{"id":"https://openalex.org/W2018874290","doi":"https://doi.org/10.1074/jbc.m109.093963","title":"Polo-like Kinase 1 Activated by the Hepatitis B Virus X Protein Attenuates Both the DNA Damage Checkpoint and DNA Repair Resulting in Partial Polyploidy","display_name":"Polo-like Kinase 1 Activated by the Hepatitis B Virus X Protein Attenuates Both the DNA Damage Checkpoint and DNA Repair Resulting in Partial Polyploidy","publication_year":2010,"publication_date":"2010-07-13","ids":{"openalex":"https://openalex.org/W2018874290","doi":"https://doi.org/10.1074/jbc.m109.093963","mag":"2018874290","pmid":"https://pubmed.ncbi.nlm.nih.gov/20624918","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943266"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.093963","doi":"https://doi.org/10.1074/jbc.m109.093963","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.093963","pdf_url":"http://www.jbc.org/article/S0021925819890634/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819890634/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049035458","display_name":"Leo L. Studach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leo Studach","raw_affiliation_strings":["Department of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070889441","display_name":"Wen\u2010Horng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Horng Wang","raw_affiliation_strings":["Departments of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015758593","display_name":"Gregory J. Weber","orcid":"https://orcid.org/0009-0008-0574-0995","observed_orcids":["https://orcid.org/0009-0008-0574-0995"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Weber","raw_affiliation_strings":["Departments of Biochemistry, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110393264","display_name":"Jiabin Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiabin Tang","raw_affiliation_strings":["Departments of Biochemistry, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032381638","display_name":"Ronald Loral Hullinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald L. Hullinger","raw_affiliation_strings":["Departments of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008576280","display_name":"Raphael A. Malbrue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raphael Malbrue","raw_affiliation_strings":["Departments of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100740693","display_name":"Xiaoqi Liu","orcid":"https://orcid.org/0000-0002-7038-333X","observed_orcids":["https://orcid.org/0000-0002-7038-333X","https://orcid.org/0000-0002-6613-1746"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqi Liu","raw_affiliation_strings":["Departments of Biochemistry, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019487904","display_name":"OURANIA M. ANDRISANI","orcid":"https://orcid.org/0000-0002-6230-0303","observed_orcids":["https://orcid.org/0000-0002-6230-0303"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ourania Andrisani","raw_affiliation_strings":["Departments of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019487904"],"corresponding_institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1681,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.74956273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"285","issue":"39","first_page":"30282","last_page":"30293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.13050000369548798,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plk1","display_name":"PLK1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hepatitis-b-virus-x-protein","display_name":"hepatitis B virus X protein","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.953000009059906},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9490000009536743},{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.8040000200271606},{"id":"https://openalex.org/keywords/claspin","display_name":"Claspin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mre11","display_name":"MRE11","score":0.8859999775886536},{"id":"https://openalex.org/keywords/p53-stabilization","display_name":"p53 stabilization","score":0.9539999961853027},{"id":"https://openalex.org/keywords/g2-m-transition","display_name":"G2/M transition","score":0.6000000238418579},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hepatocyte-transformation","display_name":"hepatocyte transformation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dna-re-replication","display_name":"DNA re-replication","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6882957816123962},{"id":"https://openalex.org/C68748289","wikidata":"https://www.wikidata.org/wiki/Q18030783","display_name":"DNA-PKcs","level":4,"score":0.687150239944458},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.6720349788665771},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.6415807008743286},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5691125988960266},{"id":"https://openalex.org/C146276462","wikidata":"https://www.wikidata.org/wiki/Q21131841","display_name":"PLK1","level":4,"score":0.5652356743812561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5506699085235596},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5075022578239441},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.501645565032959},{"id":"https://openalex.org/C145803527","wikidata":"https://www.wikidata.org/wiki/Q18032396","display_name":"DNA repair protein XRCC4","level":5,"score":0.43762046098709106},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.4143766760826111},{"id":"https://openalex.org/C2910325170","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"Checkpoint Kinase 2","level":5,"score":0.4105873107910156},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37438520789146423},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.3293114900588989},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.31688040494918823},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3145950436592102},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.31181907653808594},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.2736217975616455},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.264475017786026},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20332878828048706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14587607979774475},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.09934380650520325}],"mesh":[{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076228","descriptor_name":"MRE11 Homologue Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097869","descriptor_name":"Polo-Like Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m109.093963","doi":"https://doi.org/10.1074/jbc.m109.093963","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.093963","pdf_url":"http://www.jbc.org/article/S0021925819890634/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2182109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943266","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2943266","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943266","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20624918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20624918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.093963","doi":"https://doi.org/10.1074/jbc.m109.093963","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.093963","pdf_url":"http://www.jbc.org/article/S0021925819890634/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4337754089","display_name":"Mechanisms of Hepatocyte Transformation by the Hepatitis B Virus X Protein","funder_award_id":"R01DK044533","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5139226905","display_name":null,"funder_award_id":"DK 044533","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6297134735","display_name":"Role of Polo-like kinase (Plk-1) in Hepatitis B Virus-mediated Hepatocellular Car","funder_award_id":"R21CA135192","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000039928","display_name":null,"funder_award_id":"DK044533","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018874290.pdf","grobid_xml":"https://content.openalex.org/works/W2018874290.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1537737236","https://openalex.org/W1564224574","https://openalex.org/W1651425720","https://openalex.org/W1946974373","https://openalex.org/W1954321178","https://openalex.org/W1967880683","https://openalex.org/W1973038715","https://openalex.org/W1980725176","https://openalex.org/W1986005454","https://openalex.org/W1987957628","https://openalex.org/W1992630665","https://openalex.org/W1997769119","https://openalex.org/W1997779012","https://openalex.org/W1999554125","https://openalex.org/W2001593061","https://openalex.org/W2005207709","https://openalex.org/W2011799603","https://openalex.org/W2017619447","https://openalex.org/W2024543323","https://openalex.org/W2029108033","https://openalex.org/W2031079263","https://openalex.org/W2031292590","https://openalex.org/W2033701673","https://openalex.org/W2037139254","https://openalex.org/W2040235495","https://openalex.org/W2040562682","https://openalex.org/W2048729396","https://openalex.org/W2050784279","https://openalex.org/W2055382176","https://openalex.org/W2055965106","https://openalex.org/W2058727957","https://openalex.org/W2061382280","https://openalex.org/W2067692139","https://openalex.org/W2069078243","https://openalex.org/W2069449346","https://openalex.org/W2074134609","https://openalex.org/W2075016267","https://openalex.org/W2075135229","https://openalex.org/W2076183717","https://openalex.org/W2078612444","https://openalex.org/W2078614572","https://openalex.org/W2081383642","https://openalex.org/W2083139178","https://openalex.org/W2085323757","https://openalex.org/W2086997734","https://openalex.org/W2089716206","https://openalex.org/W2090436602","https://openalex.org/W2091148267","https://openalex.org/W2093019351","https://openalex.org/W2105912300","https://openalex.org/W2109903344","https://openalex.org/W2110817748","https://openalex.org/W2111403239","https://openalex.org/W2113517398","https://openalex.org/W2113684644","https://openalex.org/W2118919140","https://openalex.org/W2127019295","https://openalex.org/W2127766269","https://openalex.org/W2128252882","https://openalex.org/W2128752526","https://openalex.org/W2131049116","https://openalex.org/W2131761459","https://openalex.org/W2131837045","https://openalex.org/W2137310763","https://openalex.org/W2143916467","https://openalex.org/W2144458361","https://openalex.org/W2150587707","https://openalex.org/W2150651320","https://openalex.org/W2159435386","https://openalex.org/W2167003908","https://openalex.org/W2169182876","https://openalex.org/W2170121627"],"related_works":["https://openalex.org/W1500718377","https://openalex.org/W2144458361","https://openalex.org/W2904395019","https://openalex.org/W2169182876","https://openalex.org/W1518187531","https://openalex.org/W2298898192","https://openalex.org/W2118394853","https://openalex.org/W1975873758","https://openalex.org/W2001593061","https://openalex.org/W1980024259"],"abstract_inverted_index":{"Hepatitis":[0],"B":[1],"virus":[2],"X":[3],"protein":[4,80,104,112,117],"(pX),":[5],"implicated":[6],"in":[7,22,52,63,121,134,151,225],"hepatocarcinogenesis,":[8],"induces":[9],"DNA":[10,36,59,77,115,164,181,212,218,222],"damage":[11,37,60,182,213,219],"because":[12],"of":[13,18,67,82,86,100,114,125,146,169,177,195,211],"re-replication":[14],"and":[15,25,79,89,108,144,172,221],"allows":[16,33,209],"propagation":[17,210],"damaged":[19],"DNA,":[20],"resulting":[21,224],"partial":[23],"polyploidy":[24,199],"oncogenic":[26],"transformation.":[27,236],"The":[28],"mechanism":[29,232],"by":[30,160,207,214],"which":[31],"pX":[32,46],"cells":[34,127,179],"with":[35,130,139,180],"to":[38,186],"continue":[39],"proliferating":[40],"is":[41],"unknown.":[42],"Herein,":[43],"we":[44],"show":[45],"activates":[47],"Polo-like":[48],"kinase":[49,72],"1":[50],"(Plk1)":[51],"the":[53,58,64,70,122,175,217],"G(2)":[54,65,123],"phase,":[55],"thereby":[56],"attenuating":[57,216],"checkpoint.":[61],"Specifically,":[62],"phase":[66,124],"pX-expressing":[68,126,135,178],"cells,":[69,136],"checkpoint":[71,220],"Chk1":[73,92,106],"was":[74],"inactive":[75],"despite":[76],"damage,":[78],"levels":[81,113],"claspin,":[83],"an":[84],"adaptor":[85],"ataxia":[87],"telangiectasia-mutated":[88],"Rad3-related":[90],"protein-mediated":[91],"phosphorylation,":[93],"were":[94,119],"reduced.":[95],"Pharmacologic":[96],"inhibition":[97,145,168,188,192],"or":[98,193],"knockdown":[99,194],"Plk1":[101,131,141,147,159,187,196,231],"restored":[102],"claspin":[103],"levels,":[105],"activation,":[107],"p53":[109],"stabilization.":[110],"Also,":[111],"repair":[116],"Mre11":[118,137,149,162,173],"decreased":[120],"but":[128],"not":[129],"knockdown.":[132],"Interestingly,":[133],"co-immunoprecipitated":[138],"transfected":[140],"Polo-box":[142],"domain,":[143],"increased":[148,174],"stability":[150],"cycloheximide-treated":[152],"cells.":[153],"These":[154],"results":[155],"suggest":[156],"that":[157],"pX-activated":[158],"down-regulating":[161],"attenuates":[163],"repair.":[165],"Importantly,":[166],"concurrent":[167],"Plk1,":[170,205],"p53,":[171],"number":[176],"entering":[183],"mitosis,":[184],"relative":[185],"alone.":[189],"By":[190],"contrast,":[191],"reduced":[197],"pX-induced":[198],"while":[200],"increasing":[201],"apoptosis.":[202],"We":[203,227],"conclude":[204],"activated":[206],"pX,":[208],"concurrently":[215],"repair,":[223],"polyploidy.":[226],"propose":[228],"this":[229],"novel":[230],"initiates":[233],"pX-mediated":[234],"hepatocyte":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
