{"id":"https://openalex.org/W2019037346","doi":"https://doi.org/10.1172/jci111200","title":"A luteinizing hormone-releasing hormone agonist decreases biological activity and modifies chromatographic behavior of luteinizing hormone in man.","display_name":"A luteinizing hormone-releasing hormone agonist decreases biological activity and modifies chromatographic behavior of luteinizing hormone in man.","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2019037346","doi":"https://doi.org/10.1172/jci111200","mag":"2019037346","pmid":"https://pubmed.ncbi.nlm.nih.gov/6228566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/425009"},"language":"en","primary_location":{"id":"doi:10.1172/jci111200","doi":"https://doi.org/10.1172/jci111200","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci111200","pdf_url":"http://www.jci.org/articles/view/111200/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/111200/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R M Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R M Evans","raw_affiliation_strings":["Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031375489","display_name":"Gregory C. Doelle","orcid":"https://orcid.org/0000-0001-7045-0443","observed_orcids":["https://orcid.org/0000-0001-7045-0443"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G C Doelle","raw_affiliation_strings":["Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054232699","display_name":"Jill Lindner","orcid":"https://orcid.org/0000-0002-8897-7494","observed_orcids":["https://orcid.org/0000-0002-8897-7494"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Lindner","raw_affiliation_strings":["Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":null,"display_name":"V Bradley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Bradley","raw_affiliation_strings":["Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108678350","display_name":"Daniel U. Rabin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Rabin","raw_affiliation_strings":["Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedicine, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":11.7957,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.99646331,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"1","first_page":"262","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.9380000233650208},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.7749999761581421},{"id":"https://openalex.org/keywords/lh-bioactivity","display_name":"LH bioactivity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gonadotropin-response","display_name":"gonadotropin response","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lh-pulsatility","display_name":"LH pulsatility","score":0.875},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9459999799728394},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9660000205039978},{"id":"https://openalex.org/keywords/gnrh-analogs","display_name":"GnRH analogues","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.8743466138839722},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.80177903175354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7787944078445435},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6808423399925232},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6363738179206848},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.6345769166946411},{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.5798051953315735},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.568383514881134},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.544409453868866},{"id":"https://openalex.org/C197012351","wikidata":"https://www.wikidata.org/wiki/Q3099316","display_name":"Gonadotropic cell","level":4,"score":0.4367576539516449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41859152913093567},{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.4148509204387665},{"id":"https://openalex.org/C2777230143","wikidata":"https://www.wikidata.org/wiki/Q414745","display_name":"Buserelin","level":4,"score":0.4111140966415405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3343160152435303},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2530958652496338},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008186","descriptor_name":"Luteolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008186","descriptor_name":"Luteolytic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017329","descriptor_name":"Triptorelin Pamoate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci111200","doi":"https://doi.org/10.1172/jci111200","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci111200","pdf_url":"http://www.jci.org/articles/view/111200/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:425009","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/425009","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:6228566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6228566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci111200","doi":"https://doi.org/10.1172/jci111200","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci111200","pdf_url":"http://www.jci.org/articles/view/111200/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019037346.pdf","grobid_xml":"https://content.openalex.org/works/W2019037346.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1548637624","https://openalex.org/W1893651774","https://openalex.org/W1982552710","https://openalex.org/W1990280547","https://openalex.org/W1994964926","https://openalex.org/W1998854129","https://openalex.org/W2008364767","https://openalex.org/W2015213958","https://openalex.org/W2016805229","https://openalex.org/W2033417675","https://openalex.org/W2056875920","https://openalex.org/W2092226492","https://openalex.org/W2103785922","https://openalex.org/W2122382434","https://openalex.org/W2131664684"],"related_works":["https://openalex.org/W7095994217","https://openalex.org/W2277392496","https://openalex.org/W2340325966","https://openalex.org/W1993431146","https://openalex.org/W2324562794","https://openalex.org/W2088987832","https://openalex.org/W1967012029","https://openalex.org/W2014861772","https://openalex.org/W2027434076","https://openalex.org/W1976497539"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,65,72,88,114,117],"the":[3,89,115],"luteinizing":[4,12],"hormone-releasing":[5],"hormone":[6,13],"(LHRH)":[7],"agonist,":[8],"[D-Trp6,Pro9-NEth]LHRH":[9],"(LHRHA),":[10],"on":[11,54],"(LH)":[14],"bioactivity":[15,116],"was":[16],"assessed":[17],"with":[18,38,103],"a":[19,28,97],"rat":[20],"interstitial":[21],"cell":[22],"assay":[23],"in":[24,79,110,119],"four":[25],"men":[26],"during":[27,101],"14-d":[29],"treatment":[30,39,102],"period.":[31],"Biologic/immunologic":[32],"(B/I)":[33],"ratios":[34,82],"were":[35],"unchanged":[36],"initially":[37],"but":[40],"by":[41,93,112],"day":[42,55],"12":[43,56],"had":[44],"fallen":[45],"to":[46,61,108],"levels":[47],"lower":[48],"than":[49],"basal":[50],"values.":[51],"Frequent":[52],"sampling":[53],"revealed":[57,96],"blunted":[58],"gonadotropin":[59,76],"responsiveness":[60],"LHRHA":[62,106],"and":[63,83],"absence":[64],"spontaneous":[66],"LH":[67,92,118],"pulsations.":[68],"Despite":[69],"continued":[70],"administration":[71,77],"LHRHA,":[73],"human":[74],"chorionic":[75],"resulted":[78],"elevated":[80],"B/I":[81],"testosterone":[84],"levels.":[85],"Further":[86],"characterization":[87],"serum":[90],"immunoreactive":[91],"Sephadex":[94],"chromatography":[95],"later":[98],"elution":[99],"profile":[100],"LHRHA.":[104],"Thus,":[105],"appears":[107],"act,":[109],"part,":[111],"modification":[113],"man.":[120]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
