{"id":"https://openalex.org/W2018880588","doi":"https://doi.org/10.1016/s0009-2797(00)00224-6","title":"Overview \u2014 In vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites","display_name":"Overview \u2014 In vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2018880588","doi":"https://doi.org/10.1016/s0009-2797(00)00224-6","mag":"2018880588","pmid":"https://pubmed.ncbi.nlm.nih.gov/11306033"},"language":"en","primary_location":{"id":"doi:10.1016/s0009-2797(00)00224-6","doi":"https://doi.org/10.1016/s0009-2797(00)00224-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-2797(00)00224-6","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108507400","display_name":"James J. Lipsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Lipsky","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, 55905, Rochester, MN, USA","Clinical Pharmacology Unit, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","Department of Internal Medicine, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, 55905, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Clinical Pharmacology Unit, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Internal Medicine, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003566179","display_name":"Maryann L. Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryann L. Shen","raw_affiliation_strings":["Biomedical Mass Spectrometry and Functional Proteomics Facilitys-Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Mass Spectrometry and Functional Proteomics Facilitys-Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063582082","display_name":"Stephen Naylor","orcid":"https://orcid.org/0000-0001-7619-6044","observed_orcids":["https://orcid.org/0000-0001-7619-6044"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen Naylor","raw_affiliation_strings":["Biomedical Mass Spectrometry and Functional Proteomics Facilitys-Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","Clinical Pharmacology Unit, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","Department of Biochemistry and Molecular Biology and Division of Biomedical Engineering, Guggenheim, Mayo Clinic/Foundation, Rochester, MN 55905, USA","Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Mass Spectrometry and Functional Proteomics Facilitys-Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Clinical Pharmacology Unit, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and Division of Biomedical Engineering, Guggenheim, Mayo Clinic/Foundation, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim, Mayo Clinic/Foundation, 200 First Street, SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063582082"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":1.0579,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.72867868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"130-132","issue":"1-3","first_page":"81","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.3499000072479248,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.3499000072479248,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.19120000302791595,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disulfiram","display_name":"disulfiram","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase-inhibition","display_name":"aldehyde dehydrogenase inhibition","score":0.9279999732971191},{"id":"https://openalex.org/keywords/disulfiram-metabolites","display_name":"disulfiram metabolites","score":0.8510000109672546},{"id":"https://openalex.org/keywords/intramolecular-disulfide-bond","display_name":"intramolecular disulfide bond","score":0.8769999742507935},{"id":"https://openalex.org/keywords/covalent-modification","display_name":"covalent modification","score":0.753000020980835},{"id":"https://openalex.org/keywords/active-site-cysteine","display_name":"active site cysteine","score":0.7350000143051147},{"id":"https://openalex.org/keywords/carbamylation","display_name":"carbamoylation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/aversion-therapy","display_name":"aversion therapy","score":0.6129999756813049},{"id":"https://openalex.org/keywords/alcoholism-treatment","display_name":"alcoholism treatment","score":0.6819999814033508},{"id":"https://openalex.org/keywords/rat-liver-mitochondria","display_name":"rat liver mitochondria","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.781256914138794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7469998598098755},{"id":"https://openalex.org/C2778523461","wikidata":"https://www.wikidata.org/wiki/Q409665","display_name":"Disulfiram","level":2,"score":0.7147021293640137},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6785475015640259},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5751935243606567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4809374213218689},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4713054597377777},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.42211657762527466}],"mesh":[{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004050","descriptor_name":"Ditiocarb","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004050","descriptor_name":"Ditiocarb","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004050","descriptor_name":"Ditiocarb","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004221","descriptor_name":"Disulfiram","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004221","descriptor_name":"Disulfiram","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0009-2797(00)00224-6","doi":"https://doi.org/10.1016/s0009-2797(00)00224-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-2797(00)00224-6","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"pmid:11306033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11306033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W143153413","https://openalex.org/W1589027452","https://openalex.org/W1749095546","https://openalex.org/W1990237192","https://openalex.org/W2004146008","https://openalex.org/W2004760578","https://openalex.org/W2007256917","https://openalex.org/W2007648952","https://openalex.org/W2014622954","https://openalex.org/W2022390582","https://openalex.org/W2023436444","https://openalex.org/W2025193783","https://openalex.org/W2030928323","https://openalex.org/W2034275495","https://openalex.org/W2040683582","https://openalex.org/W2044294240","https://openalex.org/W2045435860","https://openalex.org/W2067176696","https://openalex.org/W2068821467","https://openalex.org/W2086017419","https://openalex.org/W2086031167","https://openalex.org/W2092194454","https://openalex.org/W2176151213","https://openalex.org/W2207908730","https://openalex.org/W2265601420","https://openalex.org/W2402056579","https://openalex.org/W2439725228","https://openalex.org/W2480314575"],"related_works":["https://openalex.org/W2086017419","https://openalex.org/W2054597549","https://openalex.org/W2149188765","https://openalex.org/W2034275495","https://openalex.org/W2007256917","https://openalex.org/W1975321108","https://openalex.org/W1969934611","https://openalex.org/W245106044","https://openalex.org/W2086031167","https://openalex.org/W2176151213"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}