{"id":"https://openalex.org/W2018937508","doi":"https://doi.org/10.1016/j.spinee.2006.09.005","title":"Matrix replenishment by intervertebral disc cells after chemonucleolysis in vitro with chondroitinase ABC and chymopapain","display_name":"Matrix replenishment by intervertebral disc cells after chemonucleolysis in vitro with chondroitinase ABC and chymopapain","publication_year":2006,"publication_date":"2006-12-23","ids":{"openalex":"https://openalex.org/W2018937508","doi":"https://doi.org/10.1016/j.spinee.2006.09.005","mag":"2018937508","pmid":"https://pubmed.ncbi.nlm.nih.gov/17526432"},"language":"en","primary_location":{"id":"doi:10.1016/j.spinee.2006.09.005","doi":"https://doi.org/10.1016/j.spinee.2006.09.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.spinee.2006.09.005","pdf_url":null,"source":{"id":"https://openalex.org/S112180307","display_name":"The Spine Journal","issn_l":"1529-9430","issn":["1529-9430","1878-1632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Spine Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062376392","display_name":"Kazuhiro Chiba","orcid":"https://orcid.org/0000-0002-4078-5258","observed_orcids":["https://orcid.org/0000-0002-4078-5258"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuhiro Chiba","raw_affiliation_strings":["Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA","Department of Biochemistry, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Biochemistry, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000662848","display_name":"Koichi Masuda","orcid":"https://orcid.org/0000-0002-5361-4415","observed_orcids":["https://orcid.org/0000-0002-5361-4415"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koichi Masuda","raw_affiliation_strings":["Department of Biochemistry, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114803380","display_name":"Gunnar B. J. Andersson","orcid":"https://orcid.org/0000-0001-7432-5228","observed_orcids":["https://orcid.org/0000-0001-7432-5228"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunnar B.J. Andersson","raw_affiliation_strings":["Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082886897","display_name":"Shigeki Momohara","orcid":"https://orcid.org/0000-0002-5954-0664","observed_orcids":["https://orcid.org/0000-0002-5954-0664"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shigeki Momohara","raw_affiliation_strings":["Department of Biochemistry, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109948648","display_name":"Eugene J.\u2010M.A. Thonar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eugene J. Thonar","raw_affiliation_strings":["Department of Biochemistry, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","Department of Internal Medicine, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Internal Medicine, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109948648"],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":{"value":4980,"currency":"USD","value_usd":4980},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.13299727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"6","first_page":"694","last_page":"700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemonucleolysis","display_name":"chemonucleolysis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/intervertebral-disc","display_name":"intervertebral disc","score":0.7770000100135803},{"id":"https://openalex.org/keywords/extracellular-matrix-repair","display_name":"extracellular matrix repair","score":0.8299999833106995},{"id":"https://openalex.org/keywords/nucleus-pulposus-cells","display_name":"nucleus pulposus cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chondroitinase-abc","display_name":"chondroitinase ABC","score":0.996999979019165},{"id":"https://openalex.org/keywords/chymopapain","display_name":"chymopapain","score":1.0},{"id":"https://openalex.org/keywords/proteoglycan-synthesis","display_name":"proteoglycan synthesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/disc-herniation","display_name":"disc herniation","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2780605044","wikidata":"https://www.wikidata.org/wiki/Q5118581","display_name":"Chymopapain","level":2,"score":0.9879146814346313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8587539196014404},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.7070814371109009},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5720619559288025},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5082802176475525},{"id":"https://openalex.org/C3018239782","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disk","level":3,"score":0.5028836131095886},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34683358669281006},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24121665954589844},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.08765572309494019},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05796179175376892},{"id":"https://openalex.org/C44575665","wikidata":"https://www.wikidata.org/wiki/Q1293405","display_name":"Lumbar","level":2,"score":0.03919464349746704},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002917","descriptor_name":"Chymopapain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007404","descriptor_name":"Intervertebral Disc Chemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019765","descriptor_name":"Chondroitin ABC Lyase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.spinee.2006.09.005","doi":"https://doi.org/10.1016/j.spinee.2006.09.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.spinee.2006.09.005","pdf_url":null,"source":{"id":"https://openalex.org/S112180307","display_name":"The Spine Journal","issn_l":"1529-9430","issn":["1529-9430","1878-1632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Spine Journal","raw_type":"journal-article"},{"id":"pmid:17526432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17526432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The spine journal : official journal of the North American Spine Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1325977886","display_name":null,"funder_award_id":"AG04736","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3228588436","display_name":"AGE RELATED DIFFERENCES IN CARTILAGE PROTEOGLYCANS","funder_award_id":"5r01ag004736-17","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G57766917","display_name":"SPECIALIZED CENTER OF RESEARCH IN OSTEOARTHRITIS","funder_award_id":"P50AR039239","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8877839404","display_name":"Program Project grant","funder_award_id":"P01AR048152","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W157925876","https://openalex.org/W200238516","https://openalex.org/W362623203","https://openalex.org/W656062553","https://openalex.org/W1533838691","https://openalex.org/W1535452485","https://openalex.org/W1617781531","https://openalex.org/W1893500736","https://openalex.org/W1967999357","https://openalex.org/W1970026238","https://openalex.org/W1980095106","https://openalex.org/W1983086809","https://openalex.org/W1985315569","https://openalex.org/W1985423510","https://openalex.org/W1987844029","https://openalex.org/W1987907478","https://openalex.org/W1990007723","https://openalex.org/W1991146769","https://openalex.org/W1991635667","https://openalex.org/W1996986107","https://openalex.org/W2002135891","https://openalex.org/W2002201489","https://openalex.org/W2002236075","https://openalex.org/W2003835724","https://openalex.org/W2006663753","https://openalex.org/W2013626689","https://openalex.org/W2018559769","https://openalex.org/W2019325183","https://openalex.org/W2020291353","https://openalex.org/W2023584561","https://openalex.org/W2027571708","https://openalex.org/W2035469813","https://openalex.org/W2035684401","https://openalex.org/W2046910335","https://openalex.org/W2051621934","https://openalex.org/W2055371580","https://openalex.org/W2058932182","https://openalex.org/W2090000200","https://openalex.org/W2105341765","https://openalex.org/W2146001934","https://openalex.org/W2148495041","https://openalex.org/W2230777536","https://openalex.org/W2242830650","https://openalex.org/W2248388752","https://openalex.org/W2317968970","https://openalex.org/W2318124506","https://openalex.org/W2333161056","https://openalex.org/W2405712607","https://openalex.org/W2416692365","https://openalex.org/W4239082956","https://openalex.org/W4319705337"],"related_works":["https://openalex.org/W2018559769","https://openalex.org/W2046910335","https://openalex.org/W2313154606","https://openalex.org/W2087003586","https://openalex.org/W2416776788","https://openalex.org/W2013626689","https://openalex.org/W1985423510","https://openalex.org/W1988341628","https://openalex.org/W2002135891","https://openalex.org/W1893500736"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}