{"id":"https://openalex.org/W2019050228","doi":"https://doi.org/10.1111/j.1471-4159.1983.tb12682.x","title":"Effects of CDPcholine and CDPethanolamine on the Alterations in Rat Brain Lipid Metabolism Induced by Global Ischemia","display_name":"Effects of CDPcholine and CDPethanolamine on the Alterations in Rat Brain Lipid Metabolism Induced by Global Ischemia","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2019050228","doi":"https://doi.org/10.1111/j.1471-4159.1983.tb12682.x","mag":"2019050228","pmid":"https://pubmed.ncbi.nlm.nih.gov/6848664"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1983.tb12682.x","doi":"https://doi.org/10.1111/j.1471-4159.1983.tb12682.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1983.tb12682.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043529612","display_name":"Robert V. Dorman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL","US"],"is_corresponding":false,"raw_author_name":"Robert V. Dorman","raw_affiliation_strings":["Department of Physiological Chemistry, The Ohio State University, Columbus, Ohio, U.S.A","Medical Research Centre, Polish Academy of Sciences, 3 Dworkowa Street, 00784, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, The Ohio State University, Columbus, Ohio, U.S.A","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Medical Research Centre, Polish Academy of Sciences, 3 Dworkowa Street, 00784, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051183636","display_name":"Zbigniew D\u0105browiecki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zbigniew Dabrowiecki","raw_affiliation_strings":["Department of Physiological Chemistry, The Ohio State University, Columbus, Ohio, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, The Ohio State University, Columbus, Ohio, U.S.A","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112717218","display_name":"Lloyd A. Horrocks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lloyd A. Horrocks","raw_affiliation_strings":["Department of Physiological Chemistry, The Ohio State University, Columbus, Ohio, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, The Ohio State University, Columbus, Ohio, U.S.A","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112717218"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":3.4224,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.90983607,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"40","issue":"1","first_page":"276","last_page":"279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/global-cerebral-ischemia","display_name":"global cerebral ischemia","score":0.875},{"id":"https://openalex.org/keywords/brain-lipid-metabolism","display_name":"brain lipid metabolism","score":0.9779999852180481},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.7889999747276306},{"id":"https://openalex.org/keywords/glycerophospholipids","display_name":"glycerophospholipids","score":0.9309999942779541},{"id":"https://openalex.org/keywords/choline-phospholipids","display_name":"choline phospholipids","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ethanolamine-phospholipids","display_name":"ethanolamine phospholipids","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cytidine-nucleotides","display_name":"cytidine nucleotides","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.7008106112480164},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6810532808303833},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5876038670539856},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.4209691882133484},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38199329376220703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3504808843135834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34560227394104004},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3435155153274536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3204052448272705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30192816257476807}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003565","descriptor_name":"Cytidine Diphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003565","descriptor_name":"Cytidine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003566","descriptor_name":"Cytidine Diphosphate Choline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003597","descriptor_name":"Cytosine Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.1983.tb12682.x","doi":"https://doi.org/10.1111/j.1471-4159.1983.tb12682.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1983.tb12682.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:6848664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6848664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W61413324","https://openalex.org/W1588008748","https://openalex.org/W1963866965","https://openalex.org/W1973743536","https://openalex.org/W2002879913","https://openalex.org/W2022474884","https://openalex.org/W2024413659","https://openalex.org/W2044239486","https://openalex.org/W2046112785","https://openalex.org/W2053850687","https://openalex.org/W2083496823","https://openalex.org/W2087421641","https://openalex.org/W2089231098","https://openalex.org/W2092572576","https://openalex.org/W2094342983","https://openalex.org/W2168526937","https://openalex.org/W2342784434","https://openalex.org/W2413592899","https://openalex.org/W2618505815","https://openalex.org/W4297847419"],"related_works":["https://openalex.org/W2065199163","https://openalex.org/W64409203","https://openalex.org/W1985986044","https://openalex.org/W1997319250","https://openalex.org/W1605492386","https://openalex.org/W2104614941","https://openalex.org/W1967315695","https://openalex.org/W2414747965","https://openalex.org/W2061981444","https://openalex.org/W2404412586"],"abstract_inverted_index":{"The":[0],"fast":[1],"turnover":[2],"pool":[3],"of":[4,13,20,38,42,53,57,68,77,101,104,114,122,132,138,146,152],"rat":[5],"brain":[6],"lipids":[7],"was":[8,110],"labeled":[9],"by":[10,84],"intracerebral":[11,51],"injection":[12,52,145],"[3H]acetate.":[14],"Cerebral":[15],"ischemia":[16,96],"for":[17],"a":[18,26,111,143],"duration":[19],"5":[21],"min":[22],"after":[23],"decapitation":[24],"caused":[25],"2.2-fold":[27],"increase":[28,113],"in":[29,31,79,118,157],"radioactivity":[30,44,69,78],"the":[32,43,66,71,75,80,102,105,130,139,150],"free":[33,81,106,115,153],"fatty":[34,82,107,116,134,154],"acids":[35,83,108,117,135,155],"and":[36,47,61,73,91,127],"loss":[37,67],"more":[39],"than":[40],"20%":[41],"from":[45,70],"choline":[46],"ethanolamine":[48],"glycerophospholipids.":[49],"An":[50],"0.6":[54],"mumol":[55],"each":[56],"cytidine":[58,62,147],"diphosphocholine":[59],"(CDPcholine)":[60],"diphosphoethanolamine":[63],"(CDPethanolamine)":[64],"prevented":[65,149],"glycerophospholipids":[72],"decreased":[74],"amount":[76],"59%":[85],"as":[86,93],"compared":[87,94],"with":[88,95,125],"control":[89,140],"values":[90],"82%":[92],"values.":[97,141],"By":[98],"GLC":[99],"assays":[100],"mass":[103],"there":[109],"threefold":[112],"ischemic":[119,123,158],"brains.":[120,159],"Pretreatment":[121],"brains":[124],"CDPcholine":[126],"CDPethanolamine":[128],"reduced":[129],"levels":[131],"unesterified":[133],"to":[136],"60%":[137],"Thus,":[142],"prior":[144],"nucleotides":[148],"release":[151],"observed":[156]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
