{"id":"https://openalex.org/W2019099488","doi":"https://doi.org/10.1002/eji.200535163","title":"MEK kinase 1 is a negative regulator of virus\u2010specific CD8+ T cells","display_name":"MEK kinase 1 is a negative regulator of virus\u2010specific CD8+ T cells","publication_year":2006,"publication_date":"2006-06-08","ids":{"openalex":"https://openalex.org/W2019099488","doi":"https://doi.org/10.1002/eji.200535163","mag":"2019099488","pmid":"https://pubmed.ncbi.nlm.nih.gov/16761309"},"language":"en","primary_location":{"id":"doi:10.1002/eji.200535163","doi":"https://doi.org/10.1002/eji.200535163","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.200535163","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200535163","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200535163","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047939792","display_name":"Tord Labuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Tord Labuda","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark. t.labuda@immi.ku.dk","Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark","Institute of Molecular Biology and Physiology, Department of Immunology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark. t.labuda@immi.ku.dk","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Institute of Molecular Biology and Physiology, Department of Immunology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012450083","display_name":"Jan Pravsgaard Christensen","orcid":"https://orcid.org/0000-0002-4299-9479","observed_orcids":["https://orcid.org/0000-0002-4299-9479"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jan\u2004Pravsgaard Christensen","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113607771","display_name":"Susanne B. Rasmussen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Susanne Rasmussen","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014056036","display_name":"Barbara Bonnesen","orcid":"https://orcid.org/0000-0001-8635-347X","observed_orcids":["https://orcid.org/0000-0001-8635-347X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Barbara Bonnesen","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056315342","display_name":"Michael Karin","orcid":"https://orcid.org/0000-0002-2758-6473","observed_orcids":["https://orcid.org/0000-0002-2758-6473"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Karin","raw_affiliation_strings":["Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046951838","display_name":"Allan Randrup Thomsen","orcid":"https://orcid.org/0000-0002-2392-9803","observed_orcids":["https://orcid.org/0000-0002-2392-9803"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Allan\u2004Randrup Thomsen","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004078001","display_name":"Niels \u00d8dum","orcid":"https://orcid.org/0000-0003-3135-5624","observed_orcids":["https://orcid.org/0000-0003-3135-5624"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Niels \u00d8dum","raw_affiliation_strings":["Institute of Molecular Biology and Physiology, Department of Immunology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Physiology, Department of Immunology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047939792"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.1261,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.51496669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"8","first_page":"2076","last_page":"2084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mekk1","display_name":"MEKK1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/virus-specific-t-cells","display_name":"virus-specific T cells","score":0.7739999890327454},{"id":"https://openalex.org/keywords/vesicular-stomatitis-virus","display_name":"vesicular stomatitis virus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/negative-regulation-of-immune-response","display_name":"negative regulation of immune response","score":0.7250000238418579},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8637959957122803},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.7151101231575012},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5073155760765076},{"id":"https://openalex.org/C3017707949","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Negative regulator","level":3,"score":0.47507232427597046},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4724103510379791},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44338881969451904},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4110986590385437},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3351719379425049},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20931419730186462},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.12629196047782898},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1224774718284607},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11697125434875488}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002678","descriptor_name":"Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014721","descriptor_name":"Vesicular stomatitis Indiana virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018353","descriptor_name":"Rhabdoviridae Infections","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018353","descriptor_name":"Rhabdoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018353","descriptor_name":"Rhabdoviridae Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018353","descriptor_name":"Rhabdoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048728","descriptor_name":"MAP Kinase Kinase Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048728","descriptor_name":"MAP Kinase Kinase Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/eji.200535163","doi":"https://doi.org/10.1002/eji.200535163","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.200535163","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200535163","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16761309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16761309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/2b2d4cb0-dd89-11dd-b5fc-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/2b2d4cb0-dd89-11dd-b5fc-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Labuda, T, Christensen, J P, Rasmussen, S, Bonnesen, B, Karin, M, Thomsen, A R & \u00d8dum, N 2006, 'MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells', European Journal of Immunology, vol. 36, no. 8, pp. 2076-84. https://doi.org/10.1002/eji.200535163","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/eji.200535163","doi":"https://doi.org/10.1002/eji.200535163","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.200535163","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200535163","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2407524486","display_name":null,"funder_award_id":"ES-04151","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320310455","display_name":"Kr\u00e6ftens Bek\u00e6mpelse","ror":"https://ror.org/03ytt7k16"},{"id":"https://openalex.org/F4320321665","display_name":"Aase og Ejnar Danielsens Fond","ror":"https://ror.org/02hcraz70"},{"id":"https://openalex.org/F4320323411","display_name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","ror":"https://ror.org/02kdrgt12"},{"id":"https://openalex.org/F4320323527","display_name":"Dansk Kr\u00e6ftforsknings Fond","ror":"https://ror.org/048016404"},{"id":"https://openalex.org/F4320323741","display_name":"Magnus Bergvalls Stiftelse","ror":"https://ror.org/040ya8k73"},{"id":"https://openalex.org/F4320324409","display_name":"L\u00e6geforeningen","ror":"https://ror.org/005n36371"},{"id":"https://openalex.org/F4320324456","display_name":"Alfred Benzon Foundation","ror":"https://ror.org/005s1m246"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320326367","display_name":"Fabrikant Einar Willumsens Mindelegat","ror":null},{"id":"https://openalex.org/F4320327561","display_name":"LEO Fondet","ror":"https://ror.org/02rgsr590"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335119","display_name":"Fonden til L\u00e6gevidenskabens Fremme","ror":"https://ror.org/02kdrgt12"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019099488.pdf","grobid_xml":"https://content.openalex.org/works/W2019099488.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1482822886","https://openalex.org/W1545423564","https://openalex.org/W1578854334","https://openalex.org/W1606265942","https://openalex.org/W1906415340","https://openalex.org/W1978373343","https://openalex.org/W1979657237","https://openalex.org/W1982697606","https://openalex.org/W1983536745","https://openalex.org/W1986559713","https://openalex.org/W1989343086","https://openalex.org/W1992970966","https://openalex.org/W1999425834","https://openalex.org/W2004829503","https://openalex.org/W2005900169","https://openalex.org/W2026939523","https://openalex.org/W2031272027","https://openalex.org/W2041061869","https://openalex.org/W2053560001","https://openalex.org/W2069340283","https://openalex.org/W2079357798","https://openalex.org/W2086402424","https://openalex.org/W2088732158","https://openalex.org/W2092109378","https://openalex.org/W2095040060","https://openalex.org/W2109170888","https://openalex.org/W2122511642","https://openalex.org/W2134199500","https://openalex.org/W2138578762","https://openalex.org/W2140058936","https://openalex.org/W2149123553","https://openalex.org/W2149288393","https://openalex.org/W2162792939","https://openalex.org/W2163361121","https://openalex.org/W2164169236","https://openalex.org/W2414742001"],"related_works":["https://openalex.org/W180036716","https://openalex.org/W7098129285","https://openalex.org/W3125342564","https://openalex.org/W4205690590","https://openalex.org/W3109262599","https://openalex.org/W2413892857","https://openalex.org/W1579118981","https://openalex.org/W2007322452","https://openalex.org/W7098818572","https://openalex.org/W2114489207"],"abstract_inverted_index":{"MEK":[0],"kinase":[1],"1":[2],"(MEKK1)":[3],"is":[4,96,105,131],"a":[5,9,39,47,60,132,138,182],"potent":[6],"JNK-activating":[7],"kinase,":[8],"regulator":[10],"of":[11,46,73,101,121,134,142,162,189],"T":[12,66,75,87,103,122,146,156,170,192],"helper":[13],"cell":[14,67,88],"differentiation,":[15],"cytokine":[16],"production":[17],"and":[18,98,168],"proliferation":[19],"in":[20,30,43,63,77,90,111,125,166,186,194],"vitro.":[21],"Using":[22],"mice":[23,52,80,92,127],"deficient":[24],"for":[25],"MEKK1":[26,37,180],"activity":[27],"(Mekk1(DeltaKD))":[28],"exclusively":[29],"their":[31],"hematopoietic":[32],"system,":[33],"we":[34],"show":[35],"that":[36,179],"has":[38],"negative":[40,183],"regulatory":[41,184],"role":[42,185],"the":[44,71,99,119,187],"generation":[45],"virus-specific":[48,97,102,143,153,190],"immune":[49],"response.":[50],"Mekk1(DeltaKD)":[51,91,112,126,144,167],"challenged":[53],"with":[54],"vesicular":[55],"stomatitis":[56],"virus":[57],"(VSV)":[58],"showed":[59],"fourfold":[61],"increase":[62],"splenic":[64,74],"CD8(+)":[65,86,145,155,191],"numbers.":[68],"In":[69,158],"contrast,":[70,159],"number":[72],"cells":[76,104,123,147,171,193],"infected":[78],"WT":[79,116,154,169],"was":[81],"only":[82],"marginally":[83],"increased.":[84],"The":[85],"expansion":[89,188],"following":[93,172],"VSV":[94,129,173],"infection":[95,130],"frequency":[100],"significantly":[106,139],"higher":[107,140],"(more":[108],"than":[109],"threefold)":[110],"as":[113,150],"compared":[114,151],"to":[115,152],"animals.":[117],"Moreover,":[118],"hyper-expansion":[120],"seen":[124],"after":[128],"result":[133],"increased":[135],"proliferation,":[136],"since":[137],"percentage":[141],"incorporated":[148],"BrdU":[149],"cells.":[157],"similar":[160],"levels":[161],"apoptosis":[163],"were":[164],"detected":[165],"infection.":[174],"These":[175],"results":[176],"strongly":[177],"suggest":[178],"plays":[181],"vivo.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}