{"id":"https://openalex.org/W2018788139","doi":"https://doi.org/10.1289/ehp.00108413","title":"Metallothionein Isoform 3 as a Potential Biomarker for Human Bladder Cancer","display_name":"Metallothionein Isoform 3 as a Potential Biomarker for Human Bladder Cancer","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2018788139","doi":"https://doi.org/10.1289/ehp.00108413","mag":"2018788139","pmid":"https://pubmed.ncbi.nlm.nih.gov/10811567","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1638035"},"language":"en","primary_location":{"id":"doi:10.1289/ehp.00108413","doi":"https://doi.org/10.1289/ehp.00108413","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.00108413","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1289/ehp.00108413","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033798889","display_name":"Mary Ann Sens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Sens","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009658338","display_name":"Seema Somji","orcid":"https://orcid.org/0000-0001-8044-5234","observed_orcids":["https://orcid.org/0000-0001-8044-5234"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Somji","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035575002","display_name":"D Lamm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Lamm","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068566357","display_name":"Scott H. Garrett","orcid":"https://orcid.org/0000-0002-4398-9213","observed_orcids":["https://orcid.org/0000-0002-4398-9213"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S H Garrett","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017287925","display_name":"Frank Slovinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Slovinsky","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J H Todd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J H Todd","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081166985","display_name":"Donald A. Sens","orcid":"https://orcid.org/0000-0002-7163-5236","observed_orcids":["https://orcid.org/0000-0002-7163-5236"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Sens","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, West Virginia 26506-9251, USA","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":6.0741,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.96407132,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"108","issue":"5","first_page":"413","last_page":"413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7730000019073486},{"id":"https://openalex.org/keywords/carcinoma-in-situ","display_name":"carcinoma in situ","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dysplastic-lesions","display_name":"dysplastic lesions","score":0.8809999823570251},{"id":"https://openalex.org/keywords/interstitial-cystitis","display_name":"interstitial cystitis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/metallothionein-expression","display_name":"metallothionein expression","score":0.6069999933242798},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.8543184399604797},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7039236426353455},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6340570449829102},{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.5457351803779602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5361660718917847},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5328645706176758},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5157673358917236},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4792482852935791},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.43494921922683716},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.41496366262435913},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.36773380637168884},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36501890420913696},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35211801528930664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31669485569000244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12440982460975647},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1289/ehp.00108413","doi":"https://doi.org/10.1289/ehp.00108413","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.00108413","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"doi:10.2307/3454381","doi":"https://doi.org/10.2307/3454381","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3454381","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:368052","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1638035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:10811567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10811567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health perspectives","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.9332","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.9332","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d2/49/Environ_Health_Perspect_2000_May_108(5)_413-418.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1289/ehp.00108413","doi":"https://doi.org/10.1289/ehp.00108413","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.00108413","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1501275346","https://openalex.org/W1614899370","https://openalex.org/W1970146654","https://openalex.org/W1972193357","https://openalex.org/W1972379271","https://openalex.org/W1975434454","https://openalex.org/W1980820931","https://openalex.org/W1983332449","https://openalex.org/W1995968305","https://openalex.org/W2017965740","https://openalex.org/W2027452172","https://openalex.org/W2034380688","https://openalex.org/W2041254257","https://openalex.org/W2045984025","https://openalex.org/W2058476332","https://openalex.org/W2084256240","https://openalex.org/W2116398096","https://openalex.org/W2138178697","https://openalex.org/W2140924728","https://openalex.org/W2143546229","https://openalex.org/W2401798203","https://openalex.org/W2405844409","https://openalex.org/W2500535367","https://openalex.org/W2622023820","https://openalex.org/W3191489173","https://openalex.org/W4250221563"],"related_works":["https://openalex.org/W7098116733","https://openalex.org/W7099479977","https://openalex.org/W2354826845","https://openalex.org/W2109275145","https://openalex.org/W2301590312","https://openalex.org/W279585842","https://openalex.org/W2352194386","https://openalex.org/W2126706413","https://openalex.org/W1975434454","https://openalex.org/W2118956613"],"abstract_inverted_index":{"The":[0,88,207,255],"goal":[1],"of":[2,12,36,56,72,90,190,202],"the":[3,10,32,68,94,203,210],"present":[4],"study":[5,236],"was":[6,97,144,162,196],"to":[7,66,173,200,228],"determine":[8],"if":[9],"expression":[11,35,71,92,186,195,259],"metallothionein":[13],"isoform":[14],"3":[15],"(MT-3)":[16],"might":[17,268],"serve":[18],"as":[19,198,226],"a":[20,54,188,217,221],"biomarker":[21,274],"for":[22,53,82,125,214,224,275],"human":[23,243],"bladder":[24,57,86,96,152,155,169,177,192,244,264,276],"cancer.":[25,277],"To":[26],"accomplish":[27],"this":[28,235,248],"goal,":[29],"we":[30],"defined":[31],"localization":[33,69],"and":[34,39,43,63,70,75,136,157,167,171,179,246],"MT-3":[37,73,83,91,103,116,126,143,160,184,215,225,239,258,267],"protein":[38,74,117],"mRNA":[40,104,185],"using":[41,109,118],"fresh":[42],"archival":[44,128],"biopsy":[45,129],"specimens":[46,130],"obtained":[47],"from":[48,131,209],"patients":[49,132],"undergoing":[50],"differential":[51],"diagnosis":[52],"variety":[55],"disorders.":[58,138],"We":[59,182],"used":[60],"immunohistochemistry,":[61],"immunoblot,":[62],"RT-PCR":[64,211],"analysis":[65,78,140],"define":[67],"mRNA.":[76],"Immunohistochemical":[77,139],"disclosed":[79,122],"no":[80,123],"immunoreactivity":[81,124],"in":[84,93,127,146,148,164,175,187,242,262],"normal":[85,95,263],"cells.":[87],"absence":[89],"further":[98],"confirmed":[99],"by":[100],"demonstrating":[101],"that":[102,142,201,238,247,257,266],"could":[105],"not":[106],"be":[107,269],"detected":[108],"reverse":[110],"transcriptase-polymerase":[111],"chain":[112],"reaction":[113,212],"(RT-PCR)":[114],"or":[115],"immunoblot.":[119],"Immunohistochemistry":[120],"also":[121],"with":[133,251],"interstitial":[134],"cystitis":[135],"related":[137],"demonstrated":[141],"expressed":[145],"carcinoma":[147],"situ":[149],"(CIS),":[150],"high-grade":[151,168],"cancer,":[153,156,170],"low-grade":[154,176],"dysplastic":[158,180],"lesions.":[159,181],"immunostaining":[161],"intense":[163],"both":[165],"CIS":[166],"low":[172],"moderate":[174],"cancer":[178,193,245],"determined":[183],"subset":[189],"these":[191],"specimens;":[194],"elevated":[197],"compared":[199,227],"housekeeping":[204],"gene,":[205],"ss-actin.":[206],"cDNA":[208],"primed":[213],"contained":[216],"FokI":[218],"restriction":[219],"site,":[220],"site":[222],"unique":[223],"other":[229],"MT":[230],"family":[231],"members.":[232],"In":[233],"conclusion,":[234],"demonstrates":[237],"is":[240,260],"up-regulated":[241],"up-regulation":[249],"increases":[250],"increasing":[252],"tumor":[253],"grade.":[254],"finding":[256],"minimal":[261],"suggests":[265],"developed":[270],"into":[271],"an":[272],"effective":[273]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}