{"id":"https://openalex.org/W2018786368","doi":"https://doi.org/10.1007/s40268-014-0040-1","title":"The Effects of Moxifloxacin on QTc Interval in Healthy Korean Male Subjects","display_name":"The Effects of Moxifloxacin on QTc Interval in Healthy Korean Male Subjects","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W2018786368","doi":"https://doi.org/10.1007/s40268-014-0040-1","mag":"2018786368","pmid":"https://pubmed.ncbi.nlm.nih.gov/24691742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4070463"},"language":"en","primary_location":{"id":"doi:10.1007/s40268-014-0040-1","doi":"https://doi.org/10.1007/s40268-014-0040-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40268-014-0040-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40268-014-0040-1.pdf","source":{"id":"https://openalex.org/S35266406","display_name":"Drugs in R&D","issn_l":"1174-5886","issn":["1174-5886","1179-6901"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs in R&amp;D","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s40268-014-0040-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027946569","display_name":"Seol Ju Moon","orcid":"https://orcid.org/0000-0001-6484-2029","observed_orcids":["https://orcid.org/0000-0001-6484-2029"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seol Ju Moon","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101419216","display_name":"Jong-Tae Lee","orcid":"https://orcid.org/0000-0002-6132-897X","observed_orcids":["https://orcid.org/0000-0002-6132-897X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jongtae Lee","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089819378","display_name":"Hyungmi An","orcid":"https://orcid.org/0000-0002-4148-8423","observed_orcids":["https://orcid.org/0000-0002-4148-8423"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyungmi An","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","Department of Statistics, Seoul National University, Seoul, Korea","Seoul National University","Seoul National University College of Medicine and Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Statistics, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Seoul National University","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Seoul National University College of Medicine and Hospital","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026322975","display_name":"Dong\u2010Seok Yim","orcid":"https://orcid.org/0000-0003-2754-7500","observed_orcids":["https://orcid.org/0000-0003-2754-7500"]},"institutions":[{"id":"https://openalex.org/I4210160144","display_name":"The Catholic University of Korea Seoul St. Mary's Hospital","ror":"https://ror.org/056cn0e37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210160144","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Seok Yim","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary\u2019s Hospital, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary\u2019s Hospital, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005301507","display_name":"Jae\u2010Yong Chung","orcid":"https://orcid.org/0000-0003-4188-2786","observed_orcids":["https://orcid.org/0000-0003-4188-2786"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Yong Chung","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, 300 Gumi-dong, Bundang-gu, Songnam, Gyeonggi-do, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Songnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, 300 Gumi-dong, Bundang-gu, Songnam, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Songnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108129595","display_name":"Kyung-Sang Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung-Sang Yu","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022675590","display_name":"Joo\u2010Youn Cho","orcid":"https://orcid.org/0000-0001-9270-8273","observed_orcids":["https://orcid.org/0000-0001-9270-8273"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joo-Youn Cho","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111863519","display_name":"Kyoung Soo Lim","orcid":"https://orcid.org/0009-0007-6603-2397","observed_orcids":["https://orcid.org/0009-0007-6603-2397"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyoung Soo Lim","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5111863519"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":0.6853,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74737363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"2","first_page":"63","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moxifloxacin","display_name":"moxifloxacin","score":1.0},{"id":"https://openalex.org/keywords/qtc-interval","display_name":"QTc interval","score":0.7879999876022339},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/positive-control","display_name":"positive control","score":0.6919999718666077},{"id":"https://openalex.org/keywords/thorough-qt-study","display_name":"thorough QT study","score":0.6700000166893005},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7789999842643738},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.5789999961853027},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cardiac-safety","display_name":"cardiac safety","score":0.8100000023841858},{"id":"https://openalex.org/keywords/korean-population","display_name":"Korean population","score":0.6060000061988831},{"id":"https://openalex.org/keywords/fluoroquinolones","display_name":"fluoroquinolones","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2778836808","wikidata":"https://www.wikidata.org/wiki/Q424940","display_name":"Moxifloxacin","level":3,"score":0.9962561726570129},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.8249877691268921},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7808167934417725},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7183682918548584},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5782121419906616},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5534994006156921},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5217498540878296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4758721888065338},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3554455637931824},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0979316234588623},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077266","descriptor_name":"Moxifloxacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s40268-014-0040-1","doi":"https://doi.org/10.1007/s40268-014-0040-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40268-014-0040-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40268-014-0040-1.pdf","source":{"id":"https://openalex.org/S35266406","display_name":"Drugs in R&D","issn_l":"1174-5886","issn":["1174-5886","1179-6901"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs in R&amp;D","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4070463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4070463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs R D","raw_type":"Text"},{"id":"pmid:24691742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24691742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs in R&D","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1007/s40268-014-0040-1","doi":"https://doi.org/10.1007/s40268-014-0040-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40268-014-0040-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40268-014-0040-1.pdf","source":{"id":"https://openalex.org/S35266406","display_name":"Drugs in R&D","issn_l":"1174-5886","issn":["1174-5886","1179-6901"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs in R&amp;D","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018786368.pdf","grobid_xml":"https://content.openalex.org/works/W2018786368.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W43308025","https://openalex.org/W206536517","https://openalex.org/W1498633049","https://openalex.org/W1512187315","https://openalex.org/W1513638558","https://openalex.org/W1975763725","https://openalex.org/W2035777806","https://openalex.org/W2081818774","https://openalex.org/W2112294291","https://openalex.org/W2132333355","https://openalex.org/W2174038367","https://openalex.org/W4292004352"],"related_works":["https://openalex.org/W7098183944","https://openalex.org/W2146869109","https://openalex.org/W2087694690","https://openalex.org/W1984220118","https://openalex.org/W1975763725","https://openalex.org/W2612515572","https://openalex.org/W2566546405","https://openalex.org/W1524573729","https://openalex.org/W1512187315","https://openalex.org/W2152867084"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVE:":[2],"Moxifloxacin":[3,201],"400":[4,154,202,218],"mg":[5,203,219],"is":[6,204],"a":[7,50,78,183,229],"widely":[8],"used":[9,222],"positive":[10,51,184,207],"control":[11,208],"in":[12,21,37,209,231],"thorough":[13],"QT":[14,103],"(TQT)":[15],"studies,":[16],"but":[17],"its":[18],"QT-prolonging":[19],"effects":[20],"Korean":[22,38,210,232],"subjects":[23,39,58,125],"have":[24],"not":[25,171],"been":[26],"studied.":[27],"The":[28,129,161],"present":[29],"study":[30,73],"was":[31,82,182],"conducted":[32,91],"to":[33,43,223],"collect":[34],"pilot":[35],"data":[36],"after":[40,92,112,137],"moxifloxacin":[41,48,95,113,188,217],"administration":[42,114],"evaluate":[44,224],"the":[45,127,177,225],"adequacy":[46],"of":[47,123,150,168,176,228],"as":[49],"control.":[52],"METHODS:":[53],"Thirty-eight,":[54],"healthy,":[55],"Korean,":[56],"male":[57],"were":[59,90,106,110,118,198],"recruited":[60],"for":[61],"pharmacokinetic":[62],"(PK)":[63],"blood":[64],"sampling":[65],"and":[66,84,115,156,163,190],"electrocardiography":[67],"(ECG)":[68],"recordings":[69,89],"at":[70,174],"three":[71],"different":[72],"sites.":[74],"On":[75],"day":[76,86],"1,":[77],"baseline":[79],"12-lead":[80],"ECG":[81,88],"recorded,":[83],"on":[85],"2,":[87],"placebo,":[93],"or":[94,97],"400-":[96],"800-mg":[98],"administration.":[99],"Baseline-corrected,":[100],"placebo-adjusted,":[101],"corrected":[102,143],"(\u0394\u0394QTc)":[104],"values":[105,149],"calculated.":[107],"Blood":[108],"samples":[109],"collected":[111],"PK":[116,196],"parameters":[117],"assessed.":[119],"RESULTS:":[120],"A":[121],"total":[122],"33":[124],"completed":[126],"study.":[128],"largest":[130],"time-matched":[131],"\u0394\u0394QTc":[132],"occurred":[133],"approximately":[134],"4":[135],"h":[136],"dosing,":[138],"with":[139],"\u0394\u0394QTcI":[140,169,191],"(QT":[141],"interval":[142],"by":[144],"individual":[145],"QT-RR":[146],"regression":[147],"model)":[148],"11.66":[151],"ms":[152,158],"(moxifloxacin":[153],"mg)":[155],"20.96":[157],"(800":[159],"mg).":[160],"mean":[162],"90":[164],"%":[165],"confidence":[166],"intervals":[167],"did":[170],"include":[172],"zero":[173],"any":[175],"measurement":[178],"time":[179],"points.":[180],"There":[181],"correlation":[185],"between":[186],"plasma":[187],"concentration":[189],"(r":[192],"=":[193],"0.422).":[194],"Dose-proportional":[195],"profiles":[197],"observed.":[199],"CONCLUSION:":[200],"an":[205],"adequate":[206],"TQT":[211],"studies.":[212],"Our":[213],"results":[214],"indicate":[215],"that":[216],"can":[220],"be":[221],"cardiac":[226],"safety":[227],"drug":[230],"subjects.":[233]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
