{"id":"https://openalex.org/W2018875017","doi":"https://doi.org/10.1371/journal.pone.0035559","title":"Cost-Effectiveness of Magnetic Resonance Imaging with a New Contrast Agent for the Early Diagnosis of Alzheimer's Disease","display_name":"Cost-Effectiveness of Magnetic Resonance Imaging with a New Contrast Agent for the Early Diagnosis of Alzheimer's Disease","publication_year":2012,"publication_date":"2012-04-20","ids":{"openalex":"https://openalex.org/W2018875017","doi":"https://doi.org/10.1371/journal.pone.0035559","mag":"2018875017","pmid":"https://pubmed.ncbi.nlm.nih.gov/22532859","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3332046"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0035559","doi":"https://doi.org/10.1371/journal.pone.0035559","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035559","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035559&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035559&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090663900","display_name":"Maria Biasutti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124158823","display_name":"Conservatoire National des Arts et M\u00e9tiers","ror":"https://ror.org/0175hh227","country_code":"FR","type":"education","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I142631665","display_name":"\u00c9cole nationale des ponts et chauss\u00e9es","ror":"https://ror.org/02nwvxz07","country_code":"FR","type":"education","lineage":["https://openalex.org/I142631665","https://openalex.org/I4210145102"]},{"id":"https://openalex.org/I4405258326","display_name":"Mod\u00e9lisation, \u00e9pid\u00e9miologie et surveillance des risques sanitaires","ror":"https://ror.org/00fmavj37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562","https://openalex.org/I4405258326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maria Biasutti","raw_affiliation_strings":["Laboratoire Mod\u00e9lisation et Surveillance des risques sanitaires - Conservatoire national des Arts et M\u00e9tiers - 75003, Paris, France","Ecole des Ponts ParisTech \u2013 77700, Marne la Vall\u00e9e, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Mod\u00e9lisation et Surveillance des risques sanitaires - Conservatoire national des Arts et M\u00e9tiers - 75003, Paris, France","institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4405258326"]},{"raw_affiliation_string":"Ecole des Ponts ParisTech \u2013 77700, Marne la Vall\u00e9e, France","institution_ids":["https://openalex.org/I142631665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091514679","display_name":"Natacha Dufour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124158823","display_name":"Conservatoire National des Arts et M\u00e9tiers","ror":"https://ror.org/0175hh227","country_code":"FR","type":"education","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I142631665","display_name":"\u00c9cole nationale des ponts et chauss\u00e9es","ror":"https://ror.org/02nwvxz07","country_code":"FR","type":"education","lineage":["https://openalex.org/I142631665","https://openalex.org/I4210145102"]},{"id":"https://openalex.org/I4405258326","display_name":"Mod\u00e9lisation, \u00e9pid\u00e9miologie et surveillance des risques sanitaires","ror":"https://ror.org/00fmavj37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562","https://openalex.org/I4405258326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Natacha Dufour","raw_affiliation_strings":["Ecole des Ponts ParisTech \u2013 77700, Marne la Vall\u00e9e, France","Laboratoire Mod\u00e9lisation et Surveillance des risques sanitaires \u2013 Conservatoire national des Arts et M\u00e9tiers \u2013 75003, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ecole des Ponts ParisTech \u2013 77700, Marne la Vall\u00e9e, France","institution_ids":["https://openalex.org/I142631665"]},{"raw_affiliation_string":"Laboratoire Mod\u00e9lisation et Surveillance des risques sanitaires \u2013 Conservatoire national des Arts et M\u00e9tiers \u2013 75003, Paris, France","institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4405258326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084139859","display_name":"Clotilde Ferroud","orcid":"https://orcid.org/0000-0001-8788-0685","observed_orcids":["https://orcid.org/0000-0001-8788-0685"]},"institutions":[{"id":"https://openalex.org/I124158823","display_name":"Conservatoire National des Arts et M\u00e9tiers","ror":"https://ror.org/0175hh227","country_code":"FR","type":"education","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Clotilde Ferroud","raw_affiliation_strings":["Laboratoire Transformations Chimiques et Pharmaceutiques \u2013 Conservatoire national des Arts et M\u00e9tiers \u2013 75003, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Transformations Chimiques et Pharmaceutiques \u2013 Conservatoire national des Arts et M\u00e9tiers \u2013 75003, Paris, France","institution_ids":["https://openalex.org/I124158823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080713459","display_name":"William Dab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124158823","display_name":"Conservatoire National des Arts et M\u00e9tiers","ror":"https://ror.org/0175hh227","country_code":"FR","type":"education","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4405258326","display_name":"Mod\u00e9lisation, \u00e9pid\u00e9miologie et surveillance des risques sanitaires","ror":"https://ror.org/00fmavj37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562","https://openalex.org/I4405258326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"William Dab","raw_affiliation_strings":["Laboratoire Mod\u00e9lisation et Surveillance des risques sanitaires \u2013 Conservatoire national des Arts et M\u00e9tiers \u2013 75003, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Mod\u00e9lisation et Surveillance des risques sanitaires \u2013 Conservatoire national des Arts et M\u00e9tiers \u2013 75003, Paris, France","institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4405258326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053329804","display_name":"Laura Temime","orcid":"https://orcid.org/0000-0002-8850-5403","observed_orcids":["https://orcid.org/0000-0002-8850-5403"]},"institutions":[{"id":"https://openalex.org/I124158823","display_name":"Conservatoire National des Arts et M\u00e9tiers","ror":"https://ror.org/0175hh227","country_code":"FR","type":"education","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4405258326","display_name":"Mod\u00e9lisation, \u00e9pid\u00e9miologie et surveillance des risques sanitaires","ror":"https://ror.org/00fmavj37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562","https://openalex.org/I4405258326"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Laura Temime","raw_affiliation_strings":["Laboratoire Mod\u00e9lisation et Surveillance des risques sanitaires \u2013 Conservatoire national des Arts et M\u00e9tiers \u2013 75003, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Mod\u00e9lisation et Surveillance des risques sanitaires \u2013 Conservatoire national des Arts et M\u00e9tiers \u2013 75003, Paris, France","institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4405258326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053329804"],"corresponding_institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4405258326"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.7958,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.82588644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"4","first_page":"e35559","last_page":"e35559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.1062999963760376,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.875},{"id":"https://openalex.org/keywords/mri-contrast-agents","display_name":"MRI contrast agents","score":0.5609999895095825},{"id":"https://openalex.org/keywords/amyloid-beta-imaging","display_name":"amyloid-beta imaging","score":0.8769999742507935},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9869999885559082},{"id":"https://openalex.org/keywords/screen-and-treat","display_name":"screen-and-treat","score":0.5849999785423279},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dementia-progression","display_name":"dementia progression","score":0.48399999737739563},{"id":"https://openalex.org/keywords/diagnostic-test-evaluation","display_name":"diagnostic test evaluation","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6299397945404053},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6044552326202393},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.597723662853241},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5643543004989624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5578269362449646},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.4159677028656006},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3688054382801056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24494284391403198},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.18609347939491272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07664263248443604},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005602","descriptor_name":"France","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0035559","doi":"https://doi.org/10.1371/journal.pone.0035559","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035559","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035559&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2339560","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3332046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22532859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22532859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3332046","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3332046/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.270.1270","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.270.1270","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7e/2e/PLoS_One_2012_Apr_20_7(4)_e35559.tar.gz","raw_type":"text"},{"id":"pmh:oai:HAL:hal-02077310v1","doi":null,"is_oa":true,"landing_page_url":"https://cnam.hal.science/hal-02077310","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 2012, 7 (4), pp.e35559. ⟨10.1371/journal.pone.0035559⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pone00:0035559","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035559","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:1f7be38f3da24b939c429fd9ad9da762","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1f7be38f3da24b939c429fd9ad9da762","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 4, p e35559 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/126362","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Cost_Effectiveness_of_Magnetic_Resonance_Imaging_with_a_New_Contrast_Agent_for_the_Early_Diagnosis_of_Alzheimer_s_Disease/126362","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0035559","doi":"https://doi.org/10.1371/journal.pone.0035559","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035559","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035559&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018875017.pdf","grobid_xml":"https://content.openalex.org/works/W2018875017.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W40759887","https://openalex.org/W110092466","https://openalex.org/W1511746535","https://openalex.org/W1751963152","https://openalex.org/W1810964460","https://openalex.org/W1871164681","https://openalex.org/W1892103738","https://openalex.org/W1962254068","https://openalex.org/W1967559409","https://openalex.org/W1969616018","https://openalex.org/W1985342884","https://openalex.org/W1993200700","https://openalex.org/W1997074193","https://openalex.org/W1997816231","https://openalex.org/W1997886955","https://openalex.org/W1999787352","https://openalex.org/W2000182266","https://openalex.org/W2001477615","https://openalex.org/W2003428745","https://openalex.org/W2013855397","https://openalex.org/W2014886338","https://openalex.org/W2027254894","https://openalex.org/W2039585634","https://openalex.org/W2056536032","https://openalex.org/W2057679568","https://openalex.org/W2063367301","https://openalex.org/W2065013480","https://openalex.org/W2069863984","https://openalex.org/W2070148953","https://openalex.org/W2070267512","https://openalex.org/W2071758656","https://openalex.org/W2092356280","https://openalex.org/W2099459734","https://openalex.org/W2104893553","https://openalex.org/W2107094473","https://openalex.org/W2123944423","https://openalex.org/W2132766843","https://openalex.org/W2133239607","https://openalex.org/W2138128905","https://openalex.org/W2148818050","https://openalex.org/W2150894960","https://openalex.org/W2153452603","https://openalex.org/W2159472982","https://openalex.org/W2161737267","https://openalex.org/W2168767913","https://openalex.org/W3023013291","https://openalex.org/W4211157318","https://openalex.org/W4318600612"],"related_works":["https://openalex.org/W1552319074","https://openalex.org/W4412432125","https://openalex.org/W2162077872","https://openalex.org/W1985342884","https://openalex.org/W4405966828","https://openalex.org/W4408661279","https://openalex.org/W4283029374","https://openalex.org/W3113322407","https://openalex.org/W4400799386","https://openalex.org/W1984608196"],"abstract_inverted_index":{"BACKGROUND:":[0],"Used":[1],"as":[2,126,128],"contrast":[3],"agents":[4],"for":[5,12,83,236],"brain":[6],"magnetic":[7],"resonance":[8],"imaging":[9],"(MRI),":[10],"markers":[11,263],"beta-amyloid":[13,262],"deposits":[14],"might":[15,211,269],"allow":[16],"early":[17,71,218,249],"diagnosis":[18,51,157],"of":[19,27,45,49,58,65,101,104,121,174,194,215,251],"Alzheimer's":[20],"disease":[21],"(AD).":[22],"We":[23,41,116,141],"evaluated":[24],"the":[25,43,63,79,99,112,139,154,160,167,187,192,197,213,233,252],"cost-effectiveness":[26,44],"such":[28,227],"a":[29,66,118,171,256],"diagnostic":[30,258],"test,":[31],"MRI+CLP":[32,46,164,195],"(contrastophore-linker-pharmacophore),":[33],"should":[34,226],"it":[35],"become":[36,166,229,240],"clinically":[37],"available.":[38],"METHODOLOGY/PRINCIPAL":[39],"FINDINGS:":[40],"compared":[42],"to":[47,111,247,264],"that":[48,208],"standard":[50,59,155],"using":[52],"currently":[53],"available":[54],"cognition":[55],"tests":[56,245],"and":[57,61,94,131,144,189],"MRI,":[60],"investigated":[62],"impact":[64],"hypothetical":[67],"treatment":[68],"efficient":[69],"in":[70,134,186,217],"AD.":[72],"The":[73,149],"primary":[74,161],"analysis":[75,162],"was":[76,153],"based":[77,260],"on":[78,261],"current":[80],"French":[81],"context":[82],"70-year-old":[84],"patients":[85,266],"with":[86,242,267],"Mild":[87],"Cognitive":[88],"Impairment":[89],"(MCI).":[90],"In":[91,159],"alternative":[92],"\"screen":[93,188],"treat\"":[95,190],"scenarios,":[96],"we":[97],"analyzed":[98],"consequences":[100],"systematic":[102],"screenings":[103],"over-60":[105,234],"individuals":[106],"(either":[107],"population-wide":[108],"or":[109,182],"restricted":[110],"ApoE4":[113],"genotype":[114],"population).":[115],"used":[117],"Markov":[119],"model":[120,124],"AD":[122,237],"progression;":[123],"parameters,":[125],"well":[127],"incurred":[129],"costs":[130],"quality-of-life":[132],"weights":[133],"France":[135],"were":[136],"taken":[137],"from":[138],"literature.":[140],"performed":[142],"univariate":[143],"probabilistic":[145],"multivariate":[146],"sensitivity":[147,181],"analyses.":[148],"base-case":[150],"preferred":[151,168,198],"strategy":[152,169,199],"MRI":[156],"strategy.":[158],"however,":[163],"could":[165],"under":[170],"wide":[172],"array":[173],"scenarios":[175],"involving":[176],"lower":[177,201],"cost":[178],"and/or":[179],"higher":[180],"specificity.":[183],"By":[184],"contrast,":[185],"analyses,":[191],"probability":[193],"becoming":[196],"remained":[200],"than":[202],"5%.":[203],"CONCLUSIONS/SIGNIFICANCE:":[204],"It":[205],"is":[206],"thought":[207],"anti-beta-amyloid":[209],"compounds":[210],"halt":[212],"development":[214],"dementia":[216],"stage":[219],"patients.":[220],"This":[221],"study":[222],"suggests":[223],"that,":[224],"even":[225],"treatments":[228],"available,":[230],"systematically":[231],"screening":[232],"population":[235],"would":[238],"only":[239],"cost-effective":[241],"highly":[243],"specific":[244],"able":[246],"diagnose":[248],"stages":[250],"disease.":[253],"However,":[254],"offering":[255],"new":[257],"test":[259],"elderly":[265],"MCI":[268],"prove":[270],"cost-effective.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}