{"id":"https://openalex.org/W2019114122","doi":"https://doi.org/10.1080/15533174.2012.682691","title":"Synthesis, Characterization, and Cytotoxic Activity on MCF-7 Cell Line of Some Novel Metal Complexes With Substituted Benzimidazole Ligands","display_name":"Synthesis, Characterization, and Cytotoxic Activity on MCF-7 Cell Line of Some Novel Metal Complexes With Substituted Benzimidazole Ligands","publication_year":2012,"publication_date":"2012-12-03","ids":{"openalex":"https://openalex.org/W2019114122","doi":"https://doi.org/10.1080/15533174.2012.682691","mag":"2019114122"},"language":"en","primary_location":{"id":"doi:10.1080/15533174.2012.682691","doi":"https://doi.org/10.1080/15533174.2012.682691","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15533174.2012.682691","pdf_url":null,"source":{"id":"https://openalex.org/S120123482","display_name":"Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry","issn_l":"1553-3174","issn":["1553-3174","1553-3182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011987778","display_name":"Ahmed M. A. El\u2010Seidy","orcid":"https://orcid.org/0000-0003-0708-7658","observed_orcids":["https://orcid.org/0000-0003-0708-7658","https://orcid.org/0000-0002-1769-9394"]},"institutions":[{"id":"https://openalex.org/I240666556","display_name":"Imam Mohammad ibn Saud Islamic University","ror":"https://ror.org/05gxjyb39","country_code":"SA","type":"education","lineage":["https://openalex.org/I240666556"]},{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Ahmed M. A. El-Seidy","raw_affiliation_strings":["a   Inorganic Chemistry Department , National Research Center ,  Cairo ,  Egypt","b   Department of Chemistry, Faculty of Science , The Imam Muhammad bin Saud Islamic University ,  Riyadh ,  Saudi Arabia","Department of Chemistry, Faculty of Science , The Imam Muhammad bin Saud Islamic University , Riyadh , Saudi Arabia","Inorganic Chemistry Department , National Research Center , Cairo , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a   Inorganic Chemistry Department , National Research Center ,  Cairo ,  Egypt","institution_ids":["https://openalex.org/I4210131959"]},{"raw_affiliation_string":"b   Department of Chemistry, Faculty of Science , The Imam Muhammad bin Saud Islamic University ,  Riyadh ,  Saudi Arabia","institution_ids":["https://openalex.org/I240666556"]},{"raw_affiliation_string":"Department of Chemistry, Faculty of Science , The Imam Muhammad bin Saud Islamic University , Riyadh , Saudi Arabia","institution_ids":["https://openalex.org/I240666556"]},{"raw_affiliation_string":"Inorganic Chemistry Department , National Research Center , Cairo , Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042138410","display_name":"Eman A.M. Elzahany","orcid":"https://orcid.org/0000-0002-6821-6567","observed_orcids":["https://orcid.org/0000-0002-6821-6567"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Eman El-Zahany","raw_affiliation_strings":["a   Inorganic Chemistry Department , National Research Center ,  Cairo ,  Egypt","Inorganic Chemistry Department , National Research Center , Cairo , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a   Inorganic Chemistry Department , National Research Center ,  Cairo ,  Egypt","institution_ids":["https://openalex.org/I4210131959"]},{"raw_affiliation_string":"Inorganic Chemistry Department , National Research Center , Cairo , Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111390408","display_name":"Atiat S. Barakat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Atiat S. Barakat","raw_affiliation_strings":["c   Inorganic Chemistry Department, Faculty of Science , Zagazig University ,  El Zagazig ,  Egypt","Inorganic Chemistry Department, Faculty of Science , Zagazig University , El Zagazig , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c   Inorganic Chemistry Department, Faculty of Science , Zagazig University ,  El Zagazig ,  Egypt","institution_ids":["https://openalex.org/I192398990"]},{"raw_affiliation_string":"Inorganic Chemistry Department, Faculty of Science , Zagazig University , El Zagazig , Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000755045","display_name":"Nabil S. Youssef","orcid":"https://orcid.org/0000-0003-1489-567X","observed_orcids":["https://orcid.org/0000-0003-1489-567X"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nabil S. Youssef","raw_affiliation_strings":["a   Inorganic Chemistry Department , National Research Center ,  Cairo ,  Egypt","Inorganic Chemistry Department , National Research Center , Cairo , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a   Inorganic Chemistry Department , National Research Center ,  Cairo ,  Egypt","institution_ids":["https://openalex.org/I4210131959"]},{"raw_affiliation_string":"Inorganic Chemistry Department , National Research Center , Cairo , Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066120991","display_name":"Shadia Ahmed Galal","orcid":"https://orcid.org/0000-0002-0320-1655","observed_orcids":["https://orcid.org/0000-0002-0320-1655","https://orcid.org/0000-0002-5440-8381"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Shadia A. Galal","raw_affiliation_strings":["d   Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research , National Research Centre ,  Cairo ,  Egypt","Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research , National Research Centre , Cairo , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"d   Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research , National Research Centre ,  Cairo ,  Egypt","institution_ids":["https://openalex.org/I4210131959"]},{"raw_affiliation_string":"Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research , National Research Centre , Cairo , Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077525188","display_name":"Elsayed Ali Drweesh","orcid":"https://orcid.org/0000-0002-4097-2854","observed_orcids":["https://orcid.org/0000-0002-4097-2854"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sayed A. Drweesh","raw_affiliation_strings":["a   Inorganic Chemistry Department , National Research Center ,  Cairo ,  Egypt","Inorganic Chemistry Department , National Research Center , Cairo , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a   Inorganic Chemistry Department , National Research Center ,  Cairo ,  Egypt","institution_ids":["https://openalex.org/I4210131959"]},{"raw_affiliation_string":"Inorganic Chemistry Department , National Research Center , Cairo , Egypt","institution_ids":["https://openalex.org/I4210131959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1635,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.53224575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"43","issue":"1","first_page":"46","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coordination-compounds","display_name":"metal complexes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/schiff-base-ligands","display_name":"Schiff base ligands","score":0.8339999914169312},{"id":"https://openalex.org/keywords/benzimidazole-ligands","display_name":"benzimidazole ligands","score":0.8019999861717224},{"id":"https://openalex.org/keywords/silver-complexes","display_name":"silver complexes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/copper-complexes","display_name":"copper complexes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tridentate-ligands","display_name":"tridentate ligands","score":0.7490000128746033},{"id":"https://openalex.org/keywords/anticancer-drug-candidates","display_name":"anticancer drug candidates","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.9184933304786682},{"id":"https://openalex.org/C2778484023","wikidata":"https://www.wikidata.org/wiki/Q415190","display_name":"Benzimidazole","level":2,"score":0.899390459060669},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6110920906066895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5632519721984863},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5436843633651733},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.48352956771850586},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4511699378490448},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41444841027259827},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3253164291381836},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.24309206008911133},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20745515823364258},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15755030512809753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1544194519519806},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13271385431289673},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1282401978969574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11830678582191467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10515505075454712},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.0},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/15533174.2012.682691","doi":"https://doi.org/10.1080/15533174.2012.682691","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15533174.2012.682691","pdf_url":null,"source":{"id":"https://openalex.org/S120123482","display_name":"Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry","issn_l":"1553-3174","issn":["1553-3174","1553-3182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W30399823","https://openalex.org/W121199693","https://openalex.org/W156288218","https://openalex.org/W257925428","https://openalex.org/W576744283","https://openalex.org/W602658979","https://openalex.org/W1482388246","https://openalex.org/W1507765034","https://openalex.org/W1897085524","https://openalex.org/W1965139535","https://openalex.org/W1969745097","https://openalex.org/W1971923258","https://openalex.org/W1976205663","https://openalex.org/W1979703236","https://openalex.org/W1979988124","https://openalex.org/W1980590245","https://openalex.org/W1983638300","https://openalex.org/W1986264534","https://openalex.org/W1993409437","https://openalex.org/W2007216164","https://openalex.org/W2008470511","https://openalex.org/W2011524623","https://openalex.org/W2013443201","https://openalex.org/W2013684836","https://openalex.org/W2015824488","https://openalex.org/W2019223809","https://openalex.org/W2020359788","https://openalex.org/W2026330019","https://openalex.org/W2028852313","https://openalex.org/W2029074383","https://openalex.org/W2029993320","https://openalex.org/W2030377299","https://openalex.org/W2033646361","https://openalex.org/W2035502255","https://openalex.org/W2043780435","https://openalex.org/W2050104743","https://openalex.org/W2059417182","https://openalex.org/W2061360450","https://openalex.org/W2065231832","https://openalex.org/W2067007135","https://openalex.org/W2069307168","https://openalex.org/W2070932360","https://openalex.org/W2074600940","https://openalex.org/W2078025139","https://openalex.org/W2078170169","https://openalex.org/W2079854743","https://openalex.org/W2087421144","https://openalex.org/W2094493456","https://openalex.org/W2105615094","https://openalex.org/W2106342584","https://openalex.org/W2107562129","https://openalex.org/W2109689528","https://openalex.org/W2116816819","https://openalex.org/W2126847809","https://openalex.org/W2126868662","https://openalex.org/W2139497193","https://openalex.org/W2164364062","https://openalex.org/W2318631809","https://openalex.org/W2319525166","https://openalex.org/W2616130022","https://openalex.org/W2774409123","https://openalex.org/W3022602249"],"related_works":["https://openalex.org/W7216493736","https://openalex.org/W1966149304","https://openalex.org/W3152643774","https://openalex.org/W4396552519","https://openalex.org/W4415985084","https://openalex.org/W7167148722","https://openalex.org/W4392055543","https://openalex.org/W3081346692","https://openalex.org/W4391446549","https://openalex.org/W4405774647"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,55,80,84],"novel":[3],"metal":[4],"complexes":[5,70],"with":[6],"the":[7,56,85,87],"Schiff":[8],"base":[9],"ligands":[10,43],"4-((((1H-benzo[d]imidazol-2-yl)methyl)imino)methyl)":[11],"benzene-1,3-diol,":[12],"H3L1,":[13],"and":[14,21,25,68,73],"(((1H-benzo[d]imidazol-2-yl)methyl)":[15],"thio)propanenitrile,":[16],"HL2,":[17],"have":[18],"been":[19],"synthesized":[20],"identified":[22],"by":[23],"elemental":[24],"spectral":[26],"(UV-vis,":[27],"IR,":[28],"1H":[29],"NMR,":[30],"mass)":[31],"analyses,":[32],"molar":[33],"conductivities,":[34],"as":[35,37,46],"well":[36],"magnetic":[38],"moment":[39],"measurements":[40],"technique.":[41],"The":[42,52],"behave":[44],"either":[45],"neutral":[47],"tridentate":[48],"or":[49],"bidentate":[50],"ligand.":[51],"antitumor":[53,95],"activity":[54],"new":[57,93],"compounds":[58],"was":[59],"tested":[60],"against":[61],"breast":[62],"cancer":[63],"cell":[64],"line":[65],"MCF\u20107.":[66],"Ag":[67],"Cu":[69],"2,":[71],"8":[72],"9":[74],"showed":[75],"a":[76,92],"remarkable":[77],"smaller":[78],"value":[79],"IC50":[81],"than":[82],"that":[83,97],"Tamoxifen,":[86],"standard.":[88],"This":[89],"would":[90],"provide":[91],"potential":[94],"drug":[96],"deserves":[98],"more":[99],"attention.":[100]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
