{"id":"https://openalex.org/W2018945802","doi":"https://doi.org/10.1021/ic034036e","title":"Metalloantimalarials: Targeting of P. falciparum Strains with Novel Iron(III) and Gallium(III) Complexes of an Amine Phenol Ligand","display_name":"Metalloantimalarials: Targeting of P. falciparum Strains with Novel Iron(III) and Gallium(III) Complexes of an Amine Phenol Ligand","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2018945802","doi":"https://doi.org/10.1021/ic034036e","mag":"2018945802","pmid":"https://pubmed.ncbi.nlm.nih.gov/12665363"},"language":"en","primary_location":{"id":"doi:10.1021/ic034036e","doi":"https://doi.org/10.1021/ic034036e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic034036e","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047378145","display_name":"Scott E. Harpstrite","orcid":"https://orcid.org/0000-0003-4472-3190","observed_orcids":["https://orcid.org/0000-0003-4472-3190"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E. Harpstrite","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017725080","display_name":"A.A. Beatty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia A. Beatty","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089940458","display_name":"Silvia D. Collins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvia D. Collins","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111201155","display_name":"Anna Oksman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Oksman","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029982946","display_name":"Daniel E. Goldberg","orcid":"https://orcid.org/0000-0003-3529-8399","observed_orcids":["https://orcid.org/0000-0003-3529-8399"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E. Goldberg","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101702771","display_name":"Vijay Sharma","orcid":"https://orcid.org/0000-0002-4985-0044","observed_orcids":["https://orcid.org/0000-0002-4985-0044"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Sharma","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S. Kingshighway Blvd., St. Louis, Missouri 63110, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670, Howard Hughes Medical Institute, and Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.2074,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.91064109,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"42","issue":"7","first_page":"2294","last_page":"2300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.3208000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.9279999732971191},{"id":"https://openalex.org/keywords/gallium-iii-complexes","display_name":"gallium(III) complexes","score":0.9309999942779541},{"id":"https://openalex.org/keywords/iron-iii-complexes","display_name":"iron(III) complexes","score":0.996999979019165},{"id":"https://openalex.org/keywords/hemozoin-formation","display_name":"hemozoin formation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/antimalarial-activity","display_name":"antimalarial activity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7260000109672546},{"id":"https://openalex.org/keywords/coordination-chemistry","display_name":"coordination chemistry","score":0.5109999775886536},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.47999998927116394},{"id":"https://openalex.org/keywords/octahedral-geometry","display_name":"octahedral geometry","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9306925535202026},{"id":"https://openalex.org/C550372918","wikidata":"https://www.wikidata.org/wiki/Q861","display_name":"Gallium","level":2,"score":0.5916697978973389},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.568612813949585},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.5498764514923096},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.5420987606048584},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5324673652648926},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4540562927722931},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.4506934583187103},{"id":"https://openalex.org/C198819137","wikidata":"https://www.wikidata.org/wiki/Q188884","display_name":"Octahedron","level":3,"score":0.43449175357818604},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.4212070107460022},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.4209924340248108},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.3889339566230774},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.35228949785232544},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.34330347180366516},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.21015998721122742},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19367092847824097},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1379224956035614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1295642852783203},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12615954875946045},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.08746877312660217},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005708","descriptor_name":"Gallium","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D005708","descriptor_name":"Gallium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005708","descriptor_name":"Gallium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019800","descriptor_name":"Phenol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021261","descriptor_name":"Parasitic Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ic034036e","doi":"https://doi.org/10.1021/ic034036e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic034036e","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:12665363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12665363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6584567779","display_name":"TARGETING CHLOROQUINE RESISTANCE WITH FE(III) COMPLEXES","funder_award_id":"R01AI045640","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W206142983","https://openalex.org/W1493715460","https://openalex.org/W1522468997","https://openalex.org/W1606371080","https://openalex.org/W1969503178","https://openalex.org/W1969873788","https://openalex.org/W1971131758","https://openalex.org/W1971275933","https://openalex.org/W1973102714","https://openalex.org/W1976399912","https://openalex.org/W1998722626","https://openalex.org/W2006761403","https://openalex.org/W2014208923","https://openalex.org/W2018026475","https://openalex.org/W2020251171","https://openalex.org/W2023744193","https://openalex.org/W2035308235","https://openalex.org/W2039654504","https://openalex.org/W2046040444","https://openalex.org/W2105668259","https://openalex.org/W2117936709","https://openalex.org/W2132923209","https://openalex.org/W2145968299","https://openalex.org/W2148053140","https://openalex.org/W2168595512","https://openalex.org/W2396251829","https://openalex.org/W2465871115","https://openalex.org/W2767369023","https://openalex.org/W2951533567","https://openalex.org/W4244280485","https://openalex.org/W4253865610"],"related_works":["https://openalex.org/W2087861570","https://openalex.org/W2113333037","https://openalex.org/W2953328847","https://openalex.org/W4411515389","https://openalex.org/W2077015114","https://openalex.org/W1971275933","https://openalex.org/W2043587312","https://openalex.org/W2024127997","https://openalex.org/W2068776515","https://openalex.org/W1588160477"],"abstract_inverted_index":{"Emergence":[0],"of":[1,9,18,30,121,145,190,219],"chloroquine":[2,180],"(CQ)-resistant":[3],"Plasmodium":[4],"falciparum":[5],"strains":[6],"necessitates":[7],"discovery":[8],"potent":[10],"and":[11,25,52,60,112,124,136,147,169,185,201],"inexpensive":[12],"antimalarial":[13,68,202],"drugs.":[14],"The":[15,79],"high":[16],"cost":[17],"new":[19],"drugs":[20],"negatively":[21],"impacts":[22],"their":[23],"access":[24],"distribution":[26],"in":[27,84,127,151,197,216,222],"the":[28,31,128,152,161,188],"regions":[29],"world":[32],"with":[33,181],"scarce":[34],"economic":[35],"resources.":[36],"While":[37],"exploring":[38],"structure-activity":[39],"relationships,":[40],"using":[41],"gallium(III)":[42,207],"as":[43,211],"a":[44,212],"surrogate":[45],"marker":[46],"for":[47,76,95,105,214],"iron(III),":[48],"we":[49],"found":[50,139],"cationic,":[51],"moderately":[53],"hydrophobic,":[54],"compounds,":[55],"[[1,12-bis(2-hydroxy-3-ethyl-benzyl)-1,5,8,12-tetraazadodecane]metal(III)](+)":[56],"(metal":[57],"=":[58],"Fe(III)":[59],"Ga(III);":[61],"[Fe-3-Eadd](+),":[62],"3;":[63],"[Ga-3-Eadd](+),":[64],"4),":[65],"that":[66,206],"possessed":[67],"activity.":[69],"Crystal":[70],"structure":[71,217],"analyses":[72],"revealed":[73],"octahedral":[74],"geometry":[75],"these":[77,175],"complexes.":[78],"RP-HPLC":[80],"analysis,":[81],"after":[82],"incubation":[83],"PBS":[85],"or":[86],"HEPES":[87],"buffer":[88],"(pH":[89],"7.4)":[90],"at":[91],"37":[92],"degrees":[93],"C":[94],"3":[96,111,135,168],"days,":[97],"detected":[98],"only":[99],"parental":[100],"compounds":[101,176],"thereby":[102],"providing":[103],"evidence":[104],"stability":[106],"under":[107],"physiological":[108],"conditions.":[109],"Both":[110],"4":[113,137,170],"demonstrated":[114],"promising":[115],"half-maximum":[116],"inhibitory":[117],"concentration":[118],"(IC(50))":[119],"values":[120,144],"approximately":[122],"80":[123],"86":[125],"nM":[126],"CQ-sensitive":[129,162],"HB-3":[130],"line,":[131,155],"respectively.":[132],"However,":[133],"both":[134],"were":[138],"to":[140,179,183,193],"possess":[141],"elevated":[142],"IC(50)":[143],"2.5":[146],"0.8":[148],"microM,":[149],"respectively,":[150],"CQ-resistant":[153],"Dd2":[154],"thus":[156],"displaying":[157],"preferential":[158],"cytotoxicity":[159,203],"toward":[160],"HB3":[163],"line.":[164],"In":[165],"cultured":[166],"parasites,":[167],"targeted":[171],"hemozoin":[172],"formation.":[173],"Thus,":[174],"acted":[177],"similarly":[178],"regard":[182],"action":[184],"resistance,":[186],"despite":[187],"lack":[189],"structural":[191],"similarity":[192,196],"quinolines.":[194],"Finally,":[195],"coordination":[198],"chemistry,":[199],"stability,":[200],"profiles":[204],"indicated":[205],"ion":[208],"can":[209],"serve":[210],"template":[213],"iron(III)":[215],"elucidation":[218],"active":[220],"molecules":[221],"solution.":[223]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}