{"id":"https://openalex.org/W2018952387","doi":"https://doi.org/10.1242/jcs.02685","title":"Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells","display_name":"Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells","publication_year":2005,"publication_date":"2005-11-30","ids":{"openalex":"https://openalex.org/W2018952387","doi":"https://doi.org/10.1242/jcs.02685","mag":"2018952387","pmid":"https://pubmed.ncbi.nlm.nih.gov/16317049"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.02685","doi":"https://doi.org/10.1242/jcs.02685","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.02685","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015722444","display_name":"Patrick E. MacDonald","orcid":"https://orcid.org/0000-0002-5439-6288","observed_orcids":["https://orcid.org/0000-0002-5439-6288"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]}],"countries":["GB","SE"],"is_corresponding":true,"raw_author_name":"Patrick E. MacDonald","raw_affiliation_strings":["Division of Diabetes, Metabolism and Endocrinology, Lund University, 221 84 Lund, Sweden","Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, OX3 7LJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Metabolism and Endocrinology, Lund University, 221 84 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, OX3 7LJ, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I4210129944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033038377","display_name":"Lena Eliasson","orcid":"https://orcid.org/0000-0002-6467-5029","observed_orcids":["https://orcid.org/0000-0002-6467-5029"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lena Eliasson","raw_affiliation_strings":["Division of Diabetes, Metabolism and Endocrinology, Lund University, 221 84 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Metabolism and Endocrinology, Lund University, 221 84 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089848866","display_name":"Patrik Rorsman","orcid":"https://orcid.org/0000-0001-7578-0767","observed_orcids":["https://orcid.org/0000-0001-7578-0767"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Patrik Rorsman","raw_affiliation_strings":["Division of Diabetes, Metabolism and Endocrinology, Lund University, 221 84 Lund, Sweden","Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, OX3 7LJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Metabolism and Endocrinology, Lund University, 221 84 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, OX3 7LJ, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I4210129944"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015722444"],"corresponding_institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2801179840","https://openalex.org/I4210129944"],"apc_list":null,"apc_paid":null,"fwci":0.7607,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.66601959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"118","issue":"24","first_page":"5911","last_page":"5920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.8629999756813049},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/membrane-fission","display_name":"membrane fission","score":0.9539999961853027},{"id":"https://openalex.org/keywords/membrane-retrieval","display_name":"membrane retrieval","score":0.8999999761581421},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7870000004768372},{"id":"https://openalex.org/keywords/ins-1-cells","display_name":"INS-1 cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glucose-stimulation","display_name":"glucose stimulation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.8980000019073486},{"id":"https://openalex.org/keywords/r-type-calcium-channels","display_name":"R-type calcium channels","score":0.9950000047683716},{"id":"https://openalex.org/keywords/deltamethrin","display_name":"deltamethrin","score":0.7670000195503235},{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.6986562013626099},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6693016886711121},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6650170087814331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6087064743041992},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.534421980381012},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4788498878479004},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.46671053767204285},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.4608146548271179},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4042015075683594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24695256352424622},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1834355592727661}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011722","descriptor_name":"Pyrethrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013549","descriptor_name":"Sweetening Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1242/jcs.02685","doi":"https://doi.org/10.1242/jcs.02685","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.02685","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:16317049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16317049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:03f6f437-8ec6-46e8-b529-64ede6ea42c2","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/149053","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0021-9533","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:joces:118/24/5911","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/118/24/5911","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1212078","https://openalex.org/W1497576400","https://openalex.org/W1548893012","https://openalex.org/W1570636004","https://openalex.org/W1599906730","https://openalex.org/W1720280203","https://openalex.org/W1915945057","https://openalex.org/W1936931129","https://openalex.org/W1965846572","https://openalex.org/W1970249565","https://openalex.org/W1973193956","https://openalex.org/W1974337917","https://openalex.org/W1978186310","https://openalex.org/W1981344194","https://openalex.org/W1981593511","https://openalex.org/W1982630258","https://openalex.org/W1992394099","https://openalex.org/W1994137221","https://openalex.org/W1995408976","https://openalex.org/W1999208340","https://openalex.org/W2006459253","https://openalex.org/W2006976345","https://openalex.org/W2007461061","https://openalex.org/W2008574946","https://openalex.org/W2011724356","https://openalex.org/W2013752106","https://openalex.org/W2023497375","https://openalex.org/W2026786451","https://openalex.org/W2031579758","https://openalex.org/W2035149692","https://openalex.org/W2035336615","https://openalex.org/W2037859627","https://openalex.org/W2050408587","https://openalex.org/W2055672024","https://openalex.org/W2057706200","https://openalex.org/W2059854083","https://openalex.org/W2060046982","https://openalex.org/W2065011201","https://openalex.org/W2067642037","https://openalex.org/W2068437038","https://openalex.org/W2070048168","https://openalex.org/W2073125666","https://openalex.org/W2076776451","https://openalex.org/W2077644186","https://openalex.org/W2085949242","https://openalex.org/W2087513927","https://openalex.org/W2087585115","https://openalex.org/W2092318898","https://openalex.org/W2092327340","https://openalex.org/W2094288810","https://openalex.org/W2098292177","https://openalex.org/W2104433712","https://openalex.org/W2105955034","https://openalex.org/W2113728164","https://openalex.org/W2118858388","https://openalex.org/W2122093151","https://openalex.org/W2122247317","https://openalex.org/W2122590647","https://openalex.org/W2140552779","https://openalex.org/W2146529473","https://openalex.org/W2163139372","https://openalex.org/W2168148059","https://openalex.org/W2404314950","https://openalex.org/W4244657081"],"related_works":["https://openalex.org/W7027222701","https://openalex.org/W1981344194","https://openalex.org/W2103188904","https://openalex.org/W2110825223","https://openalex.org/W2058833411","https://openalex.org/W7096720633","https://openalex.org/W2145215326","https://openalex.org/W1989364196","https://openalex.org/W1979004403","https://openalex.org/W1647773117"],"abstract_inverted_index":{"In":[0,38],"many":[1],"cells,":[2,40],"endocytotic":[3,16,63,93,195],"membrane":[4,32,52,137,170,201],"retrieval":[5,185],"is":[6],"accelerated":[7,160],"by":[8,24,44,78,150,161,190],"Ca2+.":[9],"The":[10],"effect":[11,73,174],"of":[12,34,42,62,68,74,80,123,134,200],"Ca2+":[13,43,84,88,106,113,129,162],"on":[14],"single":[15],"vesicles":[17,64],"and":[18,27,126,139,168,198],"fission":[19,156,202],"pore":[20,157],"kinetics":[21,158],"was":[22,70,76,89,102,148,178],"examined":[23],"measuring":[25],"capacitance":[26,61,95,101,147],"conductance":[28],"changes":[29],"in":[30,51,96,140,145,163,175,194,203],"small":[31],"patches":[33],"insulin-secreting":[35,204],"INS-1":[36,205],"cells.":[37,206],"intact":[39,166],"elevation":[41],"glucose":[45,75],"stimulation":[46],"induced":[47],"a":[48,97,191],"1.8-fold":[49],"increase":[50,144,193],"internalisation.":[53],"This":[54,72],"surprisingly":[55],"resulted":[56],"from":[57],"an":[58],"increased":[59,103],"unitary":[60],"whereas":[65],"the":[66,131,143,151,165,173],"frequency":[67],"endocytosis":[69],"unaltered.":[71],"prevented":[77,149],"inhibition":[79],"L-":[81],"or":[82],"R-type":[83],"channels.":[85],"Extracellular":[86],"(pipette)":[87],"found":[90],"to":[91,130],"regulate":[92],"vesicle":[94,146,196],"bimodal":[98,180],"manner.":[99],"Vesicle":[100],"at":[104,111],"intermediate":[105],"(2.6":[107],"mM),":[108],"but":[109],"not":[110],"high":[112],"(10":[114],"mM).":[115],"Similar":[116],"results":[117],"were":[118,159],"obtained":[119],"upon":[120],"direct":[121],"application":[122],"100":[124],"nM":[125],"0.5":[127],"mM":[128],"intracellular":[132],"surface":[133],"inside-out":[135],"excised":[136],"patches,":[138],"these":[141],"experiments":[142],"calcineurin":[152],"inhibitor":[153],"deltamethrin.":[154],"Endocytotic":[155],"both":[164],"cells":[167],"isolated":[169],"patches;":[171],"however,":[172],"this":[176],"case":[177],"neither":[179],"nor":[181],"deltamethrin":[182],"sensitive.":[183],"Membrane":[184],"can":[186],"therefore":[187],"be":[188],"upregulated":[189],"Ca2+-dependent":[192],"size":[197],"acceleration":[199]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}