org/W2024559058","https://openalex.org/W2025059119","https://openalex.org/W2025367366","https://openalex.org/W2026180423","https://openalex.org/W2026755238","https://openalex.org/W2030023744","https://openalex.org/W2032231011","https://openalex.org/W2033421234","https://openalex.org/W2034089913","https://openalex.org/W2035059547","https://openalex.org/W2035659472","https://openalex.org/W2037127704","https://openalex.org/W2038675022","https://openalex.org/W2038932806","https://openalex.org/W2040234712","https://openalex.org/W2043676713","https://openalex.org/W2044107593","https://openalex.org/W2048263136","https://openalex.org/W2049108972","https://openalex.org/W2050550914","https://openalex.org/W2052842503","https://openalex.org/W2056216005","https://openalex.org/W2060872711","https://openalex.org/W2062009657","https://openalex.org/W2068363360","https://openalex.org/W2069328568","https://openalex.org/W2069545688","https://openalex.org/W2074571991","https://openalex.org/W2075470041","https://openalex.org/W2076702777","https://openalex.org/W2077254103","https://openalex.org/W2078529961","https://openalex.org/W2079233107","https://openalex.org/W2079599988","https://openalex.org/W2083232076","https://openalex.org/W2084250387","https://openalex.org/W2090037139","https://openalex.org/W2091031681","https://openalex.org/W2093351957","https://openalex.org/W2094212271","https://openalex.org/W2096083625","https://openalex.org/W2099183701","https://openalex.org/W2099997590","https://openalex.org/W2100581810","https://openalex.org/W2105054597","https://openalex.org/W2106278490","https://openalex.org/W2109802732","https://openalex.org/W2110399580","https://openalex.org/W2111592257","https://openalex.org/W2112824334","https://openalex.org/W2113153325","https://openalex.org/W2113522043","https://openalex.org/W2114979281","https://openalex.org/W2116622696","https://openalex.org/W2121003260","https://openalex.org/W2122837076","https://openalex.org/W2123799203","https://openalex.org/W2126878399","https://openalex.org/W2131438950","https://openalex.org/W2133015139","https://openalex.org/W2138165389","https://openalex.org/W2140475749","https://openalex.org/W2140561448","https://openalex.org/W2140588503","https://openalex.org/W2141991853","https://openalex.org/W2143658931","https://openalex.org/W2143826692","https://openalex.org/W2144792857","https://openalex.org/W2145379834","https://openalex.org/W2145381472","https://openalex.org/W2146008949","https://openalex.org/W2147449506","https://openalex.org/W2147523890","https://openalex.org/W2148817601","https://openalex.org/W2149917410","https://openalex.org/W2151479824","https://openalex.org/W2152116027","https://openalex.org/W2154736293","https://openalex.org/W2157903077","https://openalex.org/W2164938051","https://openalex.org/W2165451373","https://openalex.org/W2165990385","https://openalex.org/W2166633156","https://openalex.org/W2168816122","https://openalex.org/W2169727662","https://openalex.org/W2170725825","https://openalex.org/W2485251647","https://openalex.org/W2739174192","https://openalex.org/W4211033156","https://openalex.org/W4242410054","https://openalex.org/W4246607059","https://openalex.org/W6992757371"],"related_works":["https://openalex.org/W2052436973","https://openalex.org/W2099997590","https://openalex.org/W7214753406","https://openalex.org/W2079233107","https://openalex.org/W2090650373","https://openalex.org/W2108765680","https://openalex.org/W1970623041","https://openalex.org/W2166933617","https://openalex.org/W2768753986","https://openalex.org/W1598970956"],"abstract_inverted_index":{"The":[0],"primary":[1],"role":[2],"of":[3,20,22,38,47,62,73],"the":[4,15,35,48,53,82,106,133],"nucleus":[5,59],"as":[6],"an":[7,57],"information":[8],"storage,":[9],"retrieval,":[10],"and":[11,18,81,92,105,113,136],"replication":[12],"site":[13],"requires":[14],"physical":[16],"organization":[17],"compaction":[19],"meters":[21],"DNA.":[23],"Although":[24],"it":[25],"has":[26,88],"been":[27,89],"clear":[28],"for":[29],"many":[30],"years":[31],"that":[32,66,84,110,140],"nucleosomes":[33],"constitute":[34],"first":[36],"level":[37],"chromatin":[39,74,114],"compaction,":[40],"this":[41,97],"contributes":[42],"a":[43,90],"relatively":[44],"small":[45],"fraction":[46],"condensation":[49],"needed":[50],"to":[51,128],"fit":[52],"typical":[54],"genome":[55,120],"into":[56],"interphase":[58],"or":[60],"set":[61],"metaphase":[63],"chromosomes,":[64],"indicating":[65,109],"there":[67],"are":[68],"additional":[69],"\"higher":[70],"order\"":[71],"levels":[72],"condensation.":[75],"Identifying":[76],"these":[77],"levels,":[78],"their":[79,86],"interrelationships,":[80],"principles":[83],"govern":[85],"occurrence":[87],"challenging":[91],"much":[93],"discussed":[94],"problem.":[95],"In":[96],"article,":[98],"we":[99],"focus":[100],"on":[101],"recent":[102],"experimental":[103],"advances":[104],"emerging":[107],"evidence":[108],"structural":[111],"plasticity":[112],"dynamics":[115],"play":[116],"dominant":[117],"roles":[118],"in":[119,132],"organization.":[121],"We":[122],"also":[123],"discuss":[124],"novel":[125],"approaches":[126],"likely":[127],"yield":[129],"important":[130],"insights":[131],"near":[134],"future,":[135],"suggest":[137],"research":[138],"areas":[139],"merit":[141],"further":[142],"study.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":42},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":32},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}