{"id":"https://openalex.org/W201898784","doi":null,"title":"Fonctions ubiquitine-d\u00e9pendantes de la d\u00e9ac\u00e9tylase HDAC6","display_name":"Fonctions ubiquitine-d\u00e9pendantes de la d\u00e9ac\u00e9tylase HDAC6","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W201898784","mag":"201898784"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/792423","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/792423","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-00345784","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066328923","display_name":"Cyril Boyault","orcid":"https://orcid.org/0000-0001-9614-4292","observed_orcids":["https://orcid.org/0000-0001-9614-4292"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cyril Boyault","raw_affiliation_strings":["Biologie mol\u00e9culaire et cellulaire de la diff\u00e9renciation"],"raw_orcid":"https://orcid.org/0000-0001-9614-4292","affiliations":[{"raw_affiliation_string":"Biologie mol\u00e9culaire et cellulaire de la diff\u00e9renciation","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066328923"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac6","display_name":"HDAC6","score":1.0},{"id":"https://openalex.org/keywords/vcp-p97","display_name":"VCP/p97","score":0.8149999976158142},{"id":"https://openalex.org/keywords/heat-shock-factor-1","display_name":"heat shock factor 1","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8529999852180481},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cellular-stress-response","display_name":"cellular stress response","score":0.6840000152587891},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7375689148902893},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4367362856864929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.313524067401886}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/792423","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/792423","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-00345784v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00345784","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biologie cellulaire. Universit\u00e9 Joseph-Fourier - Grenoble I, 2006. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:201898784","doi":null,"is_oa":false,"landing_page_url":"https://tel.archives-ouvertes.fr/tel-00345784","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:tel-00345784v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00345784","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biologie cellulaire. Universit\u00e9 Joseph-Fourier - Grenoble I, 2006. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7034575033","https://openalex.org/W2038744188","https://openalex.org/W4392440356","https://openalex.org/W2128761802","https://openalex.org/W623440640","https://openalex.org/W7134677591","https://openalex.org/W7147726137","https://openalex.org/W2125568224","https://openalex.org/W2030185116","https://openalex.org/W2763301729"],"abstract_inverted_index":{"Avant":[0],"le":[1,6,35,143],"d\u00e9but":[2],"de":[3,48,55,58,83,96,122,145,153,157,175,192,224],"ma":[4],"th\u00e8se,":[5],"laboratoire":[7,36],"avait":[8,37],"d\u00e9couvert":[9,166],"et":[10,22,50,178,195,202,227,239],"caract\u00e9ris\u00e9":[11],"HDAC6,":[12],"une":[13,102,139],"Histone":[14],"D\u00e9ac\u00e9tylase":[15],"atypique":[16],"qui":[17],"poss\u00e8de":[18],"deux":[19],"domaines":[20],"d\u00e9ac\u00e9tylases":[21],"peut":[23,125],"interagir":[24],"directement":[25,114],"avec":[26,42,200],"l'ubiquitine,":[27,49],"gr\u00e2ce":[28],"\u00e0":[29,98,101,161,173,235],"son":[30,92,94],"domaine":[31,95],"ZnF-UBP.":[32],"De":[33],"plus,":[34],"montr\u00e9":[38],"que":[39,80,109,167],"HDAC6":[40,84,168,194,219],"interagit":[41],"UFD3/PLAP,":[43],"un":[44,52],"r\u00e9gulateur":[45],"du":[46,217,222],"recyclage":[47],"p97/VCP,":[51],"orthologue":[53],"murin":[54],"la":[56,66,81,86,115,155,158,170,206,241,244],"chaperonne":[57],"levure":[59],"Cdc48p.":[60],"Cependant,":[61,204],"aucune":[62,132],"fonction":[63],"biologique":[64],"dans":[65,184,243],"voie":[67],"d'ubiquitination":[68],"des":[69,88,117],"prot\u00e9ines":[70,89,118,123,176,210],"n'\u00e9tait":[71],"connue":[72],"pour":[73,128],"HDAC6.":[74],"Nous":[75,187],"avons":[76,106,165,179,188],"tout":[77],"d'abord":[78],"observ\u00e9":[79],"surexpression":[82],"ralenti":[85],"d\u00e9gradation":[87],"poly-ubiquitin\u00e9es,":[90],"via":[91],"ZnF-UBP,":[93],"liaison":[97],"l'ubiquitine.":[99],"Gr\u00e2ce":[100,160],"s\u00e9rie":[103],"d'exp\u00e9riences,":[104],"nous":[105,164],"pu":[107],"montrer":[108],"les":[110,129,181],"complexes":[111,199],"HDAC6-p97/VCP":[112],"r\u00e9gulent":[113],"stabilit\u00e9":[116],"poly-ubiquitin\u00e9es.":[119],"L'accumulation":[120],"intracellulaire":[121,208],"poly-ubiquitin\u00e9es":[124,177,211],"\u00eatre":[126],"toxique":[127],"cellules":[130],"si":[131],"r\u00e9ponse":[133,171,245],"cellulaire":[134,172],"n'est":[135],"engag\u00e9e.":[136],"En":[137],"r\u00e9alit\u00e9,":[138],"telle":[140],"accumulation":[141],"active":[142],"facteur":[144],"transcription":[146],"Heat":[147],"Shock":[148],"Factor":[149],"1":[150],"(HSF1)":[151],"afin":[152],"promouvoir":[154],"survie":[156],"cellule.":[159],"ces":[162],"consid\u00e9rations,":[163],"contr\u00f4le":[169],"l'accumulation":[174],"diss\u00e9qu\u00e9":[180],"m\u00e9canismes":[182],"impliqu\u00e9s":[183],"ce":[185],"contr\u00f4le.":[186],"trouv\u00e9":[189],"qu'en":[190],"l'absence":[191],"stress,":[193],"HSF1":[196,238],"sont":[197],"en":[198,209],"p97/VCP":[201,236],"HSP90.":[203],"lorsque":[205],"concentration":[207],"augmente,":[212],"comme":[213],"lors":[214],"d'une":[215],"inhibition":[216],"prot\u00e9asome,":[218],"est":[220],"re-largu\u00e9e":[221],"complexe":[223],"mani\u00e8re":[225],"ubiquitine":[226],"ZnF-UBP":[228],"d\u00e9pendante.":[229],"Un":[230],"tel":[231],"re-largage":[232],"permet":[233],"ensuite":[234],"d'activer":[237],"d'engager":[240],"cellule":[242],"au":[246],"stress.":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}