{"id":"https://openalex.org/W2018916989","doi":"https://doi.org/10.1016/j.bmc.2006.12.039","title":"Structure\u2013activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor","display_name":"Structure\u2013activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor","publication_year":2006,"publication_date":"2006-12-31","ids":{"openalex":"https://openalex.org/W2018916989","doi":"https://doi.org/10.1016/j.bmc.2006.12.039","mag":"2018916989","pmid":"https://pubmed.ncbi.nlm.nih.gov/17234422"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmc.2006.12.039","doi":"https://doi.org/10.1016/j.bmc.2006.12.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2006.12.039","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039544077","display_name":"Dai Nozawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Dai Nozawa","raw_affiliation_strings":["Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan. dai.nozawa@po.rd.taisho.co.jp","Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan. dai.nozawa@po.rd.taisho.co.jp","institution_ids":["https://openalex.org/I144245601"]},{"raw_affiliation_string":"Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090920304","display_name":"Taketoshi Okubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taketoshi Okubo","raw_affiliation_strings":["Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takaaki Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaaki Ishii","raw_affiliation_strings":["Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038079325","display_name":"Hiroyuki Kakinuma","orcid":"https://orcid.org/0000-0002-2490-2530","observed_orcids":["https://orcid.org/0000-0002-2490-2530"]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kakinuma","raw_affiliation_strings":["Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039021133","display_name":"Shigeyuki Chaki","orcid":"https://orcid.org/0000-0003-4444-2911","observed_orcids":["https://orcid.org/0000-0003-4444-2911","https://orcid.org/0000-0001-5608-4192"]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeyuki Chaki","raw_affiliation_strings":["Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110113221","display_name":"Shigeru Okuyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Okuyama","raw_affiliation_strings":["Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113554239","display_name":"Atsuro Nakazato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuro Nakazato","raw_affiliation_strings":["Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan","institution_ids":["https://openalex.org/I144245601"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I144245601"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.8142,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.66719101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"15","issue":"5","first_page":"1989","last_page":"2005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.48579999804496765,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.48579999804496765,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.25099998712539673,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.10279999673366547,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.906000018119812},{"id":"https://openalex.org/keywords/piperazine","display_name":"piperazine","score":0.9539999961853027},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9810000061988831},{"id":"https://openalex.org/keywords/naphthyl-group","display_name":"naphthyl group","score":0.8180000185966492},{"id":"https://openalex.org/keywords/benzoyl-group","display_name":"benzoyl group","score":0.9380000233650208},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lead-compounds","display_name":"lead compounds","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8606477975845337},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6634937524795532},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5631147623062134},{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.5605571269989014},{"id":"https://openalex.org/C43295716","wikidata":"https://www.wikidata.org/wiki/Q21118676","display_name":"Melanocortin 4 receptor","level":4,"score":0.5227727293968201},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5077153444290161},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.46517300605773926},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35925087332725525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33551326394081116},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2660863995552063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06496486067771912}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044105","descriptor_name":"Receptor, Melanocortin, Type 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmc.2006.12.039","doi":"https://doi.org/10.1016/j.bmc.2006.12.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2006.12.039","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:17234422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17234422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1967711632","https://openalex.org/W1970238325","https://openalex.org/W1970529879","https://openalex.org/W1972840770","https://openalex.org/W1985557075","https://openalex.org/W1991717139","https://openalex.org/W1993853546","https://openalex.org/W2000404397","https://openalex.org/W2004670927","https://openalex.org/W2006214372","https://openalex.org/W2010142606","https://openalex.org/W2011190206","https://openalex.org/W2014391990","https://openalex.org/W2018085228","https://openalex.org/W2019421847","https://openalex.org/W2024983611","https://openalex.org/W2030765777","https://openalex.org/W2032447576","https://openalex.org/W2033094973","https://openalex.org/W2034519191","https://openalex.org/W2035170144","https://openalex.org/W2037127087","https://openalex.org/W2040393764","https://openalex.org/W2040400838","https://openalex.org/W2044216960","https://openalex.org/W2050128047","https://openalex.org/W2055348219","https://openalex.org/W2057832460","https://openalex.org/W2059956107","https://openalex.org/W2061631592","https://openalex.org/W2065389660","https://openalex.org/W2065493729","https://openalex.org/W2067286729","https://openalex.org/W2067716092","https://openalex.org/W2071462252","https://openalex.org/W2071859133","https://openalex.org/W2079254397","https://openalex.org/W2079590397","https://openalex.org/W2083116048","https://openalex.org/W2084508088","https://openalex.org/W2085867569","https://openalex.org/W2094699439","https://openalex.org/W2094828639","https://openalex.org/W2103069362","https://openalex.org/W2103204604","https://openalex.org/W2105470099","https://openalex.org/W2108622527","https://openalex.org/W2124161617","https://openalex.org/W2124259633","https://openalex.org/W2130390328","https://openalex.org/W2131273029","https://openalex.org/W2132903069","https://openalex.org/W2144221434","https://openalex.org/W2154673501","https://openalex.org/W2166477438","https://openalex.org/W2173701541","https://openalex.org/W2174558242","https://openalex.org/W2175001634","https://openalex.org/W2180359499","https://openalex.org/W4233070622"],"related_works":["https://openalex.org/W1998427071","https://openalex.org/W2073133005","https://openalex.org/W2004670927","https://openalex.org/W2037220160","https://openalex.org/W2000404397","https://openalex.org/W2180359499","https://openalex.org/W2077995665","https://openalex.org/W2175001634","https://openalex.org/W2001998853","https://openalex.org/W2116612920"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
