{"id":"https://openalex.org/W2018942320","doi":"https://doi.org/10.1186/1471-2180-11-241","title":"Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus","display_name":"Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus","publication_year":2011,"publication_date":"2011-10-27","ids":{"openalex":"https://openalex.org/W2018942320","doi":"https://doi.org/10.1186/1471-2180-11-241","mag":"2018942320","pmid":"https://pubmed.ncbi.nlm.nih.gov/22032541","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3226646"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2180-11-241","doi":"https://doi.org/10.1186/1471-2180-11-241","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2180-11-241","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-11-241","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-11-241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067691053","display_name":"Sofia Santos Costa","orcid":"https://orcid.org/0000-0002-4096-2410","observed_orcids":["https://orcid.org/0000-0002-4096-2410"]},"institutions":[{"id":"https://openalex.org/I4405255849","display_name":"Unidade de Microbiologia M\u00e9dica","ror":"https://ror.org/03g2ax673","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sofia Santos Costa","raw_affiliation_strings":["Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira 100, Lisbon, Portugal","Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira 100, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"raw_affiliation_string":"Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070932047","display_name":"Celeste Falc\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255849","display_name":"Unidade de Microbiologia M\u00e9dica","ror":"https://ror.org/03g2ax673","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Celeste Falc\u00e3o","raw_affiliation_strings":["Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077255083","display_name":"Miguel Viveiros","orcid":"https://orcid.org/0000-0001-9676-6251","observed_orcids":["https://orcid.org/0000-0001-9676-6251"]},"institutions":[{"id":"https://openalex.org/I4405255849","display_name":"Unidade de Microbiologia M\u00e9dica","ror":"https://ror.org/03g2ax673","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Miguel Viveiros","raw_affiliation_strings":["COST ACTION BM0701, ATENS","Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COST ACTION BM0701, ATENS","institution_ids":[]},{"raw_affiliation_string":"Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083039113","display_name":"Diana Machado","orcid":"https://orcid.org/0000-0003-2375-2726","observed_orcids":["https://orcid.org/0000-0003-2375-2726"]},"institutions":[{"id":"https://openalex.org/I4405255849","display_name":"Unidade de Microbiologia M\u00e9dica","ror":"https://ror.org/03g2ax673","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Diana Machado","raw_affiliation_strings":["Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","Unidade de Parasitologia e Microbiologia M\u00e9dica (UPMM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"raw_affiliation_string":"Unidade de Parasitologia e Microbiologia M\u00e9dica (UPMM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004670838","display_name":"Marta Martins","orcid":"https://orcid.org/0000-0002-0323-2857","observed_orcids":["https://orcid.org/0000-0002-0323-2857"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I4405255849","display_name":"Unidade de Microbiologia M\u00e9dica","ror":"https://ror.org/03g2ax673","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["IE","PT"],"is_corresponding":false,"raw_author_name":"Marta Martins","raw_affiliation_strings":["Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","UCD School of Public Health, Physiotherapy and Population Science, UCD Centre for Food Safety, Veterinary Sciences Centre, University College Dublin, Belfield Dublin 4, Ireland","Unidade de Parasitologia e Microbiologia M\u00e9dica (UPMM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"raw_affiliation_string":"UCD School of Public Health, Physiotherapy and Population Science, UCD Centre for Food Safety, Veterinary Sciences Centre, University College Dublin, Belfield Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Unidade de Parasitologia e Microbiologia M\u00e9dica (UPMM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079007538","display_name":"Jos\u00e9 Melo\u2010Cristino","orcid":"https://orcid.org/0000-0001-8643-1722","observed_orcids":["https://orcid.org/0000-0001-8643-1722"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4210114390","display_name":"Centro Hospitalar Lisboa Norte","ror":"https://ror.org/020sr6z07","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210114390","https://openalex.org/I4405255475"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Melo-Cristino","raw_affiliation_strings":["Centro Hospitalar Lisboa Norte E.P.E., Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Hospitalar Lisboa Norte E.P.E., Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210114390","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003609205","display_name":"Leonard Amaral","orcid":"https://orcid.org/0000-0003-3127-1295","observed_orcids":["https://orcid.org/0000-0003-3127-1295"]},"institutions":[{"id":"https://openalex.org/I4405255849","display_name":"Unidade de Microbiologia M\u00e9dica","ror":"https://ror.org/03g2ax673","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Leonard Amaral","raw_affiliation_strings":["COST ACTION BM0701, ATENS","Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","Unidade de Parasitologia e Microbiologia M\u00e9dica (UPMM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COST ACTION BM0701, ATENS","institution_ids":[]},{"raw_affiliation_string":"Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"raw_affiliation_string":"Unidade de Parasitologia e Microbiologia M\u00e9dica (UPMM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088232955","display_name":"Isabel Couto","orcid":"https://orcid.org/0000-0003-3536-2733","observed_orcids":["https://orcid.org/0000-0003-3536-2733"]},"institutions":[{"id":"https://openalex.org/I4405255849","display_name":"Unidade de Microbiologia M\u00e9dica","ror":"https://ror.org/03g2ax673","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Isabel Couto","raw_affiliation_strings":["Centro de Recursos Microbiol\u00f3gicos (CREM), Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Quinta da Torre, 2829-516, Caparica, Portugal","Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Recursos Microbiol\u00f3gicos (CREM), Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Quinta da Torre, 2829-516, Caparica, Portugal","institution_ids":["https://openalex.org/I83558840"]},{"raw_affiliation_string":"Grupo de Micobact\u00e9rias, Unidade de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT, UNL), Rua da Junqueira, 100, 1349-008, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405255849","https://openalex.org/I83558840"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5088232955"],"corresponding_institution_ids":["https://openalex.org/I4405255849","https://openalex.org/I83558840"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":5.7349,"has_fulltext":true,"cited_by_count":123,"citation_normalized_percentile":{"value":0.96582593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"241","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.1858000010251999,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.8840000033378601},{"id":"https://openalex.org/keywords/fluoroquinolone-resistance","display_name":"fluoroquinolone resistance","score":0.9160000085830688},{"id":"https://openalex.org/keywords/ciprofloxacin-resistance","display_name":"ciprofloxacin resistance","score":0.9779999852180481},{"id":"https://openalex.org/keywords/efflux-pump-inhibitors","display_name":"efflux pump inhibitors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/grla","display_name":"grlA","score":0.8529999852180481},{"id":"https://openalex.org/keywords/gyra","display_name":"gyrA","score":0.9940000176429749},{"id":"https://openalex.org/keywords/quinolone-resistance-determining-region","display_name":"quinolone resistance-determining region","score":0.9079999923706055},{"id":"https://openalex.org/keywords/efflux-pump-gene-expression","display_name":"efflux pump gene expression","score":0.9010000228881836},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.8190000057220459},{"id":"https://openalex.org/keywords/antibiotic-resistance-mechanisms","display_name":"antibiotic resistance mechanisms","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.9845398664474487},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7563133239746094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7471668720245361},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7400380373001099},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.5493965148925781},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.502500057220459},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47076916694641113},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4252716600894928},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4192768335342407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24813899397850037},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.24653387069702148}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2180-11-241","doi":"https://doi.org/10.1186/1471-2180-11-241","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2180-11-241","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-11-241","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},{"id":"pmid:22032541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22032541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3226646","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3226646/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ece193d3e7ab464c8b31035f3e7d5d24","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ece193d3e7ab464c8b31035f3e7d5d24","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Microbiology, Vol 11, Iss 1, p 241 (2011)","raw_type":"article"},{"id":"pmh:oai:www.lenus.ie:10147/192753","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10147/192753","pdf_url":null,"source":{"id":"https://openalex.org/S4306401756","display_name":"Lenus, The Irish Health Repository (Dr Steevens Hospital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1471-2180-11-241","doi":"https://doi.org/10.1186/1471-2180-11-241","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2180-11-241","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-11-241","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3089891940","display_name":"CLINICAL RELEVANCE OF EFFLUX PUMP ACTIVITY IN DRUG RESISTANCE OF STAPHYLOCOCCUS AUREUS","funder_award_id":"SFRH/BD/44214/2008","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4398123665","display_name":"THE DYNAMICS OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS: EXPLORING THE BIOLOGICAL BASIS OF MULTI- AND EXTENSIVELY DRUG RESISTANT TUBERCULOSIS (MDR/XDRTB) AS A ROUTE FOR ALTERNATIVE THERAPEUTIC STRATEGIES","funder_award_id":"SFRH/BD/65060/2009","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6252750685","display_name":"Descri\u00e7\u00e3o do mecanismo de ac\u00e7\u00e3o de adjuvantes da antibioterapia de bact\u00e9rias multirresistentes","funder_award_id":"PTDC/BIA-MIC/105509/2008","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6718231776","display_name":"TARGETING THE HUMAN MACROPHAGE WITH COMBINATIONS OF SECOND-LINE TB DRUGS AND INHIBITORS OF CA2+ AND K+ TRANSPORT TO ENHANCE THE KILLING OF INTRACELLULAR MULTI-DRUG RESISTANT M. TUBERCULOSIS (MDR-TB) - A NOVEL APPROACH TO LIMIT THE EMERGENCE OF XDR-TB","funder_award_id":"SFRH/BPD/63871/2009","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8952488736","display_name":null,"funder_award_id":"/2009","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320323459","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018942320.pdf","grobid_xml":"https://content.openalex.org/works/W2018942320.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W26641785","https://openalex.org/W72929615","https://openalex.org/W346827628","https://openalex.org/W1492617550","https://openalex.org/W1530954094","https://openalex.org/W1688808452","https://openalex.org/W1844817938","https://openalex.org/W1955612312","https://openalex.org/W1972157313","https://openalex.org/W1972176917","https://openalex.org/W1993279122","https://openalex.org/W1996557204","https://openalex.org/W2005853912","https://openalex.org/W2007422762","https://openalex.org/W2009089119","https://openalex.org/W2011291459","https://openalex.org/W2019153470","https://openalex.org/W2029875114","https://openalex.org/W2030884631","https://openalex.org/W2042505056","https://openalex.org/W2090766639","https://openalex.org/W2101021971","https://openalex.org/W2101585257","https://openalex.org/W2106377559","https://openalex.org/W2107277218","https://openalex.org/W2109816570","https://openalex.org/W2111989353","https://openalex.org/W2112046623","https://openalex.org/W2114360920","https://openalex.org/W2116502086","https://openalex.org/W2131012394","https://openalex.org/W2140642812","https://openalex.org/W2143019042","https://openalex.org/W2149709623","https://openalex.org/W2151377271","https://openalex.org/W2160869141","https://openalex.org/W2183623572","https://openalex.org/W2401435845"],"related_works":["https://openalex.org/W1824734655","https://openalex.org/W7101161707","https://openalex.org/W2162420465","https://openalex.org/W2101743071","https://openalex.org/W2076808679","https://openalex.org/W2005526848","https://openalex.org/W2050213315","https://openalex.org/W2757857226","https://openalex.org/W4381886073","https://openalex.org/W4394860257"],"abstract_inverted_index":{"BACKGROUND:":[0],"Antimicrobial":[1],"resistance":[2,64,83,100,110,134,260,300],"mediated":[3],"by":[4,59,226,293],"efflux":[5,19,35,69,88,148,242,272,294],"systems":[6,61,273,295],"is":[7],"still":[8],"poorly":[9],"characterized":[10],"in":[11,46,49,52,62,73,93,108,119,154,216,249,259,263,285,296,303],"Staphylococcus":[12],"aureus,":[13,265],"despite":[14],"the":[15,34,56,63,94,98,109,114,120,132,142,146,155,178,196,217,255,269,275,282,289,297],"description":[16],"of":[17,37,76,87,97,113,116,124,141,157,171,257,271,277,299,306],"several":[18,30],"pumps":[20,149],"(EPs)":[21],"for":[22,131,145,274],"this":[23,26,250,286],"bacterium.":[24],"In":[25],"work":[27,251],"we":[28],"used":[29],"methodologies":[31],"to":[32,43,54,65,84,187,195,220,241,261,301],"characterize":[33],"activity":[36,70],"52":[38,77],"S.":[39,234,264,307],"aureus":[40,235],"isolates":[41,78,193,213,237,305],"resistant":[42],"ciprofloxacin":[44],"collected":[45],"a":[47,105,183],"hospital":[48],"Lisbon,":[50],"Portugal,":[51],"order":[53],"understand":[55],"role":[57,291],"played":[58,292],"these":[60],"fluoroquinolones.":[66,85],"RESULTS:":[67],"Augmented":[68],"was":[71,136],"detected":[72],"12":[74],"out":[75],"and":[79,126,229],"correlated":[80],"with":[81],"increased":[82,151],"Addition":[86],"inhibitors":[89],"did":[90],"not":[91,137,164,253],"result":[92],"full":[95],"reversion":[96],"fluoroquinolone":[99],"phenotype,":[101],"yet":[102,266],"it":[103,161],"implied":[104],"significant":[106],"decrease":[107],"levels,":[111],"regardless":[112],"type(s)":[115],"mutation(s)":[117],"found":[118,192],"quinolone-resistance":[121],"determining":[122],"region":[123],"grlA":[125],"gyrA":[127],"genes,":[128,174],"which":[129],"accounted":[130],"remaining":[133],"that":[135,163,177,200,209,233],"efflux-mediated.":[138],"Expression":[139],"analysis":[140],"genes":[143],"coding":[144],"main":[147],"revealed":[150],"expression":[152,170],"only":[153,165],"presence":[156],"inducing":[158],"agents.":[159,222],"Moreover,":[160],"showed":[162,201],"different":[166,172,202],"substrates":[167],"can":[168,181],"trigger":[169],"EP":[173],"but":[175],"also":[176,191],"same":[179,197],"substrate":[180],"promote":[182],"variable":[184],"response,":[185],"according":[186],"its":[188],"concentration.":[189],"We":[190],"belonging":[194],"clonal":[198],"type":[199],"responses":[203],"towards":[204],"drug":[205],"exposure,":[206],"thus":[207],"evidencing":[208],"highly":[210],"related":[211],"clinical":[212,236,304],"may":[214,238],"diverge":[215],"efflux-mediated":[218],"response":[219],"noxious":[221],"The":[223,246],"data":[224],"gathered":[225],"real-time":[227],"fluorometric":[228],"RT-qPCR":[230],"assays":[231],"suggest":[232],"be":[239],"primed":[240],"antimicrobial":[243],"compounds.":[244],"CONCLUSIONS:":[245],"results":[247,283],"obtained":[248],"do":[252],"exclude":[254],"importance":[256],"mutations":[258],"fluoroquinolones":[262,302],"they":[267],"underline":[268],"contribution":[270],"emergence":[276],"high-level":[278],"resistance.":[279],"All":[280],"together,":[281],"presented":[284],"study":[287],"show":[288],"potential":[290],"development":[298],"aureus.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}