{"id":"https://openalex.org/W2018878305","doi":"https://doi.org/10.1371/journal.pmed.0040096","title":"HIV Patients Developing Primary CNS Lymphoma Lack EBV-Specific CD4+ T Cell Function Irrespective of Absolute CD4+ T Cell Counts","display_name":"HIV Patients Developing Primary CNS Lymphoma Lack EBV-Specific CD4+ T Cell Function Irrespective of Absolute CD4+ T Cell Counts","publication_year":2007,"publication_date":"2007-03-26","ids":{"openalex":"https://openalex.org/W2018878305","doi":"https://doi.org/10.1371/journal.pmed.0040096","mag":"2018878305","pmid":"https://pubmed.ncbi.nlm.nih.gov/17388662","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1831733"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pmed.0040096","doi":"https://doi.org/10.1371/journal.pmed.0040096","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.0040096","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0040096&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0040096&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005488543","display_name":"Olivier Gasser","orcid":"https://orcid.org/0000-0002-8235-2274","observed_orcids":["https://orcid.org/0000-0002-8235-2274"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Olivier Gasser","raw_affiliation_strings":["Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012963385","display_name":"Florian K. Bihl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florian K Bihl","raw_affiliation_strings":["Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031705923","display_name":"Marcel Wolbers","orcid":"https://orcid.org/0000-0003-4915-9015","observed_orcids":["https://orcid.org/0000-0003-4915-9015"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marcel Wolbers","raw_affiliation_strings":["Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087296098","display_name":"Elisabetta Loggi","orcid":"https://orcid.org/0000-0003-4985-9783","observed_orcids":["https://orcid.org/0000-0003-4985-9783"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabetta Loggi","raw_affiliation_strings":["Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107063354","display_name":"Ingrid Steffen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ingrid Steffen","raw_affiliation_strings":["Institute for Medical Microbiology, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020196535","display_name":"Hans Hellmuth Hirsch","orcid":"https://orcid.org/0000-0003-0883-0423","observed_orcids":["https://orcid.org/0000-0003-0883-0423"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hans H Hirsch","raw_affiliation_strings":["Institute for Medical Microbiology, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060727664","display_name":"Huldrych F. G\u00fcnthard","orcid":"https://orcid.org/0000-0002-1142-6723","observed_orcids":["https://orcid.org/0000-0002-1142-6723"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Huldrych F G\u00fcnthard","raw_affiliation_strings":["Division of Infectious Diseases and Hospital Epidemiology, University Hospital Z\u00fcrich, Z\u00fcrich, Switzerland","Division of Infectious Diseases and Hospital Epidemiology; University Hospital Zurich; Zurich Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Division of Infectious Diseases and Hospital Epidemiology; University Hospital Zurich; Zurich Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016518899","display_name":"Bruce D. Walker","orcid":"https://orcid.org/0000-0001-6122-9245","observed_orcids":["https://orcid.org/0000-0001-6122-9245","https://orcid.org/0000-0002-8506-6740"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D Walker","raw_affiliation_strings":["Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090367243","display_name":"Christian Brander","orcid":"https://orcid.org/0000-0002-0548-5778","observed_orcids":["https://orcid.org/0000-0002-0548-5778"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Brander","raw_affiliation_strings":["Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070365161","display_name":"Manuel Battegay","orcid":"https://orcid.org/0000-0002-6638-3679","observed_orcids":["https://orcid.org/0000-0002-6638-3679"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Manuel Battegay","raw_affiliation_strings":["Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012990096","display_name":"Christoph Hess","orcid":"https://orcid.org/0000-0003-0364-8825","observed_orcids":["https://orcid.org/0000-0003-0364-8825"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Christoph Hess","raw_affiliation_strings":["Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the Swiss HIV Cohort Study","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the Swiss HIV Cohort Study","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012990096"],"corresponding_institution_ids":["https://openalex.org/I2802542264"],"apc_list":{"value":6460,"currency":"USD","value_usd":6460},"apc_paid":{"value":6460,"currency":"USD","value_usd":6460},"fwci":6.6269,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.97473053,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"3","first_page":"e96","last_page":"e96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-central-nervous-system-lymphoma","display_name":"primary central nervous system lymphoma","score":0.8930000066757202},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7429999709129333},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.968999981880188},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.8429999947547913},{"id":"https://openalex.org/keywords/interferon-gamma-production","display_name":"IFN-gamma production","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hiv-associated-lymphoma","display_name":"HIV-associated lymphoma","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6242628693580627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6236410140991211},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6206249594688416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5914241671562195},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4698654115200043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41289421916007996},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4112464189529419},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39640697836875916}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pmed.0040096","doi":"https://doi.org/10.1371/journal.pmed.0040096","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.0040096","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0040096&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1831733","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1831733","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Med","raw_type":"Text"},{"id":"pmid:17388662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17388662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS medicine","raw_type":"Comment"},{"id":"pmh:oai:doaj.org/article:b6f51f1f87e0413fb62080db2a969a2e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b6f51f1f87e0413fb62080db2a969a2e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Medicine, Vol 4, Iss 3, p e96 (2007)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/152313","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/HIV_Patients_Developing_Primary_CNS_Lymphoma_Lack_EBV_Specific_CD4_T_Cell_Function_Irrespective_of_Absolute_CD4_T_Cell_Counts/152313","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:ed01a798-8fbc-4e3d-a2c3-bcb2238e60d2","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:ed01a798-8fbc-4e3d-a2c3-bcb2238e60d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1371/journal.pmed.0040096","doi":"https://doi.org/10.1371/journal.pmed.0040096","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.0040096","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0040096&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2980816087","display_name":"Impact of post kidney-allograft immunosuppression on the host immune response to Epstein-Barr virus (SCORE)","funder_award_id":"103253","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G4647654584","display_name":"Impact of post kidney-allograft immunosuppression on the host immune response to Epstein-Barr virus (zu SCORE)","funder_award_id":"103254","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6715704539","display_name":null,"funder_award_id":"3200B0","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018878305.pdf","grobid_xml":"https://content.openalex.org/works/W2018878305.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W101548742","https://openalex.org/W1034067171","https://openalex.org/W1493822493","https://openalex.org/W1496154938","https://openalex.org/W1974268928","https://openalex.org/W1984999783","https://openalex.org/W1998047078","https://openalex.org/W1999024438","https://openalex.org/W2013526772","https://openalex.org/W2032875387","https://openalex.org/W2033879292","https://openalex.org/W2038940971","https://openalex.org/W2070901154","https://openalex.org/W2097647692","https://openalex.org/W2099352670","https://openalex.org/W2123811267","https://openalex.org/W2127576962","https://openalex.org/W2135088382","https://openalex.org/W2148409327","https://openalex.org/W2154729256","https://openalex.org/W2156914406","https://openalex.org/W2159342722","https://openalex.org/W2335427526","https://openalex.org/W2470053798"],"related_works":["https://openalex.org/W2087590202","https://openalex.org/W1967504709","https://openalex.org/W2077498101","https://openalex.org/W2589479530","https://openalex.org/W2126742300","https://openalex.org/W2122585027","https://openalex.org/W2890668496","https://openalex.org/W2972268931","https://openalex.org/W7099302623","https://openalex.org/W2097789339"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,157],"chronic":[2],"HIV":[3],"infection,":[4],"antiretroviral":[5],"therapy-induced":[6],"normalization":[7,36],"of":[8,22,37,54,66,96,115,127,155,226,260,266],"CD4(+)":[9,38,46,68,76,82,138,145,166,228,241],"T":[10,39,47,69,77,83,139,146,167,229,242],"cell":[11,40,48,70,78,140,168,230,243],"counts":[12,79,141],"(immune":[13],"reconstitution":[14],"[IR])":[15],"is":[16],"associated":[17],"with":[18,105,112,186],"a":[19,211],"decreased":[20],"incidence":[21],"opportunistic":[23,32,56],"diseases.":[24],"However,":[25],"some":[26],"individuals":[27,92],"remain":[28],"at":[29],"risk":[30],"for":[31,177,201,210],"diseases":[33],"despite":[34],"prolonged":[35],"counts.":[41,71],"Deficient":[42],"Epstein-Barr":[43],"virus":[44],"(EBV)-specific":[45],"function":[49],"may":[50],"explain":[51],"the":[52,128,217,258],"occurrence":[53],"EBV-associated":[55,116],"malignancy-such":[57],"as":[58,137],"primary":[59],"central":[60],"nervous":[61],"system":[62],"(PCNS)":[63],"lymphoma-despite":[64],"recovery":[65],"absolute":[67,227],"METHODS":[72],"AND":[73],"FINDINGS:":[74],"Absolute":[75],"and":[80,100,120,216,256],"EBV-specific":[81,144,165,240],"cell-dependent":[84],"interferon-gamma":[85],"production":[86],"were":[87,103,148],"assessed":[88,149],"in":[89,107],"six":[90],"HIV-positive":[91,218,232],"prior":[93,152],"to":[94,153,188,251],"development":[95],"PCNS":[97,129,181,237],"lymphoma":[98,130,182,238],"(\"cases\"),":[99],"these":[101,253],"values":[102],"compared":[104],"those":[106],"16":[108],"HIV-infected":[109],"matched":[110,162,219],"participants":[111,215],"no":[113,208],"sign":[114],"pathology":[117],"(\"matched":[118],"controls\")":[119],"11":[121],"nonmatched":[122],"HIV-negative":[123,193,214],"blood":[124,194],"donors.":[125],"Half":[126],"patients":[131,183,233],"fulfilled":[132],"IR":[133,267],"criteria":[134],"(defined":[135],"here":[136],">or=500/microl":[142],"blood).":[143],"cells":[147],"0.5-4.7":[150],"y":[151],"diagnosis":[154],"lymphoma.":[156],"0/6":[158],"cases":[159],"versus":[160,262],"13/16":[161],"controls":[163,220],"an":[164],"response":[169,190],"was":[170,207],"detected":[171],"(p":[172,196,221],"=":[173,222],"0.007;":[174],"confidence":[175,199],"interval":[176,200],"odds":[178,202],"ratio":[179,203],"[0-0.40]).":[180],"also":[184],"differed":[185],"regards":[187],"this":[189],"significantly":[191],"from":[192],"donors":[195],"<":[197],"0.001,":[198],"[0-0.14]),":[204],"but":[205],"there":[206],"evidence":[209],"difference":[212],"between":[213],"0.47).":[223],"CONCLUSIONS:":[224],"Irrespective":[225],"counts,":[231],"who":[234],"subsequently":[235],"developed":[236],"lacked":[239],"function.":[244],"Larger,":[245],"ideally":[246],"prospective":[247],"studies":[248],"are":[249],"needed":[250],"confirm":[252],"preliminary":[254],"data,":[255],"clarify":[257],"impact":[259],"pathogen-specific":[261],"surrogate":[263],"marker-based":[264],"assessment":[265],"on":[268],"clinical":[269],"outcome.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}