{"id":"https://openalex.org/W2018940466","doi":"https://doi.org/10.1109/mlsp.2008.4685460","title":"Detection of complex interactions of multi-locus SNPS","display_name":"Detection of complex interactions of multi-locus SNPS","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2018940466","doi":"https://doi.org/10.1109/mlsp.2008.4685460","mag":"2018940466"},"language":"en","primary_location":{"id":"doi:10.1109/mlsp.2008.4685460","doi":"https://doi.org/10.1109/mlsp.2008.4685460","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mlsp.2008.4685460","pdf_url":null,"source":{"id":"https://openalex.org/S4210187912","display_name":"Machine learning for signal processing ...","issn_l":"1551-2541","issn":["1551-2541","2378-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 IEEE Workshop on Machine Learning for Signal Processing","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Guoqiang Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoqiang Yu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","Dept. of Electr. & Comput. Eng., Virginia Polytech. Inst. & State Univ., Arlington, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Virginia Polytech. Inst. & State Univ., Arlington, VA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071844909","display_name":"David M. Herrington","orcid":"https://orcid.org/0000-0002-7670-6400","observed_orcids":["https://orcid.org/0000-0002-7670-6400"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Herrington","raw_affiliation_strings":["Department of Internal Medicine, Wake Forrest University, Winston Salem, NC, USA","Dept. of Internal Med., Wake Forrest Univ., Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wake Forrest University, Winston Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Dept. of Internal Med., Wake Forrest Univ., Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030650722","display_name":"Carl D. Langefeld","orcid":"https://orcid.org/0000-0002-4266-6949","observed_orcids":["https://orcid.org/0000-0002-4266-6949"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl Langefeld","raw_affiliation_strings":["Division of Public Health Sciences, Wake Forrest University, Winston Salem, NC, USA","Div. of Public Health Sci., Wake Forrest Univ., Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Wake Forrest University, Winston Salem, NC, USA","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Div. of Public Health Sci., Wake Forrest Univ., Winston-Salem, NC","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100372002","display_name":"Yue Wang","orcid":"https://orcid.org/0000-0002-1788-1102","observed_orcids":["https://orcid.org/0000-0002-1788-1102"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","Dept. of Electr. & Comput. Eng., Virginia Polytech. Inst. & State Univ., Arlington, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Virginia Polytech. Inst. & State Univ., Arlington, VA","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.8249,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.95306859,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"316","issue":null,"first_page":"85","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.8889999985694885},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/complex-diseases","display_name":"complex diseases","score":0.7699999809265137},{"id":"https://openalex.org/keywords/genetic-risk-prediction","display_name":"genetic risk prediction","score":0.5879999995231628},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6862759590148926},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6045316457748413},{"id":"https://openalex.org/C3018605307","wikidata":"https://www.wikidata.org/wiki/Q200779","display_name":"Complex disease","level":3,"score":0.5416316390037537},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5413976907730103},{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.47940585017204285},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4498355984687805},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35685408115386963},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35618966817855835},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3347763121128082},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2252764105796814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22426378726959229},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1307832896709442},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10024723410606384}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mlsp.2008.4685460","doi":"https://doi.org/10.1109/mlsp.2008.4685460","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mlsp.2008.4685460","pdf_url":null,"source":{"id":"https://openalex.org/S4210187912","display_name":"Machine learning for signal processing ...","issn_l":"1551-2541","issn":["1551-2541","2378-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 IEEE Workshop on Machine Learning for Signal Processing","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1499959019","https://openalex.org/W1975899243","https://openalex.org/W1980175560","https://openalex.org/W1981714996","https://openalex.org/W1995751421","https://openalex.org/W2006423274","https://openalex.org/W2010160850","https://openalex.org/W2048755332","https://openalex.org/W2076220518","https://openalex.org/W2076983043","https://openalex.org/W2121398847"],"related_works":["https://openalex.org/W2024607788","https://openalex.org/W2891980998","https://openalex.org/W2093805274","https://openalex.org/W7097534192","https://openalex.org/W2558077163","https://openalex.org/W2900948986","https://openalex.org/W2531971686","https://openalex.org/W2048993554","https://openalex.org/W1562526954","https://openalex.org/W2618454934"],"abstract_inverted_index":{"Detection":[0],"of":[1,5,26,35,95],"interacting":[2],"SNPs":[3,37,49,78],"predictive":[4],"complex":[6,62],"disease":[7],"will":[8],"help":[9],"identify":[10],"individuals":[11],"at":[12],"high":[13,97],"risk,":[14],"make":[15],"personalized":[16],"treatment":[17],"possible,":[18],"and":[19,99],"provide":[20],"novel":[21],"insights":[22],"into":[23],"the":[24,27,32,41,90],"pathophysiology":[25],"conditions":[28],"in":[29,47,93],"question.":[30],"Although":[31],"interaction":[33,51,63,81],"effect":[34],"multi-locus":[36],"is":[38,67],"widely":[39],"expected,":[40],"existing":[42,86],"strategies":[43],"have":[44],"limited":[45],"power":[46],"detecting":[48],"with":[50,74],"effects.":[52,64],"This":[53],"paper":[54],"presents":[55],"a":[56,70],"new":[57],"method":[58,66],"(SCA-HCIG)":[59],"to":[60,84],"detect":[61],"The":[65],"tested":[68],"on":[69],"realistic":[71],"simulated":[72],"data":[73],"17":[75],"embedded":[76],"ground-truth":[77],"under":[79],"5":[80],"models.":[82],"Compared":[83],"six":[85],"methods,":[87],"SCA-HCIG":[88],"achieves":[89],"best":[91],"result":[92],"terms":[94],"both":[96],"sensitivity":[98],"specificity.":[100]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}