{"id":"https://openalex.org/W2018990293","doi":"https://doi.org/10.1186/1471-2172-8-3","title":"Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens","display_name":"Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2018990293","doi":"https://doi.org/10.1186/1471-2172-8-3","mag":"2018990293","pmid":"https://pubmed.ncbi.nlm.nih.gov/17352819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1851715"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2172-8-3","doi":"https://doi.org/10.1186/1471-2172-8-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2172-8-3","pdf_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-8-3","source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-8-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026174278","display_name":"Mary Kearns\u2010Jonker","orcid":"https://orcid.org/0000-0002-8989-3698","observed_orcids":["https://orcid.org/0000-0002-8989-3698"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary Kearns-Jonker","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027 USA. mkearns@chla.usc.edu","Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027 USA. mkearns@chla.usc.edu","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059292423","display_name":"Natasha S. Barteneva","orcid":"https://orcid.org/0000-0002-8109-1754","observed_orcids":["https://orcid.org/0000-0002-8109-1754","https://orcid.org/0000-0002-2499-5175"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha Barteneva","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067340861","display_name":"Robert Mencel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Mencel","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028631106","display_name":"Namath Syed Hussain","orcid":"https://orcid.org/0000-0002-8782-2909","observed_orcids":["https://orcid.org/0000-0002-8782-2909"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Namath Hussain","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027483632","display_name":"Irina Shulkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina Shulkin","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022105537","display_name":"Alan Xu","orcid":"https://orcid.org/0000-0002-8698-9301","observed_orcids":["https://orcid.org/0000-0002-8698-9301"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Xu","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061383338","display_name":"Margaret Yew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Yew","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109918591","display_name":"Donald V. Cramer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald V Cramer","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, 4650, Sunset Blvd, Mailstop #137, Los Angeles, CA, 90027, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Saban Research Institute of the Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026174278"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.5832,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8347411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"3","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenoantibodies","display_name":"xenoantibodies","score":0.8700000047683716},{"id":"https://openalex.org/keywords/natural-antibodies","display_name":"natural antibodies","score":0.6480000019073486},{"id":"https://openalex.org/keywords/xenograft-rejection","display_name":"xenograft rejection","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cdr3","display_name":"CDR3","score":0.6740000247955322},{"id":"https://openalex.org/keywords/light-chain","display_name":"light chain","score":0.4020000100135803},{"id":"https://openalex.org/keywords/immunoglobulin-heavy-chain","display_name":"immunoglobulin heavy chain","score":0.7049999833106995},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.41200000047683716},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7027161717414856},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.609616756439209},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46655935049057007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46470656991004944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4285432994365692},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4243183434009552},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2643292546272278}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000910","descriptor_name":"Antibodies, Heterophile","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000910","descriptor_name":"Antibodies, Heterophile","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015478","descriptor_name":"Antigens, Heterophile","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015478","descriptor_name":"Antigens, Heterophile","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2172-8-3","doi":"https://doi.org/10.1186/1471-2172-8-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2172-8-3","pdf_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-8-3","source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1851715","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1851715","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunol","raw_type":"Text"},{"id":"pmid:17352819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17352819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC immunology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.4922","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.4922","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/bc/f8/BMC_Immunol_2007_Mar_12_8_3.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e0310eb6220e4f3db021c53343879257","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e0310eb6220e4f3db021c53343879257","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Immunology, Vol 8, Iss 1, p 3 (2007)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2172-8-3","doi":"https://doi.org/10.1186/1471-2172-8-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2172-8-3","pdf_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-8-3","source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1013472931","display_name":"California National Primate Research Center","funder_award_id":"P51RR000169","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1224278078","display_name":null,"funder_award_id":"R01AI41582","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5058309326","display_name":"Non-Human Primate Models for Human Xenotransplantation","funder_award_id":"R01AI052079","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018990293.pdf","grobid_xml":"https://content.openalex.org/works/W2018990293.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1482494509","https://openalex.org/W1486034860","https://openalex.org/W1498452737","https://openalex.org/W1533481657","https://openalex.org/W1537865643","https://openalex.org/W1539803228","https://openalex.org/W1893934259","https://openalex.org/W1968418560","https://openalex.org/W1969943007","https://openalex.org/W1971845797","https://openalex.org/W1972357761","https://openalex.org/W1972769884","https://openalex.org/W1975113791","https://openalex.org/W1978150150","https://openalex.org/W1987793243","https://openalex.org/W1989652867","https://openalex.org/W1996822330","https://openalex.org/W1997293204","https://openalex.org/W2004900499","https://openalex.org/W2007910999","https://openalex.org/W2008780588","https://openalex.org/W2019019313","https://openalex.org/W2022967762","https://openalex.org/W2023471150","https://openalex.org/W2024664220","https://openalex.org/W2035091654","https://openalex.org/W2038061997","https://openalex.org/W2039193562","https://openalex.org/W2040394074","https://openalex.org/W2043303657","https://openalex.org/W2047213232","https://openalex.org/W2052495855","https://openalex.org/W2052860396","https://openalex.org/W2053476902","https://openalex.org/W2055202919","https://openalex.org/W2057607651","https://openalex.org/W2058493142","https://openalex.org/W2059554911","https://openalex.org/W2060913542","https://openalex.org/W2062165674","https://openalex.org/W2070132182","https://openalex.org/W2072640457","https://openalex.org/W2074534136","https://openalex.org/W2074766125","https://openalex.org/W2076724695","https://openalex.org/W2078337129","https://openalex.org/W2082816799","https://openalex.org/W2083375624","https://openalex.org/W2085403237","https://openalex.org/W2085878243","https://openalex.org/W2087878647","https://openalex.org/W2091766457","https://openalex.org/W2105273832","https://openalex.org/W2106084836","https://openalex.org/W2106364712","https://openalex.org/W2110036226","https://openalex.org/W2126657020","https://openalex.org/W2127373222","https://openalex.org/W2157203184","https://openalex.org/W2161531632","https://openalex.org/W2167795220","https://openalex.org/W2171720113","https://openalex.org/W2405666803","https://openalex.org/W2412200572","https://openalex.org/W2550698246","https://openalex.org/W3148398775","https://openalex.org/W4238594062","https://openalex.org/W4301359987","https://openalex.org/W6818843161"],"related_works":["https://openalex.org/W2086540963","https://openalex.org/W1996787930","https://openalex.org/W2043303657","https://openalex.org/W1973832527","https://openalex.org/W1893934259","https://openalex.org/W2127373222","https://openalex.org/W2022967762","https://openalex.org/W2127722696","https://openalex.org/W3174710627","https://openalex.org/W2016720466"],"abstract_inverted_index":{"BACKGROUND:":[0],"Natural":[1],"antibodies":[2,130],"directed":[3],"at":[4],"carbohydrates":[5],"reject":[6],"porcine":[7],"xenografts.":[8],"They":[9],"are":[10,17,52,136,230],"initially":[11],"expressed":[12],"in":[13,60,76,131,138,182,202,235],"germline":[14,25,58,105,246],"configuration":[15],"and":[16,78,103,154,189,226,265],"encoded":[18,151,232,243],"by":[19,91,152,160,233,244,254,276],"a":[20,240],"small":[21,98,241],"number":[22],"of":[23,29,88,100,148,193,259,298],"structurally-related":[24],"progenitors.":[26,247],"The":[27,126,145,156],"transplantation":[28],"genetically-modified":[30],"pig":[31],"organs":[32],"prevents":[33],"hyperacute":[34],"rejection,":[35],"but":[36],"delayed":[37,227],"graft":[38],"rejection":[39],"still":[40],"occurs,":[41],"partly":[42],"due":[43],"to":[44,116,165,208,289],"humoral":[45],"responses.":[46,144],"IgVH":[47,94,195],"genes":[48,72,95,234],"encoding":[49,73,96,107],"induced":[50,89,137,223],"xenoantibodies":[51,75,90,102,149,178],"predominantly,":[53],"not":[54],"exclusively,":[55],"derived":[56],"from":[57],"progenitors":[59,106],"the":[61,68,85,93,97,104,118,132,190,194,215,236,255,260,296],"VH3":[62,74,176,237],"family.":[63],"We":[64],"have":[65],"previously":[66],"identified":[67,253],"immunoglobulin":[69],"heavy":[70,263],"chain":[71,147,264],"patients":[77,140],"primates.":[79],"In":[80],"this":[81,270],"manuscript,":[82],"we":[83],"complete":[84],"structural":[86,157],"analysis":[87,162],"identifying":[92],"proportion":[99,242],"VH4":[101,133,245],"xenoantibody":[108,143],"light":[109,146,261],"chains.":[110],"This":[111,248],"information":[112,158],"has":[113],"been":[114],"used":[115,164],"define":[117],"xenoantibody/carbohydrate":[119,173],"binding":[120,207],"site":[121],"using":[122,282],"computer-simulated":[123,167,283],"modeling.":[124],"RESULTS:":[125],"VH4-59":[127],"gene":[128],"encodes":[129],"family":[134,177],"that":[135,200,214,293],"human":[139],"mounting":[141],"active":[142],"is":[150],"DPK5":[153],"HSIGKV134.":[155],"obtained":[159],"sequencing":[161],"was":[163],"create":[166],"models.":[168],"Key":[169],"contact":[170,204],"sites":[171,183,205],"for":[172,175],"interaction":[174],"include":[179],"amino":[180],"acids":[181],"31,":[184],"33,":[185],"50,":[186],"57,":[187],"58":[188],"CDR3":[191,216],"region":[192,217],"gene.":[196],"Site-directed":[197],"mutagenesis":[198],"indicates":[199],"mutations":[201],"predicted":[203],"alter":[206],"carbohydrate":[209],"xenoantigens.":[210],"Computer-simulated":[211,267,279],"modeling":[212],"suggests":[213],"directly":[218],"influences":[219],"binding.":[220],"CONCLUSION:":[221],"Xenoantibodies":[222],"during":[224],"early":[225],"xenograft":[228],"responses":[229],"predominantly":[231],"family,":[238],"with":[239,272],"restricted":[249],"group":[250],"can":[251],"be":[252,287],"unique":[256],"canonical":[257],"structure":[258,271],"chain,":[262],"CDR3.":[266],"models":[268,284],"depict":[269],"accuracy,":[273],"as":[274],"confirmed":[275],"site-directed":[277],"mutagenesis.":[278],"drug":[280],"design":[281],"may":[285,294],"now":[286],"applied":[288],"develop":[290],"new":[291],"drugs":[292],"enhance":[295],"survival":[297],"xenografted":[299],"organs.":[300]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}