{"id":"https://openalex.org/W2018935928","doi":"https://doi.org/10.1089/ars.2005.7.1078","title":"Sensitivity of Protein Tyrosine Phosphatase Activity to the Redox Environment, Cytochrome c , and Microperoxidase","display_name":"Sensitivity of Protein Tyrosine Phosphatase Activity to the Redox Environment, Cytochrome c , and Microperoxidase","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2018935928","doi":"https://doi.org/10.1089/ars.2005.7.1078","mag":"2018935928","pmid":"https://pubmed.ncbi.nlm.nih.gov/15998263"},"language":"en","primary_location":{"id":"doi:10.1089/ars.2005.7.1078","doi":"https://doi.org/10.1089/ars.2005.7.1078","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2005.7.1078","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088640506","display_name":"Scott Salsman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott J. Salsman","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK","Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK","Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104 USA","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111718974","display_name":"Kenneth Hensley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Hensley","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK","Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109321252","display_name":"Robert A. Floyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Floyd","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK","Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7529,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.66465747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"7-8","first_page":"1078","last_page":"1088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.06520000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ptp1b","display_name":"PTP1B","score":0.9929999709129333},{"id":"https://openalex.org/keywords/redox-sensitivity","display_name":"redox sensitivity","score":0.6610000133514404},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7630000114440918},{"id":"https://openalex.org/keywords/glutathionylation","display_name":"glutathionylation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/glutathione-disulfide","display_name":"glutathione disulfide","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cysteine-thiolate","display_name":"cysteine thiolate","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.6539999842643738},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9850000143051147},{"id":"https://openalex.org/keywords/microperoxidase","display_name":"microperoxidase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.7600072622299194},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7203584909439087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7068714499473572},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.626121461391449},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6097404360771179},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.49091917276382446},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4899434447288513},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.4757254421710968},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4713304042816162},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4508797228336334},{"id":"https://openalex.org/C2779179908","wikidata":"https://www.wikidata.org/wiki/Q3324838","display_name":"Glutathione disulfide","level":4,"score":0.43558475375175476},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.4101858139038086},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.22110998630523682},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000478","descriptor_name":"Alkylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019803","descriptor_name":"Glutathione Disulfide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/ars.2005.7.1078","doi":"https://doi.org/10.1089/ars.2005.7.1078","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2005.7.1078","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},{"id":"pmid:15998263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15998263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & redox signaling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2079475283","display_name":"FREE RADICALS AND CHOLINE DEFICIENT LIVER CARCINOGENESIS","funder_award_id":"R01CA082506","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2147491747","display_name":null,"funder_award_id":"CA82506","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4003100618","display_name":"NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM","funder_award_id":"R01NS044154","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G903600507","display_name":null,"funder_award_id":"NS-044154","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1651198610","https://openalex.org/W1854233595","https://openalex.org/W1967461726","https://openalex.org/W1968991720","https://openalex.org/W1975043122","https://openalex.org/W1978512775","https://openalex.org/W1991437749","https://openalex.org/W1993432903","https://openalex.org/W2005076200","https://openalex.org/W2009940961","https://openalex.org/W2031763777","https://openalex.org/W2037571897","https://openalex.org/W2052464531","https://openalex.org/W2057522312","https://openalex.org/W2060292828","https://openalex.org/W2067138633","https://openalex.org/W2085664820","https://openalex.org/W2109734459","https://openalex.org/W2150668757"],"related_works":["https://openalex.org/W2085664820","https://openalex.org/W2109734459","https://openalex.org/W1976240810","https://openalex.org/W2011855358","https://openalex.org/W2056454788","https://openalex.org/W2606565923","https://openalex.org/W2899908594","https://openalex.org/W1975267506","https://openalex.org/W2726009165","https://openalex.org/W2594118540"],"abstract_inverted_index":{"Protein":[0],"tyrosine":[1,30],"phosphatase":[2,31,83],"activity":[3,84],"depends":[4],"on":[5,10,102],"a":[6,34,152,186],"catalytic":[7],"thiolate":[8],"group":[9],"an":[11],"acidic":[12],"cysteine":[13],"residue":[14],"that":[15,125,137,180],"is":[16,28,43,55,141,146],"sensitive":[17,44,57,159],"to":[18,45,58,68,98,160],"reactive":[19],"oxygen":[20],"species.":[21],"Representative":[22],"of":[23,26,66,72,82,88,91,105,126,131,134,188],"this":[24],"family":[25],"enzymes":[27],"protein":[29],"1B":[32],"(PTP1B),":[33],"major":[35],"target":[36],"for":[37,119,201],"type":[38],"2":[39],"diabetes":[40],"therapy.":[41],"PTP1B":[42,67,150,167],"hydrogen":[46],"peroxide":[47],"(H2O2)":[48],"in":[49,52,78,85,128],"vitro":[50,79],"and":[51,94,109,151,173,191],"cells.":[53],"It":[54],"also":[56,158,185],"glutathionylation":[59,99,147],"by":[60,80,148,170],"glutathione":[61,92],"disulfide":[62],"(GSSG).":[63],"The":[64,116],"sensitivity":[65,97],"the":[69,86,103,129,161],"redox":[70],"state":[71],"its":[73],"environment":[74],"was":[75,100,114,121,168],"partially":[76],"characterized":[77],"examination":[81],"presence":[87,130],"various":[89],"concentrations":[90,133],"(GSH)":[93],"GSSG.":[95,149],"Enzyme":[96],"dependent":[101],"amount":[104],"available":[106],"thiol":[107],"groups":[108],"increased":[110],"as":[111],"GSH":[112],"concentration":[113,118],"increased.":[115],"half-inhibitory":[117],"H2O2":[120,140],"much":[122,142],"less":[123],"than":[124,145],"GSSG":[127],"low":[132],"GSH,":[135],"indicating":[136],"reaction":[138],"with":[139,197],"more":[143],"likely":[144],"related":[153],"oxidant-sensitive":[154],"phosphatase,":[155],"PTEN,":[156],"were":[157],"lipid":[162],"peroxidation":[163],"by-product":[164],"4-hydroxynonenal.":[165],"Furthermore,":[166],"inhibited":[169],"cytochrome":[171],"c":[172],"microperoxidase.":[174],"Taken":[175],"together,":[176],"these":[177],"data":[178],"suggest":[179],"not":[181],"only":[182],"H2O2,":[183],"but":[184],"variety":[187],"redox-active":[189],"metabolites":[190],"hemes":[192],"can":[193],"oxidatively":[194],"inactivate":[195],"PTPs":[196],"potentially":[198],"profound":[199],"implications":[200],"signal":[202],"transduction.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
