{"id":"https://openalex.org/W2018908310","doi":"https://doi.org/10.1371/journal.pone.0030766","title":"Quantification of miRNA-mRNA Interactions","display_name":"Quantification of miRNA-mRNA Interactions","publication_year":2012,"publication_date":"2012-02-14","ids":{"openalex":"https://openalex.org/W2018908310","doi":"https://doi.org/10.1371/journal.pone.0030766","mag":"2018908310","pmid":"https://pubmed.ncbi.nlm.nih.gov/22348024","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3279346"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0030766","doi":"https://doi.org/10.1371/journal.pone.0030766","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0030766","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030766&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030766&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079766378","display_name":"Ander Muniategui","orcid":"https://orcid.org/0000-0002-7416-912X","observed_orcids":["https://orcid.org/0000-0002-7416-912X"]},"institutions":[{"id":"https://openalex.org/I170828890","display_name":"Centro de Estudios e Investigaciones T\u00e9cnicas de Gipuzkoa","ror":"https://ror.org/022wqqf69","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I170828890"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ander Muniategui","raw_affiliation_strings":["Group of Bioinformatics, CEIT and TECNUN, University of Navarra, San Sebastian, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group of Bioinformatics, CEIT and TECNUN, University of Navarra, San Sebastian, Spain","institution_ids":["https://openalex.org/I170828890","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081010307","display_name":"Rub\u00e9n Nogales\u2010Cadenas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rub\u00e9n Nogales-Cadenas","raw_affiliation_strings":["National Center for Biotechnology-CSIC, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology-CSIC, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008971014","display_name":"Migu\u00e9l V\u00e1zquez","orcid":"https://orcid.org/0000-0002-5713-1058","observed_orcids":["https://orcid.org/0000-0002-5713-1058"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Migu\u00e9l V\u00e1zquez","raw_affiliation_strings":["Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039553666","display_name":"Xabier L. Aranguren","orcid":"https://orcid.org/0000-0002-1834-603X","observed_orcids":["https://orcid.org/0000-0002-1834-603X"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Xabier L. Aranguren","raw_affiliation_strings":["Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049487102","display_name":"Xabier Agirre","orcid":"https://orcid.org/0000-0002-6558-9560","observed_orcids":["https://orcid.org/0000-0002-6558-9560"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xabier Agirre","raw_affiliation_strings":["Hematology Department and Area of Cell Therapy, Cl\u00ednica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department and Area of Cell Therapy, Cl\u00ednica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089688879","display_name":"Aernout Luttun","orcid":"https://orcid.org/0000-0001-7902-9524","observed_orcids":["https://orcid.org/0000-0001-7902-9524"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Aernout Luttun","raw_affiliation_strings":["Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016030888","display_name":"Felipe Pr\u00f3sper","orcid":"https://orcid.org/0000-0001-6115-8790","observed_orcids":["https://orcid.org/0000-0001-6115-8790","https://orcid.org/0000-0002-3274-2450"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Felipe Prosper","raw_affiliation_strings":["Hematology Department and Area of Cell Therapy, Cl\u00ednica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department and Area of Cell Therapy, Cl\u00ednica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072639458","display_name":"Alberto Pascual-Montano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Pascual-Montano","raw_affiliation_strings":["National Center for Biotechnology-CSIC, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology-CSIC, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046603247","display_name":"\u00c1ngel Rubio","orcid":"https://orcid.org/0000-0002-3274-2450","observed_orcids":["https://orcid.org/0000-0002-3274-2450"]},"institutions":[{"id":"https://openalex.org/I170828890","display_name":"Centro de Estudios e Investigaciones T\u00e9cnicas de Gipuzkoa","ror":"https://ror.org/022wqqf69","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I170828890"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Angel Rubio","raw_affiliation_strings":["Group of Bioinformatics, CEIT and TECNUN, University of Navarra, San Sebastian, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group of Bioinformatics, CEIT and TECNUN, University of Navarra, San Sebastian, Spain","institution_ids":["https://openalex.org/I170828890","https://openalex.org/I88155538"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5046603247"],"corresponding_institution_ids":["https://openalex.org/I170828890","https://openalex.org/I88155538"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.3521,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.92753168,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"e30766","last_page":"e30766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mirna-mrna-interactions","display_name":"miRNA-mRNA interactions","score":0.949999988079071},{"id":"https://openalex.org/keywords/mirna-target-prediction","display_name":"miRNA target prediction","score":0.9070000052452087},{"id":"https://openalex.org/keywords/lasso","display_name":"LASSO","score":0.9940000176429749},{"id":"https://openalex.org/keywords/non-negativity-constraints","display_name":"nonnegativity constraints","score":0.7020000219345093},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.44699999690055847},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.7910000085830688},{"id":"https://openalex.org/keywords/translation-repression","display_name":"translation repression","score":0.5979999899864197},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.6179999709129333},{"id":"https://openalex.org/keywords/sequence-complementarity","display_name":"sequence complementarity","score":0.5849999785423279},{"id":"https://openalex.org/keywords/false-positive-reduction","display_name":"false positive reduction","score":0.4959999918937683},{"id":"https://openalex.org/keywords/human-mirnas","display_name":"human miRNAs","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6589173078536987},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.658101499080658},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6518692374229431},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6303831934928894},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.5603635311126709},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.5424668192863464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5414334535598755},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4384303689002991},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42196139693260193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4203205108642578},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29298311471939087},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2908579111099243},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.15612486004829407},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pone.0030766","doi":"https://doi.org/10.1371/journal.pone.0030766","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0030766","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030766&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2290311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3279346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22348024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22348024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3279346","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3279346/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/631669","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/631669","pdf_url":"https://lirias.kuleuven.be/retrieve/62a9a5a3-365f-4242-b0c9-8e2283e6269f","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One, vol. 7 (2), Art.No. ARTN e30766","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.779.7455","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.779.7455","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ec/c5/pone.0030766.PMC3279346.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pone00:0030766","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030766","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:dadun.unav.edu:10171/35354","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10171/35354","pdf_url":null,"source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:2caafa8f3d9849b2a130987011696966","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2caafa8f3d9849b2a130987011696966","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 2, p e30766 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/128817","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Quantification_of_miRNA_mRNA_Interactions/128817","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0030766","doi":"https://doi.org/10.1371/journal.pone.0030766","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0030766","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030766&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321705","display_name":"Eusko Jaurlaritza","ror":"https://ror.org/00pz2fp31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018908310.pdf","grobid_xml":"https://content.openalex.org/works/W2018908310.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1966241066","https://openalex.org/W1967515816","https://openalex.org/W1989493946","https://openalex.org/W1994980424","https://openalex.org/W2000491596","https://openalex.org/W2021733365","https://openalex.org/W2026570544","https://openalex.org/W2029506861","https://openalex.org/W2035459770","https://openalex.org/W2040851473","https://openalex.org/W2044832480","https://openalex.org/W2050869737","https://openalex.org/W2059073003","https://openalex.org/W2065735233","https://openalex.org/W2065946853","https://openalex.org/W2070571588","https://openalex.org/W2073764144","https://openalex.org/W2083381199","https://openalex.org/W2099111195","https://openalex.org/W2104488717","https://openalex.org/W2106120562","https://openalex.org/W2107180520","https://openalex.org/W2107203759","https://openalex.org/W2113209482","https://openalex.org/W2113390076","https://openalex.org/W2124704116","https://openalex.org/W2128391263","https://openalex.org/W2130979840","https://openalex.org/W2133968430","https://openalex.org/W2134118500","https://openalex.org/W2137476312","https://openalex.org/W2139655181","https://openalex.org/W2149475084","https://openalex.org/W2160913143","https://openalex.org/W2171698535","https://openalex.org/W2172182613","https://openalex.org/W2275002414","https://openalex.org/W2478708596","https://openalex.org/W3022380717","https://openalex.org/W4246697467","https://openalex.org/W6674851815"],"related_works":["https://openalex.org/W2103570076","https://openalex.org/W1855242665","https://openalex.org/W2149276587","https://openalex.org/W2025817032","https://openalex.org/W2470994950","https://openalex.org/W2107180520","https://openalex.org/W4293103915","https://openalex.org/W2773695511","https://openalex.org/W2608048186","https://openalex.org/W2049546253"],"abstract_inverted_index":{"miRNAs":[0,154,214],"are":[1,164,189],"small":[2],"RNA":[3],"molecules":[4],"('":[5],"22nt)":[6],"that":[7,147],"interact":[8],"with":[9,99,127,182],"their":[10],"corresponding":[11],"target":[12,25,36],"mRNAs":[13],"inhibiting":[14],"the":[15,18,24,31,35,53,110,113,116,120,131,180,186,194],"translation":[16],"of":[17,34,46,55,106,112,122,152,179],"mRNA":[19,82,132,183],"into":[20],"proteins":[21],"and":[22,63,81,83,115,155],"cleaving":[23],"mRNA.":[26,37],"This":[27,191],"second":[28],"effect":[29],"diminishes":[30],"overall":[32],"expression":[33,76,150],"Several":[38],"miRNA-mRNA":[39],"relationship":[40],"databases":[41,60],"have":[42,148],"been":[43,72],"deployed,":[44],"most":[45],"them":[47],"based":[48,85],"on":[49,130,143],"sequence":[50,84],"complementarities.":[51],"However,":[52],"number":[54],"false":[56],"positives":[57],"in":[58,173,185],"these":[59],"is":[61,192,199,207],"large":[62],"they":[64],"do":[65],"not":[66,193],"overlap":[67],"completely.":[68],"Recently,":[69],"it":[70],"has":[71],"proposed":[73],"to":[74,87,102,125],"combine":[75],"measurement":[77],"from":[78],"both":[79,104],"miRNA":[80,123],"predictions":[86],"achieve":[88],"more":[89],"accurate":[90],"relationships.":[91],"In":[92],"our":[93],"work,":[94],"we":[95],"use":[96],"LASSO":[97,108],"regression":[98],"non-positive":[100,117],"constraints":[101,118],"integrate":[103],"sources":[105],"information.":[107],"enforces":[109],"sparseness":[111],"solution":[114],"restrict":[119],"search":[121],"targets":[124],"those":[126],"down-regulation":[128],"effects":[129],"expression.":[133],"We":[134],"named":[135],"this":[136],"method":[137],"TaLasso":[138,142,163],"(miRNA-Target":[139],"LASSO).We":[140],"used":[141],"two":[144],"public":[145],"datasets":[146],"paired":[149],"levels":[151],"human":[153,213],"mRNAs.":[156],"The":[157,177],"top":[158],"ranked":[159],"interactions":[160,188],"recovered":[161],"by":[162],"especially":[165],"enriched":[166],"(more":[167],"than":[168],"using":[169,196],"any":[170],"other":[171,197],"algorithm)":[172],"experimentally":[174],"validated":[175],"targets.":[176],"functions":[178],"genes":[181],"transcripts":[184],"top-ranked":[187],"meaningful.":[190],"case":[195],"algorithms.TaLasso":[198],"available":[200],"as":[201],"Matlab":[202],"or":[203],"R":[204],"code.":[205],"There":[206],"also":[208],"a":[209],"web-based":[210],"tool":[211],"for":[212],"at":[215],"http://talasso.cnb.csic.es/.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}