{"id":"https://openalex.org/W2019078343","doi":"https://doi.org/10.1289/ehp.00108271","title":"Genomic Imprinting and Environmental Disease Susceptibility","display_name":"Genomic Imprinting and Environmental Disease Susceptibility","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2019078343","doi":"https://doi.org/10.1289/ehp.00108271","mag":"2019078343","pmid":"https://pubmed.ncbi.nlm.nih.gov/10706535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1637980"},"language":"en","primary_location":{"id":"doi:10.1289/ehp.00108271","doi":"https://doi.org/10.1289/ehp.00108271","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.00108271","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1289/ehp.00108271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007126253","display_name":"Randy L. Jirtle","orcid":"https://orcid.org/0000-0003-1767-045X","observed_orcids":["https://orcid.org/0000-0003-1767-045X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R L Jirtle","raw_affiliation_strings":["Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061561620","display_name":"Maike Sander","orcid":"https://orcid.org/0000-0001-5308-7785","observed_orcids":["https://orcid.org/0000-0001-5308-7785"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Sander","raw_affiliation_strings":["Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110032106","display_name":"J. Carl Barrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J C Barrett","raw_affiliation_strings":["Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.0685,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.86051769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"108","issue":"3","first_page":"271","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":1.0},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8550000190734863},{"id":"https://openalex.org/keywords/monoallelic-expression","display_name":"monoallelic expression","score":0.7429999709129333},{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/turner-syndrome","display_name":"Turner syndrome","score":0.7260000109672546},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9810000061988831},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.9010000228881836},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.9399999976158142},{"id":"https://openalex.org/keywords/estrogen-exposure","display_name":"estrogen exposure","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.9629999995231628},{"id":"https://openalex.org/keywords/fetal-growth","display_name":"fetal growth","score":0.6079999804496765},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C201492766","wikidata":"https://www.wikidata.org/wiki/Q84087","display_name":"Genomic imprinting","level":5,"score":0.9352516531944275},{"id":"https://openalex.org/C94715292","wikidata":"https://www.wikidata.org/wiki/Q624349","display_name":"Imprinting (psychology)","level":3,"score":0.8616750240325928},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8077248334884644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7159448266029358},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7149725556373596},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6371035575866699},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4446222484111786},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.43734073638916016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3967447280883789},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30939996242523193}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018392","descriptor_name":"Genomic Imprinting","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1289/ehp.00108271","doi":"https://doi.org/10.1289/ehp.00108271","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.00108271","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"doi:10.2307/3454445","doi":"https://doi.org/10.2307/3454445","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3454445","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:368021","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1637980","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:10706535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10706535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health perspectives","raw_type":"Conference Proceedings"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.8578","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.8578","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/43/1c/Environ_Health_Perspect_2000_Mar_108(3)_271-278.tar.gz","raw_type":"text"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/288049","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/288049","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Abstract"}],"best_oa_location":{"id":"doi:10.1289/ehp.00108271","doi":"https://doi.org/10.1289/ehp.00108271","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.00108271","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1552528612","https://openalex.org/W1608964217","https://openalex.org/W1869857596","https://openalex.org/W1963682324","https://openalex.org/W1976208541","https://openalex.org/W1978445239","https://openalex.org/W1995868723","https://openalex.org/W1997888265","https://openalex.org/W2006714294","https://openalex.org/W2006721922","https://openalex.org/W2008572767","https://openalex.org/W2020667712","https://openalex.org/W2062613953","https://openalex.org/W2068678316","https://openalex.org/W2084913211","https://openalex.org/W2094473066","https://openalex.org/W2112667282","https://openalex.org/W4250680401"],"related_works":["https://openalex.org/W7099125563","https://openalex.org/W2169798600","https://openalex.org/W2232807345","https://openalex.org/W2148300464","https://openalex.org/W2054594911","https://openalex.org/W4229489966","https://openalex.org/W2085057450","https://openalex.org/W2102408189","https://openalex.org/W2744238845","https://openalex.org/W4230334378"],"abstract_inverted_index":{"Genomic":[0,54,80],"imprinting":[1,55,105,163,170,175,233],"is":[2,68],"one":[3,40],"of":[4,9,22,33,50,103,136,149,167,194,204,232,237],"the":[5,44,51,79,101,137,147,230,235],"most":[6],"intriguing":[7],"subtleties":[8],"modern":[10],"genetics.":[11],"The":[12,20,97],"term":[13],"\"imprinting\"":[14],"refers":[15],"to":[16,37,109,234],"parent-of-origin-dependent":[17],"gene":[18,126,139,215,238],"expression.":[19],"presence":[21],"imprinted":[23,52,125,138],"genes":[24,36],"can":[25,211,219],"cause":[26],"cells":[27],"with":[28],"a":[29,57],"full":[30],"parental":[31,119],"complement":[32],"functional":[34],"autosomal":[35],"specifically":[38],"express":[39],"allele":[41],"but":[42],"not":[43],"other,":[45],"resulting":[46],"in":[47,60,106,153,171,176,208,221,245],"monoallelic":[48],"expression":[49,216,239],"loci.":[53],"plays":[56],"critical":[58],"role":[59],"fetal":[61],"growth":[62],"and":[63,66,73,82,121,131,143,160,164,174,179,182,186,190,197,217,226,252],"behavioral":[64,227],"development,":[65],"it":[67],"regulated":[69],"by":[70],"DNA":[71,209],"methylation":[72,185,189,193],"chromatin":[74,187],"structure.":[75],"This":[76],"paper":[77],"summarizes":[78],"Imprinting":[81],"Environmental":[83,200],"Disease":[84],"Susceptibility":[85],"Conference":[86,113],"held":[87],"8-10":[88],"October":[89],"1998":[90],"at":[91],"Duke":[92],"University,":[93],"Durham,":[94],"North":[95],"Carolina.":[96],"conference":[98],"focused":[99],"on":[100,249],"importance":[102],"genomic":[104],"determining":[107],"susceptibility":[108],"environmentally":[110],"induced":[111],"diseases.":[112],"topics":[114],"included":[115],"rationales":[116],"for":[117,124],"imprinting:":[118,154],"antagonism":[120],"speciation;":[122],"methods":[123],"identification:":[127],"allelic":[128],"message":[129],"display":[130],"monochromosomal":[132],"mouse/human":[133],"hybrids;":[134],"properties":[135],"cluster":[140],"human":[141,250],"11p15.5":[142],"mouse":[144],"distal":[145],"7;":[146],"epigenetics":[148],"X-chromosome":[150],"inactivation;":[151],"variability":[152],"imprint":[155,214],"erasure,":[156],"non-Mendelian":[157],"inheritance":[158],"ratios,":[159],"polymorphic":[161],"imprinting;":[162],"behavior:":[165],"genetics":[166],"bipolar":[168],"disorder,":[169],"Turner":[172],"syndrome,":[173],"brain":[177],"development":[178],"social":[180],"behavior;":[181],"aberrant":[183],"methylation:":[184],"structure,":[188],"estrogen":[191],"exposure,":[192],"tumor-suppressor":[195],"genes,":[196],"cancer":[198,225],"susceptibility.":[199],"factors":[201],"are":[202],"capable":[203],"causing":[205],"epigenetic":[206],"changes":[207],"that":[210,218],"potentially":[212],"alter":[213],"result":[220],"genetic":[222],"diseases":[223],"including":[224],"disorders.":[228],"Understanding":[229],"contribution":[231],"regulation":[236],"will":[240],"be":[241],"an":[242],"important":[243],"step":[244],"evaluating":[246],"environmental":[247],"influences":[248],"health":[251],"disease.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}