{"id":"https://openalex.org/W2018909562","doi":"https://doi.org/10.1098/rsif.2014.0706","title":"Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes","display_name":"Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes","publication_year":2014,"publication_date":"2014-08-28","ids":{"openalex":"https://openalex.org/W2018909562","doi":"https://doi.org/10.1098/rsif.2014.0706","mag":"2018909562","pmid":"https://pubmed.ncbi.nlm.nih.gov/25165605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4191102"},"language":"en","primary_location":{"id":"doi:10.1098/rsif.2014.0706","doi":"https://doi.org/10.1098/rsif.2014.0706","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsif.2014.0706","pdf_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2014.0706","source":{"id":"https://openalex.org/S129150467","display_name":"Journal of The Royal Society Interface","issn_l":"1742-5662","issn":["1742-5662","1742-5689"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of The Royal Society Interface","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2014.0706","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067798289","display_name":"Mithun Kumar Mitra","orcid":"https://orcid.org/0000-0002-1777-7356","observed_orcids":["https://orcid.org/0000-0002-1777-7356"]},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mithun K. Mitra","raw_affiliation_strings":["Department of Physics, I.I.T. Bombay, Mumbai 400076, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, I.I.T. Bombay, Mumbai 400076, India","institution_ids":["https://openalex.org/I162827531"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul R. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul R. Taylor","raw_affiliation_strings":["Systems Biology Doctoral Training Centre, University of Oxford, Oxford OX1 3QU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Doctoral Training Centre, University of Oxford, Oxford OX1 3QU, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113686460","display_name":"Chris Hutchison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190082696","display_name":"Durham University","ror":"https://ror.org/01v29qb04","country_code":"GB","type":"education","lineage":["https://openalex.org/I190082696"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris J. Hutchison","raw_affiliation_strings":["School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, UK","School of Biological & Biomedical Sciences, Durham University, Durham, DH1 3LE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, UK","institution_ids":["https://openalex.org/I190082696"]},{"raw_affiliation_string":"School of Biological & Biomedical Sciences, Durham University, Durham, DH1 3LE, UK","institution_ids":["https://openalex.org/I190082696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052385071","display_name":"Tom C. B. McLeish","orcid":"https://orcid.org/0000-0002-2025-0299","observed_orcids":["https://orcid.org/0000-0002-2025-0299"]},"institutions":[{"id":"https://openalex.org/I190082696","display_name":"Durham University","ror":"https://ror.org/01v29qb04","country_code":"GB","type":"education","lineage":["https://openalex.org/I190082696"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. C. B. McLeish","raw_affiliation_strings":["Department of Physics and Astronomy, Durham University, Durham DH1 3LE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Durham University, Durham DH1 3LE, UK","institution_ids":["https://openalex.org/I190082696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090774953","display_name":"Buddhapriya Chakrabarti","orcid":"https://orcid.org/0000-0003-2699-4157","observed_orcids":["https://orcid.org/0000-0003-2699-4157"]},"institutions":[{"id":"https://openalex.org/I182145113","display_name":"Isaac Newton Institute for Mathematical Sciences","ror":"https://ror.org/007vkej58","country_code":"GB","type":"facility","lineage":["https://openalex.org/I182145113"]},{"id":"https://openalex.org/I190082696","display_name":"Durham University","ror":"https://ror.org/01v29qb04","country_code":"GB","type":"education","lineage":["https://openalex.org/I190082696"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Buddhapriya Chakrabarti","raw_affiliation_strings":["Department of Mathematical Sciences, Durham University, Durham DH1 3LE, UK","The Isaac Newton Institute of Mathematical Sciences, University of Cambridge, Cambridge CB3 0EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, Durham University, Durham DH1 3LE, UK","institution_ids":["https://openalex.org/I190082696"]},{"raw_affiliation_string":"The Isaac Newton Institute of Mathematical Sciences, University of Cambridge, Cambridge CB3 0EH, UK","institution_ids":["https://openalex.org/I182145113","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5090774953"],"corresponding_institution_ids":["https://openalex.org/I182145113","https://openalex.org/I190082696","https://openalex.org/I241749"],"apc_list":null,"apc_paid":{"value":1632,"currency":"EUR","value_usd":1760},"fwci":0.6796,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.66532314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"100","first_page":"20140706","last_page":"20140706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-landscape","display_name":"epigenetic landscape","score":0.8830000162124634},{"id":"https://openalex.org/keywords/time-delay","display_name":"time delay","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/bistability","display_name":"bistability","score":0.6240000128746033},{"id":"https://openalex.org/keywords/induced-pluripotency","display_name":"induced pluripotency","score":0.7549999952316284},{"id":"https://openalex.org/keywords/somatic-cells","display_name":"somatic cells","score":0.6389999985694885},{"id":"https://openalex.org/keywords/feedback-circuits","display_name":"feedback circuits","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cell-development","display_name":"cell development","score":0.5849999785423279},{"id":"https://openalex.org/keywords/bifurcation-theory","display_name":"bifurcation theory","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6841683983802795},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4978635311126709},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.4932963252067566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46976256370544434},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.4606381356716156},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.45510849356651306},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.45137539505958557},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42962753772735596},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4265613853931427},{"id":"https://openalex.org/C2781349735","wikidata":"https://www.wikidata.org/wiki/Q4904824","display_name":"Bifurcation","level":3,"score":0.4236522316932678},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3745216727256775},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.335843563079834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20635578036308289},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15314576029777527},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1098/rsif.2014.0706","doi":"https://doi.org/10.1098/rsif.2014.0706","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsif.2014.0706","pdf_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2014.0706","source":{"id":"https://openalex.org/S129150467","display_name":"Journal of The Royal Society Interface","issn_l":"1742-5662","issn":["1742-5662","1742-5689"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of The Royal Society Interface","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4191102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4191102","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J R Soc Interface","raw_type":"Text"},{"id":"pmid:25165605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25165605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Royal Society, Interface","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:154995","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/154995/1/Delayed%20self-regulation%20and%20time-dependent%20chemical%20drive%20leads%20to%20novel%20states%20in%20epigenetic%20landscapes.pdf","pdf_url":"http://eprints.whiterose.ac.uk/154995/1/Delayed%20self-regulation%20and%20time-dependent%20chemical%20drive%20leads%20to%20novel%20states%20in%20epigenetic%20landscapes.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:dro.dur.ac.uk.OAI2:14205","doi":null,"is_oa":true,"landing_page_url":"http://dro.dur.ac.uk/14205/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400188","display_name":"Durham Research Online (Durham University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I190082696","host_organization_name":"Durham University","host_organization_lineage":["https://openalex.org/I190082696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of the Royal Society. Interface, 2014, Vol.11(100), pp.20140706 [Peer Reviewed Journal]","raw_type":"Article"},{"id":"pmh:oai:https://durham-repository.worktribe.com/:1416964","doi":null,"is_oa":true,"landing_page_url":"https://durham-repository.worktribe.com/output/1416964","pdf_url":"https://durham-repository.worktribe.com/preview/1416992/14205.pdf","source":{"id":"https://openalex.org/S4306400188","display_name":"Durham Research Online (Durham University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I190082696","host_organization_name":"Durham University","host_organization_lineage":["https://openalex.org/I190082696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:vital:14202","doi":null,"is_oa":true,"landing_page_url":"http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/170815","pdf_url":null,"source":{"id":"https://openalex.org/S4306400234","display_name":"FedUni ResearchOnline (Federation University Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210158496","host_organization_name":"Australian Federation of University Women \u2013 South Australia","host_organization_lineage":["https://openalex.org/I4210158496"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:dsapce.library.iitb.ac.in:100/16810","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1098/rsif.2014.0706","pdf_url":null,"source":{"id":"https://openalex.org/S4306400899","display_name":"DSpace (IIT Bombay)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I162827531","host_organization_name":"Indian Institute of Technology Bombay","host_organization_lineage":["https://openalex.org/I162827531"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1098/rsif.2014.0706","doi":"https://doi.org/10.1098/rsif.2014.0706","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsif.2014.0706","pdf_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2014.0706","source":{"id":"https://openalex.org/S129150467","display_name":"Journal of The Royal Society Interface","issn_l":"1742-5662","issn":["1742-5662","1742-5689"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of The Royal Society Interface","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3041479406","display_name":null,"funder_award_id":"1232007","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8043332045","display_name":"New Multiscale Tools for Protein Physics: Thermal Protein Dynamics in Signalling and Allostery.","funder_award_id":"EP/H051759/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"},{"id":"https://openalex.org/F4320320664","display_name":"Durham University","ror":"https://ror.org/01v29qb04"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320335088","display_name":"Biophysical Sciences Institute","ror":"https://ror.org/01v29qb04"},{"id":"https://openalex.org/F4320337380","display_name":"Division of Mathematical Sciences","ror":"https://ror.org/051fftw81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018909562.pdf","grobid_xml":"https://content.openalex.org/works/W2018909562.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1567580433","https://openalex.org/W1586658033","https://openalex.org/W1789387817","https://openalex.org/W1970779075","https://openalex.org/W1976110788","https://openalex.org/W1984326475","https://openalex.org/W1994202713","https://openalex.org/W1995538422","https://openalex.org/W2002479625","https://openalex.org/W2008855387","https://openalex.org/W2010031978","https://openalex.org/W2016180314","https://openalex.org/W2019818957","https://openalex.org/W2027703497","https://openalex.org/W2029991507","https://openalex.org/W2030945597","https://openalex.org/W2039551265","https://openalex.org/W2047365291","https://openalex.org/W2049336663","https://openalex.org/W2053911973","https://openalex.org/W2072239613","https://openalex.org/W2072319015","https://openalex.org/W2078576765","https://openalex.org/W2078723571","https://openalex.org/W2084004132","https://openalex.org/W2085601753","https://openalex.org/W2089626640","https://openalex.org/W2094631910","https://openalex.org/W2095417588","https://openalex.org/W2098170273","https://openalex.org/W2125987139","https://openalex.org/W2128940002","https://openalex.org/W2134062116","https://openalex.org/W2135086442","https://openalex.org/W2142046859","https://openalex.org/W2153824299","https://openalex.org/W2171187415"],"related_works":["https://openalex.org/W1770238002","https://openalex.org/W2757339220","https://openalex.org/W3005091851","https://openalex.org/W2949636179","https://openalex.org/W4417283336","https://openalex.org/W2109030247","https://openalex.org/W3167492598","https://openalex.org/W2979825637","https://openalex.org/W4306412227","https://openalex.org/W4416085898"],"abstract_inverted_index":{"The":[0,33],"epigenetic":[1],"pathway":[2],"of":[3,25,29,39,68,100,106,116,144],"a":[4,10,15,104,107,122,168],"cell":[5,12,94,177],"as":[6],"it":[7],"differentiates":[8],"from":[9,72],"stem":[11],"state":[13,152,165],"to":[14,62],"mature":[16],"lineage-committed":[17],"one":[18],"has":[19],"been":[20,60,81],"historically":[21],"understood":[22],"in":[23,53,92,103,141,153,176],"terms":[24],"Waddington's":[26],"landscape,":[27],"consisting":[28],"hills":[30],"and":[31,36,45,56,96,119],"valleys.":[32],"smooth":[34],"top":[35],"valley-strewn":[37],"bottom":[38],"the":[40,66,98,114,126,132,142,150],"hill":[41],"represent":[42],"their":[43],"undifferentiated":[44],"differentiated":[46],"states,":[47],"respectively.":[48],"Although":[49],"mathematical":[50],"ideas":[51],"rooted":[52],"nonlinear":[54],"dynamics":[55],"bifurcation":[57],"theory":[58],"have":[59,80],"used":[61],"quantify":[63],"this":[64,88],"picture,":[65],"importance":[67],"time":[69,101],"delays":[70],"arising":[71],"multistep":[73],"chemical":[74],"reactions":[75],"or":[76],"cellular":[77],"shape":[78],"transformations":[79],"ignored":[82],"so":[83],"far.":[84],"We":[85,111,137,157],"argue":[86],"that":[87,113],"feature":[89],"is":[90],"crucial":[91],"understanding":[93,171],"differentiation":[95],"explore":[97],"role":[99],"delay":[102,120],"model":[105],"single-gene":[108],"regulatory":[109],"circuit.":[110],"show":[112],"interplay":[115],"time-dependent":[117],"drive":[118],"introduces":[121],"new":[123],"regime":[124],"where":[125],"system":[127],"shows":[128],"sustained":[129],"oscillations":[130],"between":[131],"two":[133],"admissible":[134],"steady":[135],"states.":[136],"interpret":[138],"these":[139],"results":[140],"light":[143],"recent":[145],"perplexing":[146],"experiments":[147],"on":[148,160],"inducing":[149],"pluripotent":[151],"mouse":[154],"somatic":[155],"cells.":[156],"also":[158],"comment":[159],"how":[161],"such":[162],"an":[163],"oscillatory":[164],"can":[166],"provide":[167],"framework":[169],"for":[170],"more":[172],"general":[173],"feedback":[174],"circuits":[175],"development.":[178]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}