{"id":"https://openalex.org/W2018928899","doi":"https://doi.org/10.1620/tjem.153.137","title":"Cigarette smoke modifies bleomycin-induced lung injury to produce lung emphysema.","display_name":"Cigarette smoke modifies bleomycin-induced lung injury to produce lung emphysema.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2018928899","doi":"https://doi.org/10.1620/tjem.153.137","mag":"2018928899","pmid":"https://pubmed.ncbi.nlm.nih.gov/2446402"},"language":"en","primary_location":{"id":"doi:10.1620/tjem.153.137","doi":"https://doi.org/10.1620/tjem.153.137","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.153.137","pdf_url":"https://www.jstage.jst.go.jp/article/tjem1920/153/2/153_2_137/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/tjem1920/153/2/153_2_137/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062125642","display_name":"Kazuo Takada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUO TAKADA","raw_affiliation_strings":["The First Department of Internal Medicine, School of Medicine, University of Yamagata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, School of Medicine, University of Yamagata","institution_ids":["https://openalex.org/I112524849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101457926","display_name":"Keiji Takahashi","orcid":"https://orcid.org/0000-0001-7209-6708","observed_orcids":["https://orcid.org/0000-0001-7209-6708","https://orcid.org/0009-0002-1818-4920"]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KEIJI TAKAHASHI","raw_affiliation_strings":["The First Department of Internal Medicine, School of Medicine, University of Yamagata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, School of Medicine, University of Yamagata","institution_ids":["https://openalex.org/I112524849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111768237","display_name":"Shinobu Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHINOBU SATO","raw_affiliation_strings":["The First Department of Internal Medicine, School of Medicine, University of Yamagata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, School of Medicine, University of Yamagata","institution_ids":["https://openalex.org/I112524849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113435760","display_name":"Shoji Yasui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHOJI YASUI","raw_affiliation_strings":["The First Department of Internal Medicine, School of Medicine, University of Yamagata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, School of Medicine, University of Yamagata","institution_ids":["https://openalex.org/I112524849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I112524849"],"apc_list":null,"apc_paid":null,"fwci":0.4939,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.63676247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"153","issue":"2","first_page":"137","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bleomycin-induced-lung-injury","display_name":"bleomycin-induced lung injury","score":0.9150000214576721},{"id":"https://openalex.org/keywords/alveolar-wall-destruction","display_name":"alveolar wall destruction","score":0.6959999799728394},{"id":"https://openalex.org/keywords/pressure-volume-relationship","display_name":"pressure-volume relationship","score":0.6100000143051147},{"id":"https://openalex.org/keywords/hamster","display_name":"hamster","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.7621760964393616},{"id":"https://openalex.org/C2993351451","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Cigarette smoke","level":2,"score":0.64600670337677},{"id":"https://openalex.org/C2992836489","wikidata":"https://www.wikidata.org/wiki/Q188605","display_name":"Pulmonary emphysema","level":3,"score":0.6073004603385925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5967879891395569},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5188494920730591},{"id":"https://openalex.org/C58874564","wikidata":"https://www.wikidata.org/wiki/Q130768","display_name":"Smoke","level":2,"score":0.5007531642913818},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33055752515792847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17970845103263855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1592802107334137},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.12038075923919678},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010947","descriptor_name":"Plants, Toxic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012906","descriptor_name":"Smoke","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1620/tjem.153.137","doi":"https://doi.org/10.1620/tjem.153.137","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.153.137","pdf_url":"https://www.jstage.jst.go.jp/article/tjem1920/153/2/153_2_137/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:2446402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2446402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku journal of experimental medicine","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1620/tjem.153.137","doi":"https://doi.org/10.1620/tjem.153.137","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.153.137","pdf_url":"https://www.jstage.jst.go.jp/article/tjem1920/153/2/153_2_137/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018928899.pdf","grobid_xml":"https://content.openalex.org/works/W2018928899.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W87834436","https://openalex.org/W138598591","https://openalex.org/W1263945336","https://openalex.org/W1642679112","https://openalex.org/W1747867097","https://openalex.org/W1769710498","https://openalex.org/W1774972326","https://openalex.org/W1805008252","https://openalex.org/W1850186741","https://openalex.org/W1954735914","https://openalex.org/W1972464864","https://openalex.org/W1985051240","https://openalex.org/W2030698901","https://openalex.org/W2040146184","https://openalex.org/W2047621648","https://openalex.org/W2058080505","https://openalex.org/W2073432936","https://openalex.org/W2124873041","https://openalex.org/W2174448908","https://openalex.org/W2178579324","https://openalex.org/W2418525960","https://openalex.org/W2470177704","https://openalex.org/W2765611041","https://openalex.org/W2977027630"],"related_works":["https://openalex.org/W2035066551","https://openalex.org/W2260633709","https://openalex.org/W2012112479","https://openalex.org/W2166937792","https://openalex.org/W2904962921","https://openalex.org/W4411849943","https://openalex.org/W109748685","https://openalex.org/W4210676473","https://openalex.org/W195983811","https://openalex.org/W3126898282"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,9,19,51,60,66,69,92,118,120,137,139,145,152,157,164,169,175,177,183],"cigarette":[3,31,36,198],"smoke":[4,32,37,42,199],"exposure":[5,33,43],"on":[6],"the":[7,49,86,102,116,135,155,162,170,184],"development":[8],"bleomycin":[10],"(BLM)-induced":[11],"pulmonary":[12],"fibrosis":[13],"was":[14,44,76],"studied.":[15],"Hamsters":[16],"3":[17],"weeks":[18],"age":[20],"were":[21,88,110,129,167],"divided":[22],"into":[23],"four":[24],"groups,":[25],"control":[26],"(C),":[27],"BLM":[28,39,70],"treated":[29],"(B),":[30],"(T),":[34],"and":[35,96,108,114,122,133,180],"plus":[38],"(TB).":[40],"Cigarette":[41],"started":[45],"5":[46],"days":[47,79,83,101],"after":[48,80,84],"beginning":[50],"feeding":[52,85],"in":[53,106,127,154,161],"a":[54,58],"desiccator":[55],"which":[56],"received":[57],"flow":[59],"smoke.":[61],"A":[62],"single":[63],"intratracheal":[64],"dose":[65],"0.5":[67],"mg":[68],"per":[71],"100":[72],"g":[73],"body":[74],"weight":[75],"administered":[77],"30":[78],"feeding.":[81],"Sixty":[82],"animals":[87],"killed":[89],"for":[90],"measurement":[91],"pressure-volume":[93],"(P-V)":[94],"relationships":[95],"microscopic":[97],"observations.":[98],"At":[99],"60":[100],"deflation":[103],"P-V":[104,125],"curves":[105,126],"B":[107],"TB":[109,128,165],"shifted":[111,130],"significantly":[112,131],"downward":[113],"to":[115,134,143,200],"right":[117],"that":[119,138,144,190],"C":[121],"T,":[123],"respectively.":[124],"upward":[132],"left":[136],"B,":[140],"almost":[141],"returning":[142],"C.":[146],"Light-microscopic":[147],"examination":[148],"showed":[149],"no":[150],"evidence":[151],"emphysema":[153],"lung":[156,163,192,202],"T.":[158],"In":[159],"contrast,":[160],"there":[166],"destruction":[168],"alveolar":[171,178,185],"walls,":[172],"varying":[173],"degrees":[174],"enlargement":[176],"spaces":[179],"fibrous":[181],"thickening":[182],"septa.":[186],"These":[187],"results":[188],"suggest":[189],"BLM-induced":[191],"injury":[193],"may":[194],"be":[195],"modified":[196],"by":[197],"produce":[201],"emphysema.":[203]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}