{"id":"https://openalex.org/W2018892902","doi":"https://doi.org/10.1158/1538-7445.am2014-5244","title":"Abstract 5244: MicorRNA-27a functions as a tumor suppressor in colorectal cancer through targeting SPGG1 and Smad2","display_name":"Abstract 5244: MicorRNA-27a functions as a tumor suppressor in colorectal cancer through targeting SPGG1 and Smad2","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2018892902","doi":"https://doi.org/10.1158/1538-7445.am2014-5244","mag":"2018892902"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-5244","doi":"https://doi.org/10.1158/1538-7445.am2014-5244","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-5244","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110332731","display_name":"Yonghua Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonghua Bao","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100742800","display_name":"Zhiguo Chen","orcid":"https://orcid.org/0000-0001-6451-2265","observed_orcids":["https://orcid.org/0000-0001-6451-2265"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiguo Chen","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100966684","display_name":"Yongchen Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongchen Guo","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065798727","display_name":"Tiesuo Zhao","orcid":"https://orcid.org/0000-0002-7842-1978","observed_orcids":["https://orcid.org/0000-0002-7842-1978"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiesuo Zhao","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089869726","display_name":"Yansheng Feng","orcid":"https://orcid.org/0000-0002-9788-8012","observed_orcids":["https://orcid.org/0000-0002-9788-8012"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yansheng Feng","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045256878","display_name":"Yunjuan Jiao","orcid":"https://orcid.org/0000-0002-8909-6162","observed_orcids":["https://orcid.org/0000-0002-8909-6162"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunjuan Jiao","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103043367","display_name":"Zexin Li","orcid":"https://orcid.org/0000-0002-5033-8064","observed_orcids":["https://orcid.org/0000-0002-5033-8064"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zexin Li","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianguo Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianguo Wang","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101500519","display_name":"Weixing Zhao","orcid":"https://orcid.org/0000-0001-5746-3696","observed_orcids":["https://orcid.org/0000-0001-5746-3696"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixing Zhao","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100653523","display_name":"Kai Li","orcid":"https://orcid.org/0000-0001-5050-0175","observed_orcids":["https://orcid.org/0000-0001-5050-0175"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Li","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100391177","display_name":"Qian Wang","orcid":"https://orcid.org/0009-0000-6276-9120","observed_orcids":["https://orcid.org/0009-0000-6276-9120"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Wang","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365347","display_name":"Jiaqi Wang","orcid":"https://orcid.org/0000-0001-8841-0124","observed_orcids":["https://orcid.org/0000-0001-8841-0124","https://orcid.org/0009-0001-6668-3903","https://orcid.org/0000-0002-6548-0186"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqi Wang","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420331","display_name":"Huijuan Zhang","orcid":"https://orcid.org/0000-0003-4253-6893","observed_orcids":["https://orcid.org/0000-0003-4253-6893"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huijuan Zhang","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074110801","display_name":"Wancai Yang","orcid":"https://orcid.org/0000-0001-7437-9197","observed_orcids":["https://orcid.org/0000-0001-7437-9197"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Wancai Yang","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;","2University of Illinois at Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"2University of Illinois at Chicago, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074110801","display_name":"Wancai Yang","orcid":"https://orcid.org/0000-0001-7437-9197","observed_orcids":["https://orcid.org/0000-0001-7437-9197"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Wancai Yang","raw_affiliation_strings":["1Xinxiang Medical University, Xinxiang, China;","2University of Illinois at Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Xinxiang Medical University, Xinxiang, China;","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"2University of Illinois at Chicago, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"5244","last_page":"5244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-27a","display_name":"miR-27a","score":0.9179999828338623},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.9679999947547913},{"id":"https://openalex.org/keywords/smad2","display_name":"Smad2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/jnk1-phosphorylation","display_name":"JNK1 phosphorylation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.871999979019165},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.593999981880188},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.49900001287460327},{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/colon-cancer-cell-lines","display_name":"colon cancer cell lines","score":0.6869999766349792},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.5720000267028809},{"id":"https://openalex.org/keywords/colonic-mucosa","display_name":"colonic mucosa","score":0.3930000066757202},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.4959999918937683},{"id":"https://openalex.org/keywords/mirna-microarray","display_name":"miRNA microarray","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8592807650566101},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7263897657394409},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7256288528442383},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6791498064994812},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.672553539276123},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6235895156860352},{"id":"https://openalex.org/C111669997","wikidata":"https://www.wikidata.org/wiki/Q17163050","display_name":"Mouse model of colorectal and intestinal cancer","level":4,"score":0.5751038193702698},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5221315026283264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5013480186462402},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4526231288909912},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32698023319244385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3262680768966675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25358039140701294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09357082843780518},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04488557577133179}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-5244","doi":"https://doi.org/10.1158/1538-7445.am2014-5244","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-5244","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2062380899","https://openalex.org/W2599164481","https://openalex.org/W2960600003","https://openalex.org/W3081233069","https://openalex.org/W2378909801","https://openalex.org/W4318142548","https://openalex.org/W7097211651","https://openalex.org/W2008775304","https://openalex.org/W2021029102","https://openalex.org/W2607320763"],"abstract_inverted_index":{"Abstract":[0],"Colorectal":[1],"cancer":[2,35,87,109,179,190,226,319],"is":[3,59],"one":[4],"of":[5,15,30,41,54,63,80,104,131,143,158,186,204,208,220,243,254,328,333],"the":[6,13,55,77,217,231,252,277,329,334],"most":[7,56],"common":[8],"malignant":[9],"diseases":[10],"worldwide,":[11],"but":[12],"causes":[14],"colorectal":[16,34,48,86,225,249,260,318],"carcinogenesis":[17],"are":[18],"largely":[19],"unknown.":[20],"Using":[21,124],"a":[22,255,314],"miRNA":[23,245],"array":[24],"we":[25],"have":[26,44],"identified":[27],"differential":[28],"expression":[29,79,141,169,218],"some":[31],"microRNAs":[32],"in":[33,47,68,71,106,117,177,224,228,259,317],"and":[36,126,138,145,163,173,195,206,234,251,268,323],"adjacent":[37],"normal":[38,75,119],"mucosa.":[39],"Most":[40],"these":[42],"miRNAs":[43,58],"been":[45],"validated":[46],"tissues":[49,227,233],"by":[50],"quantitative":[51],"RT-PCR.":[52],"One":[53],"changed":[57],"miR-27a.":[60,151],"The":[61,102,140],"level":[62],"miR-27":[64,159,168,187],"was":[65,82,92,235,273],"significantly":[66,160],"reduced":[67,78,94],"colon":[69,108,120,178,189],"cancers":[70],"compared":[72,98],"with":[73,85,150],"matched":[74],"mucosa,":[76],"miR-27a":[81,91,105,132,221],"also":[83,113,170],"associated":[84],"pathological":[88,238],"stages":[89,96],"-":[90],"more":[93,256],"at":[95,276],"III/IV,":[97],"to":[99,202,230,237,248],"stage":[100],"II.":[101],"levels":[103,142,176,219],"human":[107,118],"cell":[110,122,191,197],"lines":[111],"were":[112,133,136,147,200,222],"less":[114],"than":[115],"that":[116,156,184,216,241],"epithelial":[121],"lines.":[123],"bioinformatic":[125],"systemic":[127],"analysis,":[128],"two":[129],"targets":[130],"predicted,":[134],"they":[135],"SPGG1":[137,144,162,172,267,322],"Smad2.":[139,269,324],"Smad2":[146,164,174],"negatively":[148],"correlated":[149],"Dual":[152],"luciferase":[153],"assay":[154],"showed":[155],"overexpression":[157,185],"repressed":[161],"transcriptional":[165],"activities.":[166],"Increasing":[167],"inhibited":[171,188],"protein":[175],"cells.":[180],"Functional":[181],"studies":[182],"revealed":[183],"proliferation,":[192],"promoted":[193],"apoptosis":[194],"attenuated":[196],"migration,":[198],"which":[199,262],"linked":[201],"downregulation":[203],"p-STAT3":[205],"upregulation":[207],"phosphorylated":[209],"JNK1.":[210],"Taken":[211],"together,":[212],"our":[213],"results":[214],"demonstrated":[215],"lower":[223],"comparison":[229],"non-tumor":[232],"related":[236],"stages,":[239],"suggesting":[240],"down-regulation":[242],"this":[244],"could":[246,263],"contribute":[247],"tumorigenesis":[250],"acquisition":[253],"aggressive":[257],"phenotype":[258],"cancer,":[261],"be":[264],"through":[265,320],"targeting":[266,321],"Note:":[270],"This":[271],"abstract":[272],"not":[274],"presented":[275],"meeting.":[278],"Citation":[279],"Format:":[280],"Yonghua":[281],"Bao,":[282],"Zhiguo":[283],"Chen,":[284],"Yongchen":[285],"Guo,":[286],"Tiesuo":[287],"Zhao,":[288,298],"Yansheng":[289],"Feng,":[290],"Yunjuan":[291],"Jiao,":[292],"Zexin":[293],"Li,":[294,300],"Jianguo":[295],"Wang,":[296,302,304],"Weixing":[297],"Kai":[299],"Qian":[301],"Jiaqi":[303],"Huijuan":[305],"Zhang,":[306],"Wancai":[307,309],"Yang,":[308],"Yang.":[310],"MicorRNA-27a":[311],"functions":[312],"as":[313],"tumor":[315],"suppressor":[316],"[abstract].":[325],"In:":[326],"Proceedings":[327],"105th":[330],"Annual":[331],"Meeting":[332],"American":[335],"Association":[336],"for":[337],"Cancer":[338,349],"Research;":[339],"2014":[340],"Apr":[341],"5-9;":[342],"San":[343],"Diego,":[344],"CA.":[345],"Philadelphia":[346],"(PA):":[347],"AACR;":[348],"Res":[350],"2014;74(19":[351],"Suppl):Abstract":[352],"nr":[353],"5244.":[354],"doi:10.1158/1538-7445.AM2014-5244":[355]},"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2016-06-24T00:00:00"}