{"id":"https://openalex.org/W2018848631","doi":"https://doi.org/10.1007/s11095-010-0084-z","title":"Formulation Development and In Vivo Evaluation of a New Dry Powder Formulation of Albuterol Sulphate in Beagle Dogs","display_name":"Formulation Development and In Vivo Evaluation of a New Dry Powder Formulation of Albuterol Sulphate in Beagle Dogs","publication_year":2010,"publication_date":"2010-03-15","ids":{"openalex":"https://openalex.org/W2018848631","doi":"https://doi.org/10.1007/s11095-010-0084-z","mag":"2018848631","pmid":"https://pubmed.ncbi.nlm.nih.gov/20232119"},"language":"en","primary_location":{"id":"doi:10.1007/s11095-010-0084-z","doi":"https://doi.org/10.1007/s11095-010-0084-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11095-010-0084-z","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007070596","display_name":"Philip J. Kuehl","orcid":"https://orcid.org/0000-0002-7567-3002","observed_orcids":["https://orcid.org/0000-0002-7567-3002"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip J. Kuehl","raw_affiliation_strings":["Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, New Mexico, 87108, USA, pkuehl@lrri.org","Lovelace Respiratory Research Institute, Albuquerque, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, New Mexico, 87108, USA, pkuehl@lrri.org","institution_ids":["https://openalex.org/I1305258596"]},{"raw_affiliation_string":"Lovelace Respiratory Research Institute, Albuquerque, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073050363","display_name":"Edward G. Barrett","orcid":"https://orcid.org/0000-0003-0521-0683","observed_orcids":["https://orcid.org/0000-0003-0521-0683"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward G. Barrett","raw_affiliation_strings":["Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, New Mexico, 87108, USA","Lovelace Respiratory Research Institute, Albuquerque, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, New Mexico, 87108, USA","institution_ids":["https://openalex.org/I1305258596"]},{"raw_affiliation_string":"Lovelace Respiratory Research Institute, Albuquerque, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078271521","display_name":"Jacob D. McDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob D. McDonald","raw_affiliation_strings":["Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, New Mexico, 87108, USA","Lovelace Respiratory Research Institute, Albuquerque, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, New Mexico, 87108, USA","institution_ids":["https://openalex.org/I1305258596"]},{"raw_affiliation_string":"Lovelace Respiratory Research Institute, Albuquerque, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003556349","display_name":"Karin Rudolph","orcid":"https://orcid.org/0000-0003-3606-1983","observed_orcids":["https://orcid.org/0000-0003-3606-1983"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin Rudolph","raw_affiliation_strings":["Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, New Mexico, 87108, USA","Lovelace Respiratory Research Institute, Albuquerque, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, New Mexico, 87108, USA","institution_ids":["https://openalex.org/I1305258596"]},{"raw_affiliation_string":"Lovelace Respiratory Research Institute, Albuquerque, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053314890","display_name":"David T. Vodak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Vodak","raw_affiliation_strings":["Bend Research Inc., 64550 Research Road, Bend, Oregon, 97701-8599, USA","Bend Research Inc., Bend, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bend Research Inc., 64550 Research Road, Bend, Oregon, 97701-8599, USA","institution_ids":[]},{"raw_affiliation_string":"Bend Research Inc., Bend, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009588875","display_name":"Dan E. Dobry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Dobry","raw_affiliation_strings":["Bend Research Inc., 64550 Research Road, Bend, Oregon, 97701-8599, USA","Bend Research Inc., Bend, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bend Research Inc., 64550 Research Road, Bend, Oregon, 97701-8599, USA","institution_ids":[]},{"raw_affiliation_string":"Bend Research Inc., Bend, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009931009","display_name":"David K. Lyon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Lyon","raw_affiliation_strings":["Bend Research Inc., 64550 Research Road, Bend, Oregon, 97701-8599, USA","Bend Research Inc., Bend, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bend Research Inc., 64550 Research Road, Bend, Oregon, 97701-8599, USA","institution_ids":[]},{"raw_affiliation_string":"Bend Research Inc., Bend, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007070596"],"corresponding_institution_ids":["https://openalex.org/I1305258596"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":1.0631,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.79991058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"5","first_page":"894","last_page":"904"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-powder-inhalation","display_name":"dry powder inhalation","score":0.949999988079071},{"id":"https://openalex.org/keywords/pharmaceutical-excipients","display_name":"pharmaceutical excipients","score":0.4620000123977661},{"id":"https://openalex.org/keywords/aerosol-performance","display_name":"aerosol performance","score":0.7200000286102295},{"id":"https://openalex.org/keywords/fine-particle-fraction","display_name":"fine particle fraction","score":0.9829999804496765},{"id":"https://openalex.org/keywords/spray-drying","display_name":"spray drying","score":0.4860000014305115},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bronchodilation","display_name":"bronchodilation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ragweed-sensitization","display_name":"ragweed sensitization","score":0.8870000243186951},{"id":"https://openalex.org/keywords/allergic-airway-response","display_name":"allergic airway response","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bronchoconstriction","display_name":"bronchoconstriction","score":0.7889999747276306},{"id":"https://openalex.org/keywords/beagle","display_name":"beagle dogs","score":0.5899999737739563},{"id":"https://openalex.org/keywords/nebulizer-comparison","display_name":"nebulizer comparison","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.7939512729644775},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.7922111749649048},{"id":"https://openalex.org/C2777419714","wikidata":"https://www.wikidata.org/wiki/Q1334805","display_name":"Dry-powder inhaler","level":4,"score":0.7829002141952515},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5839060544967651},{"id":"https://openalex.org/C82085835","wikidata":"https://www.wikidata.org/wiki/Q16142045","display_name":"Aerosolization","level":3,"score":0.5660791993141174},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.5605548024177551},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.5559179186820984},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5331945419311523},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5311784744262695},{"id":"https://openalex.org/C2776820430","wikidata":"https://www.wikidata.org/wiki/Q21102","display_name":"Beagle","level":2,"score":0.5260488986968994},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5192584991455078},{"id":"https://openalex.org/C2779587474","wikidata":"https://www.wikidata.org/wiki/Q1066303","display_name":"Spray drying","level":2,"score":0.502525806427002},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.49712708592414856},{"id":"https://openalex.org/C2780352487","wikidata":"https://www.wikidata.org/wiki/Q2281580","display_name":"Nebulizer","level":2,"score":0.4418051838874817},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4412062466144562},{"id":"https://openalex.org/C2780261241","wikidata":"https://www.wikidata.org/wiki/Q1394363","display_name":"Inhaler","level":3,"score":0.3213493824005127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21379026770591736},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.1685943603515625},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.16374778747558594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003890","descriptor_name":"Desiccation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008170","descriptor_name":"Lung Compliance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009330","descriptor_name":"Nebulizers and Vaporizers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011208","descriptor_name":"Powders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031164","descriptor_name":"Ambrosia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11095-010-0084-z","doi":"https://doi.org/10.1007/s11095-010-0084-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11095-010-0084-z","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:20232119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20232119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1501179348","https://openalex.org/W1529163766","https://openalex.org/W1544968111","https://openalex.org/W1569422489","https://openalex.org/W1570863417","https://openalex.org/W1900004700","https://openalex.org/W1971144371","https://openalex.org/W2014275479","https://openalex.org/W2022302637","https://openalex.org/W2023920135","https://openalex.org/W2024889831","https://openalex.org/W2043883083","https://openalex.org/W2047356902","https://openalex.org/W2064250096","https://openalex.org/W2077703534","https://openalex.org/W2090370721","https://openalex.org/W2115979562","https://openalex.org/W2124335428","https://openalex.org/W2124990893","https://openalex.org/W2145002803","https://openalex.org/W2289538256","https://openalex.org/W2292413410","https://openalex.org/W2339972486"],"related_works":["https://openalex.org/W2622364700","https://openalex.org/W2128249345","https://openalex.org/W2339972486","https://openalex.org/W2883985160","https://openalex.org/W2559297959","https://openalex.org/W1970607021","https://openalex.org/W2033805909","https://openalex.org/W2944200769","https://openalex.org/W2359778671","https://openalex.org/W2017194640"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}