{"id":"https://openalex.org/W2018789062","doi":"https://doi.org/10.1080/10715760701834552","title":"New method for the detection of reactive oxygen species in anti-tumoural activity of adriamycin: A comparison between hypoxic and normoxic cells","display_name":"New method for the detection of reactive oxygen species in anti-tumoural activity of adriamycin: A comparison between hypoxic and normoxic cells","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2018789062","doi":"https://doi.org/10.1080/10715760701834552","mag":"2018789062","pmid":"https://pubmed.ncbi.nlm.nih.gov/18297605"},"language":"en","primary_location":{"id":"doi:10.1080/10715760701834552","doi":"https://doi.org/10.1080/10715760701834552","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10715760701834552","pdf_url":null,"source":{"id":"https://openalex.org/S23349031","display_name":"Free Radical Research","issn_l":"1029-2470","issn":["1029-2470","1071-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084847108","display_name":"Tareck Rharass","orcid":"https://orcid.org/0000-0001-9406-1776","observed_orcids":["https://orcid.org/0000-0001-9406-1776"]},"institutions":[{"id":"https://openalex.org/I151295451","display_name":"Universit\u00e9 de Perpignan","ror":"https://ror.org/03am2jy38","country_code":"FR","type":"education","lineage":["https://openalex.org/I151295451"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Tareck Rharass","raw_affiliation_strings":["Universit\u00e9 de Perpignan Via Domitia, Institut de Mod\u00e9lisation et d'Analyses en G\u00e9o-Environnements et Sant\u00e9, Perpignan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Perpignan Via Domitia, Institut de Mod\u00e9lisation et d'Analyses en G\u00e9o-Environnements et Sant\u00e9, Perpignan, France","institution_ids":["https://openalex.org/I151295451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111723992","display_name":"Jean Vigo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151295451","display_name":"Universit\u00e9 de Perpignan","ror":"https://ror.org/03am2jy38","country_code":"FR","type":"education","lineage":["https://openalex.org/I151295451"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Vigo","raw_affiliation_strings":["Universit\u00e9 de Perpignan Via Domitia, Institut de Mod\u00e9lisation et d'Analyses en G\u00e9o-Environnements et Sant\u00e9, Perpignan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Perpignan Via Domitia, Institut de Mod\u00e9lisation et d'Analyses en G\u00e9o-Environnements et Sant\u00e9, Perpignan, France","institution_ids":["https://openalex.org/I151295451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111872395","display_name":"Jean\u2010Marie Salmon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151295451","display_name":"Universit\u00e9 de Perpignan","ror":"https://ror.org/03am2jy38","country_code":"FR","type":"education","lineage":["https://openalex.org/I151295451"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Marie Salmon","raw_affiliation_strings":["Universit\u00e9 de Perpignan Via Domitia, Institut de Mod\u00e9lisation et d'Analyses en G\u00e9o-Environnements et Sant\u00e9, Perpignan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Perpignan Via Domitia, Institut de Mod\u00e9lisation et d'Analyses en G\u00e9o-Environnements et Sant\u00e9, Perpignan, France","institution_ids":["https://openalex.org/I151295451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075220948","display_name":"Anne\u2010C\u00e9cile Ribou","orcid":"https://orcid.org/0000-0002-0013-395X","observed_orcids":["https://orcid.org/0000-0002-0013-395X"]},"institutions":[{"id":"https://openalex.org/I151295451","display_name":"Universit\u00e9 de Perpignan","ror":"https://ror.org/03am2jy38","country_code":"FR","type":"education","lineage":["https://openalex.org/I151295451"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Anne-Cecile Ribou","raw_affiliation_strings":["Universit\u00e9 de Perpignan Via Domitia, Institut de Mod\u00e9lisation et d'Analyses en G\u00e9o-Environnements et Sant\u00e9, Perpignan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Perpignan Via Domitia, Institut de Mod\u00e9lisation et d'Analyses en G\u00e9o-Environnements et Sant\u00e9, Perpignan, France","institution_ids":["https://openalex.org/I151295451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075220948"],"corresponding_institution_ids":["https://openalex.org/I151295451"],"apc_list":null,"apc_paid":null,"fwci":2.206,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.85770751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"42","issue":"2","first_page":"124","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hyperbaric-oxygen-therapy","display_name":"hyperbaric oxygen therapy","score":0.824999988079071},{"id":"https://openalex.org/keywords/ccrf-cem-cells","display_name":"CCRF-CEM cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/1-pyrenebutyric-acid","display_name":"1-pyrenebutyric acid","score":0.8799999952316284},{"id":"https://openalex.org/keywords/fluorescence-lifetime","display_name":"fluorescence lifetime","score":0.9589999914169312},{"id":"https://openalex.org/keywords/semiquinone-radicals","display_name":"semiquinone","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.882914125919342},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6657472252845764},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.660661518573761},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.6225751638412476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6117238402366638},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5630675554275513},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5184426307678223},{"id":"https://openalex.org/C2776370595","wikidata":"https://www.wikidata.org/wiki/Q3955012","display_name":"Semiquinone","level":3,"score":0.49280646443367004},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.48963743448257446},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.48603612184524536},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42991921305656433},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4172939956188202},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3722723126411438},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35711658000946045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31416749954223633},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.25033140182495117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20140090584754944},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.136962890625},{"id":"https://openalex.org/C2780643102","wikidata":"https://www.wikidata.org/wiki/Q412382","display_name":"Quinone","level":2,"score":0.07247978448867798},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011721","descriptor_name":"Pyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/10715760701834552","doi":"https://doi.org/10.1080/10715760701834552","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10715760701834552","pdf_url":null,"source":{"id":"https://openalex.org/S23349031","display_name":"Free Radical Research","issn_l":"1029-2470","issn":["1029-2470","1071-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research","raw_type":"journal-article"},{"id":"pmid:18297605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18297605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W110291667","https://openalex.org/W1495659193","https://openalex.org/W1503662436","https://openalex.org/W1538846621","https://openalex.org/W1585518597","https://openalex.org/W1632979324","https://openalex.org/W1969624951","https://openalex.org/W1970514669","https://openalex.org/W1977441340","https://openalex.org/W1987732969","https://openalex.org/W1993614010","https://openalex.org/W1997208169","https://openalex.org/W2009186000","https://openalex.org/W2010183849","https://openalex.org/W2021381932","https://openalex.org/W2025595360","https://openalex.org/W2032039966","https://openalex.org/W2032842235","https://openalex.org/W2038945950","https://openalex.org/W2039149747","https://openalex.org/W2039207179","https://openalex.org/W2042029389","https://openalex.org/W2047785585","https://openalex.org/W2056842005","https://openalex.org/W2064484287","https://openalex.org/W2086969755","https://openalex.org/W2098712005","https://openalex.org/W2106926141","https://openalex.org/W2112530582","https://openalex.org/W2114762265","https://openalex.org/W2122347701","https://openalex.org/W2125257427","https://openalex.org/W2160664732","https://openalex.org/W2162355751","https://openalex.org/W2165623186","https://openalex.org/W2171074980","https://openalex.org/W2394623002","https://openalex.org/W2409607298","https://openalex.org/W2414738121"],"related_works":["https://openalex.org/W6991686809","https://openalex.org/W101031448","https://openalex.org/W2069421701","https://openalex.org/W1828898949","https://openalex.org/W1970040025","https://openalex.org/W2075530229","https://openalex.org/W7064602070","https://openalex.org/W2909413347","https://openalex.org/W2155879824","https://openalex.org/W2057918838"],"abstract_inverted_index":{"Tumour":[0],"hypoxia":[1,110],"plays":[2],"a":[3,94],"role":[4],"in":[5,7,78,141],"chemoresistance":[6],"several":[8],"human":[9],"tumours.":[10],"However,":[11],"how":[12],"hyperbaric":[13],"oxygen":[14,28,115],"leads":[15],"to":[16,55,82,98,145],"chemotherapeutic":[17],"gain":[18],"is":[19],"unclear.":[20],"This":[21],"study":[22],"investigates":[23],"the":[24,61,104,121],"relation":[25],"of":[26,35,64,125,133,148],"reactive":[27],"species":[29],"(ROS)":[30],"generation":[31],"with":[32],"anti-tumoural":[33],"effect":[34],"adriamycin":[36],"(ADR)":[37],"on":[38],"CCRF-CEM":[39],"cells":[40,80],"under":[41,109],"hypoxic":[42,83],"(2%":[43],"O(2))":[44,48],"and":[45,111,116],"normoxic":[46,79,142],"(21%":[47],"conditions.":[49],"A":[50],"new":[51],"method":[52],"was":[53],"used":[54],"measure":[56],"intracellular":[57],"ROS":[58,76,89,117,139],"variations":[59],"through":[60],"fluorescence":[62],"lifetime":[63],"1-pyrenebutyric":[65],"acid.":[66],"At":[67],"24":[68],"h,":[69],"ADR,":[70],"probably":[71],"via":[72],"semiquinone":[73],"radical,":[74],"enhances":[75],"levels":[77],"compared":[81],"cells.":[84],"Long-term":[85],"studies":[86],"show":[87],"that":[88,114,130],"are":[90],"also":[91],"generated":[92],"by":[93],"second":[95],"mechanism":[96],"related":[97],"cell":[99,105,149],"functions":[100],"perturbation.":[101],"ADR":[102,134],"arrests":[103],"cycle":[106],"progression":[107],"both":[108],"normoxia,":[112],"indicating":[113],"does":[118],"not":[119],"influence":[120],"DNA":[122],"damaging":[123],"activity":[124],"ADR.":[126],"The":[127],"findings":[128],"reveal":[129],"moderate":[131],"improvement":[132],"cytotoxicity":[135],"results":[136],"from":[137],"higher":[138],"formation":[140],"cells,":[143],"leading":[144],"elevated":[146],"induction":[147],"death.":[150]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}