{"id":"https://openalex.org/W2018945271","doi":"https://doi.org/10.1007/bf00225245","title":"Modulation of functional activities in cultured rat hepatocytes","display_name":"Modulation of functional activities in cultured rat hepatocytes","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2018945271","doi":"https://doi.org/10.1007/bf00225245","mag":"2018945271","pmid":"https://pubmed.ncbi.nlm.nih.gov/6621517"},"language":"en","primary_location":{"id":"doi:10.1007/bf00225245","doi":"https://doi.org/10.1007/bf00225245","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00225245","pdf_url":null,"source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2018945271"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004029396","display_name":"Christiane Guguen\u2010Guillouzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210124872","display_name":"H\u00f4pital Pontchaillou","ror":"https://ror.org/02r25sw81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christiane Guguen-Guillouzo","raw_affiliation_strings":["Unit\u00e9 de Recherches H\u00e9patologiques U 49 de l'INSERM, H\u00f4pital de Pontchaillou, Rennes Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Recherches H\u00e9patologiques U 49 de l'INSERM, H\u00f4pital de Pontchaillou, Rennes Cedex, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111702807","display_name":"A. Guillouzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210124872","display_name":"H\u00f4pital Pontchaillou","ror":"https://ror.org/02r25sw81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Andr\ufffd Guillouzo","raw_affiliation_strings":["Unit\u00e9 de Recherches H\u00e9patologiques U 49 de l'INSERM, H\u00f4pital de Pontchaillou, Rennes Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Recherches H\u00e9patologiques U 49 de l'INSERM, H\u00f4pital de Pontchaillou, Rennes Cedex, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":13.5718,"has_fulltext":false,"cited_by_count":217,"citation_normalized_percentile":{"value":0.99178172,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"53-54","issue":"1-2","first_page":"35","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-culture","display_name":"hepatocyte culture","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hepatocyte-differentiation","display_name":"hepatocyte differentiation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/hepatocyte-viability","display_name":"hepatocyte viability","score":0.6679999828338623},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.6549999713897705},{"id":"https://openalex.org/keywords/liver-epithelial-cells","display_name":"liver epithelial cells","score":0.7250000238418579},{"id":"https://openalex.org/keywords/albumin-synthesis","display_name":"albumin synthesis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/drug-conjugation","display_name":"drug conjugation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9190000295639038},{"id":"https://openalex.org/keywords/liver-enzyme-induction","display_name":"liver enzyme induction","score":0.6510000228881836},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7400000095367432},{"id":"https://openalex.org/keywords/serum-free-medium","display_name":"serum-free medium","score":0.859000027179718},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6369262337684631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5975406765937805},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5386635065078735},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5366816520690918},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5136775374412537},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.511508584022522},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.44481581449508667},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4398540258407593},{"id":"https://openalex.org/C2992672570","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Liver cell","level":2,"score":0.4396977722644806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4324856102466583},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4300180971622467},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.41576915979385376},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41386276483535767},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3621215522289276},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29691022634506226},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00225245","doi":"https://doi.org/10.1007/bf00225245","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00225245","pdf_url":null,"source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:6621517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6621517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":178,"referenced_works":["https://openalex.org/W19445925","https://openalex.org/W93751334","https://openalex.org/W96790785","https://openalex.org/W148019521","https://openalex.org/W203873990","https://openalex.org/W206773894","https://openalex.org/W568929793","https://openalex.org/W1486230207","https://openalex.org/W1489798343","https://openalex.org/W1490154674","https://openalex.org/W1495801986","https://openalex.org/W1499316111","https://openalex.org/W1505121735","https://openalex.org/W1505976283","https://openalex.org/W1515310937","https://openalex.org/W1525693046","https://openalex.org/W1534980247","https://openalex.org/W1541653515","https://openalex.org/W1543190445","https://openalex.org/W1557370431","https://openalex.org/W1559425094","https://openalex.org/W1561379144","https://openalex.org/W1565037888","https://openalex.org/W1565526431","https://openalex.org/W1567136952","https://openalex.org/W1583798495","https://openalex.org/W1587900371","https://openalex.org/W1627511965","https://openalex.org/W1633684113","https://openalex.org/W1668992842","https://openalex.org/W1748043009","https://openalex.org/W1826262926","https://openalex.org/W1847173671","https://openalex.org/W1963548164","https://openalex.org/W1963731790","https://openalex.org/W1964882227","https://openalex.org/W1965723839","https://openalex.org/W1965892920","https://openalex.org/W1966569385","https://openalex.org/W1967150322","https://openalex.org/W1969581986","https://openalex.org/W1970733758","https://openalex.org/W1970938899","https://openalex.org/W1972709496","https://openalex.org/W1973864691","https://openalex.org/W1973941358","https://openalex.org/W1975673211","https://openalex.org/W1976588543","https://openalex.org/W1980469918","https://openalex.org/W1982268590","https://openalex.org/W1982946675","https://openalex.org/W1983670214","https://openalex.org/W1984178141","https://openalex.org/W1984463469","https://openalex.org/W1985385114","https://openalex.org/W1987375895","https://openalex.org/W1988189227","https://openalex.org/W1988217054","https://openalex.org/W1991501430","https://openalex.org/W1992921060","https://openalex.org/W1995470478","https://openalex.org/W1997171790","https://openalex.org/W2000834887","https://openalex.org/W2001780331","https://openalex.org/W2002605249","https://openalex.org/W2003441704","https://openalex.org/W2003682592","https://openalex.org/W2005316365","https://openalex.org/W2005358947","https://openalex.org/W2006126999","https://openalex.org/W2006911672","https://openalex.org/W2008578830","https://openalex.org/W2010209395","https://openalex.org/W2014814905","https://openalex.org/W2015735321","https://openalex.org/W2016150537","https://openalex.org/W2019179422","https://openalex.org/W2021058149","https://openalex.org/W2021427461","https://openalex.org/W2021878044","https://openalex.org/W2022204035","https://openalex.org/W2022304114","https://openalex.org/W2023229316","https://openalex.org/W2027403976","https://openalex.org/W2028077355","https://openalex.org/W2030485204","https://openalex.org/W2031187654","https://openalex.org/W2031479527","https://openalex.org/W2031896298","https://openalex.org/W2032397817","https://openalex.org/W2035050930","https://openalex.org/W2036489323","https://openalex.org/W2036651415","https://openalex.org/W2037153882","https://openalex.org/W2039049291","https://openalex.org/W2044748534","https://openalex.org/W2045038478","https://openalex.org/W2048307364","https://openalex.org/W2048552122","https://openalex.org/W2048554393","https://openalex.org/W2052024250","https://openalex.org/W2052718982","https://openalex.org/W2053956518","https://openalex.org/W2057201908","https://openalex.org/W2058153935","https://openalex.org/W2060886466","https://openalex.org/W2062507888","https://openalex.org/W2063575272","https://openalex.org/W2063688715","https://openalex.org/W2066180046","https://openalex.org/W2067159565","https://openalex.org/W2068554546","https://openalex.org/W2069500966","https://openalex.org/W2069952360","https://openalex.org/W2070256254","https://openalex.org/W2070350236","https://openalex.org/W2071180078","https://openalex.org/W2071585705","https://openalex.org/W2072482644","https://openalex.org/W2073782163","https://openalex.org/W2073785437","https://openalex.org/W2078614733","https://openalex.org/W2083163456","https://openalex.org/W2084718298","https://openalex.org/W2085308880","https://openalex.org/W2085485280","https://openalex.org/W2086565983","https://openalex.org/W2088009291","https://openalex.org/W2088468259","https://openalex.org/W2088704179","https://openalex.org/W2089023321","https://openalex.org/W2089158753","https://openalex.org/W2089166827","https://openalex.org/W2092567560","https://openalex.org/W2095390159","https://openalex.org/W2096615661","https://openalex.org/W2096990783","https://openalex.org/W2102600010","https://openalex.org/W2105884082","https://openalex.org/W2108358343","https://openalex.org/W2109769822","https://openalex.org/W2120621148","https://openalex.org/W2122102594","https://openalex.org/W2129307251","https://openalex.org/W2138970194","https://openalex.org/W2142901643","https://openalex.org/W2145933357","https://openalex.org/W2146855233","https://openalex.org/W2152498802","https://openalex.org/W2155871767","https://openalex.org/W2157195707","https://openalex.org/W2171627417","https://openalex.org/W2227414950","https://openalex.org/W2227470433","https://openalex.org/W2236955045","https://openalex.org/W2251489118","https://openalex.org/W2298548186","https://openalex.org/W2329309002","https://openalex.org/W2332151196","https://openalex.org/W2345132165","https://openalex.org/W2394627674","https://openalex.org/W2398203232","https://openalex.org/W2401048592","https://openalex.org/W2402476547","https://openalex.org/W2402525801","https://openalex.org/W2403473425","https://openalex.org/W2406930032","https://openalex.org/W2410213444","https://openalex.org/W2413236661","https://openalex.org/W2415014782","https://openalex.org/W2416687244","https://openalex.org/W2418393334","https://openalex.org/W2461356528","https://openalex.org/W2471316838","https://openalex.org/W2476144830","https://openalex.org/W3215500138","https://openalex.org/W3216268027","https://openalex.org/W4298481698"],"related_works":["https://openalex.org/W142501542","https://openalex.org/W2074977658","https://openalex.org/W2009993960","https://openalex.org/W2071356981","https://openalex.org/W18695919","https://openalex.org/W1973405449","https://openalex.org/W2072054808","https://openalex.org/W2007297144","https://openalex.org/W2210002449","https://openalex.org/W2159396437"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}