{"id":"https://openalex.org/W201890761","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.807.11","title":"Overexpression of Desnutrin in Adipose Tissue Attenuates Diet Induced Obesity","display_name":"Overexpression of Desnutrin in Adipose Tissue Attenuates Diet Induced Obesity","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W201890761","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.807.11","mag":"201890761"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.807.11","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.807.11","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.807.11","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103512536","display_name":"Maryam Ahmadian","orcid":"https://orcid.org/0000-0002-8326-8752","observed_orcids":["https://orcid.org/0000-0002-8326-8752"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Ahmadian","raw_affiliation_strings":["Nutritional Sciences and Toxicology UC Berkeley Berkeley CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences and Toxicology UC Berkeley Berkeley CA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057486939","display_name":"Robin E. Duncan","orcid":"https://orcid.org/0000-0002-3926-2740","observed_orcids":["https://orcid.org/0000-0002-3926-2740"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin Elaine Duncan","raw_affiliation_strings":["Nutritional Sciences and Toxicology UC Berkeley Berkeley CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences and Toxicology UC Berkeley Berkeley CA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038863786","display_name":"Hei Sook Sul","orcid":"https://orcid.org/0000-0002-3372-5097","observed_orcids":["https://orcid.org/0000-0002-3372-5097"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hei Sook Sul","raw_affiliation_strings":["UC Berkeley Berkeley CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC Berkeley Berkeley CA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03208985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.07859999686479568,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triacylglycerol-lipase","display_name":"triacylglycerol lipase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.7889999747276306},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/transgene-overexpression","display_name":"transgenic overexpression","score":0.6949999928474426},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.4169999957084656},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.640999972820282},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.9700000286102295},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.9100000262260437},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.8109999895095825},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.9239000082015991},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.9020281434059143},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.8223136067390442},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7737812995910645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7578697800636292},{"id":"https://openalex.org/C17675752","wikidata":"https://www.wikidata.org/wiki/Q12898553","display_name":"Adipose tissue macrophages","level":4,"score":0.5622546672821045},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.4731922149658203},{"id":"https://openalex.org/C2777062983","wikidata":"https://www.wikidata.org/wiki/Q21126841","display_name":"Adipose triglyceride lipase","level":4,"score":0.45625194907188416},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.4517742991447449},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.4381110668182373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42616042494773865},{"id":"https://openalex.org/C2781227529","wikidata":"https://www.wikidata.org/wiki/Q408499","display_name":"Hormone-sensitive lipase","level":4,"score":0.42305296659469604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4035744369029999},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0937495231628418}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.807.11","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.807.11","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.807.11","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096993367","https://openalex.org/W264883526","https://openalex.org/W98946124","https://openalex.org/W3176241364","https://openalex.org/W7005346221","https://openalex.org/W2115909158","https://openalex.org/W7096266927","https://openalex.org/W1987849310","https://openalex.org/W2017650269","https://openalex.org/W2098518710"],"abstract_inverted_index":{"During":[0],"energy":[1,169,200],"deprivation,":[2],"triacylglycerol":[3],"(TAG)":[4],"stored":[5],"in":[6,23,49,57,67,78,96,113,138,158,174,179,194,206],"adipose":[7,50,58,84,97,107,114,139,181,195],"tissue":[8,108],"is":[9,35,53,61],"hydrolyzed":[10],"by":[11],"the":[12,79,83,135,159],"action":[13],"of":[14,87,146],"lipases.":[15],"We":[16],"have":[17,90,102,153],"identified":[18],"a":[19,40,121,203],"novel":[20],"TAG":[21,47,148],"lipase":[22,34,48],"adipocytes,":[24],"induced":[25],"upon":[26],"fasting,":[27],"and":[28,110,131,150,171,202],"designated":[29],"it":[30],"desnutrin.":[31],"Hormone":[32],"sensitive":[33],"now":[36],"considered":[37],"to":[38,76,198],"be":[39],"diacylglycerol":[41],"lipase,":[42],"while":[43],"desnutrin":[44,95,207],"functions":[45],"as":[46],"tissue.":[51,98,115,182],"Desnutrin":[52,70,99,116],"expressed":[54],"most":[55],"highly":[56],"tissue,":[59,140,196],"but":[60],"also":[62,119],"found":[63],"at":[64],"lower":[65,103],"levels":[66,157],"other":[68],"tissues.":[69],"null":[71],"mice":[72,93,101,118,142,162],"die":[73],"early":[74],"due":[75],"defects":[77],"heart.":[80],"To":[81],"examine":[82],"specific":[85],"effect":[86],"desnutrin,":[88],"we":[89],"generated":[91],"transgenic":[92,100,117,208],"overexpressing":[94],"body":[104],"weights,":[105],"decreased":[106],"mass":[109],"increased":[111,136,154,164,187],"lipolysis":[112,137,188],"exhibit":[120,163],"more":[122],"favorable":[123],"metabolic":[124],"profile,":[125],"with":[126,167],"improved":[127],"serum":[128],"lipid":[129],"parameters":[130],"glucose":[132],"tolerance.":[133],"Despite":[134],"these":[141],"show":[143],"an":[144],"absence":[145],"ectopic":[147],"storage":[149],"do":[151],"not":[152],"fatty":[155,191],"acid":[156,192],"blood.":[160],"These":[161,183],"thermogenesis":[165],"associated":[166],"higher":[168,199],"expenditure":[170,201],"genes":[172],"involved":[173],"oxidative":[175],"metabolism":[176],"are":[177],"upregulated":[178],"white":[180],"results":[184],"suggest":[185],"that":[186],"may":[189],"promote":[190],"oxidation":[193],"contributing":[197],"leaner":[204],"phenotype":[205],"mice.":[209]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}