{"id":"https://openalex.org/W2019002829","doi":"https://doi.org/10.1055/s-2006-924230","title":"Five Weeks of Treatment with the GLP-1 Analogue Liraglutide Improves Glycaemic Control and Lowers Body weight in Subjects with Type 2 Diabetes","display_name":"Five Weeks of Treatment with the GLP-1 Analogue Liraglutide Improves Glycaemic Control and Lowers Body weight in Subjects with Type 2 Diabetes","publication_year":2006,"publication_date":"2006-10-13","ids":{"openalex":"https://openalex.org/W2019002829","doi":"https://doi.org/10.1055/s-2006-924230","mag":"2019002829","pmid":"https://pubmed.ncbi.nlm.nih.gov/17039422"},"language":"en","primary_location":{"id":"doi:10.1055/s-2006-924230","doi":"https://doi.org/10.1055/s-2006-924230","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-924230","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology & Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067359287","display_name":"Michael Albrecht Nauck","orcid":"https://orcid.org/0000-0002-5749-6954","observed_orcids":["https://orcid.org/0000-0002-5749-6954","https://orcid.org/0000-0003-2455-0472"]},"institutions":[{"id":"https://openalex.org/I4210124421","display_name":"Diabeteszentrum Bad Lauterberg","ror":"https://ror.org/02tv28881","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210124421"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Nauck","raw_affiliation_strings":["Diabeteszentrum, Bad Lauterberg im Harz, Germany. M.Nauck@diabeteszentrum.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabeteszentrum, Bad Lauterberg im Harz, Germany. M.Nauck@diabeteszentrum.de","institution_ids":["https://openalex.org/I4210124421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044166679","display_name":"Marcus Hompesch","orcid":"https://orcid.org/0000-0001-5867-2131","observed_orcids":["https://orcid.org/0000-0001-5867-2131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Hompesch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055762193","display_name":"R. Filipczak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Filipczak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152812076","display_name":"T. Le","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Le","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059007137","display_name":"Marija D. Zdravkovic","orcid":"https://orcid.org/0000-0003-4059-0263","observed_orcids":["https://orcid.org/0000-0003-4059-0263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Zdravkovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011207294","display_name":"Jakub Janusz Gumprecht","orcid":"https://orcid.org/0000-0002-0575-9150","observed_orcids":["https://orcid.org/0000-0002-0575-9150"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Gumprecht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.7333,"has_fulltext":false,"cited_by_count":144,"citation_normalized_percentile":{"value":0.99316487,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"114","issue":"08","first_page":"417","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liraglutide","display_name":"liraglutide","score":1.0},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9369999766349792},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glimepiride","display_name":"glimepiride","score":0.9390000104904175},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fasting-serum-glucose","display_name":"fasting serum glucose","score":0.8949999809265137},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8569999933242798},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.8100000023841858},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/antidiabetic-drug-combination","display_name":"antidiabetic drug combination","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2781308992","wikidata":"https://www.wikidata.org/wiki/Q2526479","display_name":"Liraglutide","level":4,"score":0.9936482310295105},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9537049531936646},{"id":"https://openalex.org/C2776307423","wikidata":"https://www.wikidata.org/wiki/Q425027","display_name":"Glimepiride","level":4,"score":0.8743007183074951},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8472119569778442},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7767698168754578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5098268389701843},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5029403567314148},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5002636909484863},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.497210294008255},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.4821619391441345},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3808646500110626},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.20558372139930725}],"mesh":[{"descriptor_ui":"D000069450","descriptor_name":"Liraglutide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069450","descriptor_name":"Liraglutide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069450","descriptor_name":"Liraglutide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2006-924230","doi":"https://doi.org/10.1055/s-2006-924230","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-924230","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology & Diabetes","raw_type":"journal-article"},{"id":"pmid:17039422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17039422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2390934805","https://openalex.org/W28050928","https://openalex.org/W1266121913","https://openalex.org/W4365136001","https://openalex.org/W4383115047","https://openalex.org/W2047286813","https://openalex.org/W2012275906","https://openalex.org/W2163502113","https://openalex.org/W2384655444","https://openalex.org/W4200099789"],"abstract_inverted_index":{"AIMS:":[0],"Effects":[1],"of":[2,31,49,134,159,162,232],"the":[3,114,119,141,163,211,230],"long":[4],"acting":[5],"GLP-1":[6],"analogue--liraglutide":[7],"in":[8,72,91,113,153,194,198,218],"subjects":[9,19],"with":[10,34,68,93,136,189],"type":[11,16,233],"2":[12,17,57,176,234],"diabetes.":[13,235],"METHODS:":[14],"144":[15],"diabetic":[18],"on":[20],"metformin":[21,35,42,64,94,96,115,120,221],"treatment":[22,32,231],"(1000":[23],"mg":[24,58,177],"BID)":[25],"were":[26,129],"randomised":[27],"to":[28,56,63,157,175,208,220],"5":[29],"weeks":[30],"(double-blind)":[33],"plus":[36,43,97,116,121,222],"liraglutide,":[37],"liraglutide":[38,50,90,117,137,148,170,180,204],"or":[39,41],"metformin,":[40],"glimepiride":[44,98,122],"(open":[45],"label).":[46],"The":[47],"dose":[48],"was":[51,66,110,140,151,201,216],"increased":[52],"weekly":[53,168],"from":[54],"0.5":[55],"OD.":[59],"RESULTS:":[60],"Liraglutide":[61,224],"added":[62],"monotherapy":[65],"associated":[67],"a":[69,167,226],"significant":[70],"reduction":[71],"fasting":[73],"serum":[74],"glucose":[75],"(FSG)":[76],"(-3.9":[77],"mM":[78,103],"-4.9;":[79],"-2.9)":[80],"(primary":[81],"objective),":[82],"and":[83,155],"HbA1c":[84],"levels":[85],"(-0.8%":[86],"-1.2;":[87],"-0.4).":[88],"Furthermore,":[89],"combination":[92],"vs.":[95,118],"significantly":[99,111],"reduced":[100,217],"FSG":[101,195],"(-1.2":[102],"-2.2;":[104],"-0.2).":[105],"In":[106,210],"addition,":[107],"body":[108,214],"weight":[109,215],"lower":[112],"group":[123],"(-2.9":[124],"kg":[125],"-3.6;":[126],"-2.1).":[127],"There":[128],"no":[130],"biochemically":[131],"confirmed":[132],"episodes":[133],"hypoglycaemia":[135],"treatment.":[138,191],"Nausea":[139],"most":[142],"frequently":[143],"reported":[144],"adverse":[145],"event":[146],"following":[147],"therapy,":[149],"it":[150],"transient":[152,182],"nature,":[154],"led":[156],"withdrawal":[158],"only":[160],"4%":[161],"subjects.":[164],"CONCLUSIONS:":[165],"Using":[166],"dose-titration":[169],"is":[171,225],"well":[172],"tolerated":[173],"up":[174],"daily.":[178],"While":[179],"caused":[181],"gastrointestinal":[183],"side":[184],"effects,":[185],"this":[186],"rarely":[187],"interfered":[188],"continuing":[190],"An":[192],"improvement":[193],"over":[196],"that":[197],"control":[199],"groups":[200],"seen":[202],"for":[203,229],"as":[205],"an":[206],"add-on":[207],"metformin.":[209],"latter":[212],"case,":[213],"comparison":[219],"glimepiride.":[223],"promising":[227],"drug":[228]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}