{"id":"https://openalex.org/W2018857232","doi":"https://doi.org/10.1210/jc.87.7.3221","title":"Prospective Study of the Spontaneous Course of Subclinical Hypothyroidism: Prognostic Value of Thyrotropin, Thyroid Reserve, and Thyroid Antibodies","display_name":"Prospective Study of the Spontaneous Course of Subclinical Hypothyroidism: Prognostic Value of Thyrotropin, Thyroid Reserve, and Thyroid Antibodies","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2018857232","doi":"https://doi.org/10.1210/jc.87.7.3221","mag":"2018857232","pmid":"https://pubmed.ncbi.nlm.nih.gov/12107228"},"language":"en","primary_location":{"id":"doi:10.1210/jc.87.7.3221","doi":"https://doi.org/10.1210/jc.87.7.3221","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.87.7.3221","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065837820","display_name":"Gerold Huber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gerold Huber","raw_affiliation_strings":["University Clinic of Medicine B (G.H.), CH-4031 Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic of Medicine B (G.H.), CH-4031 Basel, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110167284","display_name":"Jean-Jacques Staub","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Jacques Staub","raw_affiliation_strings":["Division of Endocrinology (J.J.S., C.M., C.M., M.G.), CH-4031 Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (J.J.S., C.M., C.M., M.G.), CH-4031 Basel, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024507792","display_name":"Christian Meier","orcid":"https://orcid.org/0000-0002-0619-821X","observed_orcids":["https://orcid.org/0000-0002-0619-821X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Meier","raw_affiliation_strings":["Division of Endocrinology (J.J.S., C.M., C.M., M.G.), CH-4031 Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (J.J.S., C.M., C.M., M.G.), CH-4031 Basel, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029646876","display_name":"Cristina Mitrache","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Mitrache","raw_affiliation_strings":["Division of Endocrinology (J.J.S., C.M., C.M., M.G.), CH-4031 Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (J.J.S., C.M., C.M., M.G.), CH-4031 Basel, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089670837","display_name":"Merih Guglielmetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merih Guglielmetti","raw_affiliation_strings":["Division of Endocrinology (J.J.S., C.M., C.M., M.G.), CH-4031 Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (J.J.S., C.M., C.M., M.G.), CH-4031 Basel, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103409290","display_name":"Peter Huber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Huber","raw_affiliation_strings":["Department of Medicine and Central Laboratories (P.H.), University Hospital Basel, CH-4031 Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Central Laboratories (P.H.), University Hospital Basel, CH-4031 Basel, Switzerland;","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072728955","display_name":"Lewis E. Braverman","orcid":"https://orcid.org/0000-0003-1263-1099","observed_orcids":["https://orcid.org/0000-0003-1263-1099"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis E. Braverman","raw_affiliation_strings":["Brigham and Women\u2019s Hospital and Harvard Medical School (L.E.B.), Boston, Massachusetts 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital and Harvard Medical School (L.E.B.), Boston, Massachusetts 02118","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5065837820"],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":6.1056,"has_fulltext":true,"cited_by_count":417,"citation_normalized_percentile":{"value":0.97368421,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"87","issue":"7","first_page":"3221","last_page":"3226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subclinical-hypothyroidism","display_name":"subclinical hypothyroidism","score":1.0},{"id":"https://openalex.org/keywords/overt-hypothyroidism","display_name":"overt hypothyroidism","score":0.9380000233650208},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.8679999709129333},{"id":"https://openalex.org/keywords/trh-test","display_name":"TRH stimulation test","score":0.859000027179718},{"id":"https://openalex.org/keywords/anti-thyroid-peroxidase-antibodies","display_name":"thyroid peroxidase antibodies","score":0.871999979019165},{"id":"https://openalex.org/keywords/antimicrosomal-antibodies","display_name":"antimicrosomal antibodies","score":0.8880000114440918},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9399999976158142},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.8726425170898438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7861019968986511},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.673479437828064},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6531031131744385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6263052225112915},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5526663064956665},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4879452586174011},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.4825936555862427},{"id":"https://openalex.org/C180650514","wikidata":"https://www.wikidata.org/wiki/Q419502","display_name":"Thyroid peroxidase","level":3,"score":0.4552336037158966},{"id":"https://openalex.org/C50181227","wikidata":"https://www.wikidata.org/wiki/Q1943709","display_name":"Anti-thyroid autoantibodies","level":4,"score":0.4117826819419861},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3833184242248535},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.29959025979042053},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22120803594589233},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.086558997631073},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013959","descriptor_name":"Thyroid Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015993","descriptor_name":"Life Tables","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jc.87.7.3221","doi":"https://doi.org/10.1210/jc.87.7.3221","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.87.7.3221","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jcem.87.7.8678","doi":"https://doi.org/10.1210/jcem.87.7.8678","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.87.7.8678","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:12107228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12107228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310466","display_name":"Universit\u00e4t Basel","ror":"https://ror.org/02s6k3f65"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1545572940","https://openalex.org/W1970709107","https://openalex.org/W1971576580","https://openalex.org/W1976274614","https://openalex.org/W1992865180","https://openalex.org/W2007219542","https://openalex.org/W2011659584","https://openalex.org/W2024691000","https://openalex.org/W2026809390","https://openalex.org/W2032837942","https://openalex.org/W2063384143","https://openalex.org/W2064379780","https://openalex.org/W2066467884","https://openalex.org/W2066654051","https://openalex.org/W2078514644","https://openalex.org/W2085556990","https://openalex.org/W2087975771","https://openalex.org/W2094912659","https://openalex.org/W2097165278","https://openalex.org/W2120126551","https://openalex.org/W2133547068","https://openalex.org/W2142296338","https://openalex.org/W2148458830","https://openalex.org/W2152975528","https://openalex.org/W2175579169","https://openalex.org/W2253590988","https://openalex.org/W2285653157","https://openalex.org/W2314357784","https://openalex.org/W2317254357","https://openalex.org/W2602084316","https://openalex.org/W4232853842","https://openalex.org/W4234045237","https://openalex.org/W4243976325","https://openalex.org/W4249320909","https://openalex.org/W6733549539"],"related_works":["https://openalex.org/W2147034580","https://openalex.org/W1988454911","https://openalex.org/W4289731001","https://openalex.org/W2164170289","https://openalex.org/W2031519196","https://openalex.org/W2108071280","https://openalex.org/W2026270187","https://openalex.org/W1996812320","https://openalex.org/W1582651579","https://openalex.org/W4309878647"],"abstract_inverted_index":{"Subclinical":[0],"hypothyroidism":[1,54,87,113,147,187,190,242],"is":[2,20],"a":[3,25,57,178,195],"frequent":[4],"syndrome":[5],"affecting":[6],"about":[7],"10":[8,121,204],"million":[9],"people":[10],"in":[11,40,149,199,244],"the":[12,31,35,41,98,109,138,181,200,221,237,245],"United":[13],"States.":[14],"The":[15,82,143,206],"management":[16],"of":[17,37,43,61,85,108,111,145,180,183,208,223,240,247],"such":[18],"patients":[19,51,128,150,184,248],"open":[21],"to":[22,97,235,251,253],"debate.":[23],"In":[24],"long-term":[26,173],"prospective":[27,172],"study":[28,174,233],"we":[29],"analyzed":[30],"spontaneous":[32,238],"course":[33,239],"and":[34,74,93,117,161,193,213,243],"value":[36],"predictive":[38],"factors":[39],"development":[42,222],"overt":[44,86,112,146,189,224,254],"thyroid":[45,65,67,72,153,214,225],"failure.":[46],"We":[47],"studied":[48],"82":[49],"female":[50],"with":[52,129,151,185],"subclinical":[53,186,201,241],"prospectively":[55],"over":[56,191],"mean":[58],"observation":[59],"period":[60],"9.2":[62],"yr.":[63,205],"TSH,":[64,209],"hormones,":[66],"reserve":[68,154,215],"after":[69,120,203],"TRH":[70],"administration,":[71],"antibodies,":[73,212],"clinical":[75],"parameters":[76],"were":[77,114,136],"assessed":[78],"at":[79],"yearly":[80],"intervals.":[81],"cumulative":[83,139],"incidence":[84,110,140,144],"was":[88,141],"calculated":[89],"using":[90],"life-table":[91],"analysis":[92],"Kaplan-Meier":[94,106],"curves.":[95],"According":[96],"initial":[99,217],"serum":[100],"TSH":[101,130],"concentrations":[102],"(TSH,":[103],"4-6/>6-12/>12":[104],"mU/liter),":[105],"estimates":[107],"0%,":[115],"42.8%,":[116],"76.9%,":[118],"respectively,":[119],"yr":[122],"(P":[123],"<":[124],"0.0001).":[125],"When":[126],"only":[127,177],"levels":[131],"greater":[132],"than":[133],"6":[134],"mU/liter":[135],"analyzed,":[137],"55.3%.":[142],"increased":[148],"impaired":[152],"(52.6%":[155],"vs.":[156,166],"38.1%;":[157],"P":[158,168],"=":[159,169],"0.05)":[160],"positive":[162],"microsomal":[163,210],"antibodies":[164],"(58.5%":[165],"23.2%;":[167],"0.03).":[170],"This":[171],"demonstrates":[175],"that":[176,194],"part":[179],"cohort":[182],"develops":[188],"time":[192],"major":[196],"group":[197],"remains":[198],"state":[202],"measurement":[207],"(thyroperoxidase)":[211],"allows":[216],"risk":[218],"stratification":[219],"for":[220],"failure":[226],"(risk":[227],"ratio":[228],"ranging":[229],"from":[230],"1.0-15.6).":[231],"Our":[232],"helps":[234],"recognize":[236],"identification":[246],"most":[249],"likely":[250],"progress":[252],"hypothyroidism.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}