{"id":"https://openalex.org/W2018990753","doi":"https://doi.org/10.1371/journal.pone.0085874","title":"Dopamine Signaling Regulates Fat Content through \u03b2-Oxidation in Caenorhabditis elegans","display_name":"Dopamine Signaling Regulates Fat Content through \u03b2-Oxidation in Caenorhabditis elegans","publication_year":2014,"publication_date":"2014-01-22","ids":{"openalex":"https://openalex.org/W2018990753","doi":"https://doi.org/10.1371/journal.pone.0085874","mag":"2018990753","pmid":"https://pubmed.ncbi.nlm.nih.gov/24465759","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3899111"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0085874","doi":"https://doi.org/10.1371/journal.pone.0085874","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0085874","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085874&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085874&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101174986","display_name":"Alexandre Guimar\u00e3es de Almeida Barros","orcid":"https://orcid.org/0000-0002-0517-4865","observed_orcids":["https://orcid.org/0000-0002-0517-4865"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4405279278","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular","ror":"https://ror.org/017vk0880","country_code":"BR","type":"facility","lineage":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alexandre Guimar\u00e3es de Almeida Barros","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086717948","display_name":"J\u00e9ssika Cristina Bridi","orcid":"https://orcid.org/0000-0002-7692-9866","observed_orcids":["https://orcid.org/0000-0002-7692-9866"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4405279278","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular","ror":"https://ror.org/017vk0880","country_code":"BR","type":"facility","lineage":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jessika Cristina Bridi","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051680603","display_name":"Bruno Rezende Souza","orcid":"https://orcid.org/0000-0002-7064-7956","observed_orcids":["https://orcid.org/0000-0002-7064-7956"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno Rezende de Souza","raw_affiliation_strings":["Departamento de Fisiologia e Biof\u00edsica, Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023379403","display_name":"C\u00e9lio Jos\u00e9 de Castro","orcid":"https://orcid.org/0000-0002-0063-4471","observed_orcids":["https://orcid.org/0000-0002-0063-4471"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4405279278","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular","ror":"https://ror.org/017vk0880","country_code":"BR","type":"facility","lineage":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"C\u00e9lio de Castro J\u00fanior","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028105808","display_name":"Karen Torres","orcid":"https://orcid.org/0000-0002-2943-4350","observed_orcids":["https://orcid.org/0000-0002-2943-4350"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4405279278","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular","ror":"https://ror.org/017vk0880","country_code":"BR","type":"facility","lineage":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karen Cec\u00edlia de Lima Torres","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054221868","display_name":"Leandro M. Malard","orcid":"https://orcid.org/0000-0003-4207-9653","observed_orcids":["https://orcid.org/0000-0003-4207-9653"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leandro Malard","raw_affiliation_strings":["Departamento de F\u00edsica, Instituto de Ci\u00eancias Exatas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de F\u00edsica, Instituto de Ci\u00eancias Exatas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036004866","display_name":"Ado J\u00f3rio","orcid":"https://orcid.org/0000-0002-5978-2735","observed_orcids":["https://orcid.org/0000-0002-5978-2735"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ado Jorio","raw_affiliation_strings":["Departamento de F\u00edsica, Instituto de Ci\u00eancias Exatas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de F\u00edsica, Instituto de Ci\u00eancias Exatas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076820886","display_name":"D\u00e9bora Marques de Miranda","orcid":"https://orcid.org/0000-0002-7081-8401","observed_orcids":["https://orcid.org/0000-0002-7081-8401","https://orcid.org/0009-0009-8622-9757"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4405279278","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular","ror":"https://ror.org/017vk0880","country_code":"BR","type":"facility","lineage":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"D\u00e9bora Marques de Miranda","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079959585","display_name":"Kaveh Ashrafi","orcid":"https://orcid.org/0000-0002-5887-0346","observed_orcids":["https://orcid.org/0000-0002-5887-0346"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaveh Ashrafi","raw_affiliation_strings":["Department of Physiology, University of California San Francisco, San Francisco, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of California San Francisco, San Francisco, California, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082202542","display_name":"Marco Aur\u00e9lio Romano\u2010Silva","orcid":"https://orcid.org/0000-0002-6558-4639","observed_orcids":["https://orcid.org/0000-0002-6558-4639"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4405279278","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular","ror":"https://ror.org/017vk0880","country_code":"BR","type":"facility","lineage":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Marco Aur\u00e9lio Romano-Silva","raw_affiliation_strings":["Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ci\u00eancia e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422","https://openalex.org/I4405279278"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082202542"],"corresponding_institution_ids":["https://openalex.org/I110200422","https://openalex.org/I4405279278"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.0295,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.69465021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"e85874","last_page":"e85874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.4948999881744385,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.4948999881744385,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.25589999556541443,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.1454000025987625,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopaminergic-neurotransmission","display_name":"dopamine signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fat-oxidation","display_name":"fat oxidation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.871999979019165},{"id":"https://openalex.org/keywords/fat-deposition","display_name":"fat deposition","score":0.4909999966621399},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8970000147819519},{"id":"https://openalex.org/keywords/dopamine-receptors","display_name":"dopamine receptors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/fat-depots","display_name":"fat depots","score":0.7559999823570251},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.8653628826141357},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.817578911781311},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7234503030776978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5594557523727417},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.5162989497184753},{"id":"https://openalex.org/C2909816965","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine Plasma Membrane Transport Proteins","level":5,"score":0.5122441649436951},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.48247960209846497},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.46922382712364197},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4685541093349457},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4646778702735901},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4526120126247406},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.41167712211608887},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30209726095199585},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17167624831199646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1410946249961853},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005223","descriptor_name":"Fats","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pone.0085874","doi":"https://doi.org/10.1371/journal.pone.0085874","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0085874","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085874&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2885541","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3899111","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24465759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24465759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3899111","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3899111/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:qt0pp9r9np","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/0pp9r9np","pdf_url":"http://www.escholarship.org/uc/item/0pp9r9np","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ashrafi, Kaveh; De, AGA; Bridi, JC; De, BR; De, CC; De, KC; \u00c2\u00a0et al.(2014). Dopamine signaling regulates fat content through \u00ce\u00b2-oxidation in Caenorhabditis elegans. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0pp9r9np","raw_type":"article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.815.324","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.815.324","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/be/5b/pone.0085874.PMC3899111.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7c829fa902f843f0aff66846c60ce7d2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c829fa902f843f0aff66846c60ce7d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 1, p e85874 (2014)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt0pp9r9np","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0pp9r9np","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt26b2r71r","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/26b2r71r","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, vol 9, iss 1","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/908825","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Dopamine_Signaling_Regulates_Fat_Content_through_Oxidation_in_Caenorhabditis_elegans_/908825","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0085874","doi":"https://doi.org/10.1371/journal.pone.0085874","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0085874","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085874&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320321178","display_name":"Governo Brasil","ror":"https://ror.org/00n0s9w57"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018990753.pdf","grobid_xml":"https://content.openalex.org/works/W2018990753.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W86145587","https://openalex.org/W1493815403","https://openalex.org/W1504624663","https://openalex.org/W1526576192","https://openalex.org/W1849896091","https://openalex.org/W1921244251","https://openalex.org/W1924308766","https://openalex.org/W1944127002","https://openalex.org/W1964817556","https://openalex.org/W1967763112","https://openalex.org/W1971764800","https://openalex.org/W1975751348","https://openalex.org/W1980216636","https://openalex.org/W1984160651","https://openalex.org/W1987533430","https://openalex.org/W2001920462","https://openalex.org/W2004192853","https://openalex.org/W2012383052","https://openalex.org/W2026075326","https://openalex.org/W2030155143","https://openalex.org/W2031313941","https://openalex.org/W2041114226","https://openalex.org/W2043075431","https://openalex.org/W2043588350","https://openalex.org/W2044399205","https://openalex.org/W2046753623","https://openalex.org/W2046859247","https://openalex.org/W2050684182","https://openalex.org/W2052722944","https://openalex.org/W2057337991","https://openalex.org/W2071274854","https://openalex.org/W2075139515","https://openalex.org/W2079395662","https://openalex.org/W2084043096","https://openalex.org/W2084856509","https://openalex.org/W2085893593","https://openalex.org/W2088026826","https://openalex.org/W2092703117","https://openalex.org/W2096267165","https://openalex.org/W2099440512","https://openalex.org/W2101641567","https://openalex.org/W2105472469","https://openalex.org/W2105899699","https://openalex.org/W2106789000","https://openalex.org/W2108024591","https://openalex.org/W2108244474","https://openalex.org/W2114570899","https://openalex.org/W2122112571","https://openalex.org/W2128126637","https://openalex.org/W2132350109","https://openalex.org/W2133782035","https://openalex.org/W2138724749","https://openalex.org/W2141889774","https://openalex.org/W2142395012","https://openalex.org/W2144371887","https://openalex.org/W2149067866","https://openalex.org/W2152311269","https://openalex.org/W2152430821","https://openalex.org/W2158016476","https://openalex.org/W2159155203","https://openalex.org/W2164125772"],"related_works":["https://openalex.org/W7096303272","https://openalex.org/W2972519978","https://openalex.org/W2142395012","https://openalex.org/W2020261966","https://openalex.org/W2005478403","https://openalex.org/W2771284822","https://openalex.org/W2060405987","https://openalex.org/W2619945784","https://openalex.org/W1970459957","https://openalex.org/W2888670973"],"abstract_inverted_index":{"The":[0],"regulation":[1,103],"of":[2,19,36,81,91,104],"energy":[3,20,48,61],"balance":[4],"involves":[5],"an":[6,33,98],"intricate":[7],"interplay":[8],"between":[9],"neural":[10],"mechanisms":[11,43,56],"that":[12,65,76,108,116],"respond":[13],"to":[14],"internal":[15],"and":[16,22,88,106],"external":[17],"cues":[18],"demand":[21],"food":[23],"availability.":[24],"Compelling":[25],"data":[26],"have":[27],"implicated":[28],"the":[29,41,77],"neurotransmitter":[30],"dopamine":[31,46,59,66,82,109],"as":[32],"important":[34],"part":[35],"body":[37],"weight":[38],"regulation.":[39],"However,":[40],"precise":[42],"through":[44,57,114],"which":[45,58],"regulates":[47,68],"homeostasis":[49],"remain":[50],"poorly":[51],"understood.":[52],"Here,":[53],"we":[54],"investigate":[55],"modulates":[60],"storage.":[62],"We":[63,74],"showed":[64],"signaling":[67,110],"fat":[69,78,92,105,120],"reservoirs":[70],"in":[71],"Caenorhabditis":[72],"elegans.":[73],"found":[75],"reducing":[79],"effects":[80],"were":[83],"dependent":[84],"on":[85],"dopaminergic":[86,102],"receptors":[87],"a":[89],"set":[90],"oxidation":[93],"enzymes.":[94],"Our":[95],"findings":[96],"reveal":[97],"ancient":[99],"role":[100],"for":[101],"suggest":[107],"elicits":[111],"this":[112],"outcome":[113],"cascades":[115],"ultimately":[117],"mobilize":[118],"peripheral":[119],"depots.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}