{"id":"https://openalex.org/W2018963701","doi":"https://doi.org/10.1016/j.jconrel.2012.01.045","title":"Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth","display_name":"Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth","publication_year":2012,"publication_date":"2012-02-08","ids":{"openalex":"https://openalex.org/W2018963701","doi":"https://doi.org/10.1016/j.jconrel.2012.01.045","mag":"2018963701","pmid":"https://pubmed.ncbi.nlm.nih.gov/22342644","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3348392"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2012.01.045","doi":"https://doi.org/10.1016/j.jconrel.2012.01.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2012.01.045","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0168365912000776-fx1_lrg.jpg","source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0168365912000776-fx1_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103730023","display_name":"Mohammad Aminur Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Aminur Rahman","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036760441","display_name":"A.R.M. Ruhul Amin","orcid":"https://orcid.org/0000-0001-9144-2960","observed_orcids":["https://orcid.org/0000-0001-9144-2960"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.R.M. Ruhul Amin","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407887","display_name":"Xu Wang","orcid":"https://orcid.org/0000-0002-6646-0515","observed_orcids":["https://orcid.org/0000-0002-6646-0515","https://orcid.org/0009-0008-3871-1031"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xu Wang","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061317769","display_name":"Jonathan E. Zuckerman","orcid":"https://orcid.org/0000-0001-9758-2147","observed_orcids":["https://orcid.org/0000-0001-9758-2147"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan E. Zuckerman","raw_affiliation_strings":["Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031517455","display_name":"Chung Hang Jonathan Choi","orcid":"https://orcid.org/0000-0003-2935-7217","observed_orcids":["https://orcid.org/0000-0003-2935-7217"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung Hang J. Choi","raw_affiliation_strings":["Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904469","display_name":"Bingsen Zhou","orcid":"https://orcid.org/0009-0002-4366-1207","observed_orcids":["https://orcid.org/0009-0002-4366-1207"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bingsen Zhou","raw_affiliation_strings":["Department of Clinical and Molecular Pharmacology, City of Hope National Medical Center, Duarte, CA 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Pharmacology, City of Hope National Medical Center, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101767828","display_name":"Dongsheng Wang","orcid":"https://orcid.org/0000-0003-2594-8140","observed_orcids":["https://orcid.org/0000-0003-2594-8140"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongsheng Wang","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088965012","display_name":"Sreenivas Nannapaneni","orcid":"https://orcid.org/0000-0002-3869-6512","observed_orcids":["https://orcid.org/0000-0002-3869-6512","https://orcid.org/0009-0002-0937-8707"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sreenivas Nannapaneni","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039871155","display_name":"Lydia Koenig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lydia Koenig","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042210553","display_name":"Zhengjia Chen","orcid":"https://orcid.org/0000-0002-6301-4931","observed_orcids":["https://orcid.org/0000-0002-6301-4931"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengjia Chen","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.,","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086434823","display_name":"Zhuo Chen","orcid":"https://orcid.org/0000-0002-3522-9660","observed_orcids":["https://orcid.org/0000-0002-3522-9660"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuo (Georgia) Chen","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009104622","display_name":"Yun Yen","orcid":"https://orcid.org/0000-0003-0815-412X","observed_orcids":["https://orcid.org/0000-0003-0815-412X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Yen","raw_affiliation_strings":["Department of Clinical and Molecular Pharmacology, City of Hope National Medical Center, Duarte, CA 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Pharmacology, City of Hope National Medical Center, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010404427","display_name":"Mark E. Davis","orcid":"https://orcid.org/0000-0001-8294-1477","observed_orcids":["https://orcid.org/0000-0001-8294-1477","https://orcid.org/0000-0001-5886-4790","https://orcid.org/0000-0003-2480-7338"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Davis","raw_affiliation_strings":["Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010399375","display_name":"Dong Moon Shin","orcid":"https://orcid.org/0000-0002-8245-4174","observed_orcids":["https://orcid.org/0000-0002-8245-4174"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dong M. Shin","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010399375"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":5.3941,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.97041935,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"159","issue":"3","first_page":"384","last_page":"392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-nanoparticles","display_name":"siRNA nanoparticles","score":0.9210000038146973},{"id":"https://openalex.org/keywords/rrm2","display_name":"RRM2","score":0.8450000286102295},{"id":"https://openalex.org/keywords/systemic-drug-delivery","display_name":"systemic drug delivery","score":0.6510000228881836},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5559999942779541},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5360000133514404},{"id":"https://openalex.org/keywords/intravenous-injection","display_name":"intravenous injection","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.758832573890686},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6951919198036194},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6492283344268799},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5818011164665222},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5091454386711121},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4807279407978058},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46993571519851685},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4579663574695587},{"id":"https://openalex.org/C4710235","wikidata":"https://www.wikidata.org/wiki/Q420089","display_name":"Ribonucleotide reductase","level":4,"score":0.4273911118507385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35005611181259155},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34470707178115845},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.30532586574554443},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.23314884305000305},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.18676447868347168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1397283375263214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07135671377182007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07000288367271423}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012262","descriptor_name":"Ribonucleoside Diphosphate Reductase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012262","descriptor_name":"Ribonucleoside Diphosphate Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jconrel.2012.01.045","doi":"https://doi.org/10.1016/j.jconrel.2012.01.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2012.01.045","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0168365912000776-fx1_lrg.jpg","source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:22342644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22342644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2646811","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3348392","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3348392","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3348392","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Control Release","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:32238","doi":null,"is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/32238/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.jconrel.2012.01.045","doi":"https://doi.org/10.1016/j.jconrel.2012.01.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2012.01.045","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0168365912000776-fx1_lrg.jpg","source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3049806640","display_name":null,"funder_award_id":"U54-CA119347","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3697868392","display_name":null,"funder_award_id":"CA138292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G50212507","display_name":"NanoSystems Biology Cancer Center","funder_award_id":"5u54ca119347-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5320621710","display_name":"UCLA-Caltech Medical Scientist Training Program","funder_award_id":"T32GM008042","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G701400689","display_name":null,"funder_award_id":"CA128613","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7933644463","display_name":"SPORE in Head and Neck Cancer","funder_award_id":"P50CA128613","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8101367251","display_name":"Toxicity and Efficacy of Gold Nanoparticle Photothermal Therapy in Cancer","funder_award_id":"U01CA151802","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000060737","display_name":null,"funder_award_id":"CA138292","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000881663","display_name":"Winship Cancer Institute Cancer Center Support Grant","funder_award_id":"P30CA138292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018963701.pdf","grobid_xml":"https://content.openalex.org/works/W2018963701.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1504844653","https://openalex.org/W1536062643","https://openalex.org/W1565276921","https://openalex.org/W1647075334","https://openalex.org/W1964146045","https://openalex.org/W1970238359","https://openalex.org/W1977179006","https://openalex.org/W1978643345","https://openalex.org/W2000465781","https://openalex.org/W2006165138","https://openalex.org/W2012694727","https://openalex.org/W2014509855","https://openalex.org/W2015511149","https://openalex.org/W2015700471","https://openalex.org/W2019515908","https://openalex.org/W2021905258","https://openalex.org/W2025228190","https://openalex.org/W2030621748","https://openalex.org/W2038036999","https://openalex.org/W2049775573","https://openalex.org/W2057944226","https://openalex.org/W2062991743","https://openalex.org/W2079048802","https://openalex.org/W2082511916","https://openalex.org/W2086439640","https://openalex.org/W2087913780","https://openalex.org/W2093390138","https://openalex.org/W2108882170","https://openalex.org/W2109689528","https://openalex.org/W2118137379","https://openalex.org/W2122761469","https://openalex.org/W2135283089","https://openalex.org/W2140093304","https://openalex.org/W2149464340","https://openalex.org/W2152183134","https://openalex.org/W2163276935","https://openalex.org/W2224915174"],"related_works":["https://openalex.org/W2320365283","https://openalex.org/W2516017983","https://openalex.org/W2163276935","https://openalex.org/W3003964623","https://openalex.org/W3049312721","https://openalex.org/W1899587175","https://openalex.org/W2060764878","https://openalex.org/W2014509855","https://openalex.org/W4412041638","https://openalex.org/W2135334810"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
