{"id":"https://openalex.org/W2018961628","doi":"https://doi.org/10.1111/exd.12233","title":"Deletion of the activating NKG 2C receptor and a functional polymorphism in its ligand HLA \u2010E in psoriasis susceptibility","display_name":"Deletion of the activating NKG 2C receptor and a functional polymorphism in its ligand HLA \u2010E in psoriasis susceptibility","publication_year":2013,"publication_date":"2013-08-23","ids":{"openalex":"https://openalex.org/W2018961628","doi":"https://doi.org/10.1111/exd.12233","mag":"2018961628","pmid":"https://pubmed.ncbi.nlm.nih.gov/24079744","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3813441"},"language":"en","primary_location":{"id":"doi:10.1111/exd.12233","doi":"https://doi.org/10.1111/exd.12233","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.12233","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3813441","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103167186","display_name":"Xue Zeng","orcid":"https://orcid.org/0000-0003-4980-0984","observed_orcids":["https://orcid.org/0000-0003-4980-0984"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xue Zeng","raw_affiliation_strings":["Department of Dermatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China","Department of Dermatology, University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Department of Dermatology, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044175096","display_name":"Haoyan Chen","orcid":"https://orcid.org/0000-0001-6722-8534","observed_orcids":["https://orcid.org/0000-0001-6722-8534"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Haoyan Chen","raw_affiliation_strings":["Department of Dermatology, University of California San Francisco, San Francisco, CA, USA","Department of Gastroenterology Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive Diseases Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Gastroenterology Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive Diseases Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103825647","display_name":"Rashmi Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rashmi Gupta","raw_affiliation_strings":["Department of Dermatology, University of California-San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of California-San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097989721","display_name":"Oscar Paz\u2010Altschul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar Paz\u2010Altschul","raw_affiliation_strings":["Department of Dermatology, University of California-San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of California-San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012790096","display_name":"Anne M. Bowcock","orcid":"https://orcid.org/0000-0001-8691-9090","observed_orcids":["https://orcid.org/0000-0001-8691-9090"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anne M. Bowcock","raw_affiliation_strings":["Cancer Genomics and National Heart and Lung Institute; Imperial College; London; UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics and National Heart and Lung Institute; Imperial College; London; UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078581958","display_name":"Wilson J. Liao","orcid":"https://orcid.org/0000-0001-7883-6439","observed_orcids":["https://orcid.org/0000-0001-7883-6439"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wilson Liao","raw_affiliation_strings":["Department of Dermatology, University of California-San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of California-San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078581958"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":2.7646,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.89681201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"22","issue":"10","first_page":"679","last_page":"681"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.12710000574588776,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nkg2c","display_name":"NKG2C","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hla-e","display_name":"HLA-E","score":0.9279999732971191},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nk-cell-receptors","display_name":"NK cell receptors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6579999923706055},{"id":"https://openalex.org/keywords/hla-c","display_name":"HLA-C","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gene-deletion","display_name":"gene deletion","score":0.5590000152587891},{"id":"https://openalex.org/keywords/polymorphism","display_name":"polymorphism","score":0.46700000762939453},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.8909299373626709},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7141170501708984},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6853698492050171},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5632524490356445},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.551818311214447},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5403431057929993},{"id":"https://openalex.org/C2780027760","wikidata":"https://www.wikidata.org/wiki/Q3124896","display_name":"HLA-G","level":4,"score":0.5038582682609558},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.49893999099731445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42098987102508545},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41880881786346436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3107231855392456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2845146656036377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2433219850063324},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.16790291666984558},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097625","descriptor_name":"HLA-E Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055654","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055654","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/exd.12233","doi":"https://doi.org/10.1111/exd.12233","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.12233","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:24079744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24079744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:3813441","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3813441","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Exp Dermatol","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt47c8d5br","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/47c8d5br","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Experimental Dermatology, vol 22, iss 10","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3813441","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3813441","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Exp Dermatol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5458504750","display_name":"Genetic Analysis of the TNF Pathway in Psoriasis","funder_award_id":"K08AR057763","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6742162472","display_name":"Identification of Causal Variants in Psoriasis","funder_award_id":"R01AR065174","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7986662237","display_name":"Genome-Wide SNP Association in Psoriasis","funder_award_id":"R01AR050266","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8206328141","display_name":null,"funder_award_id":"AR050266","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1487296367","https://openalex.org/W1663011875","https://openalex.org/W1965924746","https://openalex.org/W1974871174","https://openalex.org/W1978239858","https://openalex.org/W1980938282","https://openalex.org/W1984327193","https://openalex.org/W1986696487","https://openalex.org/W1995413594","https://openalex.org/W1999355254","https://openalex.org/W2011647218","https://openalex.org/W2014901519","https://openalex.org/W2018997003","https://openalex.org/W2021747720","https://openalex.org/W2027266738","https://openalex.org/W2030307609","https://openalex.org/W2036348602","https://openalex.org/W2039317941","https://openalex.org/W2041980962","https://openalex.org/W2055679291","https://openalex.org/W2065779257","https://openalex.org/W2086416049","https://openalex.org/W2105842551","https://openalex.org/W2108380253","https://openalex.org/W2122412498","https://openalex.org/W2134534481","https://openalex.org/W2143429821","https://openalex.org/W2151186939","https://openalex.org/W2561759163"],"related_works":["https://openalex.org/W1992663350","https://openalex.org/W1811604864","https://openalex.org/W4233546044","https://openalex.org/W2111182680","https://openalex.org/W2055679291","https://openalex.org/W2108380253","https://openalex.org/W2113209831","https://openalex.org/W2299739597","https://openalex.org/W2039317941","https://openalex.org/W7097951050"],"abstract_inverted_index":{"Psoriasis":[0],"is":[1],"an":[2],"inflammatory,":[3],"immune-mediated":[4],"disease":[5],"of":[6,32,44,72,137,144,154],"the":[7,33,47,82,135,142,152],"skin.":[8],"Several":[9],"studies":[10,139],"have":[11],"suggested":[12],"that":[13,81],"natural":[14,35],"killer":[15,36],"(NK)":[16],"cells":[17,130,146],"and":[18,58,76,133,147],"their":[19,148],"receptors":[20,150],"may":[21],"be":[22],"important":[23],"for":[24,128],"its":[25,63],"pathogenesis.":[26],"Here,":[27],"we":[28],"examined":[29],"whether":[30],"deletion":[31,57,84],"activating":[34],"receptor":[37],"gene":[38],"NKG2C,":[39],"which":[40],"has":[41],"a":[42,59,69,124],"frequency":[43],"20%":[45],"in":[46,62,68,88,131],"European":[48],"population,":[49],"was":[50,85,107,117],"associated":[51,108],"with":[52,91,109],"psoriasis":[53,74,110,132],"susceptibility.":[54],"The":[55,103],"NKG2C":[56,83],"functional":[60],"polymorphism":[61],"ligand":[64],"HLA-E":[65],"were":[66],"genotyped":[67],"Caucasian":[70],"cohort":[71],"611":[73],"cases":[75,89],"493":[77],"controls.":[78],"We":[79],"found":[80],"significantly":[86],"increased":[87],"compared":[90],"controls":[92],"[0.258":[93],"vs":[94],"0.200,":[95],"P":[96],"=":[97,100,112],"0.0012,":[98],"OR":[99],"1.43":[101],"(1.15-1.79)].":[102],"low-expressing":[104],"HLA-E*01:01":[105],"allele":[106],"(P":[111],"0.0018),":[113],"although":[114],"this":[115],"association":[116],"dependent":[118],"on":[119],"HLA-C.":[120],"Our":[121],"findings":[122],"support":[123],"potential":[125],"immunoregulatory":[126],"role":[127],"NK":[129,145],"suggest":[134],"importance":[136],"future":[138],"to":[140,151],"investigate":[141],"contribution":[143],"regulatory":[149],"pathogenesis":[153],"psoriasis.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}